MITCHELL, Joseph Stanley v2

MITCHELL_JOSEPH_STANLEY_Vol1_v2

Catalogue of the papers and correspondence of JOSEPH STANLEY MITCHELL FRS (1909 - 1987) Compiled by Timothy E. Powell and Peter Harper VOLUME I List of Contents General Introduction Sections A - E Deposited in Cambridge University Library 1992 All rights reserved University of Bath NCUACS 36/4/92 NCUACS 36/4/92 J.S. Mitchell The work of the National Cataloguing Unit for the Archives of Contemporary Scientists, and the production of this catalogue, are made possible by the support of the following societies and organisations: The Biochemical Society The British Library British Petroleum plc The Geological Society The Institute of Physics The Royal Society The Royal Society of Chemistry The Society of Chemical Industry The Wellcome Trust NCUACS 36/4/92 J.S. Mitchell NOT ALL THE MATERIAL IN THE COLLECTION IS YET AVAILABLE FOR CONSULTATION. ENQUIRIES SHOULD BE ADDRESSED IN THE FIRST INSTANCE TO: KEEPER OF MANUSCRIPTS AND UNIVERSITY ARCHIVES CAMBRIDGE UNIVERSITY LIBRARY CAMBRIDGE NCUACS 36/4/92 J.S. Mitchell LIST OF CONTENTS GENERAL INTRODUCTION SECTION A BIOGRAPHICAL SECTION B CAMBRIDGE B.1-B.1054 SECTION C NOTEBOOKS C.1-C.134 SECTION D RESEARCH D.1-D.595 E.1-E.147 F.1-F.467 G.1-G.101 SECTION F SECTION H CORRESPONDENCE H.1-H.500 SECTION E SECTION G VISITS AND CONFERENCES SOCIETIES AND ORGANISATIONS PUBLICATIONS, LECTURES AND BROADCASTS INDEX OF CORRESPONDENTS NCUACS 36/4/92 J.S. Mitchell GENERAL INTRODUCTION PROVENANCE The papers were received in September 1987 and July and November 1988 from the estate of Professor J.S. Mitchell. OUTLINE OF THE CAREER OF J.S. MITCHELL Joseph Stanley Mitchell was born in Birmingham on 22 July 1909. He was educated at local schools until the age of 12 when he won a scholarship to the King Edward VI High School. In 1926 Mitchell won a State Scholarship to Birmingham University and in 1928 an Entrance Scholarship to St John’s College Cambridge. He took a First Class in each part of the Natural Sciences Tripos, specialising in physics in Part Il. He had decided on a career in medicine at an early age and therefore also took the examinations in pre-clinical subjects which would allow him to take the Cambridge MB and BChir after completing his postgraduate clinical training. Mitchell returned to Birmingham in 1931 for this in 1943 with the opening of a Radiotherapeutic Centre at Addenbrooke’s Hospital. In 1944, at the request of J.D. Cockcroft, Mitchell joined the British and Canadian Atomic Energy working with radiations and to direct the Project’s medical programme. At the end of 1945 Mitchell returned to Cambridge to take up the Chair in Radiotherapeutics within the newly established School awarded his PhD in 1937. He was then elected to a Research Fellowship at St John’s College. training. He was awarded the Cambridge MB and BChir in 1934 and after a period as house physician at the General Hospital, Birmingham, began research for his PhD on the irradiation of thin protein films under E.K. Rideal at the Colloid Science Laboratory at Cambridge. Mitchell was Project at Chalk River, Canada. He was asked to investigate radiobiological hazards to those Radiotherapy in the Cambridge University Department of Medicine. This post was made permanent In 1938 Mitchell began his first clinical work in radiotherapy, initially as Resident Radiological Officer at the Christie Hospital and Holt Radium Institute, Manchester, then as Assistant in Research in at Addenbrooke’s Hospital which had been set up in 1943. of Clinical Research and Postgraduate Teaching, and the Directorship of the Radiotherapeutic Centre NCUACS 36/4/92 J.S. Mitchell In 1957 Mitchell succeeded Sir Lionel Whitby as Regius Professor of Physic. Despite the onerous administrative duties this imposed he remained active as Director of the Radiotherapeutic Centre and continued his full-time research in the Department of Radiotherapeutics, of which he also remained head. As Regius Professor Mitchell was instrumental in building up the School of Clinical Research and Postgraduate Teaching. He also argued for the establishment in Cambridge of a complementary pre-graduate clinical school in order that Cambridge medical students should not have to go to London teaching hospitals to receive their clinical training. His efforts were rewarded when in 1968 the Royal Commission on Medical Education recommended that a clinical school be established at Cambridge, largely on the basis of the strength of the existing Medical School. The School of Clinical Medicine opened its doors to students in 1976. Mitchell resigned from the Regius Chair a year early in 1975 to allow his successor W.J.H. (later Sir John) Butterfield to preside over the new School from the start and resumed his Professorship of Radiotherapeutics for a year. After retirement from the Chair Mitchell continued work, supported by funds from the Professor J.S. Mitchell Cancer Research Fund, and was an active researcher until his death in 1987. Among the honours accorded to Mitchell were the CBE in 1951, election to the Fellowship of the Royal Society in 1952 (serving on Council 1955-57) and an Honorary D.Sc. from Birmingham University in 1958. He delivered the Dunham Lectures at Harvard University and the Withering received the Pirogoff Medal of the USSR Academy of Medical Sciences. He was elected a Fellow National Science Academy in 1974. biophysics of protein monolayers. From the late 1930s he began to investigate ionising radiations, his first paper on this subject being published in 1940 (‘Wave length effect in the reaction of human skin to x- and gamma-radiation’, Nature, Lond. 145, 105-107). On his move to Chalk River in 1944 effects of fast and thermal neutrons. His interest in this area led to his service on a number of Lectures at Birmingham University in 1958, the Silvanus Thompson Lecture at the Royal Institute of Radiology in 1968 and the Linacre Lecture at St John’s College Cambridge in 1970. In 1967 Mitchell Mitchell’s early research was carried out at the Colloid Science Laboratory under Rideal on the of the Royal Colleges of Physicians, Radiology and Surgery and a Foreign Fellow of the Indian to assist the British and Canadian Atomic Energy Project Mitchell began to study the biological radiotherapy. Canada Mitchell also made one of his most significant contributions to cancer research - the recommendation (with J.V. Dunworth) that the radioisotope cobalt-60 was suitable for use in Medical Research Council, Ministry of Supply and Ministry of Health committees which continued after his active research into biological effects of fast and thermal neutrons had ceased. While in NCUACS 36/4/92 J.S. Mitchell On his return to Cambridge and his appointment to the Chair of Radiotherapeutics Mitchell’s research concentrated on attempts to develop radiotherapeutic techniques to cure cancer. In 1946 he began to investigate the use of radiosensitising drugs as anti-cancer agents. It appeared that certain drugs concentrated in malignant cells and rendered them more sensitive to ionising radiations. Mitchell’s team found that synkavit, menadiol sodium diphosphate, seemed effective against certain tumours and clinical trials began in 1952. Mitchell then began work on the development of a radioactive drug by modifying the radiosensitising drug to enable it to carry its own source of radiation to the malignant tissue. The radiation source selected was tritium and trials with tritiated synkavit were started in 1959 and continued into the 1970s. The next step was to investigate whether an isotope more effective than tritium could be found and Mitchell was studying this at his death. In 1946 Mitchell and his colleague L.H. Gray had prepared a paper for the Medical Research Council on the radiotherapeutic use of high energy beta and gamma radiations. In 1949 Mitchell’s Department of Radiotherapeutics received one of the two 30 Mev synchrotrons funded by the Medical Research Council. Although the machine was not used to treat as many patients as was hoped, the synchrotron gave Mitchell and his team valuable experience of the effectiveness of high energy radiations. Later Mitchell pioneered the use of randomised trials to assess the efficacy of different kinds of treatment. The King’s College Hospital London - Addenbrooke’s Hospital DESCRIPTION OF THE COLLECTION collection covers almost all aspects of Mitchell’s professional career. psychological factors might play in the treatment of cancer. The material is presented in the order given in the List of Contents. This large and comprehensive treatment of this form of cancer. Mitchell was also among the first to consider the part that Cambridge Breast Trial of therapy for ‘early’ breast cancer, which Mitchell helped organise, was one of the first of its kind and led the way to larger scale trials which have significantly improved the proclaiming ‘The aim of this department is to improve the treatment of cancer’. Section A, Biographical, consists principally of Mitchell’s own biographical records of his career, and family and personal correspondence. It includes summaries by Mitchell of his research activities, and an album used for newspaper cuttings and other memorabilia relating to the Radiotherapeutic Centre and Department of Radiotherapeutics. At A.84 is the notice displayed in the Department NCUACS 36/4/92 J.S. Mitchell Section B, Cambridge, is the largest in the collection. The very substantial material is presented in four subsections: (1) the Department of Radiotherapeutics/Radiotherapeutic Centre; (2) Addenbrooke’s Hospital; (3) University of Cambridge; and (4) Lectures. The first subsection documents establishment and general administration, accommodation, staffing and equipment (synchrotron, linear accelerator etc) of the Department and the Centre, the funding of Mitchell’s research (especially the British Empire Cancer Campaign and Mitchell’s own Cancer Research Fund), and the future of the Department after Mitchell’s retirement in 1976. The second subsection documents Mitchell’s wide-ranging involvement in hospital affairs as head of the Department and Centre and as Regius Professor of Physic. Of particular interest are the extensive records relating to the development of the new Hills Road hospital site which was of great importance to Mitchell because of his plans for the University Medical School. The third subsection presents Mitchell’s Faculty Board of Medicine/Faculty Board of Clinical Medicine papers and his extensive Medical School files which document the development of the Postgraduate Medical School from his acceptance of the Regius Chair to the mid 1960s and the establishment of the pre-graduate Clinical School. This subsection also includes documentation of miscellaneous university boards, committees, departments, colleges and societies and Mitchell’s university examining. Of particular interest are the papers relating to the development of medical psychology in the Department of Medicine and those relating to the Cambridge Graduates’ Medical Club which include Mitchell’s annual reports on the Medical School. The final subsection brings together Mitchell’s departmental lectures (correspondence re arrangements, drafts, illustrative material etc) and documentation of conjunction with the hospital and Medical School. Section C comprises Notebooks, used by Mitchell for research notes, bibliographical notes, notes taken during visits and conferences, etc. Of particular interest are Mitchell’s research notebooks, as an undergraduate and during pre-clinical and clinical training, and later notebooks recording his bulky holding substantial quantities of additional material either intercalated loose or clipped to pages of the volume. This material is integral to the notebooks as Mitchell used them to ‘file’ papers courses and symposia for general medical practitioners and medical students organised in which cover the period 1926-81. They include some used by Mitchell at Birmingham and Cambridge work after the Second World War on radiosensitising and radioactive drugs. These are often very subject titles inscribed thereon. There are three subsections. The first is Mitchell’s early (1930s) Mitchell’s notebooks, from the early work under Rideal to his final clinical research project started in 1985. The bulk of the material was found in Mitchell’s own folders and envelopes, sometimes with Section D, Research, documents all aspects of Mitchell’s research, other than that recorded in relevant to his current research activities and may include correspondence, reprints, photographs, figures and graphs, and manuscript and typescript notes. NCUACS 36/4/92 J.S. Mitchell research. This chiefly relates to his investigations carried out at the Colloid Science Laboratory in Cambridge. The second subsection documents his research into the biochemistry of ionising radiations, particularly with reference to the health risks involved, chiefly carried out 1941-49. It includes work carried out while in Canada. The third subsection is the largest. It relates to Mitchell’s principal research activity - his effort to find a cure for cancer - and documents both his work as a scientist undertaking research into radiotherapeutic techniques and as a doctor treating patients with cancer. The material includes manuscript and typescript notes, reports by Mitchell and others, correspondence and memos, notes on the literature, data from experiments, patient records, notes on meetings with colleagues, protocols for and results of clinical trials etc. Also of interest is the material at D.98-D.104 relating to the sterilisation by radiation of foodstuffs and medicines. This arose out of ICI interest in this area in 1946. Mitchell felt the idea was worth pursuing and served on an informal group supporting such research. Section E, Publications, lectures and broadcasts, brings together material for some of Mitchell’s published papers, public lectures and broadcasts. It includes material on the 1984 WHO-IAEA compendium ‘Cobalt-60 teletherapy’ which Mitchell edited with M. Cohen. Also in this section are drafts, background material and correspondence relating to a planned book ‘Principles in Radiotherapeutic Oncology’, which Mitchell started but never completed. A set of Mitchell’s published papers is to be found at E.147. material includes committee papers, reports by Mitchell and others, notes and correspondence. The radiation, and attending a number of the British-US-Canadian Tripartite Conferences on the uses of Medical Research Council. Mitchell saw extensive service for the MRC from 1946, sitting on Section F, Societies and organisations, documents Mitchell’s association with 38 British, overseas nuclear energy. He also assisted, on behalf of the MRC, Danish investigations into thorotrast, a solution of thorium dioxide which had been widely used in Denmark for radiological investigations and international organisations. The organisation for which there is most documentation is the and which had been identified as a possible cause of illness in a number of patients. The MRC section also presents comprehensive documentation of the establishment and work of the Anglo- numerous committees and panels to advise on radiation hazards and the medical applications of Organisation. German Medical Society. Mitchell was a founder of the Society, formed in 1959 principally to promote contacts between academic and research doctors in UK and West Germany, and was President of the British Section to 1968. Other societies and organisations represented include the International Union Against Cancer, the Ministries of Health and Supply and the World Health NCUACS 36/4/92 J.S. Mitchell Section G, Visits and conferences, presents a chronological sequence, 1946-86, of some of Mitchell’s engagements, both in the UK and abroad. It includes Mitchell’s attendance at the first four United Nations Conferences on the Peaceful Uses of Atomic Power, held in 1955, 1958, 1964 and 1971. He made many visits to Germany, some of which are documented in the material relating to the Anglo-German Medical Society in Section F and others in the Notebooks Section. Section H, Correspondence, is a substantial section comprising Mitchell’s correspondence files arranged alphabetically, and subsections of shorter scientific correspondence arranged chronologically and references and appointments. The principal alphabetical sequence includes extended exchanges with a number of friends, colleagues and former students including J.D. Abbatt and E.D. Allen-Price, concerning radioactivity in water supplies in West Devon, G.D.H. Bell, concerning collaborative research into mutations in plants, G.C. de Hevesy, a friend of Mitchell’s from the 1940s, H. Langendorff, Director of the Radiological Institute at Freiburg University to which Mitchell was a frequent visitor, E. Marsden, concerning soil radioactivity, E.E. Pochin, who shared Mitchell’s interest in radiological protection, and G. Stein of the Hebrew University of Jerusalem. Also included here is correspondence and lectures material of C.L. Smith, Assistant Director of Research in the Radiotherapeutic Centre, some of whose papers were inherited by Mitchell on his death. ACKNOWLEDGEMENTS encouragement. There is also an index of correspondents. We are very grateful to Miss M.J. Crichton, Mitchell’s secretary 1954-76 and 1983-87, for her invaluable assistance in preparing the papers for transport to Bath and for her advice and 1992 Timothy E. Powell Peter Harper BATH NCUACS 36/4/92 J.S. Mitchell SECTION A BIOGRAPHICAL BIOGRAPHICAL AND BIBLIOGRAPHICAL A.15-A.38 CAREER, HONOURS AND AWARDS A.39-A.55 APPOINTMENT DIARIES FAMILY A.64-A.74 PERSONAL CORRESPONDENCE A.75-A.80 MISCELLANEOUS BIOGRAPHICAL MATERIAL A.81-A.84 NON-PRINT MATERIAL NCUACS 36/4/92 J.S. Mitchell BIOGRAPHICAL AND BIBLIOGRAPHICAL Memoir by D.H. Marrian, Biographical Memoirs of Fellows of the Royal Society, 34, 1988. The Times obituary, 24 February 1987. Daily Telegraph obituary by |. Brown (with 4pp typescript draft). Lancet obituary, 14 March 1987. Hospital Physicist’s Association Bulletin obituary by J.L. Haybittle (with 3pp typescript draft). Typescript drafts of obituaries for the British Journal of Radiology by N.M. Bleehen and J.L. Haybittle (5pp) and M. Cohen (1p). Curricula vitae. c.1958; c.1971; c.1975. 1974-82. 15 July 1944; 13 March 1949 (photocopy of staff file). Press profiles ‘Man who heads fight against cancer’, Cambridge Evening News, 1 July 1976 and ‘Boy who vowed to beat cancer’, Birmingham Mail, 28 July 1976. 1983-86. Requests for information from publishers of biographical source-books, 1974-86, with Mitchell’s entries. NCUACS 36/4/92 J.S. Mitchell Biographical information for Mitchell was elected to the Academy in 1974 (see A.30). Indian National Science Academy 1975. List of ‘Papers published by Professor J.S. Mitchell 1932-1987’, ‘List of major publications’ up to 1975, ‘Professor Joseph Mitchell Cancer Research Fund List of Publications’, 1977-81. ‘General statement Miscellaneous summaries of research activities: concerning publications of J.S. Mitchell’, 23 January 1959, ‘Statement of main aspects of original work’ c.1971, letter to L. Ehrenberg, 25 October 1973, on ‘some developments in radiotherapy ... with particular reference to the work of my Department’, ‘Researches to date ... Clinical and laboratory studies in relation to the treatment of patients with cancer’ post 1974. List of university and hospital ‘Committees on which JSM served’; list of staff files of Department of Radiotherapeutics, Radiotherapeutic Centre and Department of Medicine, 1947-76, and of Mitchell’s Research Laboratories, 1976-88; ‘List of staff, research workers, visitors etc’ at the Department of Radiotherapeutics and Radiotherapeutic Centre; index (incomplete) to Mitchell’s filing system. Testimonials from supporting Mitchell’s application for a Stokes Studentship. Wilkinson K.D. E.K. and CAREER, HONOURS AND AWARDS Album used for newspaper cuttings, photographs and other memorabilia re Mitchell, the Radiotherapeutic Centre, the Department of Radiotherapeutics and the Professor Joseph Mitchell Cancer Research Fund. Includes loose material intercalated. September 1937. Letters from Sir Arthur Hall to J.A. Ryle, and J.S.B. Stopford to H.R. Dean, May 1937, offering advice on medical research centres at which Mitchell could gain experience in radiation therapy; notice of appointment as resident Medical Officer, Christie Hospital & Holt Radium Institute, 21 Note of Mitchell’s election to fellowship of St. John’s College Cambridge, Nature, 16 May 1936; notification of renewal of fellowship for a further three years, 28 January 1939. Rideal November 1935 NCUACS 36/4/92 J.S. Mitchell Correspondence re renewal of Mitchell’s Beit Fellowship at Cambridge for a fourth year, May 1938. Invitation from J.A. Ryle to Mitchell ‘to join the Department of Medicine as Assistant in Research in Radiotherapy’, 30 September 1938; conditions of appointment, 28 June 1939. from Letter Pharmacology at Birmingham, with draft of Mitchell’s reply. Wilkinson, February 1939, K.D. re 8 Readership in The letter asks Mitchell for recommendations for suitable candidates and adds ‘I suppose there is no possibility of your thinking of the job’. Mitchell’s reply explains why he could not accept the post. Correspondence and papers re arrangements for move to Canada, 1944; note re maintaining contact with ‘Tube Alloys’ project in UK, May 1945. Mitchell was asked by J.D. Cockcroft to head medical investigations at the Montreal Laboratory of the National Research Council of Canada (the joint British and Canadian atomic energy project). He returned to Cambridge at the end of 1945. to 14 and February, Letters of congratulation on appointment to Chair in Radiotherapeutics at Cambridge the of Radiotherapeutic Centre of Addenbrooke’s Hospital, 12 August 1946. Directorship University, Letter of appointment as temporary head of the Medical Department, Atomic Energy Research Establishment, Harwell, 5 June 1946. Letter of appointment as Honorary Physician of Addenbrooke’s Hospital, 28 December 1946. Letter from Mitchell to R.H. Parker ‘to let you know that | am no longer prepared to consider resignation from the Honorary Directorship of the Radiotherapeutic Centre’, 23 February 1947. Election to Fellowship of the Royal Society, 1952. NCUACS 36/4/92 J.S. Mitchell A.23, A.24 Appointment to Regius Chair of Physic, Cambridge University, 1957. Correspondence re appointment, including Mitchell’s letter setting out the terms on which he would accept the appointment and letter of appointment from the Prime Minister’s office; notice of appointment, British Journal of Radiology, 30 (1957). Letters of congratulation. Letter re arrangements for award of Cambridge University MD to Mitchell, July 1957. Award of University of Birmingham Honorary DSc to Mitchell, 17 July 1958. Brief correspondence re offer of Chair in Radiotherapy at Birmingham University, November 1963. re extension of Radiotherapy with papers, 1974-75, re Mitchell’s United Correspondence and appointment in Cambridge Hospitals beyond the age of 65. Consultant Honorary 1971-76, papers, as Mitchell’s appointment as Election to Fellowship of Deutsche Rontgengesellschaft, 20 April 1967. Correspondence and Professor of Radiotherapeutics and Emeritus Professor of Physic. Mitchell retired from the Regius Chair in 1975, before his term of office expired, in order to allow his successor, Sir John Butterfield, time in which to prepare for the opening of the School of Clinical Medicine in October 1976. The Chair in Radiotherapeutics was then re-established for Mitchell 1975-76. notes for Mitchell’s speech at his retirement party (held in 1978). Election to Indian National Science Academy, 1974. Retirement from Chair of Radiotherapeutics, 1976. Includes manuscript NCUACS 36/4/92 J.S. Mitchell Offer of ‘Guest Professorship’ in Department of Radiation Therapy, Catholic University Medical College, Nijmegen, February 1979. Seventieth birthday, 1979. Includes photocopies of profiles of Mitchell from Strahlentherapie and Fortschritte auf dem Gebiete der Rontgenstrahlen Erganzungsband. Seventy-fifth birthday, 1984. Election to Fellowship of Vereinigung Deutscher Strahlenschutzarzte, 15 June 1984. Mitchell’s death. Letters of condolence. Miscellaneous correspondence re posthumous arrangements. APPOINTMENT DIARIES Order of service for Mitchell’s funeral, Cambridge Crematorium, 27 February 1987. ‘Thanksgiving Service for Joseph and Mary Mitchell’, Chapel of the Holy Spirit, Addenbrooke’s Hospital, 10 April 1987. Notice, order of service, ‘Address’ by Rev. Dr. F.W. Stephani, message from Sir John Butterfield read at the service. functions and conferences and notes of appointments. With the exception of A.55, a pocket diary, the following are all desk diaries. Most contain intercalated material, chiefly notices of meetings, NCUACS 36/4/92 J.S. Mitchell 1973. Loose papers intercalated include material re the celebration of the 30th Anniversary of the opening of the Radiotherapeutic Centre. NCUACS 36/4/92 J.S. Mitchell Pocket diary 1985-86. FAMILY A.56-A.60 Lilian Mary Mitchell (née Buxton), wife. Testimonials from Edinburgh University, 1924. Miscellaneous correspondence, 1976-82. British Medical Journal obituary of L.M. Mitchell, 5 March 1983; notice of memorial service. Letters of condolence. Christopher G.B. (‘Kit’) Mitchell, son. Janet Mitchell, daughter. List of those receiving cards for the memorial service. Other family material. NCUACS 36/4/92 J.S. Mitchell PERSONAL CORRESPONDENCE 1945, 1946 1957-64 1965-70, 1973 1974-78 1979-81 1982-84 1985 (1) 1985 (2) 1985 (3) 1986-87 Nd MISCELLANEOUS BIOGRAPHICAL MATERIAL Passports A.75 1946 A.76 1956 Correspondence re Cambridge Liberal Association, 1964, and South East Cambridgeshire Liberal Association, 1984-85. Mitchell was re-elected President of the S.E. Cambridgeshire Association in 1984. Brief correspondence re Animal Cancer Treatment Fund, 1976. Correspondence and papers re the Medical and Scientific Campaign for Soviet Jewry, 1977, and the International Campaign - Orlov & Shcharansky, 1984. Miscellaneous memorabilia. NCUACS 36/4/92 J.S. Mitchell NON-PRINT MATERIAL See also A.14 A.81-A.83 Photographs ‘Opening of Univ. Dept Radiotherapeutics & MRC Building by The Queen. 28 May 1962’. ‘BCRU [British Committee on Radiological Units] special meeting at NPL on 27 September 1978’. With key. Mitchell is not present. Mitchell with H.D. Franke, Cambridge, September 1979. Photographs of Mitchell, nd. Radiotherapeutic Centre staff. With key. Nd. This notice was displayed in the Department of Radiotherapeutics from Notice reading ‘The aim of this department is to improve the treatment of cancer’ (5%" x 18" wooden board). 1946. NCUACS 36/4/92 J.S. Mitchell SECTION B CAMBRIDGE B.1-B.1054 DEPARTMENT OF RADIOTHERAPEUTICS/ RADIOTHERAPEUTIC CENTRE With an introductory note. B.338-B.584 ADDENBROOKE’S HOSPITAL With an introductory note B.585-B.881 UNIVERSITY OF CAMBRIDGE B.882-B.1054 LECTURES NCUACS 36/4/92 J.S. Mitchell DEPARTMENT OF RADIOTHERAPEUTICS/RADIOTHERAPEUTIC CENTRE The Department of Radiotherapeutics (with the Radiotherapeutic Centre) was the focus of Mitchell’s clinical work, teaching and research from his return to Cambridge at the end of the Second World War to his Official retirement thirty years later. In a note on the work of the Department written in 1973 (B.26) Mitchell provides an account of the historical background: ‘The first official reference to the Department of Radiotherapeutics of the University of Cambridge was in the Report of the Inter-Departmental Committee on Medical Schools (The Goodenough Report), 1944, page 127, para.60. The relevant part of this is as follows: “The Council of the Senate has suggested that research and training units for specialists might be formed in experimental medicine, radiotherapy, and psychiatry, basing these units on an association between the hospital and the strong departments already existing in the University in the fundamental sciences of biochemistry, pathology, biology, physics and experimental psychology. So far as the latter departments are concerned, no university in Great Britain could offer greater advantages. The clinical side of the work would demand a large measure of help from Addenbrooke’s Hospital. We hope that the University and the governors of Addenbrooke’s Hospital will collaborate in establishing, as soon as facilities permit, the three units mentioned above.” This was in line with my own thinking. The Radiotherapeutic Centre of Addenbrooke’s Hospital had been founded on ist March 1943 with myself as Medical Officer on the hospital staff and the late D.E. Lea as Honorary Physicist. |! had, of course, worked in Addenbrooke’s Hospital as a member of Professor J.A. Ryle’s Department since | returned to Cambridge from Manchester in October 1938. The Chair and Department of Radiotherapeutics was started in January 1946. At a meeting in (?) 1944 in Professor [H.R.] Dean’s room to which | was invited, the founding of the Chair and department was discussed in some detail. At the suggestion of the late Professor D. Keilin, it was agreed that the scope of its work should include the study of the chemotherapy of cancer. | was then told that the Department would be started when | returned to Cambridge after the war. research are included in this subsection at B.327-B.337. The documentation is principally correspondence and papers exchanged with university and hospital authorities, colleagues and others relating to matters of departmental administration, the funding of Mitchell’s research and the future of the Department on Mitchell’s retirement in 1976. For convenience administrative matters relating to Mitchell’s post-retirement the of The Chair of Radiotherapeutics was a personal Chair for one tenure only. When | became Regius Professor of Physic in 1957, it was agreed that | should remain Head of the University Department of Radiotherapeutics and Honorary Director of the Radiotherapeutic Centre, in addition to becoming Head of Radiotherapeutics was suppressed by Grace.’ R.P.P.’s Department of Medicine, Chair and the NCUACS 36/4/92 J.S. Mitchell The material is presented as follows: B.1-B.62 Establishment and general administration B.63-B.82 Accommodation B.83-B.103 Staff B.104-B.205 Equipment and supplies B.206-B.215 Radiation protection B.216-B.314 Funding of research B.315-B.337 Future of the Department of Radiotherapeutics Establishment and general administration Early history. Manuscript note by Mitchell on staff relations in the X-ray Department, Addenbrooke’s Hospital, c. 1942. ‘Second report of the committee appointed by the Faculty Board to consider the conditions necessary for the development of a school of clinical research and postgraduate teaching’, nd. ‘Report of a conference held at Addenbrooke’s Hospital, Cambridge, on Friday, March 26th 1943, regarding the future treatment of cancer in the Eastern counties.’ Letter appointing Mitchell Medical Officer in charge of the Radiotherapeutic Centre to be established at Addenbrooke’s, 25 February 1943, with terms of appointment. finances, equipment, accommodation, etc. Memorandum by Mitchell on the requirements of a university department for the study of radiotherapy. Manuscript draft dated 22 August 1944, typescript draft, manuscript notes etc. Departmental administration, 1945-75. Mitchell’s correspondence with the University central administration re NCUACS 36/4/92 J.S. Mitchell 1945 August-November. 1946 January, February. Professorship of Radiotherapeutics. Includes correspondence re establishment of 1946 March-August. 1946 October-December. 1947 January-April. Department of Radiotherapeutics’, dated 21 March. Includes note by Mitchell on the ‘Development of the 1947 May, June. Includes note by Mitchell on the ‘Research Interests of the Department of Radiotherapeutics’, 7 May. with National Radium May-September. 1948 Commission re loan of radium, 25 September. Includes agreement 1948 January-April. 1947 July-December. Includes note by Mitchell for university pamphlet on facilities for study and research at Cambridge, 4 August. estimates, principally for 1957-62. Contents of Mitchell’s folder divided into three for ease of reference: to preparation of quinquennial correspondence and University imprest accounts for Radiotherapeutics, 1947-49. papers relating 1952, 1954. B.15-B.17 NCUACS 36/4/92 J.S. Mitchell 1962, 1965-68. Correspondence 1962 re takeover on to university funds of activities hitherto financed by Medical Research Council. 1971-73, 1975, nd. Includes note by Mitchell on the Department, 21 March 1973 and undated note on general organisation and research. B.20-B.26 Radiotherapeutic Centre administration, 1945-76. Mitchell’s correspondence with Addenbrooke’s Hospital re accommodation, equipment, staff, costs, etc. central administration University and 1945 August-December. 1947-48. 1960-69. B.27-B.34 Includes Mitchell’s acceptance of Honorary Directorship of 1951-57. 1952. Includes information for Annual Report to Ministry of Health for 1949. Radiotherapeutic Centre, August. Patient statistics, 1938-67. 1970-76. Includes note by Mitchell on work of the Radiotherapeutic Centre, 30 September 1974. Correspondence, committee papers, administrative schemes, tables, etc re the keeping of patient records. Radiotherapeutic Centre patient records, 1949-75. NCUACS 36/4/92 J.S. Mitchell ‘Statistics Consultations, Treatments etc’. Contents of Mitchell’s folder so inscribed, various dates 1949-68. B.28-B.31 ‘Records’. ease of reference, various dates c. 1950s-68. Contents of Mitchell’s folder so inscribed divided into four for Correspondence and papers re revision of medical records system, 1960. B.33, B.34 ‘R.T.C. Medical Records’. Contents of Mitchell’s folder so inscribed divided into two for ease of reference, 1971-75. Isotopes, 1965-68. Duplicated papers re administration and costs of radioisotope work. folders. 2 30th Anniversary of Opening of Radiotherapeutic Centre at Addenbrooke’s Hospital, 1973. B.37-B.45 B.37, B.38 B.47-B.49 Lists of those invited. B.40-B.44 Letters of acceptance, regret, thanks etc. 5 folders. Correspondence and papers re arrangements. 2 folders. complete sequence. 3 folders. Lists of papers by members of the Department of Radiotherapeutics, various dates, 1946-74. Copy of lecture by Sir George Godber on ‘Cancer and the Community’. Annual Reports of the Department of Radiotherapeutics, 1947-67. Not a NCUACS 36/4/92 J.S. Mitchell B.50-B.62 Departmental stencils 1952-76, nd. chronological A Radiotherapeutics/ Radiotherapeutic Centre duplicated circulars, memoranda, information sheets. Department 13 folders. sequence of of Accommodation Correspondence and papers re accommodation for Radiotherapeutic Centre and Department of Radiotherapeutics, 1945-49, 1951. Principally re Trumpington Street. the temporary use of accommodation at “Kenmare”, B.64-B.67 Correspondence and papers re Radiotherapeutic Centre extension at Addenbrooke’s Hospital, 1944, 1947-51. 1944, 1947. Includes manuscript and typescript drafts of memorandum by Mitchell on the requirements of the Department and Radiotherapeutic Centre, 7 October 1947. divided into three for ease of reference. ‘New building planning file 1951’. Contents of Mitchell’s folder so inscribed divided into three for ease of reference. ‘New building planning file July-December 1950’. folder so inscribed. ‘New building planning file 1952’. Contents of Mitchell’s folder so inscribed Contents of Mitchell’s B.72-B.74 B.69-B.71 NCUACS 36/4/92 J.S. Mitchell B.75-B.81 Architects’ plans, specifications for Radiotherapeutic Centre extension. folders. 7 Official opening of the new extension, 15 May 1953. B.83-B.85 Correspondence and papers re Radiotherapeutic Centre staff, 1943-46. Includes information about patient numbers. B.86-B.90 1945-46. 1947-48. 1970-72. Correspondence and papers re Department of Radiotherapeutics staff, 1947- 48, 1962-75. Material 1972-75 relates to staff concerns in respect of the development of the School of Clinical Medicine and the future of the Department when Mitchell retired in 1976. proposed School of Clinical Medicine on assistant staff in the Department. 1973. Includes notes of meeting, 12 December, to discuss effects of 1962-69. Includes staff lists. NCUACS 36/4/92 J.S. Mitchell 1974-75. Includes staff lists, and draft estimates for the Clinical School for 1975-76. B.91-B.96 Correspondence and papers re Department of Radiotherapeutics ‘Policy Meetings’, 1964-71. These were meetings of senior staff to discuss accommodation, equipment, expenditure and personnel. 1964. Chiefly re annual statement of needs for new developments for 1965- 66. 1965. Includes list of departmental equipment and agendas and minutes of meetings. 1966. Includes agendas and minutes of meetings. 1971 and nd. B.97-B.103 visit or work in Mitchell’s laboratory, 1968-69. Includes agendas of meetings. Correspondence re requests to arranged in a chronological sequence, 1946-77. 31 October 1955. 1952, 1954-55. Includes material re visit of Russian doctors to Cambridge, 1946, 1948-49, 1951. NCUACS 36/4/92 J.S. Mitchell 1960, 1962-63. 1965-69. Includes material re visit of German doctors to Cambridge, 4 May 1967. 1970-73. 1974-77. Includes material re visit of Russian doctors to Cambridge, 26 May 1976. Equipment and supplies B.104-B.134A Synchrotron B.135-B.154 Linear Accelerator B.155-B.169 Research reactor Synchrotron B.104-B.123 B.195-B.205 Shorter correspondence B.187-B.194 ‘Customs & Excise forms & import licences’ B.181-B.186 Grand Island Biological Company B.170-B.180 Roche Products Limited 1949 January, February. The synchrotron was built by the English Electric Company, with funding from the Medical Research Council for the equipment and its housing at Addenbrooke’s. Correspondence and papers re installation, operation and maintenance of 30 MeV synchrotron at Addenbrooke’s Hospital, 1948-59. NCUACS 36/4/92 J.S. Mitchell 1949 March. 1949 April. 1949 May. Includes report on visit to English Electric to see progress made on the 30 MeV synchrotron. 1949 June. Cambridge. Includes notes of meetings at Stafford (English Electric) and 1949 July, August. Includes notes of discussion meeting at Stafford. 1949 September. Includes report on reliability test of 30 MeV synchrotron electronic equipment and notes of meeting on synchrotron donuts. procedure for assembling Includes 1951 January-June. 1951 August-October. Includes notes on visits to Stafford. 1950. Includes notes of meetings at MRC headquarters and Stafford. 1949 October-December. and dismantling synchrotron magnet and preliminary operating instructions for synchrotron generator. development. 1951 November, December. Includes copy of Brown Boveri Mitteilungen on the betatron. Includes notes of meetings on _ synchrotron 1952 January-June. NCUACS 36/4/92 J.S. Mitchell 1952 July-December. Includes notes of meeting on synchrotron guns and donuts. 1953. Includes notes of meeting on synchrotron guns and donuts. 1954-55. 1956-57. Includes outline ‘history of synchrotron’ 1949-56. B.124-B.128 Synchrotron housing. Architects’ drawings. 5 folders. B.129-B.134 Miscellaneous correspondence and papers re synchrotron found separately from main sequence B.104-B.123, 1946-52 and nd. 1946 (1). Mitchell’s manuscript notes re betatron and paper MRC 46/186 (with L.H. Gray) on ‘The therapeutic applications of high energy beta and gamma radiations, with especial reference to betatrons for voltages up to 50 MEV and the present state of development of linear accelerators’. Radiotherapeutics, Cambridge University’. 1947-48. Includes proposed programme of research on nuclear physics in medicine at to Telecommunications Research Establishment, Malvern by D.J. Allen-Williams and R.K. Appleyard in respect of MRC synchrotron physical investigations, note on targets wanted for the MRC beta-synchrotron to be used by the Department of Radiotherapeutics, Cambridge, and ‘Some considerations affecting the design of a 30 MeV betasynchrotron for the Department of 1946 (2). Includes technical report on the medical cyclotron prepared by Mitchell, Gray and J.W. Boag for MRC Committee on the Medical and Biological Application of Nuclear Physics Clinical Sub Committee, MRC 46/172. Cancer Hospital, the Royal London, note on visit NCUACS 36/4/92 J.S. Mitchell 1949-51. Includes note on ‘Electron extraction from the synchrotron. Present achievements at T.R.E’, Malvern, 11 May 1950, ‘Draft of a paper on the synchrotron’ by Mitchell, R. Braams, C.L. Smith and D.J. Allen-Williams, 23 June 1951, and note of a visit by R. Braams to the Géttingen betatron on 19 and 20 July 1951. 1952. Information re 2 MeV electrostatic generator. Photographs. Linear Accelerator B.135-B.154 Correspondence and papers 1949, 1956-75, 1985. 1949. Cancer and Radiotherapy Advisory Committee, 28 October; meeting held at the Ministry of Health, 16 December. Minutes of meeting of Central Health Services Council Standing note of a In 1959 the MRC financed the transfer to Cambridge of an Atomic Energy Research Establishment, Harwell, 15 MeV linear accelerator which replaced the synchrotron. It was used in clinical and laboratory research and a limited number of routine treatments. In 1974 a 20 MeV linear accelerator was installed in Addenbrooke’s Hospital (new site) with National Health Service funding. Accelerator. 2 folders. 1956 July. Includes two papers on linear accelerators presented at 8th International Congress of Radiology, Mexico City and information about the Brown Boveri betatron. 1956 August. Includes report on maintenance of 4 MeV Linear Accelerator at Medical Research Council Betatron Research Unit. B.138, B.139 1956 November. Information re Metropolitan-Vickers 4 MeV Linear NCUACS 36/4/92 J.S. Mitchell 1956 November, December. Harwell, 2 December. Includes memorandum of meeting at AERE 1957 January-March. Includes memorandum on electron microscopes, 19 February and report on visit to Mullards Research Laboratories, 26 February. 1957 April-November. 1958 January-April. 1958 June-December. Includes paper on ‘Techniques and early results of treatment of carcinoma of the larynx and pharynx by supervoltage radiation’ for British Institute of Radiology Annual Conference, December and paper on ‘The treatment of carcinoma bronchus by supervoltage therapy’ for ‘Cancer Congress 1958’. 1959 January-October. Band Linear Accelerator. Includes information about the Vickers 4 MeV X- 1960-61, 1963. from Harwell to Cambridge. Includes technical report on transfer of linear accelerator 1964, 1966-67. Includes ‘Report on the progress of work with the 14 MeV linear accelerator from ist June 1964 - 30th May 1967’. 1970 March-August. Includes ‘Research programme for which the 15 MeV Linear Accelerator at Cambridge will be used’. 1972 January-September. 1970 September-November. Megavoltage Linear Accelerator. Includes information about MEL SL 75-20 1971 July-December. NCUACS 36/4/92 J.S. Mitchell 1973 January-June. 1974-75, 1985. Includes ‘Physical Aspects of the Clinical Use of the Philips’ 20 MeV Linear Accelerator at Cambridge’ by R.L. Thomas, 1975 or later. Photographs. Research reactor B.155-B.169 Correspondence and papers re Mitchell’s interest in obtaining a reactor for research in radiotherapeutics 1955-63, 1973. 1955, 1957. Includes minutes of meeting of the National Institute [for Research 1958. in Nuclear Science] Special Committee for Research Reactors, 21 January and programme of Symposium on Clinical Uses of Nuclear Reactors, MIT, 19 March. 1961 January-April. 1960 January-February (1). nuclear reactor for research and teaching in Cambridge’. Includes Mitchell’s ‘Report on the need for a Seattle. 1961 May-December. Includes American Machine & Foundry Company Newsletter re nuclear research reactor at University of Washington in 1960 February (2)-November. Includes note prepared by Vickers-Armstrongs of meeting at Addenbrooke’s re Triga nuclear reactor, 9 March. NCUACS 36/4/92 J.S. Mitchell 1962-63, 1973 and nd. program using the Triga reactor’ and Mitchell’s manuscript notes. Includes ‘Research, development and training Pye Limited technical drawings: General arrangement of 100 KW Educator Reactor, Manchester University. Cast concrete and process pit. Pictorial views of reactor. Details of location of experimental tank Reactor core. Functional diagram of control system. Schematic flow diagram. B.164-B.169 Miscellaneous background information. 6 folders. Roche Products Limited B.170-B.180 Correspondence and papers, 1946-75. B.170 1946 B.176 1954 B.186 B.179 1960-69 B.180 1970 B.178 1956-59 B.174 1952 B.175 1953 B.171 1947-48 B.172 1949 B.177,..1955 B.173 1950-51 Grand Island Biological Company reference manual Correspondence and papers, 1965-71. Includes price and B.181-B.186 B.183 1967 B.182 1966 B.184 1968-69 B.185 1969-71 B.181 1965 NCUACS 36/4/92 J.S. Mitchell ‘Customs & Excise forms & import licences’ B.187-B.194 Contents of Mitchell’s folder so inscribed, 1947-60, 1966-70. B.187 1947-49 B.191 1952 B.188 1948-49 B.192 1953-55 B.189 1950-51 B.193 1957-60 B.190 1951 B.194 1966-70 Shorter correspondence B.195-B.205 Shorter correspondence re equipment and supplies, 1945-78. ‘Therapeutic Gamma ray Sources and Ra. Beryllium Sources’. Contents of Mitchell’s folder so inscribed. 1945-50. 1946-47 (1). 1946-47 (2). 1951-58. ‘H.V. Generator’. Contents of Mitchell’s folder so inscribed. 1946, 1948. 1962-69. Supply of mice with tumours for experiment on chemo-therapeutic agents and x-radiation, 1952. Electron microscope, 1957. NCUACS 36/4/92 J.S. Mitchell Oxygen chamber, 1962-65. 1972-74, 1977-78. Radiation protection B.206-B.210 ‘Radiation Protection Officer - Correspondence - internal’ (1). Contents of Mitchell’s folder so inscribed, 1957, 1959-69. B.206 1957, 1959-61 B.209 1968 B.207 1963-66 B.210 1969 B.208 1967 B.211-B.213 B.214, B.215 B.214 1963-66 B.215 1967-75 B.211 1970 B.212 1971 B.213 1972-77 Contents of Mitchell’s folder so inscribed, 1963-75. Contents of Mitchell’s folder so inscribed, 1970-77. ‘Radiation Protection Officer - Correspondence - external’. ‘Radiation Protection Officer - Correspondence - internal’ (2). Shorter correspondence Department of Radiotherapeutics Research Fund Professor Mitchell’s Cancer Research Fund Funding of research B.216-B.288 British Empire Cancer Campaign B.289-B.293 B.294-B.304 B.305-B.314 NCUACS 36/4/92 J.S. Mitchell British Empire Cancer Campaign(later Cancer Research Campaign) B.216-B.288 Principally re the work of the Correspondence and papers, 1943-81. Cambridge University Committee of the British Empire Cancer Campaign. The Committee assessed locally originating requests for funding on behalf of the London headquarters of the Campaign. The documentation reflects the importance of the Campaign as a source of funding for Mitchell’s research and provides some record of a wider range of cancer research in Cambridge. From 1961 when Mitchell became chairman of the Committee he kept the papers for its annual meetings as a separate sequence. B.216-B.255 General correspondence and papers, 1943-67, 1972-81. B.216 1943-46 B.236 1960 November-December B.217 1947 B.218 1948 B.237 1961 January-May B.238 1961 June-December B.219 1949-50 B.239 1962 B.220 1951 B.240 1963 January-June B.241 B.246 1966 B.247 1967 B.221 1952 B.222 1953 B.223 1954 B.226 1956 B.244 B.245 B.242 B.243 1965 January-May 1964 January-May 1964 July-December 1965 June-November B.227 1957 January-May B.225 1955 July-December B.224 1955 January-June 1963 August-December Nd. 1960 June-September B.232 1959 July-December 1958 July-December 1957 July-December 1959 January-June 1958 January-June B.233 1960 January-May B.248 1972 B.253 1976 B.254 1977-81 B.235 1960 October B.250 1974 (1) B.251 1974 (2) B.249 1973 B.228 B.229 B.230 B.231 B.234 B.252 1975 B.255 NCUACS 36/4/92 J.S. Mitchell B.256-B.285 Committee papers 1961-65, 1970-77. the Cambridge University Cancer Research Mitchell was chairman of Committee of the British Empire Cancer Campaign for the period covered by the papers. Special meeting, 27 February 1961. Annual meeting, 18 July 1961. Annual meeting, 12 July 1962. Annual meeting, 13 July 1963. Annual meeting, 14 July 1964. Annual meeting, 13 July 1965. Annual meeting, 13 July 1971. 3 papers only re Mitchell’s Department. Annual meeting, 14 July 1970. Annual meeting, 27 June 1972. 5 folders. Annual meeting, 17 June 1975. 2 folders. Annual meeting, 26 June 1973. 5 folders. Annual meeting, 25 June 1974. 4 folders. B.264-B.268 B.269-B.273 B.274-B.277 B.278, B.279 NCUACS 36/4/92 J.S. Mitchell Annual meeting, 22 June 1976. B.281-B.285 Annual meeting, 21 June 1977. 5 folders. B.286-B.288 Annual reports of the Department of Radiotherapeutics to the British Empire Cancer Campaign. Circulation lists. Printed reports: 1950-51, 1951-52, 1953, 1955. Printed reports: 1958, 1959, 1963, 1965, 1966. Department of Radiotherapeutics Research Fund B.289-B.292 B.294-B.304 B.299 B.291 1965-69 B.292 1970-71 B.289 1954-59 B.290 1960-64 Other grants 1953-54, 1957. Professor Mitchell’s Cancer Research Fund Correspondence from University central administration re payment of research student supervision fees into Departmental Research Fund, 1954-71. 1982 Correspondence and papers 1965-66, 1974-87. B.296 1976-77 B.297 1978-79 B.294 1965-66 B.295 1974-75 B.303 Nd (1) B.301 1984-85 B.298 1980-81 B.300 1983 B.302 1987 B.304 Nd (2) NCUACS 36/4/92 J.S. Mitchell Shorter correspondence Bequests 1964-65, 1981. Ernest and Minnie Dawson Cancer Trust 1968, 1978-79. International Atomic Energy Agency 1960. Leverhulme Trust 1975-77, 1982. Eli Lilly and Company 1946-47, 1949. Medical Research Council 1956, 1962-63, 1971. Nuffield Foundation 1960. Wellcome Trust 1965. Rockefeller Foundation 1948, 1957. World Health Organisation 1977-78. Biology under the direction of S. Brenner. In 1975 the Medical Research Council established a new Unit of Clinical Oncology and Radiotherapeutics at Cambridge with N.M. Bleehen as At the same time the Cancer Research Campaign endowed a Director. University Chair in Clinical Oncology for Bleehen. These developments provided for the continuation after Mitchell’s retirement in September 1976 of for collaboration between the new Unit and the MRC Laboratory of Molecular Future of the Department of Radiotherapeutics Cambridge’s longstanding interest in radiotherapeutics and NCUACS 36/4/92 J.S. Mitchell Mitchell continued his personal research, until his death in 1987, in the Research Laboratories of the Cambridge University School of Clinical Medicine funded by his own Cancer Research Fund. See B.294-B.304. The material is presented as follows: B.315-B.326 Clinical Oncology B.327-B.337 Research Laboratories of the School of Medicine Clinical Clinical Oncology B.315-B.326 Correspondence and papers re establishment of MRC Unit of Clinical Oncology and Radiotherapeutics 1972-76. B.315 1972 B.321 1974 July (1) B.316 1973 January-March B.322 1974 July (2) B.317 1973 April-June B.323 1974 August, September B.318 1973 July-December B.324 1974 October-December B.320 B.327 B.325 1975 B.326 1976 B.319 1974 January 1974 February-May 1976 January, February Research Laboratories of the School of Clinical Medicine Correspondence and papers re establishment, administration, research programmes, funding, etc. of the Research Laboratories, 1976-84. experiments on living animals, 1977-84. 2 folders. 1976September-November 1976 July, August Correspondence and papers re Home Office licences to perform B.328 1976 March B.329 1976 April, May B.330 1976 June B.334 1978-84 B.333 1977 B.331 B.332 B.327-B.334 B.335, B.336 NCUACS 36/4/92 J.S. Mitchell Annual report 1986-87 of the Research Laboratories, April 1987. Mitchell died in February 1987 and the report was written by his colleague, |. Brown. ADDENBROOKE’S HOSPITAL Addenbrooke’s Hospital is the district general hospital for Cambridge and the surrounding area, and is also the teaching hospital associated through the Medical School with the University of Cambridge. For many years the hospital occupied a central Cambridge site on Trumpington Street but the need for more space became so pressing after the Second World War that an entirely new site on Hills Road on the southern boundary of the city was purchased so that all the hospital facilities for Cambridge could be provided on the one site. As head of the Department of Radiotherapeutics and Radiotherapeutic Centre and as Regius Professor of Physic Mitchell had a wide ranging involvement in hospital affairs. This is reflected, for example, in the extensive sequence of general correspondence and papers and the records of the committees on which he served or whose papers he received. later transfer of B.368-B.437 Committees B.438-B.464 Appointments B.338-B.367 General correspondence and papers The material is presented as follows: The new Hills Road site was of particular importance to Mitchell because of his plans for the development of the Postgraduate Medical School. A part of the new site was reserved for the Medical School and the first buildings there comprised the Medical Research Council’s Laboratory of Molecular Biology and the Department of Radiotherapeutics which were officially Mitchell’s files on the new site provide extensive opened in May 1962. documentation of these developments and the the Radiotherapeutic Centre from Trumpington Street to the Hills Road site. Miscellaneous hospital administration B.465-B.563 ‘Addenbrooke’s New Site’ B.564-B.584 NCUACS 36/4/92 J.S. Mitchell General correspondence and papers B.338-B.365 Correspondence and papers re hospital administration, Mitchell’s own department, etc., 1948-84. B.338 1948 B.339 1949-50 B.340 1951-52 B.341 1953 B.342 1954 B.343 1955-56 B.344 1957-58 B.345 1959 B.346 1960 B.347 1961 B.352 1965-67 B.353 1969 (1) B.354 1969 (2) B.355 1970 B.356 1971 B.357 1972 (1) B.358 1972 (2) B.359 1973 B.360 1974 (1) B.361 1974 (2) B.348 1962 (1) B.362 1975 Committees B.363 1976 B.366, B.367 B.364 1978 B.350 1963 (1) B.349 1962 (2) B.365 1979-84 B.351 1963 (2) B.367 1977-84 B.366 1974-76 Correspondence with East Anglian Regional Health Authority, 1974-84. 1972-73 Board of Governors 1948-49, 1954-73 B.370 1956-59 B.369 1954-55 B.368 1948-49 B.371 1960 (1) B.372 1960 (2) 1965, 1968-70 B.368-B.377 1961 1962 1963 NCUACS 36/4/92 J.S. Mitchell B.378-B.387 Medical Committee 1948-72 B.378 1948 B.379 1949 B.380 1950-51 B.381 1952-54 B.382 1955-56 1957-58 1960-62 1963-65 1969-70 1971-72 B.388-B.391 Consultant Staff Committee 1948-75 B.388 1948-49 B.389 1950-54 1955 1957, 1962-63, 1969, 1975 B.392-B.394 Medical Records Committees 1948-61 B.392 1948 1953, 1957, 1961 B.393 1949-50 B.398-B.411 Awards Committee 1949, 1962-63 Building Committee 1949, 1956, 1959-62. General Purposes Committee 1951, 1960-63. 1972-73 School of Radiography Committee 1951-57, 1967-73 B.400 1952 (2) B.399 1952 (1) B.403 1954-55 B.398 1951 B.402 1953 (2) B.401 1953 (1) 1969 1970 1967 1968 B.409 1971 (1) B.410 1971 (2) B.405 B.406 B.407 B.408 B.404 1956-57 B.411 NCUACS 36/4/92 J.S. Mitchell Planning Liaison Committee 1952-63 House Committee 1961-62 Nurses Education Committee 1961-63 B.415-B.417 Medical Staffing Review Committee 1962-63 B.415 1962 (1) B.416 1962 (2) B.417 B.418-B.421 Radioisotope Sub-Committee 1964-69 B.418 1964-66 B.420 1968 B.419 1967 B.421 1967-69 B.422-B.424 B.426-B.433 B.423 1973 B.424 1974-76 B.422 1965-72 Future Policy Sub-Committee 1968 Radiological Safety Committee 1965-76 Division of Radiology, Radiotherapy, Nuclear Medicine and Medical Physics 1972-77, 1980-81. 1975 Regional Radiotherapy Advisory Committee 1974-76 B.429 1974 B.436 1976 B.433 1980-81 B.427 1973 (1) B.426 1972 B.428 1973 (2) B.432 1977 B.430 1975 B.431 1976 B.434-B.436 B.434 1974 B.435 NCUACS 36/4/92 J.S. Mitchell Hospitals’ Medical Committee 1974-78. Appointments University Haematologist 1957-59. B.439-B.444 Consultant Psychiatrist 1957-60. 6 folders. B.445-B.453 Consultant General Physician 1962. 9 folders. B.454-B.464 Miscellaneous 1955-76. B.454 1955, 1957-58 B.455 1959-60 B.456 1961 1969 1970 1971 B.459 1963 1972-73 1975-76 B.457 1962 (1) B.458 1962 (2) ‘Addenbrooke’s New Site’ Contents of Mitchell’s boxes so inscribed: correspondence and papers re accommodation for Department of Radiotherapeutics, MRC Laboratory of Molecular Biology and Postgraduate Medical School on the site of the new Addenbrooke's Hospital, Hills Road Cambridge. 1956-74. architects and suppliers and Mitchell’s medical and scientific colleagues. Correspondents include hospital and university authorities, funding bodies, NCUACS 36/4/92 J.S. Mitchell B.465-B.485 Correspondence and papers, 1956-59. B.465 1956 June-September 1959 July B.466 1956 October, November 1959 August (1) B.467 1957 January-June 1959 August (2) B.468 1957 July-December 1959 September (1) B.469 1958 January-March 1959 September (2) B.470 1958 April-October 1959 October (1) B.471 1958 November 1959 October (2) B.472 1958 December 1959 November B.473 1959 January 1959 December (1) B.474 1959 February-April 1959 December (2) B.475 1959 May, June of B.486 1957 July B.487 1957 August B.495 B.486-B.495 B.491 B.492 B.493 1959 January 1958 June-September B.488 1957 September 1958 November, December B.489 1957 October-December ‘New buildings for Departments of Radiotherapeutics and Medicine - Appeals’. Contents of Mitchell’s folder so inscribed: correspondence and papers re fundraising for his departments and the Postgraduate Medical School in Cambridge. Mitchell’s letter 8 July 1957 to the Vice-Chancellor of Cambridge University (B.486) sets out his ‘proposals and plans for carrying out the duties of the Regius Professorship of Physic’. 1959 September B.490 1958 January-March B.494 1959 February-July NCUACS 36/4/92 J.S. Mitchell B.496-B.519 Correspondence and papers, 1960-61. B.496 1960 January (1) 1960 November, December B.497 1960 January (2) B.498 1960 February B.499 1960 March B.500 1960 April B.501 1960 May B.502 1960 June, July B.503 1960 August (1) B.504 1960 August (2) B.505 1960 September B.506 1960 October (1) 1961 January 1961 February 1961 March 1961 April 1961 May 1961 June 1961 July 1961 August (1) 1961 August (2) 1961 September B.507 1960 October (2) 1961 October-December 1963 May 1963 June B.524 1962 March (2) B.522 1962 January, February B.523 1962 March (1) Correspondence and papers, 1962-65. the Board of Governors’ Proposals for Hospital Building ‘Addenbrooke’s Rebuilding News’, March, June and September 1961. ‘Report on 1961/71’, Addenbrooke’s Hospital, Cambridge, 29 May 1961. 1965 1962 September-December 1963 November, December 1964 October-December 1964 January, February B.532 1963 January-April B.530 1962 July, August 1964 March 1964 April B.526 1962 May (1) B.527 1962 May (2) B.528 1962 June (1) B.529 1962 June (2) 1964 May-September B.525 1962 April 1963 October 1963 July-September B.522-B.543 B.531 NCUACS 36/4/92 J.S. Mitchell ‘UGC - New Building’. correspondence, manuscript notes, drawings etc., c.1961-65. Contents of Mitchell’s folder so inscribed: B.545-B.551 Correspondence and papers, 1966-74. B.545 B.546 B.547 B.548 1966-68 1969-70 1971 1972 January-March B.549 B.550 B.551 1972 April-July 1972 August-December 1973-74 B.552-B.557 ‘Commissioning Team - Dr A. Hargreaves’. Contents of Mitchell’s folder so inscribed: correspondence and papers, 1967-71. Hargreaves was the chairman of the Commissioning Team which was responsible for equipping and bringing into use the new hospital buildings on the Hills Road site. B.552 1967 B.553 1968 B.555 1969 July-October B.556 1970 B.554 1969 February-June B.557.. 2197.1 B.558-B.561 B.564-B.574 B.564-B.570 draft report on the Mitchell Nd. Architects’ drawings. 4 folders. Miscellaneous hospital administration cover exercise book used for Soft by development and extension of Addenbrooke’s Hospital. Miscellaneous drawings, notes, lists of equipment, and photograph of MRC Laboratory of Molecular Biology. 1960-62 General correspondence and papers, 1946-76 Pharmaceutical Department. B.564 1946-48 B.566 1955-59 B.565 1950-54 B.569 1965-69 B.568 1963-64 B.570 1970-76 B.567 NCUACS 36/4/92 J.S. Mitchell B.571-B.574 Pharmaceutical Bulletin 1949-55. No.1 September 1949; No.2 January 1950; No.3 May 1950. No.5 February 1951; No.6 June 1951; No.7 September 1951. No.8 January 1952; No.9 May 1952; No.10 November 1952. No.11 April 1953; No.14 October 1954; No.15 March 1955. B.575, B.576 Maternity Hospital. Clinical report of the Maternity Hospital Cambridge for 1953. 2 folders. Experimental Surgical Unit. Correspondence and papers 1960. Cancer Care Unit Correspondence and papers 1970-71 B.579-B.582 National Health Service Reorganisation. Correspondence and papers 1972-74. 4 folders. Correspondence and papers 1974-75. 2 folders. B.583, B.584 Mammography. NCUACS 36/4/92 J.S. Mitchell UNIVERSITY OF CAMBRIDGE B.585-B.708 Faculty Board of Medicine/Faculty Board of Clinical Medicine B.709-B.801 Medical School B.802-B.862 Boards, Committees, Departments, Colleges, Societies B.863-B.881 Examining Faculty Board of Medicine/Faculty Board of Clinical Medicine B.585-B.705 General correspondence and papers, 1953-76. B.585 1953 B.637-B.642 1964 6 folders B.586,B.587 1954 2 folders B.643-B.653 1965 11 folders B.588,B.589 1955 2 folders B.654-B.661 1966 8 folders B.590,B.591 1956 2 folders B.662-B.670 1967 9 folders 1971 B.592-B.595 B.596-B.599 B.629-B.636 B.697 1974 B.673-B.682 B.600-B.603 1959 4 folders B.683 B.671,B.672 B.604-B.609 1960 6 folders 1957 4 folders B.610-B.614 1961 5 folders B.615-B.628 1962 14 folders 1958 4 folders B.684-B.696 1972 13 folders B.698, B.699 1975 2 folders 1963 8 folders 1968 2 folders 1969 10 folders Working Party on Central Medical Library, 1972-73. 3 folders. B.700-B.705 1976 6 folders B.706-B.708 NCUACS 36/4/92 J.S. Mitchell Medical School B.709-B.716 General administration and committees B.717-B.747 B.748-B.801 of Clinical School Medical Teaching With an introductory note Research and Postgraduate School of Pre-graduate Clinical Medicine (Clinical School) With an introductory note General administration and committees Education Committee 1953-55. B.710-B.713 Medical Library Sub-Committee 1954-55. 4 folders. Visit of Medical Sub-Committee of the University Grants Committee 1965. Miscellaneous correspondence 1961-71. Medical Libraries Fund 1955. School of Clinical Research and Postgraduate Medical Teaching This had The School of Clinical Research and Postgraduate Medical Teaching (the Postgraduate Medical School) was established under the Faculty Board of Medicine in 1946 on the recommendation of the Report of the Inter- Departmental (Goodenough) Committee on Medical Schools. The School had four departments: Radiotherapy, Haematology, Experimental Medicine and Human Ecology, plus the Hospital Laboratory Service. On his appointment to the Regius Chair of Physic in 1957 Mitchell stated that his priority would be the further development of the Postgraduate Medical School (see B.486 and B.717) in conjunction with the new site for Addenbrooke’s Hospital (see B.465-B.563), which he recognised should take precedence over the creation of a pre-graduate clinical school. NCUACS 36/4/92 J.S. Mitchell been proposed in 1952 by the United Cambridge Hospitals (see below B.748-B.760). Mitchell supported the May 1959 Report of Council of Senate which concluded the proper course for the University was to concentrate on the development of the Postgraduate Medical School. In 1960 Mitchell put forward plans for the expansion of the School to six departments to replace Experimental Medicine, Human Ecology and Radiotherapeutics (B.720). His plans included offering salaries higher than the university scale to attract and retain high-quality clinical staff in the School. The University rejected these controversial proposals in ballots of the Regent House in February and December 1961 (B.723 and B.735), the second of which, Mitchell believed, cast doubt on the commitment of the University to the Postgraduate Medical School. Reviewing his position in the light of the University decision Mitchell determined to continue his efforts to expand the Postgraduate Medical School. The University Grants Committee had already indicated that it was unwilling to fund expansion unless the question of salary differentials was resolved. Mitchell therefore proposed that the School opt for ‘extra-mural’ status as an ‘Institute of Post-graduate Medical Studies’ (B.736). This was rejected instead recommended a small expansion in the School and that Postgraduate Medical School staff be offered part-time paid consultancies with the United Cambridge Hospitals to supplement salaries. The Report was approved by a ballot of the Regent House in January 1964 (B.743). This support from the University for the Postgraduate Medical School allowed the continued development of that part of the new Addenbrooke’s site reserved for it. General Report Board which 1962 July by a of Includes B.717-B.747 Correspondence and papers, 1957-65. 1957. Mitchell’s memorandum on the Postgraduate Medical School, 19 August. Mitchell’s appointment as Regius Professor of Physic. Correspondents include university and hospital authorities, Ministry of Health and Mitchell’s scientific and medical colleagues. Medicine and the General Board. 1960 the Postgraduate Medical School submitted by Mitchell to the Faculty Board of Includes Memorandum on the development of January. NCUACS 36/4/92 J.S. Mitchell 1960 March-December. Includes revised memorandum and Mitchell’s ‘Contribution to the Discussion’ at the meeting of Senate, 15 November. Principally re Medical School salaries. 1961 January-February. Includes Mitchell’s Memorandum on the future of the Medical School dated 10 February and submitted to the General Board. Re Regent House vote on clinical salaries, 2 and 3 February 1961. 1961 March-April. Includes Mitchell’s introductory statement for meeting of Medical Sub-Committee of the University Grants Committee in Cambridge, 1 March. 1961 May. 1961 June. 1961 July. B.728, B.729 Papers for Meeting of the Faculty Board of Medicine, 24 July 1961. The only item of business was the future of the Medical School. Papers for Special Meeting of Council of the Medical School, 17 July 1961. Include Mitchell’s ‘Further Statement on the Development of the School of Clinical Research and Postgraduate Teaching’. 2 folders. Medicine and the Council of the Medical School, 10 October. 1961 October. Includes papers for Special Meeting of the Faculty Board of 1961 July, August. 1961 September. NCUACS 36/4/92 J.S. Mitchell 1961 November, December. Re Regent House vote on clinical salaries, 6 and 7 December 1961. 1962 January. Includes Mitchell’s memorandum ‘A new proposal for the development of the postgraduate medical school in Cambridge’, 11 January. 1962 February. 1962 March-July 1962 August. 1962 September, October. House] Discussion on 16th October 1962’. Includes Mitchell’s ‘Contribution to [Regent Includes Report of the General Board on the 1963 February-July. Postgraduate Medical School. 1963 October-December. Includes Mitchell’s ‘Discussion in the Senate House on Tuesday, 26th November, 1963’ re the report of the General Board. Re Regent House vote on the future of the Postgraduate Medical School 16 and 17 January 1964. Includes letters of congratulation received by Mitchell on the successful outcome for the Medical School. 1965 March-December. 1964 March-October. NCUACS 36/4/92 J.S. Mitchell Draft statement to be made to the General Board of the University by United Cambridge Hospitals on the future of the Postgraduate Medical School, nd [21961]. ‘Extracts from documents relating to the development of the present position as between the University of Cambridge and the United Cambridge Hospitals, in relation to the School of Clinical Research and Post-graduate Teaching (The Medical School)’, nd. Miscellaneous notes and drafts by Mitchell, nd. School of Pre-graduate Clinical Medicine (Clinical School) clinical teaching could The 1944 Goodenough Report on Medical Education concluded that before a pre-graduate school of be established at Cambridge, offering the degrees of MB and BChir, the hospital services in the area would have to be improved and the Postgraduate Medical School built up. By 1952 the United Cambridge Hospitals felt these criteria had been met and recommended the University proceed with a clinical school. Mitchell was in favour of this proposal but after lengthy consultation the University decided to concentrate on the development of the Postgraduate Medical School, a view which was supported by Mitchell as Regius Professor in October 1958 (B.749). Mitchell presented the case to the Faculty Board of Medicine (B.751), who recommended to the General Board in October 1965 that a clinical school be established from 1967, pointing out the changes in medical training which made this defer consideration until the Royal Commission on Medical Education, set up in 1965, had reported (B.752). 1968 the Report of the Royal Commission supported the establishment of a clinical school in Cambridge. In 1964 the University gave a clear commitment to the development of the Medical School in conjunction with the new site of Addenbrooke’s Hospital, which in turn offered an improvement in the hospital facilities available in Cambridge. It appeared the criteria of the Goodenough Report would be fulfilled and Mitchell believed that the establishment of a pre-graduate clinical school was now practicable, a belief expressed in a letter to Sir George Godber, Chief Medical Officer, Ministry of Health in August 1964 (B.750). Committee was established. In March 1969 the General Board recommended the University approve in principle the institution of a course of clinical teaching leading to the degrees of MB, BChir and the establishment of a Clinical School was Clinical School Planning approved by Regent House in June and a pressing. The General In April Board decided to NCUACS 36/4/92 J.S. Mitchell a clinical school. It was decided that In October 1971 the University Grants Committee approved in principle the establishment of the existing Postgraduate Medical School would be merged with the new body to create a single School. The UGC announced that funding for the new School would become available from October 1975. The Faculty Board of Clinical Medicine held its first meeting in January 1975 and the Clinical School was opened on 27 September 1976 (B.760). Mitchell resigned his Regius Chair in 1975 a year before official retirement to enable his successor, W.J.H. Butterfield, to take charge of the Clinical School from the outset. B.748-B.760 Correspondence and papers re establishment of Clinical School 1952, 1957- 58, 1964-76. 1952 July, August. Re meeting of Addenbrooke’s Hospital Consultant Staff Committee, 7 August, to discuss the possibility of making the hospital a centre of clinical teaching. a letter to R.A. McCance, 31 In support for the proposal. July, Mitchell indicates his very strong 1957-59. Correspondence between Mitchell and Secretary General of the Faculties re formulation of a reply from the Vice-Chancellor to Board of Governors of Addenbrooke’s Hospital on the possibility of the university establishing a clinical school. In his letter of 25 November 1957 Mitchell advised that ‘the idea of a pre- graduate medical school should be dropped, at least for very many years’. 1965. Includes Report of the Faculty Board of Medicine Sub-Committee on the Creation of a Clinical School in Cambridge, submitted 19 October. 1964. Includes letter to Sir George Godber, 26 August, re the possibility of establishing a clinical school at Cambridge. memoranda from R.Y. Calne and I.H. Mills. Includes General Board papers re proposed Clinical School and 1966. university submission to Royal Commission on Medical Education. 1967. Re meeting between representatives of the University and members of Includes the Royal Commission on Medical Education, 15 May. NCUACS 36/4/92 J.S. Mitchell B.754, B.755 1968. Biology ‘B’ and Medicine on the proposed Clinical School. 2 folders. Papers of Joint Committee of the Faculty Boards of Biology ‘A’, 1969. Minutes of meeting of joint university/hospital committee on planning the clinical course, 17 October. Folder also includes ‘Draft Fly Sheet’ urging members of the Regent House to support the clinical school, nd. [71969]. Includes Report of the General Board on the establishment of a 1970. School of Pre-graduate Clinical Medicine. 1971. Papers re meeting of Faculty Board of Medicine Sub-Committee on the Constitution of the Proposed Board of Clinical Medical Studies, 20 December. Re Mitchell’s activities and duties as Regius Professor of Physic 1973. especially Medical School developments. B.761-B.772 ‘Students (Prospective)’ Contents of Mitchell’s folder so inscribed divided into twelve for ease of reference. 1975-76. 1975-76. Includes Mitchell’s remarks on the opening of the Clinical School, 27 September 1976. M.D. Committee 1978, 1980, 1985-86. General Board of the Faculties Clinical School Planning Committee Finance and Estimates Sub-Committee 1973-74. 9 folders. School of Clinical Medicine Finance and Establishments Committee 1975-76. 7 folders. B.773-B.790 Committees. B.773-B.781 B.782-B.788 NCUACS 36/4/92 J.S. Mitchell Appeals Sub-Committee 1980-82. B.791-B.797 Meetings with successor as Regius Professor of Physic. Mitchell’s manuscript notes successor as Regius Professor of Physic, 1975-80. 7 folders. of meetings with W.J.H. Butterfield, his B.798-B.801 Miscellaneous correspondence. 1975-78. Re entry for Cambridge in International Directory of Specialized 1977. Cancer Research and Treatment Establishments. 1980. Re opening of the Clinical School by the Chancellor, 21 November. 1984-85. B.802-B.812 B.802-B.804 B.834-B.844 Colleges B.845-B.862 Societies B.813-B.833 Departments Boards and Committees Boards, Committees, Departments, Colleges, Societies Board of Graduate Studies 1984. Assistant Staff Board 1963-74. 3 folders. Boards and Committees NCUACS 36/4/92 J.S. Mitchell Committee of Science Professors 1947-48. Council of the School of Biological Sciences 1958. B.808-B.810 Committee on Animal Accommodation 1964-66. 3 folders. Committee for Precautions against lonising Radiation and Laser Beams 1975-78. Committee on Student Health nd. Departments Anaesthetics 1962. B.816-B.831 Medicine 1957-66. Genetics 1959. Dermatology 1959-60, 1967. 1962-63, 1966. NCUACS 36/4/92 J.S. Mitchell B.817-B.831 ‘Psychiatrists’. Contents of Mitchell’s folder so inscribed: correspondence and papers re development of medical psychology within the Department of Medicine; includes material re Department of Experimental Psychology (O.L. Zangwill) and proposed Student Mental Health Unit. 1957-65. also B.817 1957 June-December B.825 1961 B.818 1957 November B.826 1962 B.819 1957 December B.827 1963 B.820 1958 January, February B.828 1964 January-March B.821 1958 March-May B.829 1964 May-July B.822 1958 June-December B.830 1964 August-November B.831 1964-65 B.823 1959 B.824 1960 Pathology 1957-61. Surgery 1967. Colleges Darwen College 1964. St John’s College 1944, 1961-62, 1975-86. Mitchell was a Fellow of St John’s College from 1936. 1981-85 General correspondence and papers. B.836 1975-79 B.835 1944, 1961-62 B.837 1980 B.835-B.844 B.835-B.838 B.838 NCUACS 36/4/92 J.S. Mitchell B.839-B.842 Linacre Lectures. Correspondence re arrangements, votes of thanks. B.839 1976-79 B.840 1980-83 B.841 1984 B.842 1985-86 St John’s Medical Society 1978-87. Meeres Senior Studentship for Medical Research 1978-84. Societies Cambridge University Medical Society 1944, 1961. B.846-B.862 Cambridge Graduates’ Medical Club 1958-77. B.855 1969 B:857" 1971 B.856 1970 B.858 1972 B.846 1958-59 B.848 1962 B.849 1963 B.850 1964 B.847 1960-61 Correspondence and papers principally relating to the Club’s annual general meeting and dinner. From 1959-65 Mitchell gave a speech at the dinner on the progress of the Medical School. From 1966 the speech was replaced by a typed report circulated at the dinner. 1968 1976-77 B.853 1967 B.852 1966 B.851 1965 B.860 1974 B.859 1973 B.854 B.861 1975 B.862 NCUACS 36/4/92 J.S. Mitchell Examining B.863-B.874 Final M.B. Examinations 1972-74. B.863 1972 1973 November, December B.864 1973 January-March 1974 January-March B.865 1973 April-June 1974 April-June B.866 1973 July 1974 July, August B.867 1973 August, September 1974 September, October B.868 1973 October 1974 November, December B.875-B.881 Higher degrees, various dates 1948-86. B.875 1948 B.876 1961 B.879 1979-81 B.880 1981 B.877 1966-70 B.881 1982, 1986 LECTURES B.882-B.1022 B.882-B.888A B.889-B.1004 Drafts B.878 1975-77 Departmental lectures Correspondence re arrangements Medical isotopes courses Long vacation courses for medical students Courses practitioners and B.1005-B.1021 Lecture lists and bibliographies B.1023-B.1041 symposia for general medical B.1022 Tape recording B.1042-B.1051 B.1052-B.1054 NCUACS 36/4/92 J.S. Mitchell Departmental Lectures Correspondence re arrangements 1946-50 1951-53 1954-55 1956-59 Drafts B.886 1960-65 B.887 1966-69 B.888 1970-75 B.888A Nd Mitchell’s bulky folders have been divided for ease of reference. Where appropriate his inscriptions on the original folders (not kept) have been reproduced in the catalogue entries. The sequence includes notes and illustrative material found with the drafts. Lectures 1949. B.889-B.892 ‘Lectures 1947’. 4 folders. ‘Old papers & lectures’ 1947-52. 5 folders. ‘Introductory course of lectures on Radiotherapy’ 1950-51. 3 folders. Lecture course 1952-53. 4 folders. ‘Lectures 8/9/52 to 24/9/52’. 4 folders. ‘Dosimetry’. 1950, 1953. B.893-B.897 B.899-B.901 B.903-B.906 B.907-B.910 NCUACS 36/4/92 J.S. Mitchell B.911-B.913 Lectures 1953. 3 folders. Lecture 1954. Illustrative material for ?lectures. Includes items dated 1954, 1955. B.916-B.926 Lectures 1955-56. 11 folders. ‘For lecture - 7/10/55’. ‘For lecture 11/10/55’. ‘Lecture 24/1/56’. ‘Lecture 2/3/56’. ‘Lecture 30 October 1956’. ‘Lecture - 16 November 1956’. ‘Lecture notes 19/10/56 - 30/10/56’. ‘Lecture 7/12/56’. ‘Treatment of Carcinoma of the Mouth’, 20 November 1956. B.935-B.938 Lectures October, November 1956. 4 folders NCUACS 36/4/92 J.S. Mitchell ‘Lecture 29 January 1957’. ‘Lecture - 12 February 1957’. B.942-B.945 Lectures January-March 1957. 4 folders. ‘Investigations of practical interest’ 1957. ‘Ca Thyroid’. lectures material. 1958. Notes and drafts on carcinoma of the thyroid found with Lectures December 1958. B.949-B.952 Undated lectures ?1950s. 4 folders. Lectures 1960. Lectures 1964. ‘Typed lectures 1966-1967’. Include manuscript notes and lecture dated 10 October 1964. 2 folders. 2 folders. Miscellaneous lectures notes and drafts nd ?1960s. 7 folders. ‘Introductory Lectures’. Notes, data etc, latest reference 1971. B.958-B.962 Lectures 2-12 nd ?1960s. 5 folders. Lecture 1969. B.955, B.956 B.963-B.969 B.970, B.971 NCUACS 36/4/92 J.S. Mitchell Lecture 1973. B.973, B.974 Illustrative material for ?lectures. 1973, 1975. 2 folders. B.975-B.982 Lectures A1-A6, A8-A10, A12-A15. 1975-76. 8 folders. B.983-B.986 Background material. Possibly related to series A lectures. 4 folders. B.987-B.1001 Lectures B1-B15. 1975-76. 15 folders. Lecture on treatment of cancer of the uterine cervix nd ?1970s. Lecture paginated 4-17 nd. B.1005-B.1021 1965-76. 17 folders. Tape recording ‘Synopsis of lectures’ nd. Lecture lists and bibliographies Lectures 8 and 12 February 1957. NCUACS 36/4/92 J.S. Mitchell Courses and symposia for general medical practitioners B.1023-B.1041 Correspondence and papers 1948-76. Documentation may include correspondence re arrangements, programmes, lists Mitchell’s be demonstrated, introductory remarks and lecture drafts. participants, cases lists to of of B.1023 1948-51 B.1033 1968 (1) B.1024 1952-55 B.1034 1968 (2) B.1025 1956-57 B.1026 1959 B.1027 1960-61 B.1028 1962-63 B.1029 1964 B.1030 1965 B.1031 1966 B.1035 1969 B.1036 1970 B.1037 1971 B.1038 1972 B.1039 1973 B.1040 1974 B.1041 1975-76 B.1032 1967 B.1042 1947 B.1042-B.1051 Correspondence and papers 1947-69. Long vacation courses for medical students Documentation may include correspondence re arrangements, programmes, lists of participants, reading lists. See B.1046 for Mitchell’s lecture on rays and their uses in medicine. 1969 B.1048 1964-65 B.1047 1961-62 B.1050 1968 B.1044 1955-56 B.1045 1957-58 B.1046 1959 B.1043 1950-53 B.1049 1967 B.1051 NCUACS 36/4/92 J.S. Mitchell Medical isotopes courses B.1052-B.1054 Programmes, lists of participants, 1958, 1967-69, nd. B.1052 1958 B.1054 Nd B.1053 1967-69 NCUACS 36/4/92 J.S. Mitchell SECTION C NOTEBOOKS C.1-C.134 RESEARCH AND CLINICAL C.59-C.78 BIBLIOGRAPHICAL C.79-C.99 VISITS, CONFERENCES AND LECTURES C.100-C.130 JOTTERS C.131, 0.132 ILLUSTRATIVE MATERIAL C.133, C.134 GERMAN LANGUAGE NCUACS 36/4/92 J.S. Mitchell RESEARCH AND CLINICAL The sequence of notebooks presented here covers the period 1926-81. Many of the notebooks used during and after the Second World War hold substantial quantities of additional material, either clipped to pages of the notebook or intercalated loose into the volume. This material is integral to the notebooks as Mitchell used the notebooks to ‘file’ papers pertinent to his calculations, correspondence, reprints, photographs, figures and graphs as well as manuscript and typescript notes on experimental procedures, dosages, case histories, bibliographical references etc. The original order of this material within the notebooks has been preserved. activities research include current may and it The notebooks should be consulted in conjunction with the substantial body of research material in Section D. Where applicable reference has been made to the bibliography in the Royal Society memoir of Mitchell (A.1) in the form Bibliog. ... Green hardback sketchbook inscribed inside front cover ‘[...] University of Birmingham’. Used from the front for diagrams for ‘Practical Botany’ and from the back for ‘Zoology’. The last of the pages used from the back has a manuscript note ‘[?] Birmingham 7 Dec. 1926’. Loose manuscript note at front. Mitchell won a scholarship to Birmingham University in 1926. Hardback notebook inscribed inside front cover ‘[...] Birmingham’. Used from the front and from the back for physics notes (including some notes taken at Cambridge c.1928-31). Loose material enclosed in book. Latest reference January 1931. After two years at Birmingham Mitchell won an entrance scholarship to St John’s College Cambridge to study for the Natural Sciences Tripos. He specialised in physics for Part Il. While at Cambridge Mitchell was advised to take examinations in pre-clinical subjects to allow him to take the Cambridge MB, BChir at a later date. January 1930. Hardback notebook used for undergraduate physics notes at Cambridge. Latest bibliographical reference 1929. Hardback notebook inscribed inside front cover ‘[...] Cambridge’. Used from the front for physics notes. St John’s College Latest reference NCUACS 36/4/92 J.S. Mitchell Hardback notebook used from the front for notes on ‘Bonhoeffer & Harteck. Photochemistry’ der Photochemie, Dresden 1933) and for later notes on the literature (latest reference 1940), and from the back for calculations. Grundlagen Bonhoeffer Harteck, (K.F. and P. Hardback notebook used for medical notes taken at Birmingham c. 1931-34 and later physics notes taken at Cambridge (includes notes on ‘Lord Rutherford: lonisation & Radioactivity Easter 1935’). Mitchell returned to Birmingham University in 1931 for the postgraduate He was clinical training necessary to obtain the Cambridge MB, BChir. awarded these in 1934 and thereafter began research for his PhD on irradiation of thin protein films under E.K. Rideal at the Colloid Science Laboratory in Cambridge. Hardback binder used for typescript draft [? ultraviolet light on proteins. September 1934 - February 1936’. of thesis] ‘The action of Hardback notebook used for physics notes, including notes on lectures by J.E. Lennard-Jones, W.L. Bragg, W.T. Astbury, G.I. Finch, T.M. Lowry and R.G.W. Norrish, probably taken during a conference. Latest reference ‘Soc. 1935’ (lecturers include D. Jordan Lloyd, Exp. J.D. Bernal, Astbury, P.W. Bridgman and D. Wrinch). Loose material intercalated. Biol. Manchester July Hardback notebook used for miscellaneous notes, chiefly bibliographical. Latest reference 1935. Loose material at front. Hardback ‘Physics Book’ used for notes on experiments, 9 November 1936 - c.July 1937. Loose material intercalated. these are [? earlier] notes on bone diseases. Loose material intercalated. Hardback notebook inscribed inside front cover ‘Wavelength Effects’. Used principally for notes on the literature re effectiveness of radiations of different wavelengths, latest bibliographical reference 1937. At the end of NCUACS 36/4/92 J.S. Mitchell Hardback ‘Physics’ notebook inscribed inside front cover ‘J.S. Mitchell [...] Cheadle Hulme m/c’. Used for notes on experiments, 6 April 1939 - 24 July 1940. Loose material at front, including correspondence, dated 1940-42. In 1938 Mitchell worked at the Christie Hospital and Holt Radium Institute in Manchester. He returned to Cambridge in 1939 as Assistant in Research in Radiotherapy in the Department of Medicine, a post made permanent in 1943. Hardback notebook used for notes on experiments, 17 June 1942 - 29 June 1944. Paginated. Loose material intercalated includes typescript introduction and list of slides for lecture on ‘Some aspects of the therapeutic action of radiation’, 5 January 1945 (also delivered at New Haven 6 April 1945), notes, graphs and photographs. In 1944, at the request of Sir John Cockcroft, Mitchell went to Canada to work at the British and Canadian Atomic Energy Project at Chalk River. He was asked to investigate radiobiological hazards to those working with radiations and to direct a medical programme at the Project. of and for Hardback notebook labelled ‘National Research Laboratories Ottawa Canada Division ‘Medical investigations’ on the ionising effect of radiations on tissue, November 1944 to November 1945. Paginated. Engineering’ Electrical Physics used First page inscribed ‘J.S. Mitchell c/o Mr M. Perrin D.S.I.R. 16 Old Binder. Queen St. Westminster London SW1’. Contains manuscript notes on ‘METHODS. Chemical & Histological’, ‘ANIMAL EXPERIMENTS DATA’, ‘POST MORTEM REPORTS’ and ‘LABORATORY EQUIPMENT’. Loose material intercalated. Latest reference 1945. Much additional material, dating principally 1945-47, intercalated including photographs, figures, correspondence, memoranda, notes, reprints and drafts. Among this material is Mitchell’s 5pp typescript draft ‘Provisional calculation of the tolerance flux of fast neutrons’, 19 January 1947 (Bibliog. 26), and memoranda on developments of ionisation chambers for neutron dosimetry, February and April 1945. Addenbrooke’s Radiotherapeutic Centre. Hardback notebook inscribed inside front cover ‘J.S. Mitchell Addenbrooke’s Hospital Cambridge’. Used for notes on neutron irradiation experiments, 1945. Loose material intercalated. At the end of 1945 Mitchell returned to Cambridge to take up the newly created Chair of Radiotherapeutics and the Honorary Directorship of NCUACS 36/4/92 J.S. Mitchell Hardback notebook inscribed inside front cover ‘[...] J.S. Mitchell Dept of Radiotherapeutics Cambridge’. Used for plans of experiments, 4 September - 23 October 1947. Most pages not used. Loose material intercalated. Hardback notebook used for rough minutes taken during MRC ‘Clinical Sub- Committee 20 Jan 49. 11 am’ (see F.262). Loose material intercalated includes draft ‘Summary of discussion with Dr D.R. Charles & Dr Thomas at Rochester, NY, on 7th April 1948’. Hardback notebook inscribed inside front cover ‘[...] Syncavit Clinical |’. Used from 23 July 1949 for notes on cases treated with the radiosensitising drug synkavit. Loose material intercalated. Hardback notebook inscribed inside front cover ‘[...] Syncavit Clinical II [...]’. Used from 24 January 1950 for notes on cases treated with synkavit. Loose material intercalated. Hardback notebook used for notes on treatment of patients with cancer and notes on the literature. Latest reference ‘28.3.50’. Latest bibliographical Hardback notebook used for miscellaneous notes. reference 1950. Some pages loose. Hardback notebook inscribed inside front cover ‘J.S. Mitchell Addenbrooke’s Used for draft on histological changes in patients produced by Hospital’. irradiation. Paginated up to 64 but pages 1-55 are missing from the notebook and the draft is unfinished. Most pages unused. Committee 10 August 1951 (see F.418-F.420). Loose material intercalated includes 44pp typescript draft by Mitchell ‘Practical aspects of radio-active isotopes in relation to medical treatment’ (Bibliog. 39) described as ‘Abridged version of lecture delivered to the Society of Apothecaries of London on 4th December, 1950’; Atomic Energy Research Establishment (AERE) of haematological techniques and records’ by A.C. Chamberlain and F.M. Turner; and papers for meetings of the Ministry of Supply AERE Harwell Project Health ‘Statistical review NCUACS 36/4/92 J.S. Mitchell Hardback notebook used for manuscript notes and calculations, probably for work for the Medical Research Council. dating material, additional c.1950-60, intercalated Much including correspondence with the MRC in connection with applications to the Advisory Panel on the Allocation of Radioactive Isotopes for Clinical Research (F.209-F.237), manuscript and typescript notes and calculations, figures and reprints. It also includes papers for ?1950 meeting of the Tracer Elements Subcommittee of the MRC’s Committee on the Medical and Biological Applications of Nuclear Physics (F.248-F.319), and ‘Summary of proceedings of meetings during the year ending 1/5/52’ prepared for the Subcommittee on Internal Radiations of the MRC’s Committee on Protection Against lonising Radiations (F.322-F.372). Hardback notebook inscribed inside front cover ‘Joseph S. Mitchell [...] 6.9.50’. Used for notes on experiments using radiosensitising drugs, including synkavit, September 1950 - October 1953. material additional correspondence, Much all Mitchell), photographs, manuscript and calculations and graphs. It also includes duplicated typescript ‘Notes on Demonstrations’ prepared for a meeting of the Cambridge Philosophical Society at the Department of Radiotherapeutics, 19 November 1951. intercalated typescript including (not notes by First page titled ‘Survey of Ca of bronchus (cont) Hardback notebook. 7.1.51’. Used for notes on cases treated with synkavit combined with x-ray therapy. Loose material intercalated. ‘Sectional pad’ inscribed on front cover ‘RATS WALKER CARCINOMA J.S.M. TOTAL BODY IRRADIATION EXPT. XV’ and, by Mitchell’s secretary M.J. Crichton, c. 1987, ‘Notes by Mr [E.A.] King - JSM’s Chief Technician who carried out these expts. for JSM’. Notes on experiments, 27 December 1950 - 29 May 1951. and O.M. Henriques’s ‘Report from the Finsen Much including correspondence, manuscript and typescript notes (not all by Mitchell), calculations, reprints and graphs. It also includes Mitchell’s 58pp duplicated typescript report ‘Clinical and laboratory studies of the effects of Thorotrast’ and his 3pp duplicated typescript ‘Abstract of published cases of human malignant tumours attributed to Thorotrast’ prepared for the MRC’s Subcommittee on Internal Radiations of the Committee on Protection against lonising Radiations, 1951; ‘Summary of Work of Sub-Committee from May, 1952 to September 1954’ reporting on thorotrast investigations, annotated by Mitchell; Hardback notebook used during July 1951 visit to the Finsen Laboratory, Copenhagen, in connection with work for the MRC on thorotrast (see F.326- F.333) and for later notes on thorotrast investigations, 1952 and 1953. intercalated c.1951-55, additional material, dating NCUACS 36/4/92 J.S. Mitchell Laboratory [...] on Internal Radioactive Contamination’ prepared for the subcommittee, 1952. Hardback notebook. Latest bibliographical reference 1952. Loose material intercalated. Hardback notebook inscribed on first page ‘Synkavit investigation Inoperable ca. of bronchus Cases no 1-151. - first X ray tr. between 1 April 51 & 31 Dec 53. Loose material intercalated. Assessed 30 June 1954’ and dated ‘12.7.54’. Hardback notebook used for notes on experiments on rats, 29 December 1953 - 21 December 1954 and 18 July 1955 - 26 March 1956. Much additional material intercalated including correspondence, manuscript and typescript notes (not all by Mitchell), calculations, photographs, reprints and graphs. It also includes typescript copy of Mitchell’s ‘Programme of research for the calendar year 1953’ submitted to the British Empire Cancer Campaign and 11pp typescript draft and 4pp abstract of ‘Laboratory studies and clinical trials of some chemical radiosensitisers’ by Mitchell (Bibliog. 47). Hardback notebook used from the front for notes on results of ‘Ca. cervix treated RTC’, October 1954. Hardback notebook used for notes September 1955, probably on dangers from emissions from nuclear power plants. Hardback notebook inscribed on first page ‘Clinical trials of Synkavit Randomised trial in inoperable ca. bronchus Cases 1-203 inclusive. Results assessed to 18 Dec 1955’. Used for notes on the results of various series of treatments (indicated by Mitchell’s bookmarks pasted into the notebook). Loose material at back. radiosensitisers on plant growth’. Much additional material intercalated including correspondence, manuscript and typescript notes (not all by Mitchell), and photographs. Among the correspondence is letter from R.H.N. Whitehouse of the Cambridge University Plant Breeding Institute detailing ‘progress in the investigation of Hardback notebook used for notes on synkavit experiments 123 to 146 (November 1954 - October 1955), and for notes on experiments using synkavit and other drugs, June 1956 - August 1957. a NCUACS 36/4/92 J.S. Mitchell Exercise book used for draft on lung cancer incidence by L.M. Mitchell. Latest reference 1955. Exercise book used for draft on results of treatment of lip cancer by L.M. Mitchell. Latest reference 1956. Exercise book used for notes on the literature and calculations. reference 1956. Most pages not used. Latest Hardback notebook used for notes on pilot trial of oxygen and synkavit with randomised allocation ‘14.9.57’, ‘Reassessed 3.1.58’. Some pages loose. Hardback notebook inscribed inside front cover ‘J.S. Mitchell [...] 9.8.1957’. Used for notes on experiments, August - November 1957 and February 1958 - October 1959. material, dating material, additional Much including correspondence and memoranda, manuscript and typescript notes (not all by Mitchell), graphs, photographs and reprints, including papers presented at the Second United Nations International Conference on the Peaceful Uses of Nuclear Power, September 1958 (see G.13, G.14). intercalated 1955-59, dating additional c.1958-61, intercalated Hardback ‘Physics Book’ used for notes on experiments, February 1960 - April 1961. Much including correspondence, memoranda, manuscript and typescript notes (not all by Mitchell), graphs and reprints. M [?aher]. Hardback notebook used from 14 February 1961 chiefly for notes on lectures delivered by Gabriel Stein of the University of Jerusalem, possibly in his course ‘Recent advances in the radiation chemistry of aqueous systems with special reference to biological systems’ (see H.384). Stein was spending a sabbatical year working in the Department of Radiotherapeutics. Towards the back of the notebook are notes on lecture ‘17 March 61 Dr R NCUACS 36/4/92 J.S. Mitchell Hardback notebook used for notes on experiments using TRA 119, TRK 219 and other compounds, c.November 1961 to June 1964. additional Much including correspondence and memoranda, manuscript and typescript notes (not all by Mitchell), graphs and reprints. intercalated material, 1961-65, dating Hardback notebook inscribed on first page ‘TRA 119’ used for notes on patients treated with this drug, 1962-64, and with TRK 219, 1964-65. Paginated 49-103, not all pages used. Loose material intercalated. Hardback notebook used for notes on discussions with Sir William Penney and J. Gaunt (? and others) re the UK presentation at UN Conference on Peaceful Uses of Atomic Power, Geneva, 1964 (see G.25-G.32), and for bibliographical references and notes on the literature (in German). Hardback ‘Physics Book’ used for notes on experiments, June 1964 - October 1965. material, dating 1964-68, Much additional material, dating c. 1964-65 and 1973, intercalated including correspondence, memoranda, manuscript and typescript notes (not all by Mitchell) and reprints. including additional Much intercalated correspondence, manuscript and typescript notes and reprints. Hardback ‘Physics Book’ used for notes on experiments, October 1965 - January 1967. Hardback ‘Physics Book’ used for notes on experiments, January 1967 - March 1968. and typescript notes and reprints. Much additional material intercalated including manuscript and typescript notes and reprints. Hardback ‘Physics Book’ used for notes on experiments, March 1968 - May 1970. Much additional material intercalated including correspondence, manuscript NCUACS 36/4/92 J.S. Mitchell Hardback ‘Physics Book’ used, principally towards the back, for notes on experiments, April - July 1969. Loose material intercalated. Most pages not used. Hardback notebook used from the front for notes on work of G. Di Vita, a visiting researcher studying the cerebellum of normal and irradiated Xenopus laevis in the Department of Radiotherapeutics, 3 July - November 1969. Loose material intercalated. Hardback ‘Physics Book’ used for notes on patients and experiments, January 1970 - March 1974. dating material, additional Much including correspondence and memoranda, manuscript and typescript notes (not all by Mitchell), photographs and reprints. It also includes 6pp typescript draft by and Mercaptoacetic acid’. Indanetrione intercalated c.1967-74, between reaction Hydrate D.H. Marrian ‘The Hardback ‘Physics Book’ used for notes on treatment of patients, 15 May 1970 - 2 August 1971, and on experiments with 6-'25 iodo MNDP, and other compounds, 2 June - 24 October 1978. material including additional intercalated Much additional material intercalated including manuscript notes and ‘certificates of analysis’. Hardback ‘Physics Book’ used for notes on treatment of patients, 22 May 1970 - January 1971 and May 1971 - August 1972. correspondence, Much memoranda, manuscript and typescript notes (not all by Mitchell) and reprints. reference 1973. Loose material intercalated. Hardback thumb-index notebook labelled on front cover ‘Tumour Tissue Culture’. Used for notes (not by Mitchell) on treatment of patients. Latest Hardback HMSO notebook inscribed on front cover ‘Patients for bronchus trial 1972’. Most pages not used. Loose material at front. NCUACS 36/4/92 J.S. Mitchell Hardback notebook dated on first page ‘13.6.74’. patients and on experiments, June 1974 - September 1977. Used for notes on additional Much including correspondence and memoranda, manuscript and typescript notes (not all by Mitchell), and reprints. intercalated material, 1974-78, dating Softback ‘Science Book’ used for notes on experiments, 15 May - 25 June 1981. Loose material intercalated. Softback ‘Science Book’ used for notes on experiments, 17 June - October 1981. Loose material intercalated. 15 BIBLIOGRAPHICAL Most pages loose. Some With the exception of C.59 these are hardback notebooks dating from the 1960s and 1970s used by Mitchell during visits to Germany. The notebooks were used for bibliographical references to German research, notes on the literature (principally in German) and some notes taken during conferences and meetings in Germany. Latest reference 1960. Additional material intercalated. Latest reference 1960. Additional material intercalated. Inscribed inside front cover ‘Bibliography’. references intercalated. Latest reference 1944. Latest reference 1962. Latest reference 1961. Loose material intercalated including programme of meeting of the Vereinigung Deutscher Strahlenschutzarzte, Essen, 3-6 January 1962 (see G.19). Smaller format. Latest reference 1960. Additional material intercalated. NCUACS 36/4/92 J.S. Mitchell Latest reference 1962. An official envelope of the Radiologisches Institut der Universitat Freiburg has been pasted to the first page, probably indicating where Mitchell was working at the time. Loose material includes programme of ‘Kolloquium Uber Biochemie der Strahlenmutation und Struktur der Desoxyribonukleinsaure’, Freiburg, 8-9 March 1963. Latest reference 1963. There is much intercalated material, dating 1957-63, including reprints and manuscript and typescript notes (not all by Mitchell). Latest reference 1964. An envelope of the Radiologisches Institut of Freiburg clipped to the first page, probably indicating where Mitchell was working at the time. Inscribed inside front cover ‘13 March 1965 Freiburg.i.Br.’. Inscribed inside front cover ‘29.7.65 Freiburg’. Latest reference 1966. Loose material at front including programme of the 4. Strahlenschitzkurs fiir Sanitatsoffiziere der Bundeswehr, Freiburg, 21 March - 1 April 1966. Inscribed inside front cover ‘July 1966’. Latest reference 1966. Programme for the ‘ROntgentagung in Freiburg im Breisgau’, 23-25 September 1966, clipped to the first page. material intercalated. Inscribed inside front cover ‘8. September 1968 [...] FREIBURG i Br’ and on frontispiece ‘Strahlensensibilisierende Substanzen und ihr Einfluss auf die Strahlenempfindlichkeit von Tumoren’. The first pages of the notebook are used for notes in English. Inscribed inside front cover ‘[...] Freiburg i Br [...] 1.August 1969’ and on first page ‘Uber die Méglichkeit der Entwicklung radioaktiver Pharmaka’. Loose NCUACS 36/4/92 J.S. Mitchell Inscribed Radiologisches Institut der Universitat 78 Freiburg i Br’. 20.3.70 inside cover front ‘[...] bei Prof. H. Langendorff Latest reference 1970. of Freiburg clipped to the first page. Loose material intercalated. An official envelope of the Radiologisches Institut Latest reference 1971. of Freiburg clipped to the first page. An official envelope of the Radiologisches Institut Larger format. reference 1971. Loose material intercalated. Inscribed inside front cover ‘[...] FREIBURG i Br’. Latest VISITS, CONFERENCES AND LECTURES Spiral bound notebook used during visit to the USA, March-April 1948. Includes notes taken during discussions with US colleagues. Loose material intercalated. See also F.184-F.194. Hardback notebook inscribed inside front cover ‘J.S. Mitchell C.C.S.O. 1785 Massachusetts av. N.W. Washington D.C.’ to USA. Includes notes taken during discussions with US colleagues. Used during visit Spiral bound notebook used during visit to the USA, March-April 1948. Includes notes taken during discussions with US colleagues. Loose material intercalated. See also F.184-F.194. Additional material intercalated including ‘Minutes of a Meeting to discuss the Image Amplifier held at the Department of Radiotherapeutics on 8th June 1949’, and reprints. Latest bibliographical reference 1954. Softback notebook inscribed inside front cover ‘J.S. Mitchell c/o Prof. Sven Hultberg Radiumhemmet [...] Stockholm’. Using during visit to Sweden. Spiral bound notebook inscribed on front cover ‘23/4/54. Architects.’ Shorthand notes only. See E.122 for typescript of lecture. Lecture to NCUACS 36/4/92 J.S. Mitchell notebook Softback Radiumhemmet Karolinska Sjukhuset Stockholm’. Sweden, February-March 1955. Loose material intercalated. inscribed inside ‘J.S. Used during visit front cover Mitchell [...] to Hardback notebook used for notes on proceedings of chemotherapy meeting held by the International Union Against Cancer Subcommittee for Great Britain and Ireland of the Committee on Chemotherapy, ICI Alderley Edge, 6-7 November 1958 (see F.160, F.161). Loose material intercalated including papers re arrangements for the meeting and programme of the International Symposium on the Chemotherapy of Cancer, Cambridge, 13-15 July 1958 (see F.153-F.159). Hardback notebook used principally for notes taken during departmental colloquia 1961. Hardback notebook possibly used during visit to Freiburg 1961. material intercalated. Loose Hardback notebook used for notes on proceedings of 4th Annual Meeting of the Anglo-German Medical Society, Cambridge, 25-28 September 1963. (See F.23-F.30). Loose material intercalated including programme of the meeting. Most pages not used. Hardback notebook labelled on front cover ‘Attendance list of Professor Mitchell’s lectures’ at Cambridge. Used 9 October 1965 - 10 March 1972. Pocket spiral bound notebook labelled on front cover ‘Professor Mitchell’s lectures Michaelmas Term 1964’. Used for attendance lists for lectures at Cambridge. ‘Edinburgh 12-15 Oct 1966’. Also includes later manuscript notes. Hardback notebook used for notes on proceedings of British Institute of Radiology meeting on the Radiobiology of Organised Animal Tissues Fractionation Phenomena, London, 19 November 1965. Most pages not used. Loose material intercalated including programme of the meeting. Hardback notebook used for notes on proceedings of conference at NCUACS 36/4/92 J.S. Mitchell Hardback notebook used for notes on proceedings of Royal Medical Society symposium on Immunological Aspects of Cancer, Edinburgh, 16-17 October 1970. Most pages not used. Loose at front is symposium programme. Hardback notebook used for notes on proceedings of UN International Conference on the Peaceful Uses of Nuclear Power, Geneva, September 1971 (see G.44-G.46). Loose material intercalated includes Mitchell’s ‘Draft to large dose fractions] on 3rd January 1972’. [of radiosensitisers in radiotherapy with start the trial Notebook used for attendance lists for Mitchell’s lectures at Cambridge, 11 October 1972 - 12 March-1976. Hardback notebook used for notes on proceedings of meeting dedicated to Mitchell on Clinical Applications of Short Term Cultures of Human Tumour and for notes on Biopsy Specimens, Cambridge, 26-27 September 1974; proceedings of Research AGM and Symposium on Viruses and Cancer, Cambridge, 23-25 March 1977. Loose material intercalated including papers re arrangements for both meetings. for Cancer Association British Hardback notebook used for notes on unidentified conference. Nd. JOTTERS Spiral bound notebook used for shorthand notes on unidentified lecture. Undated. Hardback notebook used for notes on proceedings of conference at Cambridge. Participants include C. Auerbach, F.S. Dainton and J. Rotblat. Undated. X Ray Dept)’. Used for notes during visit to USA. Small format pocket notebooks used by Mitchell, sometimes during visits abroad, for rough jottings of research ideas, calculations etc., and brief notes of bibliographical references, names and addresses, telephone numbers etc. Many have loose pages and intercalated material. Labelled on front cover by [? Mitchell’s secretary] ‘Milton Friedman ca 1945’ and inscribed inside front cover ‘[...] Royal Victoria Hospital Montreal (c/o NCUACS 36/4/92 J.S. Mitchell Latest reference 5 February 1946. Used for notes on medical requirements for Harwell. Mitchell was temporary Head of the Medical Department at Harwell (see A.20) and served on the Harwell Project Health Committee (F.418-F.420). Latest reference 26 October 1951. Latest reference 19 May 1952. Latest reference 5 September 1952. Latest reference 16 April 1953. Latest reference 9 June 1954. Latest reference 22 July 1954. Used on visit to Sweden, February-March 1955. Used on visit to Sweden, February-March 1955. Includes notes on Swedish grammar. Used on visit to Switzerland. Latest reference 24 July 1956. See G.10. Used on visit to Sweden, February-March 1955. Latest reference 1955. Latest reference 12 January 1956. NCUACS 36/4/92 J.S. Mitchell Includes notes on Cancer Chemotherapy Conference July 1957. reference 1959. Latest Latest reference 6 December 1957. Latest reference 4 April 1958. Lacks cover. Latest reference 28 May 1958. Latest reference 26 November 1958. Latest reference August 1959. Latest reference 9 July 1960. Latest reference 1961. Latest reference 7 September 1963. Latest reference 25 October 1963. Latest reference 8 October 1972. Enclosed loose is Mitchell’s 4pp the proposed postgraduate Latest reference 29 September 1962. typescript ‘Contribution to discussion [on medical school] on 16th October 1962’. Latest reference 30 July 1976. Latest reference 10 December 1975. NCUACS 36/4/92 J.S. Mitchell Latest bibliographical reference 1976. Latest reference 30 March 1978. Possibly radiotherapeutic oncology. Latest reference 11 February 1980. towards rough notes book used for a on problems of ILLUSTRATIVE MATERIAL Hardback binders containing illustrative material (graphs and figures, formulae, equipment, text etc) used by Mitchell and other members of the department for lectures and possibly publications. The material is small- format photographs and other figures probably reproduced from slides. Sets of illustrations used by Mitchell, 1957-71. GERMAN LANGUAGE Sets of illustrations used by other members of the Department, identified by name. Mitchell was a frequent visitor to Germany. He attended many conferences in that country and helped found the Anglo-German Medical Society to foster links between medical academics and practitioners in Britain and West Germany. A number of Mitchell’s lectures and publications were in German. back. Latest reference 1959. These notebooks document Mitchell’s efforts to improve his command of the language. Hardback notebook used as English-German glossary. Loose material at Softback notebook used for notes on the German language, c. 1954. NCUACS 36/4/92 J.S. Mitchell SECTION D RESEARCH D.1-D.595 Some documentation of Mitchell’s research may be found in notebooks, listed in Section C (C.1- C.58). The papers presented in this section should therefore be consulted in conjunction with the notebooks. The bulk of Mitchell’s research, however, was found in considerable disorder in folders or envelopes, or as loose notes. This material, which covers Mitchell’s entire research career from postgraduate studies in 1933 to his death in 1987, has been divided into three subsections to correspond with distinct stages in his career. The first, Early research, consists of material dating principally from Mitchell’s postgraduate and postdoctoral work on the biophysics of protein monolayers with E.K. Rideal at the Colloid Science Laboratory in Cambridge, 1933-38. The second subsection, Biochemistry of ionising radiations, comprises research carried out chiefly 1941-49. There is a little documentation of Mitchell’s work from 1939 as Assistant in Research in Radiotherapeutics in the Cambridge Department of Medicine, but the bulk of the material is research undertaken during and just after the war on the radiobiological hazards to health of those working with or exposed to ionising radiations. This includes Mitchell’s work with the British and Canadian period. These were made available by Mitchell shortly before his death. serving as a member of several Medical Research Council, Ministry of Supply and Ministry of Health was appointed Professor of Radiotherapeutics at Cambridge and Director of the Radiotherapeutic The third subsection, Cancer research, is by some way the largest. It documents Mitchell’s main research effort; his long-standing determination to find a cure for cancer*. After the war Mitchell D.138-D.144 is Mitchell’s own selection of his most important papers relating to his work in this committees which continued after his active research into radiobiological hazards had ceased. At Atomic Energy Project at Chalk River, Canada, 1944-45. Mitchell’s interest in this subject led to his at the age of six, a neighbour dying of cancer (see A.5). * Visitors and researchers at Mitchell's Department of Radiotherapeutics in Cambridge would be met by a notice (A.84) proclaiming ‘The aim of this department is to improve the treatment of cancer’. A similar ‘mission statement’ would be appropriate for Mitchell himself. His determination to find an effective treatment for cancer was inspired by his witnessing, Centre at Addenbrooke’s Hospital. Although Mitchell viewed the two posts as complementary it meant there were two distinct sides to his research: as well as a scientist studying cancer, he was also a doctor treating patients. This is reflected in the presentation of the material which documents both Mitchell’s scientific work to develop radiotherapeutic techniques to cure cancer and his treatment of those suffering from the disease. NCUACS 36/4/92 J.S. Mitchell Mitchell’s first major contribution to cancer research had been in the early 1940s, when he demonstrated that doses of x and gamma radiation inhibited DNA synthesis in the nucleus of cells. During his period in Canada with the atomic energy project Mitchell produced two reports (with J.V. Dunworth) reviewing possible medical applications of radio-isotopes. He identified the gamma-ray emitting isotope cobalt-60 as potentially the most suitable for use in radiotherapy, a view confirmed by its subsequent worldwide use (see D.144). Mitchell’s main research effort thereafter was to examine how radiation could be delivered to cancerous Cells in order to stop their reproducing. This work concentrated on radiosensitising and radioactive drugs. In November 1946 Mitchell started his investigation of radiosensitising drugs as anti-cancer agents. These drugs concentrate in malignant cells and render affected tissue more sensitive to the effects of ionising radiations. It was found that synkavit, menadiol sodium diphosphate, concentrated in malignant cells of certain tumours. Clinical trials using this drug began in 1952. From August 1953 a trial began using synkavit in conjunction with oxygen to discover whether this could enhance the drug’s effectiveness. Mitchell and his team then began work on modifying radiosensitising drugs to carry their own radiation source, thus to create radioactive drugs (whose action would resemble the treatment of beta-ray emitter. Trials with tritiated synkavit began in 1959. Various drugs were tried; TRA 72 with one tritium atom was used 1960-61, TRA 119, which had three, was used 1962-63 and TRK 219, with thyroid tumours by radio-iodine). It was hoped the drug would concentrate in malignant tissue where its radioactivity would create a radiotherapeutic effect with minimal changes to normal tissue. atoms: TRK 397 (1970-72), TRQ 347 (1973) and TRQ 368 (1973). The next step was to investigate whether an isotope more effective than tritium could be found and Mitchell was studying this at his two, was used 1964-70. The compound was then prepared in different forms with four tritium The radiation source selected by Mitchell was the radioisotope tritium (an isotope of hydrogen), a contribution to cancer research in pioneering randomised trials to assess the efficacy of different ‘Unfortunately, the selective uptake was not of sufficient magnitude to produce the desired effect with the required tumour selectivity. The idea was, and still is, first class and comparable techniques, with monoclonal antibodies to target radiation, are now being developed. Once again Mitchell was far ahead in his field and with a little more luck could have made even greater improvements in the treatment of cancer.’ Marrian wrote in his memoir of Mitchell, (Biographical Memoirs of Fellows of the Royal Society, 34 (1988), p.601): death. Mitchell’s work with radiosensitising and radioactive drugs did not fulfil his expectations. As D.H. The remainder of this subsection covers Mitchell’s treatment of patients as a physician, including his NCUACS 36/4/92 J.S. Mitchell kinds of treatment. The King’s College Hospital London - Addenbrooke’s Hospital Cambridge Breast Trial of therapy for ‘early’ breast cancer (D.408-D.466), which Mitchell helped organise, was one of the first of its kind and led the way to larger scale trials which have significantly improved the treatment of this common form of cancer. He was also among the first to suggest that psychological factors might play an important part in the onset, cure and recurrence of cancer and encouraged research into this as first Chairman of the Faith Courtauld Cancer Research Unit (D.512- D.535). The material is presented as follows: D.1-D.22 EARLY RESEARCH D.23-D.144 BIOCHEMISTRY OF IONISING RADIATIONS D.145-D.595 © CANCER RESEARCH D.145-D.205 General and miscellaneous D.206-D.308 Radiosensitising drugs D.536-D.595 D.309-D.394 Radioactive drugs D.395-D.535 Treatment of cancers Patient records and case notes NCUACS 36/4/92 J.S. Mitchell EARLY RESEARCH Correspondence between E.K. Rideal and Adam Hilger Ltd., 1933-34, re cutting a quartz prism and lenses for a monochromatic illuminator for the Cambridge Department of Colloid Science. Folder also includes manuscript calculation by Mitchell ‘Colinear relationship of object space and image space’ found with the correspondence. ‘Ultra-violet light and spectroscopy’. inscribed divided into seven for ease of reference: graphs etc. c.1934-45. Contents of Mitchell’s envelope so notes, calculations, Material includes report beginning ‘During the last three years we have been investigating the photochemistry of proteins, from the point of view of radiation therapy’, 12pp typescript, annotated by Mitchell ‘Radiobiology Committee July 1937’ (D.3); ‘On the photochemical decomposition of some organic anions and free acids in ultraviolet light’ by L. Farkas and O.H. Wansbrough-Jones, ‘Proposed investigations, Michaelmas, 1937. Mitchell and [C.B.] Allsopp’ (D.4). 17pp typescript (D.4); ‘Physical chemistry’. Contents of Mitchell’s folder so inscribed: manuscript notes, latest bibliographical reference 1934. Manuscript and typescript data on amino acid constituents of proteins, latest bibliographical reference 1935. ‘The present position of the complement fixation reaction’ by Mitchell, 12pp typescript ‘prepared for Prof. E.K. Rideal about 1935 or early 1936’. ‘Ultraviolet photomicrography’. Contents of Mitchell’s envelope so inscribed divided into notes, calculations, graphs, correspondence from manufacturers of scientific apparatus etc., c. 1936-54. reference. ‘Dispersal of light by absorbing and refracting cylinder (chromosome)’. Contents of Mitchell’s envelope so inscribed divided into four for ease of Includes of photographs found therewith (D.14). ‘Ultra-violet irradiation five for ease of reference: leucocytes’, 11pp typescript with D.12-D.16 D.17-D.20 NCUACS 36/4/92 J.S. Mitchell D.17, D.18 Manuscript calculations paginated 1-59. Page 30 is written on verso of ‘Abstract of unconfirmed minutes of [?St John’s College Cambridge] Council 25th January 1940’. 2 folders. Miscellaneous calculations. 2 folders. Miscellaneous manuscript notes, references etc. 2 folders. BIOCHEMISTRY OF IONISING RADIATIONS Minutes of ‘TQ’ meetings on tolerance doses of radiation, 26 March, 25 June, 3 and 10 December 1941. D.24-D.29 ‘Tissue culture notes’. Contents of Mitchell’s folder so inscribed divided into six for ease of reference. D.25-D.28 4 folders. letter, February 1942; manuscript notes; Photographs of tissue culture. Miscellaneous photographs found with preceding. Notes on experiments on chick tissue culture, 1941. Contents of Mitchell’s folder so ‘Chromosome breakage by radiation’. inscribed: ‘The effects of fractionated x-ray dosage on restitution and reunion’ by K.C. Bora, c.1951, 5pp typescript. W.A. Akers, December 1946, re paper by Brasch and Huber; etc. ‘Gene mutations and chromosome breakage (summary)’. Mitchell’s folder so inscribed divided into three for ease of reference. Draft ‘Second Note on “Electronized Chemicals” based on discussion with Professor J.S. to letter from Mitchell E.C. Bate-Smith; Mitchell’ by D.31-D.33 Contents of NCUACS 36/4/92 J.S. Mitchell ‘Translation of part of a “confidential” Swedish report: “Studies of the influence of Roentgen irradiation, with and without the addition of protecting substance, upon the fertility and mutation frequency in mice” - by K.G. Lining’; etc. Manuscript notes, 1957. ‘Chromosome breakage by genetic effects. Carcinogenesis’. Contents of Mitchell’s notes, bibliographical references etc., c.1948-72. manuscript typescript inscribed: and folder so_ Manuscript notes, 21 April 1942; ‘Carcinoma of the lung’, 4pp typescript with Mitchell’s manuscript corrections, c. 1944. D.36-D.41 ‘Metabolic effects’. Contents of Mitchell’s folder so inscribed divided into six for ease of reference. Includes correspondence with J.N. Davidson, 1943, re work on nucleotides; application for renewal of British Empire Cancer Campaign grant, 1943, including outline of proposed research; manuscript notes. Correspondence with R.E. Stowell, 1944-45, re experimental results in Mitchell’s three papers on ‘Disturbance of nucleic acid metabolism produced by therapeutic gamma radiation’ published in Br. J. exp. Path. 23 (1942) (Bibliog. 18-20); manuscript notes. Correspondence with W.M. Dale, 1943-44, re ‘ionic efficiency’ including draft of proposed letter to Nature by Dale; ‘Report on investigations of the therapeutic action of X and gamma radiations’ by Mitchell, 5pp typescript, 4 July 1944; manuscript note on ‘Interview with Dr Bach 7.6.46’. of correspondence received by R.A. McCance, 1936-37. ‘Some aspects of the therapeutic action of radiation’, typescript introduction plus 3pp list of slides for ‘Lecture 5.1.45’; manuscript notes, some on verso NCUACS 36/4/92 J.S. Mitchell Letter from F.W. Gunz, June 1945, enclosing ‘figures of the photometer measurements of a set of plates from a leukaemic bone marrow treated for the first time’. Folder includes the photographs to which the figures refer, and two other photographs found with them. Includes Annual Reports to the British Empire Cancer Campaign for 1948; ‘Lecture 7. 20.1.48 Department of Anatomy’ on ‘the metabolic effects of therapeutic doses of X and gamma radiations’, 9pp typescript. ‘Tolerance’. Contents of Mitchell’s folder so inscribed divided into two for ease of reference. ‘Industrial Technical Letter’ re Photocopy of use and care of minometers’, 1 January 1944, issued by G.E. X-ray Corporation, with figures for thickness of lead required for protection against x-radiation found attached; ‘The calculation of the tolerance flux of fast neutrons’ by J.H. Tait, 4 February 1949; etc. ‘The Lisco, Letter from H. a ‘Standard Man’ for calculations of tolerances to radioactive isotopes; correspondence, 1949; including some annotated ‘Strontium Lisco 1947’. 15 September 1947, enclosing draft data for manuscript notes D.44-D.54 ‘Determination of the number of neutrons emitted by a Radium-Beryllium source’ by E. Bretscher et a/, BR 382, stamped ‘18 Feb 1944’. Contents of Mitchell’s folder: papers and reports on fast and thermal neutrons, 1944-50. Where applicable the official report number has been given. Kinsey and S.G. Cohen, BR 452, stamped ‘24 Jun 1944’. ‘Neutron flux measurements (D+D and C+D neutrons)’ by E. Bretscher and A.P. French, BR 386, stamped ‘18 Feb 1944’. ‘The energy spectrum of the neutrons from the lithium (p.n.) reaction’ by B.B. NCUACS 36/4/92 J.S. Mitchell ‘Lectures on Pile Theory. ll. Diffusion of Thermal Neutrons’ by G. Volkoff, TL 2. (Lectures of Sept. 27th and Oct. 4th [1944}). ‘Lectures on Pile Theory (Lectures of October 11, 18, 25) Ill. Slowing-down of fast neutrons’ by G. Volkoff, TL 3. Manuscript calculations by Mitchell intercalated. ; ‘The range/energy relation for particles of 0-5.3 MeV in ethylene and polythene’ by D.H. Wilkinson, BR 639, May 1945. ‘Measurement of a flux of fast neutrons with a counting pressure ionisation chamber’ by K.W. Allen, BI 93, October 1945. ‘Bremsung und Absorption von Neutronen in Beton’ by P. Jensen and O. Ritter, sent to Mitchell, 24 April 1946. ‘Summary of Report on “Atomic Bombs, Hiroshima and Nagasaki ... May 1946’, NP/P/19. ” (29th ‘The neutron spectra of Po-B and Po-Be’ by L.H. Perlman et a/, MDDC 39, ‘Document declassified 7/9/46’. ‘Stars produced in nuclear emulsions by 150 MeV neutrons’ and ‘Hammer tracks in neutron and proton induced stars’ by E.W. Titterton, 1950. ‘Experiments on the mechanism of the biological action of fast neutrons using the summation method for lethal effects in mice’ by Mitchell, 12pp typescript plus references and tables, Bibliog. 31; ‘The thermal neutron distribution in a slab of paraffin’ by J.H. Tait and B. Smith, for publication in Nature, sent to Mitchell 12 August 1949; etc. Not used. ‘The action of neutrons on bacteria’ by F.G. Spear, nd. ‘Reduction in neutron density caused by an absorbing disc’ by T.H.R. Skyrme, MS 91, nd. Miscellaneous notes and figures. NCUACS 36/4/92 J.S. Mitchell D.56-D.59 ‘Radiation Carcinogenesis & Radiation Injury’. Contents of Mitchell’s box so labelled divided into four for ease of reference. ‘Problems in relation to the protection of personnel’ by Mitchell, 2pp typescript, 15 November 1944; ‘Some aspects of the biological action of X and y radiations introduction to colloquium’, 3pp typescript, 16 November 1944 plus 2 plates; data, 1945; correspondence and papers, 1951-56. Typescript extracts from published papers re radiation injury. ‘A re-evaluation of the maximum permissible concentration for radium’ by W.B. Looney, sent to Mitchell for comment, 30 July 1957. Manuscript and typescript notes; 8pp typescript ‘Bibliography’. Ministry of Supply Health Sub-Committee Memorandum SCH-12 ‘Notes on Industrial Tolerance Conference National Cancer Institute, Bethesda, Maryland. January 23-24, 1945. By J.S. Mitchell’. D.61-D.64 D.65-D.67 Duplicated typescript reports by Mitchell, prepared while working in Canada. ‘Note on tolerance levels for X’ by Mitchell, 16 September 1945 (no.H-12), 4pp. ‘Montreal experiments’. Manuscript and typescript notes so labelled on experiments on irradiation of mice, 1945. Not all the manuscript notes are in Mitchell’s hand. 4 folders. 14 November 1945, 20pp. ‘Note on the preparation of radioactive isotopes for use in medicine and biology (Supplement to Memorandum on “Application of Nuclear Physics to Medicine and Biology”)’ by Mitchell and J.V. Dunworth, 17 October 1945 (no.HI-13), 15pp. ‘Applications of recent advances in nuclear physics to medicine’ by Mitchell, NCUACS 36/4/92 J.S. Mitchell D.68-D.71 Contents of Mitchell’s folder: miscellaneous typescript and manuscript notes, papers, correspondence etc., various dates, 1944-46, but most dated November 1945. importance recommended for Includes memorandum to J.D. Cockcroft from Mitchell re ‘Subjects of medical 29 November 1945, referring to declassification of wartime reports, list of ‘Documents for Dr Mitchell’, 12 December 1945, and lists of papers sent to Mitchell 29 December 1945 and 15 January 1946. publication’, release and Includes ‘Biological effects of high doses [of radiation]’, 4pp typescript, and invitation to contribute to Symposium on Nucleic Acid organised by the Society for Experimental Biology (see also G.1). Correspondence, October-November 1945; manuscript note by Mitchell on ‘Meeting with Dr K. Williams on 2 April 46 at 12 noon in Addenbrooke’s Hospital’. 2 folders. D.72-D.86 ‘External Irradiation’. ‘HAZARDS’. Contents of Mitchell’s box so labelled. The material was found in folders with subject titles are reproduced in the catalogue entries. Where appropriate Mitchell’s bulky folders have been subdivided for ease of reference. inscribed thereon and these titles Photocopy of ‘Biochemistry at Chalk River’ by A.M. Marko, G.C. Butler and D.K. Myers, Bulletin of the Canadian Biochemical Society 23 (1986), 11-19. Sent to Mitchell by Myers as it includes a note on Mitchell’s work at Chalk River 1944-45 on p.14. Reprints etc. Includes material re leukaemia, 1945; draft note ‘Health precautions in atomic and nuclear physics’ by E.S. Shire sent to Mitchell for comment, 6 December 1947; letter from D.H. Wilkinson, 19 October 1950, re exposure to irradiation of workers in the Cavendish Laboratory. ‘Fall out’. 4 folders. NCUACS 36/4/92 J.S. Mitchell D.78-D.80 ‘Genetic effects’. 3 folders. Includes ‘Preliminary Note on Tolerance for Total Body Gamma Irradiation’ by Mitchell, Hl-11, 18 September 1945; abstract from HI-18, November 1945. ‘Genetic effects of radioactive pollution’ by T.C. Carter, 1958; work of L.B. and W.L. Russell. material re Medical Research Council papers including material for Experimental Genetics Committee, 1958, 1960. ‘Protection’. Reprints ‘Statistics’. Manuscript and typescript notes. D.87-D.90 D.83-D.86 ‘Various Reprints’. 4 folders. ‘Hazards’. Contents of Mitchell’s folder so inscribed divided into four for ease of reference. Ministry of Supply Health Subcommittee Memorandum SCH-11 ‘The problem of clinical tests for the early detection of permanent radiation damage’ by Mitchell, 1946; manuscript notes. Correspondence and papers, various dates, 1956-66. ‘Applications of recent advances in nuclear physics to radiotherapeutics’ by duplicated typescript notes on Mitchell, 4pp typescript, 6 October 1947; ‘informal discussion of the radioiodine treatment of thyroid carcinoma ... ’, heavily annotated by Mitchell. NCUACS 36/4/92 J.S. Mitchell Manuscript and typescript notes. D.91-D.93 ‘Hazards: divided into three for ease of reference. Genetic effects’. Contents of Mitchell’s folder so inscribed Ministry of Supply Tolerance Dose Committee papers ‘The inapplicability of Brues Law for the incidence of sarcoma in the tolerance range’ and ‘The tolerance amount of Ra, Sr and Pu in the human body’ by K. Fuchs, 1948. Median Lethal Dose for Men exposed Includes ‘Presentation by Dr Failla in a radioactive fall-out field’ prepared for the Tripartite Conference, 1956, sent to Mitchell for comment; letter from E.E. Pochin re meeting to ‘discuss the pathological effects result from bone concentrations of radiostrontium’, 24 October 1957, heavily annotated by Mitchell. likely to Miscellaneous notes and papers, c. 1955-59. Typescript notes of meetings, September and November 1946, to discuss the measurement of radiation in bone and tissue. Manuscript notes, dated ‘25.10.46’, of meeting on radioactive hazards; other manuscript notes found therewith, first sheet, on ‘Fibre proteins’, annotated ‘K. Bailey’. Memorandum to J.D. Cockcroft from J. Thewlis, 13 March 1946, outlining ‘X- Ray work at Harwell’; ‘Simultaneous treatment of malignant neoplasms by means of “short waves” and X or Y radiation’ by G.R. Newbery, 6pp typescript, 26 February 1946; ‘Dosage measurements on two MeV x-rays’ by A.J. Cipriani and W.V. Mayneord, 27 May 1946; manuscript notes, May, July 1946; etc. binder. ‘A course in nuclear physics, 1946’. Photostat of lecture course paginated 1-77 and stamped ‘Directorate of Atomic Energy ... ’, retained in original NCUACS 36/4/92 J.S. Mitchell D.98-D.104 | Material re the sterilisation of foodstuffs and medicaments by radiation. In December 1946 Sir Wallace Akers, Research Director of ICI, asked Mitchell for his views.on an American report on the sterilisation of foodstuffs by electron bombardment. Mitchell replied ‘The presentation is poor and the biological work not very convincing but | think the underlying idea is right’. He recommended further any experimental work necessary. ICI subsequently decided not to pursue this but research was taken up at the Low Temperature Research Station (LTRS) at Cambridge. Mitchell felt ‘this whole question of sterilisation of foodstuffs by radiation should be considered in this country because | gather indirectly that a number of American commercial firms are interested in An informal group was established, of which Mitchell was a member, to support such research. investigation offering advise it’. to on Correspondence, 1946-48. Includes ‘Sterilisation by low dose of x-rays’ by S.W. Bogyo sent to Mitchell for comment. Correspondence and papers re 2nd and 3rd meetings of the informal group, 19 December 1950 and 13 December 1951. Papers for MRC informal conference on the Electronic Sterilisation of Medicaments and Foods, 9 February 1953. Mitchell was unable to attend. Correspondence with MRC re current position of research into sterilisation of foodstuffs by radiation, December 1951; minutes of meeting to discuss the electronic sterilisation of pharmaceutical products, 30 April 1952; etc. Correspondence and papers, 1954-57. Includes general correspondence with colleagues at LTRS re Cobalt-60 Source used by the LTRS for work on sterilising food and medicines. to and ownership of the Cobalt-60 Source. Correspondence and papers for LTRS Symposium on Radiation Processing of Foods, 26-27 September 1957. Mitchell was unable to attend. Correspondence with colleagues at LTRS, 1957-60, chiefly re improvements NCUACS 36/4/92 J.S. Mitchell D.105-D.122 Material re dosimetry. D.105-D.108 Contents of Mitchell’s folder divided into four for ease of reference. ‘Radioactivity Units and Standards’ by R.D. Evans, 15 April 1947. ‘Calorimetric measurement of the energy released in a one range Uranium cyclotron target by 189-MeV deuterons’ by R.M. Horning et a/, Livermore Research Laboratory, December 1953. Manuscript and typescript notes. Includes ‘Memorandum by Dr L.H. Gray on:- The adoption of the Rad by radiotherapy departments’ sent to Mitchell for comment, 3 February 1955, and pages of typescript draft on units of measurement of radiation (possibly part of draft at D.116). Memoranda by G.R. Newbery, Radiotherapeutic Research Unit, London, re use of the neutron beam from the MRC Cyclotron; sent to Mitchell prior to discussion, 14 June 1955. D.109-D.122 Contents of Mitchell’s folder divided into fourteen for ease of reference. Typescript ?extract from ‘Cosmic-ray induced fission’ by D.K. Froman et al, declassified 20 June 1947; US National Bureau of Standards report ‘The problem of radiation dosimetry in the multimillion-volt energy range’ sent to Mitchell for comment 29 August 1947; typescript draft on radiotherapeutic possibilities of radiophosphorus and radioiodine by Mitchell, 10 September 1947 (first page missing). December 1950. US Atomic Energy Commission report ‘lonization chamber studies of energy transfer from 100 MeV neutrons to light nuclei’ by R. Loevinger, 21 October 1947. 3 folders. D.110-D.112 Manuscript notes etc., some dated December 1949, November and NCUACS 36/4/92 J.S. Mitchell National Bureau of Standards reports ‘Penetration and diffusion of X rays Mathematical techniques’ by ‘The distribution of linear energy transfer or “ion density” for fast neutrons in water’ by J.W. Boag, 15 November 1953. L.V. Spencer, 3 March 1951, and US Naval School of Aviation Medicine Research Reports ‘Graphs and tables for the hit frequencies from heavy nuclei of the primary cosmic radiation’, 4 August 1954 and 11 February 1955. ‘Some aspects of radiation dosimetry’ by Mitchell, incomplete typescript draft paginated 1-4 with extensive manuscript correction and annotation. This may be the first part of the draft at D.107. Circuit diagrams; instructions for use of potentiometer. D.118-D.122 Miscellaneous manuscript and typescript notes. 5 folders. D.123-D.128 Material on fast and thermal neutrons. E.D. Dyson’ re the use of photographic films Typescript and manuscript notes, 1947. ‘Preliminary considerations on the energy distribution due to a flux of fast neutrons’ by R.K. Appleyard, 21 April 1947, 8pp manuscript; comments by D. Lee on draft by Mitchell ‘The provisional calculation of the tolerance flux for fast neutrons’, 3 May (with draft and manuscript calculations found attached; letter from K. Chackett and G.R. Martin re the published paper; ‘Note on visit to Prof. Mitchell ... Cambridge on 7th October by Dr J.W.J. Fay and Dr for personnel monitoring. neutrons’ by Mitchell. ‘Preliminary draft of report of Subcommittee on Permissible External Exposure of [US] National Committee on Radiation Protection’ by G. Failla, September 1949; manuscript note ‘Average energy loss per collision by fast ‘Biological effects of inscribed divided into two for ease of reference. fast neutrons’. Contents of Mitchell’s folder so D.124, D.125 D.126, D.127 2 folders. NCUACS 36/4/92 J.S. Mitchell Letter to J.W. Boag, 26 March 1952, enclosing ‘Tolerance levels for fast and thermal neutrons’, 10pp typescript plus references (Bibliog. 40); letter to A Citron, 20 April 1953, advising ‘on tolerances in connection with shielding of high energy machines’; manuscript notes etc. ‘Proposed program for computing the REM dose due to irradiation by fast neutrons’ by W.S. Snyder and J. Neufeld to be submitted to the National Bureau of Standard’s Subcommittee on Heavy Particles. Sent to Mitchell for comment, 1 March 1955. Folder also includes ‘Maximum permissible neutron flux for fast and thermal neutrons’ by Snyder and Neufeld found with it. ‘The biological basis of maximum permissible exposures for workers in the field of atomic energy’ by G.C. Butler, Canadian National Research Council Atomic Energy Project, 20 August 1947. Manuscript notes, not in Mitchell’s hand, dated 1948; manuscript calculation by Mitchell dated 16 May 1948. D.131, D.132 ‘Biochemical effects of radiation’. inscribed divided into two for ease of reference. Contents of Mitchell’s envelope so 1957’; D.133, D.134 Manuscript and typescript notes. Note from E.E. Pochin of ‘meeting on radiostrontium at the Medical Research Council on September 30th ‘Changes in the urinary excretion of 8-amino-isobutyric acid after irradiation’, 12pp typescript plus abstract and figures, latest bibliographical reference 1963. Nd. ‘Mechanisms of action’. Contents of Mitchell’s folder so inscribed divided into two for ease of reference: manuscript and typescript notes. Latest bibliographical reference 1963 but includes much earlier material. Manuscript notes on treatment of overexposure to radiation; dangers of exposure to radon. material on NCUACS 36/4/92 J.S. Mitchell Notes on ‘Discussion with Dr Charles’ re ‘production of genetic effects in mice by means of one MV X radiation’, nd; ‘The radiation chemistry of systems of biological interest’, 3pp typescript, nd. Manuscript notes, nd. D.138-D.144 Mitchell’s selection of his own most important papers on atomic energy and radio-cobalt in radiotherapy. ‘Notes on Visit to Rochester (March 14-16, 1945) by J.S. Mitchell’, 12 April 1945, HI-4. ‘Visit to Chicago, 18-19 April, 1945. Notes by J.S. Mitchell’. HI-6. 1 June 1945, ‘Applications of recent advances in nuclear physics to medicine’, November 1945, HI-15. 14 ‘Notes on visit to Rochester (9th-10th November, 1945)’, 19 November 1945, HI-18. ‘Provisional calculation of the tolerance flux of fast neutrons’, 4pp typescript plus tables with manuscript correction, 1947. ‘Memorandum on some aspects of the biological action of radiations, with especial reference to tolerance problems’, 20 November 1945, HI-17. how this arose’. 2pp typescript with manuscript correction. ‘Notes for speech at presentation of portrait at Dr Harry Richard’s house on 6th March 1977 Sunday am’ beginning ‘I would like to say a few words about the “Idea” - which was the proposal to use 6°60 in radiotherapy and NCUACS 36/4/92 J.S. Mitchell CANCER RESEARCH D.145-D.205 General and miscellaneous D.206-D.308 Radiosensitising drugs D.309-D.394 Radioactive drugs D.395-D.535 Treatment of cancers D.536-D.595 Patient records and case notes General and miscellaneous D.145, D.146 ‘Radioisotopes older work’. divided into two for ease of reference. Contents of Mitchell’s folder so inscribed ‘Therapeutic possibilities of radio-phosphorus’ by Mitchell, 4pp typescript, 27 December 1946, Bibliog. 27 (1947), with manuscript notes found with it; ‘Note on therapeutic applications of radioactive isotopes’ by Mitchell, 5pp typescript, Radioactive isotopes for therapeutic investigations’ by Mitchell, prepared for the MRC’s Committee on the Medical and Biological Applications of Nuclear Physics Clinical Sub-committee, 21 January 1948 (see F.256); etc. ‘Revised draft statement 10 September 1947; ‘6th Lecture [...] 21.11.50’ on ‘radioactive isotopes in radiotherapy’ by Mitchell, 1Spp typescript; ‘Ist draft’ of introduction to dissertation on , 5pp typescript, latest bibliographical reference 1955; etc. dosimetry of | Contents of Mitchell’s folder divided into five for ease of reference. Material re clinical use of radioactive isotopes. Includes ‘Caution in the clinical use of radioactive isotopes especially radiophosphorus’ by Mitchell, 2pp typescript, latest bibliographical reference 1947; letter from K. Fuchs re |'79 ‘MRC synchrotron physical investigations. Notes on a visit to T.R.E. Malvern July 12th-23rd 1948’ by D.J. Allen-Williams. . 24 June 1948. D.149-D.153 NCUACS 36/4/92 J.S. Mitchell Copy of ‘Total cross sections of nuclei for 280 MeV neutrons-l’ by R. Fox et al, 1950; typescript tables of methods and results of treatment of cancers, c.1951. California Radiation 26 January Laboratory, University of Includes ‘Report of work by L. Burkinshaw, Sept. 1952 - Sept. 1953’, 13pp typescript. Incomplete typescript text of lecture on treatment of tumours, paginated 21- 41. Photographs for slides for the above. Manuscript and typescript notes on radioisotopes. D.154-D.156 ‘Radioactive isotopes’. Contents of Mitchell’s folder so inscribed divided into three for ease of reference: miscellaneous manuscript and typescript notes etc., c.1950-58. D.159-D.162 Contents of ‘General radiotherapy and problems of malignant growth’. Mitchell’s folder so inscribed divided into four for ease of reference. Correspondence, September-November 1951, re supply of c'-labelled adenine to Mitchell by the Sloan-Kettering Institute, New York. Manuscript notes re Victoreen chamber, used to measure synchrotron dose, 1952. Also includes photographic negatives and x-rays found with the notes. notes, 1955. ‘The concentration of substances in tumours’, 8pp typescript and manuscript draft, latest bibliographical reference 1952. ‘Director’s visit to US and Canada, March 1952 Part 14 - Treatment of brain tumours with Pile neutrons’ by J.D. Cockcroft, 1p typescript; manuscript NCUACS 36/4/92 J.S. Mitchell ‘Report on the visit of Dr V.B. Levison to the Radiumhemmet August/ September 1968’, 22pp duplicated typescript. Manuscript and typescript notes, various dates 1961-69. ‘Relative biological efficiency of pulsed 30 MeV X-rays and ip’ gamma rays’ by Mitchell, 2pp abstract on work of K.C. Bora, latest bibliographical reference 1953; to Mitchell from J.L. Haybittle, 27 July 1954, enclosing his ‘Annual Report’; miscellaneous material re Ir ~~. letter D.164-D.168 ‘Cancer chemotherapy’. Contents of Mitchell’s folder so inscribed divided into five for ease of reference. ‘The reaction of substituted maleimides with thiols’ by D.H. Marrian, 11pp typescript, c.1955; manuscript and typescript notes found therewith. Minutes of meetings of American Cancer Society Committee to study the Problem of Cancer Quackery, June and November 1955. Cancer plus references etc. 2 folders. D.166, D.167 symposium on See F.140- from Papers Chemotherapy of Cancer, Oslo, 21-25 May 1956. F.145. International Against Union Manuscript tables of ‘Chemotherapeutic agents’, 1958, and ‘Some carcino- chemotherapeutic agents’, 1971. Churchill-Davidson et a/, July 1958. ‘The x- and ¥ irradiation of ferrous sulphate in dilute aqueous solution’ by J.L. Latest bibliographical reference 1955. ‘Various therapeutic methods’. Contents of Mitchell’s folder so inscribed: ‘Oxygenation in radiotherapy results of treatment December 1956’ by I. Churchill-Davidson et a/; manuscript notes. ‘High-pressure oxygen and radiotherapy Results of treatment’ by 15pp typescript Haybittle et a/, I. NCUACS 36/4/92 J.S. Mitchell ‘High-pressure oxygen and radiotherapy Davidson et a/, July 1962. Results of treatment’ by Churchill- ‘High-pressure oxygen and radiotherapy Results of treatment of cases treated on new unit from June, 1959’ by Churchill-Davidson et a/, July 1962. Includes re cobalt sources, 5 September 1960, and typescript tables of Contents of Mitchell’s folder: letter information on radioactive isotopes, c. 1960. manuscript and typescript notes. Manuscript data from experiments with co-enzyme Q10 on monolayer cultures, 1961-62. Not in Mitchell’s hand. Clinical trial of anti-sickness drugs in radiotherapy. Duplicated typescript results of pilot trial and protocol for second trial, May 1962; results of second trial and protocol for third trial, July 1964. 1 ‘Summary of recent work’ by G. DiVita, 10pp typescript with manuscript annotation by Mitchell, 11 May 1964. See C.50. ‘5th-9th September 1966 Comments on culture work at Homburg’ by P.P. Dendy, 5pp typescript. Questionnaire on ‘The medical uses of low energy (5-50kV) x-rays in the United Kingdom’ completed by J.L. Haybittle for the Radiotherapeutic Centre, with brief correspondence arising, 1969. Manuscript notes and bibliographical references, c.1974-75. 2 folders. ‘Cancer Chemotherapy’. Contents of Mitchell’s folder so inscribed divided into four for ease of reference. Material Radiotherapeutics, 1969-72. 2 folders. P.P. Dendy and re work of D.181, D.182 D.179-D.182 D.179, D.180 others in the Department of NCUACS 36/4/92 J.S. Mitchell Proposals and draft protocols for clinical trials using the linear accelerator MEL SL 75-20, dated ‘31.10.74’. ‘Progress Report on Project RAD 5 “In vitro assays of tumour cell sensitivity to cytotoxic drugs” 14 August 1974; manuscript notes of meetings found with it. Mitchell, 3pp typescript, by ’ Contents of Mitchell’s folder: dosages, latest reference 1976. miscellaneous material chiefly re radiation Papers for meetings of the MRC Working Party on Radiotherapy and High- Tension for Hyperbaric Oxygen, 1976-77, sent to Mitchell for reference and comment. D.187-D.189 Contents of Mitchell’s folder divided into three for ease of reference. D.187, D.188 Unidentified graphs and data, August-November 1977. 2 folders. effects of radioactive molecular biological and ‘Biochemical chemotherapeutic agents’. manuscript notes, 1979. ‘Line Sources Measured 31.10.77 & template’. Photographs. and Contents of Mitchell’s folder so inscribed: Mitchell’s manuscript notes on meetings with research, 1983-84. Radiotherapeutics (Oxford, 1960). Miscellaneous manuscript and typescript notes, 1979-85, nd. P.P. Dendy to discuss D.192-D.195 book Studies in Notes removed Mitchell’s copy of his D.192 1979-81 D.193 1982-84 D.195 Nd D.194 1985 from NCUACS 36/4/92 J.S. Mitchell D.197-D.200 Manuscript notes on the literature, 1983-85. 4 folders. Print-outs from literature searches on ‘alkaline phosphatase and neoplastic disease’ and ‘malignant disease in pigeons’, undertaken for Mitchell, May 1983. D.202-D.205 ‘List of reprints sent for and copied’. labelled divided into four for ease of reference. Contents of Mitchell’s folder so Radiosensitising drugs D.206-D.216 ‘Synkavit’. Contents of Mitchell’s box so inscribed divided into eleven for ease of reference. ‘Combination of some effects of x-radiation and a synthetic vitamin k’ by Mitchell 1947); miscellaneous material found therewith. Simon-Reuss, manuscript (Bibliog. 5pp and 30, |. trials of etc. 2-methyl-1:4 tetra-sodium ‘Chemotherapy of multiple myelomatosis’ by Mitchell, 3pp manuscript and 3pp typescript drafts plus references, 4 September 1947 (Bibliog. 32); material found therewith. naphthohydroquinone ‘Clinical diphosphate, in conjunction with X-ray therapy’ by Mitchell, 16pp typescript plus summary and references, 27 August 1948, ‘Revised 20.9.48’ (Bibliog. 35); Patient notes, 1946-48. 4 folders. Typescript and manuscript tables, notes and correspondence on results of experiments with radiosensitisers, including synkavit, 1958. Miscellaneous notes, pages of drafts, calculations etc. D.212-D.215 D.210, D.211 2 folders. NCUACS 36/4/92 J.S. Mitchell Index cards of patient notes, 1947-48. D.217, D.218 ‘Current Expts Synkavit’. Contents of envelope so inscribed divided into two for ease of reference. Correspondence, 1949-50, re synkavit; Empire Cancer Campaign’ of manuscript notes, graphs etc. 1950 ‘Annual Report to the British the Department of Radiotherapeutics; Abstracts of eight cases treated with synkavit, sent to Mitchell 1949. D.219-D.225 inscribed ‘Radiosensitive chemicals and tissue cultures’. Contents of Mitchell’s folder so data from experiments with radiosensitisers; manuscript and typescript notes, graphs etc. 1949-57. into seven for reference: ease of divided Correspondence re results of clinical trial on carcinoma of the bronchus, 1950-51. of tetra-sodium Duplicated typescript results of treatment by intra-venous and intra-muscular administered synkavit, April 1951 - December 1952. This trial compared the results of treatment by x-rays only, with treatment by x-rays and synkavit. ‘Concentration 2-methyl-1:4-naphthohydroquinone diphosphate [synkavit] in the Walker rat carcinoma 256, and normal rat tissues’, ‘Revised 18.11.51’. bibliographical reference 1951. ‘Further clinical trials of tetra-sodium 2-methyl-1:4-naphthohydroquinone diphosphate in conjunction with x-ray therapy in inoperable cases of carcinoma latest Contents of Mitchell’s folder divided into four for ease of reference. bronchus’ by D.229-D.232 of the Mitchell, 14pp typescript, NCUACS 36/4/92 J.S. Mitchell ‘Factors which influence radiosensitivity’ 6pp typescript, latest reference 1951. Includes reference to bronchus trials carried out by Mitchell. D.231, D.232 Manuscript notes, tables, calculations. Various dates 1949-66. 2 folders. D.233-D.237 Data from experiments, 1952-53, possibly on effects of synkavit on rats with and without doses of ionising radiation. 5 folders. D.238-D.241 Similar data to preceding, 1953-54. 4 folders. D.242-D.244 ‘Synkavit’. Contents of Mitchell’s folder so inscribed divided into three for ease of reference: data from experiments with synkavit and 2-ethylenimino- 1:4-naphthoquinone, 1952, 1954. Typescript and duplicated typescript material re trials of synkavit, 1952-53 and nd. Letter from B. Jolles, Radiotherapy Department Northampton General Hospital, 16 May 1953, enclosing ‘graphs relating to experiments with rabbits and rats’ with synkavit and whole-body irradiation. ‘Clinical therapeutic trial of a radiosensitiser Summary of results’. Results assessed 31 May 1953. D.248-D.255 Protocol for trial; miscellaneous notes. ‘Pilot trial Feb 1954 Clinical trials of oxygen and synkavit with randomised allocation’. Contents of Mitchell’s box so inscribed divided into eight for ease of reference. This trial compared results of treatment of patients by x-ray therapy and intramuscular synkavit, x-rays and intravenous synkavit, x-rays and oxygen, and x-rays and intravenous synkavit and oxygen. NCUACS 36/4/92 J.S. Mitchell D.249-D.255 Patient notes. X-ray therapy with intravenous synkavit. D.250, D.251 X-ray therapy with intramuscular synkavit. 2 folders. D.252, D.253 X-ray therapy with oxygen. 2 folders. D.254, D.255 X-ray therapy with oxygen and intravenous synkavit. 2 folders. ‘Clinical therapeutic trial of compound | as a radiosensitiser results to 18th December, 1954’. Typescript tables. Summary of Data re prolongation of life from cases treated with x-rays and intravenous or intramuscular synkavit. Latest reference 1954. D.258, D.259 D.260-D.266 Material re work of E. Friedmann, 1954-58. D.260, D.261 Contents of Mitchell’s envelope divided into two for ease of reference. Contents of Mitchell’s folder divided into two for ease of reference: from experiments on rats with 2-ethylenimino-1:4-naphthoquinone, 1954. data entdeckt worden’. ‘Biological implications suggested by the study of the effect of x-rays on the naphthoquinone (or unsaturated imide)- -SH reaction’ by Friedmann, 11pp typescript; 15pp typescript draft beginning ‘Die Hemmung der Mitose durch Chinone ist von E. Lehmann bei der Untersuchung von Tubifex Eiern Letter from E. Friedmann about his work, 1954; correspondence between Friedmann and R. Meier of CIBA, 1955; manuscript notes. NCUACS 36/4/92 J.S. Mitchell D.262-D.266 ‘Ernst Friedmann’. Contents of Mitchell’s folder so inscribed divided into five for ease of reference. ‘Annual Report’ on compounds with quinones and their derivatives’ by Friedmann, 1956. ‘investigation of the interaction of sulphydryl the D.263, D.264 Manuscript and typescript notes re the effect of adenosine triphosphate and D-methionine on mitotic inhibition by quinones. 2 folders. Manuscript data from experiments, 1955-56, 71958. Bibliographical references and notes on the literature. Letter from D.R. Maxwell, 9 March 1955, enclosing ‘the results of the C-14 Synkavit experiments’. D.269-D.271 Manuscript data from experiments, 1955-56. 3 folders. 24 February 1956. Typescript results of treatment of bronchial cancer by x-ray therapy with and without synkavit. ‘Reclassification 30.12.55’. Protocol for ‘Clinical trial of compound XIV ... Comparison of Compound XIV and Synkavit as radiosensitizers in the treatment of inoperable carcinoma of the bronchus with randomized allocation’. Also includes manuscript note re trial. January 1957. Protocol for ‘Clinical trial of compound XXVIII: a comparison of compound XXVIIl and Synkavit as radiosensitisers in the treatment of inoperable carcinoma of the bronchus with randomised allocation’. The trial began 21 ‘Radiosensitisers & radio-active incorporation’. envelope so inscribed: chiefly material re hydroquinones, 1956-57. Contents of Mitchell’s NCUACS 36/4/92 J.S. Mitchell D.275-D.278 ‘Clinical therapeutic trial of compound | as a radiosensitiser cases’. Typescript results assessed October 1957. 4 folders. Summary of ‘Pilot trial of the combination of compound I, oxygen inhaled at atmospheric pressure and x-ray therapy [...] in the treatment of patients with certain types of advanced and recurrent malignant tumours’. Typescript results, December 1957 and January 1958. Typescript results of experiments with radiosensitisers, with material found with them, 1957-58. Case reports on treatment of dogs and cats by synkavit and x-rays, c. 1957- 61; photographs. Protocol for ‘Clinical trial of radiosensitisers in the treatment of inoperable carcinoma of the bronchus’ (trial begun 11 February 1958); ‘Interim Report’, results obtained to June 1960; ‘Second interim report’, results obtained to 30 November 1962. ‘Annual report 1959-60 - Tissue culture’ by |. Simon-Reuss, 4pp typescript plus data. D.285, D.286 Contents of Mitchell’s envelope divided into two for ease of reference. Protocols for ‘Clinical trials of oxygen inhaled at atmospheric pressure, intravenous synkavit and intravenous compound XXVIII in the treatment of inoperable cases of carcinoma of the bronchus’. The trial began 11 February 1958. Miscellaneous notes. Exchange with O.C.A. Scott re synergistic effect of synkavit, March-April 1960; calculations and notes re ‘Importance of penetration of compounds into cells + distribution within cells’. NCUACS 36/4/92 J.S. Mitchell ‘Evaluation of synkavit sensitised radiation therapy in the treatment of radio- resistant and oral carcinomas’ by V. Shanta and S. Krishnamurthi, 6pp typescript, latest bibliographical reference 1961. With comments on the paper by J.L. Haybittle. ‘Instructions for the intravenous injection of synkavit’, 1p typescript, 6 February 1962; ‘Non-surgical treatment of bronchial carcinoma’ by Mitchell, 2pp typescript plus figure, 21 June 1963; copy of letter from J.L. Haybittle re survival rates, c.1963. ‘Results of bronchus trial Mitchell by Haybittle, 23 March 1964; trial reassessed on 1.1.65’, 3pp manuscript. to date’, 6pp typescript plus figures, sent to data from trial ‘22.7.64’; ‘Bronchus D.290-D.293 ‘Radiation protection and sensitisation’. inscribed divided into four for ease of reference. Contents of Mitchell’s folder so Correspondence and papers, 1967, 1970, 1971. ‘Clinical typescript plus references, Bibliog. 96 (1973); manuscript notes etc. of radiosensitizers and fractionation’ trials by Mitchell, 3pp D.294-D.303 List of patients, sent to Mitchell August 1970. Data from experiments on rats with TRQ 348, May 1973. Final ‘Results of the piridoxal-5-P’ series sent to Ladner, 1 September 1970. ‘Dr Ladner Pyridoxal-5-Phosphate Expts 3-11’. Contents of Mitchell’s folder so inscribed divided into five for ease of reference. H.-A. Ladner was studying the effects of this compound on growth and radiosensitivity of Walker rat carcinoma. See also H.200, H.201. Manuscript data from experiments on rats, 1968-70. 4 folders. D.294-D.297 NCUACS 36/4/92 J.S. Mitchell D.299-D.303 ‘Prof Ladner’s expts’. Contents of envelope so inscribed divided into five for ease of reference. ‘Das Verhalten einiger B-Vitamine beim Karzinompatienten wahrend der Strahlentherapie |. Zur Vitamin-B,-Rolle bei der Lokalbestrahlung von Tumorratten’ by Mitchell, Ladner, E.A. King and R. Weisselberg, 10pp typescript plus references. Bibliog. 105 (1979). D.300, D.301 ‘Zur Vitamin-B,-Rolle beim bestrahlten Tumortrager’ by Mitchell, Ladner and King. Manuscript and typescript drafts. 2 folders. Untitled 13pp typescript draft beginning ‘Trotz der grossen Fortschritte, die bisher bei der Behandlung des Krebses mit energiereichen ionisierenden Strahlen erzielt wurden, missen fiir die Strahlentherapie neue Wege gesucht werden’. Miscellaneous manuscript and typescript notes, drafts etc. D.305-D.307 Radioactive drugs Data from experiments with tritiated synkavit, February and June 1958; Untitled 5pp typescript draft re experiment with synkavit on mitosis in tissue with and without irradiation. Nd. ‘Radioprotecting substances and chemical radiosensitisers’. Contents of Mitchell’s envelope so inscribed divided into three for ease of reference: manuscript notes etc., c.1972-76. ‘Revised draft’ 21 June 1972 and ‘Further revision’ 6 April 1973 of trial of radiosensitisers in radiotherapy with large dose fractions. The trial began 3 January 1972. “13.5.59 Plans for trials of tritiated synkavit’. NCUACS 36/4/92 J.S. Mitchell Untitled 3pp manuscript draft beginning ‘This paper gives a preliminary account of a new way of treating some human malignancies’, not in Mitchell’s hand though reporting on work carried out by him at Cambridge. Latest bibliographical reference 1958. Data from experiments on rat tissue and organs, April 1959. D.312-D.319 ‘Tritiated synkavit’. Contents of Mitchell’s folder so inscribed divided into eight for ease of reference. D.312-D.316 Duplicated typescript notes of meetings ‘to discuss arrangements for investigation of tritiated synkavit and other tritiated drugs, e.g., tritiated thymidine’ held in the Radiotherapeutic Centre, Cambridge, October 1959 - October 1962. 5 folders. Minutes of meeting of ‘the tritium group’, 4 June 1962; Notes of meeting on ‘Plans for the investigation of TRK 219’, 12 May 1964. Miscellaneous correspondence and papers, 1959-66. tritiated “Synkavit” by dehalogenation of the Miscellaneous material re tritiated synkavit, 1960, 1962. Correspondence re provision of TRA 119 for research, 1963. Patent specifications filed by D.H. Marrian (Cambridge) and E.A. Evans (Radiochemical Centre, Amersham). manuscript additions interleaved. ‘Production of 6-iodo compound with tritium gas’, 10 February 1961; ‘Preparation and purification of tri-tritiated synkavit’, 14 September 1962; ‘Novel Naphthaquinols and a Process for the Manufacture thereof’, 25 September 1963. ‘The development of radioactive drugs, with special reference to tritiated drugs as radiotherapeutic agents’ by Mitchell, ‘Report submitted to the Medical Research Council [...] 11pp typescript with 14 May 1962’. NCUACS 36/4/92 J.S. Mitchell Typescript data from experiments on shelflife and uptake by cells of TRA 72 and TRA 119, October-November 1963. Typescript data from experiments on shelflife and uptake by cells of TRA 72 and TRA 119, December 1963; Radiochemical Centre ‘Report on In Vitro studies on the uptake of TRA 72 and TRA 119 by malignant and normal cells’ sent to Mitchell 11 December 1963. Data from experiments with TRA 119 on rats, 1963-64. ‘Excretion of tritium after injections of tritiated drugs’, report on work carried out in Cambridge Department of Radiotherapeutics, 1963. 17pp typescript plus tables and figure. D.327-D.346 ‘TRK’. Contents of Mitchell’s box so inscribed divided into twenty for ease of reference. ‘Stability of tetrasodium 2-methyl-1, tritium’ by E.A. Evans, Letter from Radiochemical Centre, Amersham, re ‘problem of erratic biological activity of tritium-labelled “Synkavit” ’, 28 August 1963; ‘report of a meeting at [...] Department of Radiotherapeutics, 16th January, 1964 ... to discuss the latest developments with TRA 72 and TRA 119’; etc. ‘Distribution of tritium in tissues of patients treated with tritiated drugs’ by B. Chipperfield, 18pp typescript plus tables and figures, sent to Mitchell for comment, 17 January 1964; 4- naphthaquinol diphosphate labelled with 3pp typescript, 17 May 1965. TRA 119, 1963-65. Correspondence with R.Y. Calne, August 1966, re possibility of collaboration in work on development of a radioactive drug for the treatment of carcinoma of the gastro-intestinal tract. Batch details from tritiated synkavit supplied by the Radiochemical Centre, some annotated by Mitchell. D.330-D.335 NCUACS 36/4/92 J.S. Mitchell D.331-D.334 TRK 219, 1964-70. 4 folders. TRK 397 and others, 1970-75. D.336-D.346 Patient notes, 1959-67. 11 folders. Departmental memoranda on investigation of TRK 219, July 1964. D.348-D.350 ‘TRK and synkavit recent 1965’. Contents of Mitchell’s envelope so inscribed divided into three for ease of reference. Correspondence, various dates 1955-65; introduction to ‘An attempt to develop a radioactive drug for cancer chemotherapy’ by Mitchell et a/, 5pp typescript (Bibliog. 78, 1965); ‘Annual Report 1962-63’ by B. Chipperfield. ‘Metabolism of tritiated and '4C-labelled compounds in diagnostic use’ by G.P. Howells, paper for MRC Subcommittee on Permissible Levels, 1963. ‘Studies of the uptake of tritium labelled Mepacrine by tumours’ by J.M. Young et a/, 11pp typescript plus table, c.1965; manuscript notes. Manuscript tables of results of cases treated with tritiated synkavit to 1965. ‘TRK and related problems’. Contents of Mitchell’s envelope so inscribed: miscellaneous material chiefly re TRK 219, c.1965. 1969. Memorandum on ‘Experience with TRK 219 in Dogs and Cats’ by |.A. Silver, with copy of data, latest reference 1966; ‘Preliminary discussion of clinical trials of the treatment of patients with malignant melanoma Notes of a discussion held on 12th August 1967 ...’ dated 10 August; miscellaneous material dated 1968-70. ‘Memo on reactions to intravenous compounds in the radioactive isotope unit to Professor Mitchell’ by J. Stone and K. Szaz, 10pp typescript, 17 April NCUACS 36/4/92 J.S. Mitchell D.355, D.356 ‘TRK and synkavit and related topics’. inscribed divided into two for ease of reference. Contents of Mitchell’s folder so ‘Diagnostische und therapeutische Anwendungen der radioaktiven Pharmaka in der Tumorbehandlung’ by Mitchell, 12pp typescript plus summary and table, Bibliog. 91 (1969); ‘Radioactive drugs in the treatment and diagnosis of tumours’, English version of preceding. Miscellaneous manuscript and typescript material. Data from experiments with 6-1 ~ -iodo-MNDP on rats and tissue sample, 1970. 131 D.358, D.359 Data and manuscript notes from experiments with 6-1'3'_iodo-MNDP on rats, 1971. 2 folders. Data and manuscript notes from experiments with TRK 397 on rats, 1971. D.361, D.362 Data and manuscript notes from experiments with 6-1'3'-iodo-MNDP and TRK 397 on rats, 1972. 2 folders. Data from experiment with TRQ 368 on rats, 19 March 1973. Contents of Mitchell’s folder: data from experiments with TRK 397 on rats, 1974, 1975. Experiment, using HEp/2 telophase pairs’, December 1975. ‘JSM Gell cycle exp’. Contents of Mitchell’s folder so inscribed: typescript accounts of ‘Experiments to show the uptake of Tritiated Thymidine and Tritiated Synkavit in HEp/2 cells at different stages of the cell cycle’, October 1975 - April 1976, and ‘Continuous labelling with 3H Thymidine NCUACS 36/4/92 J.S. Mitchell ‘Contribution to Discussion of Paper by Dr S.J. Lukiewicz’ by Mitchell, IAEA Coordinated Research Programme on improvement in radiotherapy of cancer using modifiers of cells, second meeting, Cambridge, 26-29 November 1979. radiosensitivity of ‘The in vitro selective concentration of an 1251 iodinated compound in human tumour cells’ by Mitchell et a/, summary for XVth International Congress of Radiology, Brussels, 24 June - 1 July 1981. D.367-D.382 Data from experiments with 6-'75|.iodo-MNDP, 1979-81. D.367-D.369 Cloning experiments with HEp2 cells, 1979-80. 3 folders. D.370-D.382 Uptake experiments with normal and malignant cells, 1979-81. 13 folders. Correspondence with H.A. Moser, 1979-80. Moser, of CIBA, Basel, was sent data from Mitchell’s team for evaluation. D.384, D.385 Computer print-outs received from Moser; supplied by Moser. manuscript notes on results D.387, D.388 ‘Approximate calculation of specific y-ray constant, c7, for 21T At. Note by J.S. Mitchell’, 4pp typescript, 20 December 1982. Manuscript notes on experiments with 6-2''At-MNDP on mice, 1982. folders. 2 London.’ Mitchell died in February 1987 before the plan reached fruition. An attached note by Mitchell’s secretary explains: ‘Professor hoped to have started clinical trials with the new compound being made by him and members of the laboratory but it had not got off the ground at Addenbrooke’s and Dr. Brown hoped he might at some stage make arrangements for trials in ‘Clinical studies of therapy with [...] 6-[7! : At]-astato MNDP; a plan for three years work by J.S. Mitchell, |. Brown and R.N. Carpenter (13th March 1985)’. 6pp typescript plus forms for documentation etc. Reports on work in progress with 21" At, 1983. NCUACS 36/4/92 J.S. Mitchell ‘Report to synthesize tritiated synkavit’, 4pp typescript, nd. Medical Research Council the A. Hodgson Attempts to Manuscript and typescript data from experiments on tritium activity in ‘MK’ and ‘HeLa’ cells, nd. Manuscript notes on work on At— and ‘AtCpd’, nd. Typescript data on 6-7" At-astato-MNDP, nd. Treatment of cancers The material is arranged as follows: D.395-D.400 Conduct of clinical trials D.401-D.468 Breast cancer Conduct of clinical trials D.395, D.396 D.397-D.399 D.498-D.411 Other cancers D.512-D.535 Faith Courtauld Cancer Research Unit D.469-D.497 = Cervical cancer ‘Statistics’. Contents of Mitchell’s folder so inscribed divided into two for ease of reference: miscellaneous notes, drafts and memoranda re statistical methods of assessing cancer treatment, various dates 1955-68. etc. ‘The estimation of the proportion of patients cured after treatment for cancer of the breast’ by J.L. Haybittle, 15pp typescript plus figures, tables and references (photostat), latest bibliographical reference 1959; ‘Revised draft of the trial started on 3rd January 1972 Radiotherapeutic Centre [...]’;_ ‘Clinical trials’. Contents of Mitchell’s folder so inscribed divided into three for ease of reference. NCUACS 36/4/92 J.S. Mitchell ‘The reporting of non-significant results in clinical trials’ by J.L. Haybittle, 8pp typescript plus references etc., 1978; ‘Significance tests and decision- making in clinical trial applications’, 8pp typescript annotated by Mitchell ‘discussed 17.1.79 L. Freedman’. Manuscript notes, reprints etc. at the Radiotherapeutic Centre Addenbrooke’s ‘Drugs for clinical trial Hospital, Cambridge’, 2pp duplicated typescript with manuscript annotation by Mitchell. Nd. Breast cancer D.401, D.402 ‘Cancer of breast’. Contents of Mitchell’s folder so inscribed divided into two for ease of reference. ‘Carcinoma breast’ by R. McWhirter, 13pp typescript sent to Mitchell 4 February 1948; correspondence with B. McN. Truscott re the staging of carcinoma of the breast, 1950; miscellaneous papers, 1951-54. Manuscript and typescript notes, latest bibliographical reference 1956. ‘Ca. breast’. Contents of Mitchell’s envelope so inscribed: correspondence and papers, 1957-71. Annual reports on Addenbrooke’s Hospital ‘clinical trial of treatment of stage II carcinoma of the breast by either radical mastectomy plus x-rays or modified simple mastectomy plus x-rays’. The trial began 1 October 1958. 1963-64. D.404, D.405 1959-60; 1960-61. 1961-62; 1962-63; NCUACS 36/4/92 J.S. Mitchell ‘The cured group in Haybittle. a series of treated breast cancer patients’ by J.L. Letter to British Journal of Radiology, 22 May 1968. ‘Clinical evaluation of ST.272 in the hormone treatment of breast cancer’, 3pp typescript, nd; information on ST.272 from Leo Pharmaceutical Products. D.408-D.466 King’s-Cambridge Breast Trials, 1969-86. value In 1969 King’s College Hospital London and Addenbrooke’s Hospital trial on the treatment of ‘early’ carcinoma of the breast to planned a determine the in combination with simple mastectomy. The trial began on 1 May 1970 and by January 1972 involved over 900 patients. The target of 2000 patients was reached in 1974 and the trial ceased to admit new cases from April 1975. The follow-up was to continue until all treated patients had been observed for 10 years. post-operative radiotherapy immediate of In 1973 it was decided to begin a second trial to test the effectiveness of adjuvant chemotherapy with melphalan and methotrexate in treating ‘early’ breast cancer. This trial was started in 1975. D.410 A-B D.410-D.416 Replies to preliminary enquiries re participation in trial, June-July 1969. Correspondence with those invited and other possible participants in the trial, July-October 1969, arranged alphabetically by correspondent. Invitation to meeting to discuss the proposed trial, Addenbrooke’s Hospital, 27 September 1969, including draft protocol for the trial; lists of those invited; correspondence re arrangements. during meeting. Typescript draft of Mitchell’s introductory remarks; manuscript notes taken Annotated programme of meeting; lists of participants. D.412 F-G D.413 H-K D.416 T-Y D.411 C-E D.414 L-M D.415 N-S NCUACS 36/4/92 J.S. Mitchell D.419-D.421 Typescript transcriptions of proceedings. 3 folders. Correspondence and papers, October-December 1969. Correspondence and papers re meeting of Breast Trial working party, 14 January 1970, including drafts of protocol and proforma. Correspondence, April-May 1970; protocol and proforma. Correspondence, June-November 1970. D.426, D.427 Correspondence and papers re first AGM of the breast trial, Royal College of Surgeons, London, 19 December 1970. Includes list of surgeons, pathologists and radiotherapists involved in the trial. Mitchell’s manuscript notes on proceedings; Ross. summary of AGM by W.M. Papers re meetings of trial working party, 19 March and 25 June 1971, including first Progress Report. Papers re meeting of working party, 4 November 1971; first draft of ‘The treatment of “early” cancer of the breast’ by M. Baum to be submitted to The Lancet; correspondence, October-November 1971. trial. Papers re meeting of working party, 21 February 1972; correspondence, March-June 1972; graph of current and projected numbers of patients in the Correspondence and papers re second AGM, Royal College of Surgeons,, 11 December 1971. NCUACS 36/4/92 J.S. Mitchell Papers re meeting of working party, 13 July 1972; Year Progress Report August 1972’. ‘Newsletter and Two ‘Thirty month Progress Report October, 1972’; correspondence and papers, August-November 1972. Papers re meeting of working party, 15 November 1972; ‘Thirty three month Progress Report February 1973’; correspondence and papers, January- March 1973. Papers re meetings of working party, correspondence, March 1973. 7 March and 25 April 1973; Papers re third AGM, Royal College of Surgeons, 31 March 1973. Papers re meetings of chemotherapy sub-group, 20 June 1973; the working party, 13 July 1973, and the ‘Three Year Progress Report’. 23 July 1973; typescript, Papers re meetings of working party, 19 November 1973 and 22 January 1974. ‘Note on the development of chemical agents of low toxicity as non-specific stimulants of host responses against malignant tumours’ by Mitchell, 3pp duplicated ‘40 month Progress Report’; correspondence and papers, July and November 1973. Papers re fourth AGM, Royal College of Surgeons, 14 June 1974. ‘Progress Report January, 1974’; papers for meetings of working party and the chemotherapy sub-committee, 20 March; correspondence and papers, January-May. Correspondence and papers re meetings of working party, 10 May and 13 June 1974. Mitchell’, circulated before the meeting of 13 June. Includes ‘C.R.C. Working Party. Note by J.S. NCUACS 36/4/92 J.S. Mitchell Correspondence and papers re meeting of working party, 11 October 1974. This meeting discussed the commencement of the chemotherapy trial and whether or not to end the radiotherapy and surgery trial. ‘Progress correspondence, November-December 1974. Report November 1974’ with Mitchell’s manuscript notes; Correspondence and papers re meetings of working party, 22 January and 14 April 1975. Papers re meeting of working party, 27 June 1975. Includes ‘New study of adjuvant chemotherapy in “early” cancer of the breast’, annotated by Mitchell. Correspondence, September-October 1975, re draft of article ‘Management of “early” cancer of the breast: Cancer Research Campaign Study’ by J.G. Murray. Correspondence and papers, January-March 1976, chiefly re Murray’s proposed article and working party meeting, 2 March. Correspondence, April-June 1976, chiefly re Murray’s article published in the British Medical Journal, and the publication in The Lancet of a paper by three of Murray’s team. Papers re AGM, London, 10 December 1976. Correspondence and papers re meetings of pathology working party, 22 July and 22 October, and radiotherapy working party, 10 September 1976. Papers re meeting of working party, 25 June 1976; correspondence, June 1976. Protocols for chemotherapy trial, June 1976. NCUACS 36/4/92 J.S. Mitchell Correspondence and papers re meetings of working parties, 1977. Graphs and tables of results of chemotherapy trial, 1977. Correspondence and papers, 1978, chiefly re meetings of working parties, and the AGM, 22 November. Correspondence and meeting of pathology working party, 2 February and AGM of chemotherapy trial, 14 February. papers, January-February 1979, re Draft protocol for expansion of the chemotherapy trial sent to Mitchell, 19 February 1979. Correspondence and papers, July 1979 - February 1980. Includes data from trial circulated at working party meeting, 8 November. Correspondence and papers, August-October 1980. new trial of chemotherapy on breast cancer. Includes protocol for Correspondence and papers, 1981-82. Correspondence re draft papers, March-May 1980. ‘First draft of the definite paper’ on the results of the trial after ten years prepared by M. Baum, J.L. Haybittle and J. Houghton, sent to Mitchell for comment, 17 January 1980. Papers for meeting on ‘ist Breast Trials update’, 8 February 1985. Draft of ‘The Cancer Research Campaign (King’s/Cambridge) trial for early breast cancer: an analysis of the radiotherapy data’ by D.M. Brinkley et al, sent to Mitchell, 24 May 1983. NCUACS 36/4/92 J.S. Mitchell Papers for breast cancer trials AGM, 21 March 1986. D.467, D.468 Miscellaneous material re breast cancer. 2 folders. Cervical cancer ‘Technique used in the treatment of carcinoma of the uterine cervix at Addenbrooke’s Hospital, Cambridge, in 1949, 1950 and 1951’ by Mitchell, 2pp typescript. Untitled typescript draft beginning ‘The treatment of recurrent cases of carcinoma of the cervix raises many problems’, 12pp plus tables. Latest bibliographical reference 1954. Miscellaneous manuscript and typescript material re treatment of cervical cancer, chiefly dating 1954-58. 1 May 1957. 5 June, 10 July 1957. 9 October, 11 December 1957. D.471-D.480 14 November 1956, 16 January 1957. Papers re meetings of members of the gynaecology, radiotherapy and pathology departments of Addenbrooke’s Hospital to discuss the treatment of carcinoma of the uterine cervix, corpus uteri and ovary, 1956-68. 1962. 5 February, 3 December 1958; 20 January, 20 April 1960. November 1960; 3 May, 8 November 1961; 21 February, 20 December NCUACS 36/4/92 J.S. Mitchell 20 November 1963, 19 February 1964. 4 November 1964; 3 March, 12 December 1965. 16 November, 14 December 1966; 1 February, 17 May 1967. 14 June, 22 November 1967; 22 August, 19 December 1968. Typescript results of treatment of patients at Addenbrooke’s Hospital, 1962- 64. ‘Treatment policy for carcinoma of the cervix at Addenbrooke's Hospital up to October 1963’, 4pp duplicated typescript. of the cervix completed uteri for at the D.483-D.485 on treatment Data Addenbrooke’s_ Radiumhemmet, Stockholm, by L.M. Mitchell. of carcinoma of 1969, 3 folders. Hospital, 1943-66 cases and D.486-D.491 D.492-D.494 ‘Ca. Cervix Uteri’. three for ease of reference: 1972-74. Contents of Mitchell’s folder so inscribed divided into manuscript and typescript material, chiefly ‘Ca. cervix and hyperbaric oxygen’. Contents of Mitchell’s folder so labelled divided into six for ease of reference: manuscript and typescript material, various dates 1947-73. Miscellaneous material re cancer of the corpus uteri. Report on ‘Cancer of the cervix - Addenbrooke’s Hospital Cambridge, 1946- 70’ by J.L. Haybittle, 2pp typescript plus manuscript figures, December 1978. Miscellaneous material re cancer of the ovary. NCUACS 36/4/92 J.S. Mitchell Other cancers Bladder. Duplicated typescript papers on carcinoma of the bladder, c. 1966. D.499-D.502 Bronchus. D.499-D.500 Contents of Mitchell’s folder divided into two for ease of reference. Copies of manuscript data on cases treated at the Leeds Radiotherapy Department, 1940-50. Manuscript and typescript material, various dates 1948-70. Contents of Mitchell’s folder: manuscript and typescript material, 1954-56. D.503, D.504 ‘Cerebral tumours’. Correspondence and papers from MRC re clinical trials, 1961-64. Contents of Mitchell’s envelope so inscribed divided into two for ease of reference: manuscript notes, latest reference 1969. Typescript and manuscript data, 1951. Contents of Mitchell’s envelope so inscribed: manuscript notes, 1971-73. ‘Hodgkin’s disease’. Larynx. NCUACS 36/4/92 J.S. Mitchell Mouth. ‘Cases treated at the Radiotherapeutic Centre, Addenbrooke’s Hospital, Cambridge from 1938 to 1950 inclusive’. 2pp typescript tables. Thyroid. Manuscript and typescript notes on treatment of thyrotoxicosis and carcinoma of the thyroid, c.1956. D.509-D.511 ‘Malignant tumours in childhood and young people’. Contents of Mitchell’s envelope so inscribed divided into three for ease of reference. Exchange with T. Rowntree re malignant synovioma, November 1943, with later material found attached; ‘Radiotherapy in malignant diseases of children’ by Mitchell, 3pp typescript, 2 July 1948. Did 0)) 540 Manuscript and typescript notes, c.1950. 2 folders. into the Faith Courtauld Cancer Research Unit Mitchell was interested in the effect of psychological factors on the onset and progress of cancers and served on the Courtauld Research Committee, 1971-86, as Chairman from 1971 and Vice-Chairman from 1978. During this This Unit at King’s College Hospital London was founded in 1971 by a donation from Mrs Fay Courtauld ‘for research on as broad a front as possible relationship between psychological, hormonal and immunological factors in the onset and course of cancer with particular reference to the psychological aspects of the disease’. period it supported research into breast cancer. NCUACS 36/4/92 J.S. Mitchell D.512-D.531 Correspondence and papers for meetings, 1971-86. DB 512a) 1974 D513 1972 D.514 1973 D.515 1974 (1) D.516 1974 (2) D.517 1975 (1) D.518 1975 (2) D.519 1976 (1) D.520 1976 (2) D.521 1977 D.522 1978 D.523 1979 D.524 1980 D.525 1981 D.526 1982 D.527 1983 D.528 1984 D.529 1985 (1) D.530 1985 (2) D.531 1986 D.532-D.535 Protocols and personality test sheets. 4 folders. Patient records and case notes D.536, D.537 D.538-D.542 in original alphabetical sequence. The photographs are Contents of Mitchell’s folder divided into two for ease of reference: chiefly correspondence with A. Gliicksmann re specimens from biopsies of patients dying of cancer, sent to Mitchell for analysis 1938-40. Contents of Mitchell’s thumb index file of photographic patient records, retained in Mitchell’s envelopes with the patient’s name inscribed thereon. Some dated 1939 or 1940. 5 folders. ease of reference. Contents of Mitchell’s folder inscribed ‘Case summaries’ and (at a later date) ‘Early patients’: typescript case notes covering 1939-48. D.544-D.551 ‘Old results’. Contents of Mitchell’s box so inscribed divided into eight for NCUACS 36/4/92 J.S. Mitchell D.544, D.545 Manuscript and typescript data re cases treated by gamma and x radiation, 1940-41. 2 folders. D.546-D.551 Photographic records and manuscript case notes, retained in Mitchell’s original envelopes. 6 folders. D.552, D.553 Manuscript and typescript notes on patients treated by x-rays, reference 1948. 2 folders. latest Manuscript notes on patients given toluidine blue, 1947-49. Not in Mitchell’s hand. Case notes re treatment of dogs with cancer, 1955-56. D.556-D.559 Mitchell’s manuscript tables of cases treated 1959-73. Case numbers 1-48, 1959-61. Case numbers 49-124, 1962-65. Case numbers 125-193, 1965-68. Case numbers 206-266, 1969-73. correspondence, 1965-70. Contents of Mitchell’s thumb index file of patient records, retained in original alphabetical sequence. The records principally cover the period 1963-71. 22 folders. Patient records and case notes, 1950s. 8 folders. Contents of Mitchell’s folder so _ inscribed: ‘Letters re patients’. D.560-D.567 D.568-D.589 NCUACS 36/4/92 J.S. Mitchell D.591, D.592 Patient records and case notes, 1960s. 2 folders. D.593-D.595 Correspondence and case notes, 1973-82. 3 folders. NCUACS 36/4/92 J.S. Mitchell SECTION E PUBLICATIONS, LECTURES AND BROADCASTS E.1-E.147 PUBLICATIONS E.118-E.142 LECTURES E.143-E.146 BROADCASTS REPRINTS NCUACS 36/4/92 J.S. Mitchell PUBLICATIONS E.1-E.104 Drafts 2 °105-E:117 Editorial correspondence A chronological sequence of material relating to publications, or to the intention to publish. Where applicable reference has been made to the Bibliography in the Royal Society memoir of Mitchell (A.1) in the form Bibliog. ... ‘The action of ultra-violet radiation on proteins. !| Some aspects of the photo-oxidation of the tyrosine chromophor’, with C.B. Allsopp. Probably relates to Bibliog. 10, 1937. 20pp manuscript. ‘The photochemistry of proteins’. Communicated to Royal Society May 1937 but not published in this form. 34pp typescript plus 2pp Appendix. 18pp typescript plus summary, references and figures. ‘Photochemistry of glycyl-tyrosine’. Communicated to Royal Society May 1937 but not published. Manuscript notes, figures. 37pp typescript of ‘Part Il with Appendix’ by E.N. Willmer and O.A. Trowell. NCUACS 36/4/92 J.S. Mitchell ‘Disturbance of nucleic acid metabolism produced by therapeutic doses of X and gamma radiations’. Published in three parts, Bibliog. 18-20, 1942. 2pp typescript ‘Summary of unpublished paper. (9.5.42).’ section of the draft not accepted for publication. May refer to a ‘Therapeutic possibilities of radio-phosphorus’. Bibliog. 27, 1947. Invitation to write and related correspondence, 1946-47. ‘Applications of recent advances in nuclear physics to cancer research’. Bibliog. 29, 1947. 9pp typescript plus references and tables. ‘Caution in the clinical phosphorus’. Not published, latest bibliographical reference, 1947. use of radio-active isotopes especially radio- Manuscript draft paginated 1-11. Typescript summary, tables. ‘Nuclear Physics, in relation to medical treatment’. Bibliog. 38, 1951. 19pp typescript. ‘Chemotherapy of cancer’. Probably draft of Bibliog. 34, 1948. Manuscript draft paginated 1-45 plus list of references. 2 folders. ‘Clinical trials of tetra-sodium 2-methyl-1:4 naphthohydroquinone diphosphate, in conjunction with X-ray theory’. Bibliog. 35, 1948. Correspondence with British Medical Journal. ‘Practical aspects of radioactive isotopes in relation to medical treatment’. Bibliog. 39, 1951. See also C.23. E.14-E.16 NCUACS 36/4/92 J.S. Mitchell E15, E16 61pp typescript plus references. 2 folders. ‘Methods and techniques : isotopes’. Not listed in Bibliog. but prepared for an encyclopaedia, 1953. 13pp typescript with manuscript corrections plus references, table, etc. Manuscript notes. E.19, E.20 ‘Some quantitative considerations of irradiation in Man’. 1954. of chronic Not listed in Bibliog., latest bibliographical reference, genetic effects the Extensively corrected typescript and manuscript draft. 2 folders. ‘Carcinoma of the skin appearing 49 years after a single diagnostic roentgen exposure’, with J.L. Haybittle. Bibliog. 51, 1955. Extensively corrected typescript and manuscript draft. Bibliog. 55, 8pp duplicated typescript plus tables. Letter from publishers; first page of draft. ‘Nuclear radiations for radiotherapy with external sources’. 1956. ‘Some clinical and laboratory studies of chemical radiosensitizers’. Bibliog. 59, 1957. 22pp typescript with manuscript corrections plus summary and references. ‘A study of the treatment of inoperable malignant tumours in dogs’, with 1.A. Silver. Bibliog. 60, 1957. NCUACS 36/4/92 J.S. Mitchell study ‘A J.L. Haybittle. Bibliog. 61, 1958. of dose levels in radio-iridium gamma-ray therapy’, with 15pp typescript with manuscript corrections plus summary and tables. ‘Clinical and laboratory studies of the therapeutic possibilities of tritiated synkavit, mainly by intra-arterial administration’, with H. Horwitz et al. Bibliog. 62, 1959. 36pp manuscript. 2 folders. ‘Radiosensitisation by oxygen and chemicals’. Bibliog. 65, 1959. 24pp typescript plus tables and bibliography. ‘Radiotherapy’, Concise Encyclopaedia of Atomics. Latest bibliographical reference 1959. Not listed in Bibliog. 15pp typescript with extensive manuscript correction. E.30-E.35 incomplete manuscript and typescript rough draft. 6 folders. E.30-E.36 Studies in Radiotherapeutics. Blackwells, Oxford, 1960. ‘Revision of Chapter 3 Practical applications’. Contents of Mitchell’s folder so inscribed: miscellaneous manuscript notes, data etc. Latest reference 1960. It was based on series of lectures given in This was Mitchell’s first book. 1958: the Dunham Lectures delivered at Harvard (E.124-E.126) and the William Withering Memorial Lectures given at Birmingham University (E.127). 117pp typescript plus references. 3 folders. ‘Laboratory and clinical studies of some quinol diphosphates and related compounds as chemical radiosensitisers and the development of a radioactive drug’, with D.H. Marrian and B. Marshall. Bibliog. 67, 1961. E.37-E.39 NCUACS 36/4/92 J.S. Mitchell ‘Laboratory and clinical studies of some chemical radiosensitizers and the development of a radioactive drug’, with Marrian and Marshall. Possibly earlier draft of preceding. 31pp typescript. E.41, E.42 ‘Investigation of a radioactive drug (TRA 119) with special reference to autoradiographic and related studies’, with E.A. King et al. Bibliog. 72, 1963. 42pp typescript plus references and legends for figures. Proof copy with manuscript correction and annotation. review ‘A radiotherapy’. Bibliog. 75, 1965. clinical and of laboratory studies of radiosensitizers in 14pp typescript with manuscript corrections plus references and summary. 30pp manuscript plus legends for figures, references etc. 2 folders. 19pp manuscript and typescript draft. ‘An attempt to develop a radioactive drug for cancer chemotherapy’, with D.H. Marrian et al. Bibliog. 78, 1965. Uber die Méglichkeit der Verwendung radioaktiver Pharmaka’. Bibliog. 76. 1965. Correspondence with Cambridge University Press 1965-70; reviews. This volume, edited by Mitchell, was based on a lecture course organised by the Cambridge School of Clinical Research and Postgraduate Medical Training. The treatment of cancer, with special reference to radiotherapy. Cambridge University Press, 1965. ‘Assessment of new methods of treatment of cancer’. Bibliog. 79, 1965. 18pp typescript. NCUACS 36/4/92 J.S. Mitchell E.49-E.51 ‘Some aspects of the effects of radiations on the metabolism of tissues and tumours’, Handbuch der medizinischen Radiologie I! i, Springer-Verlag Berlin, 1966. Not listed in Bibliog. Brief correspondence with publishers 1961, 1964, 1965. Manuscript notes, references etc. found with the preceding. 2 folders. ‘Ein Beitrag zur Untersuchung radioaktiver Pharmaka’. Bibliog. 82, 1966. 10pp typescript with manuscript corrections plus references and legends for figures. ‘The use of tritium-labelled compounds’. Bibliog. 84, 1967. 26pp typescript. radio-isotope scanning’, ‘Strahlensensibilisierende Substanzen und ihr Einfluss auf die Strahlenempfindlichkeit von Tumoren’. Bibliog. 86, 1967. 28pp typescript with manuscript correction plus references and legends for figures. ‘The preparation of 6-'3'.-iodo-MNDP and some studies of its uptake in certain human tumours by means of with D.H. Marrian et a/. Not listed in Bibliog. but probably an early draft of Bibliog. 90, 1969. 1970. 33pp typescript plus references, summary etc. Manuscript notes found with the preceding. ‘Uber die Méglichkeit der Entwicklung radioaktiver Pharmaka’. Bibliog. 92, NCUACS 36/4/92 J.S. Mitchell 28pp typescript with extensive manuscript correction. Legends for figures and references. ‘Neuere Untersuchungen zur Frage der therapeutischen Anwendungen von tritium-markierten organischen Substanzen’. Bibliog. 93, 1971. 20pp typescript plus references. ‘Testing anti-cancer drugs’, with P.P. Dendy et a/. Bibliog. 94, 1972. 2pp typescript. ‘Effects of ionising radiation and other physical treatments on short-term cultures’. Not listed in Bibliog., latest bibliographical reference, 1974. 7pp typescript, with 7pp typescript tables found therewith. Principles of Radiotherapeutic Oncology. Manuscript drafts of List of Contents and Preface. Correspondence with Cambridge University Press, 1975-80. In October 1975, a year before his retirement, Mitchell suggested to Cambridge University Press that he write a book based on his lecture course ‘Selected topics in radiotherapeutics and clinical oncology’. The Press agreed and a contract was signed in December giving July 1977 as the completion date. However the book was never completed. Mitchell’s envelope so inscribed. ‘Clinical Radiotherapeutic Oncology. Its changing role in the treatment of cancer’. 11pp typescript draft of General Introduction plus tables. ‘Unrevised text of Chapter 1 - to be kept till book finished’. Contents of NCUACS 36/4/92 J.S. Mitchell 16pp typescript plus tables etc; manuscript references. Manuscript references for the chapter. Later draft of chapter 1. 21pp typescript plus tables and references. Draft of chapter 2. 31pp typescript plus tables. Background material including correspondence with manufacturers and others re costs of Cobalt-60 therapy units compared with other types of radiotherapy units, 1977-78. chapter for 2 E.69-E.72 General background material. E.70-E.72 E.73-E.76 3 folders. Manuscript notes, references etc. ‘Guidelines in clinical radiotherapeutic oncology’, 17pp typescript. See also E.95. ‘Attempts to develop radioactive drugs in the treatment of cancer’, Bibliog. 99, 1977, Tables and references for the preceding. Editorial correspondence, 1973-75. 17pp manuscript rough draft. NCUACS 36/4/92 J.S. Mitchell 30pp typescript including tables and references. ‘Further assessment of an in vitro screening test of cytotoxic agents in the treatment of advanced malignant disease’, with A. Dawson and P.P. Dendy. Submitted to Oncology 1977 but not published. 16pp photocopied typescript plus references and figures; covering letter to Oncology. Obituaries and biography of F.R. Berridge, 1978 and 1981. Mitchell wrote obituaries of Berridge for the British Medical Journal (10 June 1978) and the Lancet (24 June). He was then asked to write a biography for the 6th volume of the Royal College of Physicians’ ‘Munk’s Roll’. This was published in 1981. Mitchell's Correspondence with BMJ and the Lancet with copies of manuscript draft of Mitchell’s address at the Opening of the obituaries; Berridge Room, Department of Radiology, Cambridge; correspondence with Berridge’s widow re obituaries. Correspondence with Royal College of Physicians; information including curricula vitae. drafts; background E.82-E.86 6pp typescript ‘Annotated text ... 18.8.79’ plus figures; material found with it. miscellaneous ‘Investigation of 6- 1251-iodo-2-methyl-1, 4-naphthoquinol bis (diammonium I]-MNDP) as a radioactive drug’, with |. Brown et al. phosphate) (6-['2 Bibliog. 103, 1979. 1982. ‘6-['51]-iodo-2-methyl-1, 4-naphthoquinol bis (diammonium phosphate) as a potential radio-halogenated anti-cancer agent: in vitro investigations and possible clinical implications’, with |. Brown and R.N. Carpenter, Bibliog. 108, Correspondence, principally with B. Haigh 1980-81, re comments on the volume with a view to its publication by Pergamon Press; copy of Mitchell’s Foreword. Foreword to Bone injuries resulting from radiation therapy of tumours by K. Shimanovskaya, 1981. NCUACS 36/4/92 J.S. Mitchell 27pp typescript and manuscript ‘Corrected copy 11.11.80’ plus summary. 2 folders. 20pp typescript and manuscript draft ‘Revised 21.4.81’ plus references. Miscellaneous manuscript notes, some dated 1979-81, graphs, pages of old drafts etc. found with the preceding. 2 folders. ‘Approximate calculation of specific y-ray constant, Cy, for 211 at Note by J.S. Mitchell’. Not listed in Bibliog. but dated 20 December 1982. 2pp typescript plus references. E.88, E.89 ‘a-particle track autoradiography for localisation of a [7''At]-astatinated drug’, with |. Brown and R.N. Carpenter. Not listed in Bibliog. but published in Experientia 39 (1983), 337-339. 7pp manuscript plus tables, references etc. ‘Pre-publication working copy’, 1982. ‘Cobalt-60 teletherapy: a compendium of international practice’, edited with M. Cohen. Bibliog. 113, 1984. 12pp typescript; brief correspondence with Nature and Experientia, 1982- 83. Work began on the compendium, a joint undertaking by the World Health Organisation and the International Atomic Energy Agency, in 1977. It was part of an IAEA series, an Atlas of Radiation Dose Distributions. The material consists chiefly of drafts and related correspondence. Correspondence, chiefly with M. Cohen, co-editor, and R. Beck of IAEA. E.90-E.93 Photocopied typescript and manuscript draft. 4 folders. E.90-E.100 E.95-E.100 NCUACS 36/4/92 J.S. Mitchell 1977. Includes amendments to chapter IV ‘Guidelines in clinical radiation oncology’ from Z. Hlasivec (a co-author of the chapter) and Mitchell. A draft of this chapter was kept by Mitchell with the material for his planned book on Principles of Radiotherapeutic Oncology (E.69). 1979, 1980. Includes arrangements for visit to Vienna, 13-19 May. 1981, 1982. Includes arrangements for visit 1984. correspondence re the published volume. to Vienna, 20-24 February and 1985, 1986. Review of the compendium. ‘Radioactive derivatives of 2-methyl-1, 4-naphthoquinol bis (disphosphate salt) as anti-cancer drugs with high LET radiations’, with |. Brown and R.N. Carpenter. Bibliog. 116, 1984. 9pp photocopied typescript; editorial correspondence. See also G.96. Correspondence with Experientia re revision, 1984. 6pp typescript ‘final copy’ plus tables. See also G.97, G.98. ‘Die Entwicklung radioaktiver Derivate von 2-Methyl-1, 4-naphthochinol bis (Diphosphat Salz) als Pharmaka mit Strahlen von hohem LET gegen den Krebs’, with Brown and Carpenter. Bibliog. 117, 1985. 14pp photocopied typescript and manuscript ‘1st draft’. ‘a-particle track autoradiographic study of the distribution of a ef Atl astatinated drug in normal tissues of the mouse’, with Brown and Carpenter. Bibliog. 118, 1985. ‘The effects of alkaline phosphatase activity on the selectivity to human cells of a potential endoradiotherapeutic drug’, with Brown and Carpenter. Not listed in Bibliog. Latest bibliographical reference 1985. NCUACS 36/4/92 J.S. Mitchell Editorial correspondence Arranged alphabetically by publisher or journal title. Blackwell Scientific Publications Ltd. Request for comment on proposed new journal. British Journal of Radiology various dates 1953-86 Chiefly re refereeing. E.107-E.109 British Medical Journal various dates 1946-74 1946-49. Chiefly re ‘annotations’ for the BMJ. Cambridge University Press Excerpta Medica Foundation 1950-58. Chiefly re ‘annotations’ and reviews. 1963, 1972, 1974. Includes letter of 15 July 1974 to the Editor suggesting a voluntary reduction of salaries in the medical profession. E112 E.111-E.114 Experientia Refereeing. eit NCUACS 36/4/92 J.S. Mitchell International Journal of Cancer 1982, 1983, nd Refereeing. Nature Physics in Medicine and Biology Editorial Board meeting. Proceedings of the Medical Association for the Prevention of War Review. Radiation Research Refereeing. 1957, 1958 Taylor & Francis Ltd. 1957, 1958 Hull, 12 LECTURES Proposed new journal. A chronological sequence of material relating to Mitchell’s public and invitation lectures. For Mitchell’s departmental lectures see section B. lectures. Untitled 10pp typescript of lecture on research work at the Department of Radiotherapeutics, Hospital Physicists Association AGM, Cambridge, 28-29 September 1951. ‘Some contributions of physics to the treatment of cancer’, November 1953. 13pp manuscript; miscellaneous notes and sections of drafts for similar NCUACS 36/4/92 J.S. Mitchell E.120; £121 ‘Therapeutic doses of isotopes including iridium teletherapy and interstitial infiltration with radioactive colloid gold’, Copenhagen, 20 March 1954. Incomplete 13pp typescript draft paginated 7-19, with figures clipped to the pages; covering letter from J. Nielsen (in Danish). 38pp typescript with extensive manuscript correction (p.1 introduction). is Nielsen’s Untitled lecture on the use of radioactive isotopes for diagnostic and therapeutic purposes, ‘given to Architects 23.4.54’. 6pp typescript. See C.82 for notebook containing shorthand notes taken by Mitchell’s secretary. ‘Further thoughts about the White Paper on the hazards to Man of nuclear and allied radiations’, Cambridge University Scientists’ Lunch Club, 15 November 1956. 4pp typescript ‘Notes for lecture’. E.124-E.126 E.124, £.125 radiations’, ‘Laboratory and_ clinical investigations in radiotherapeutics’, Edward K. Dunham Lectures, Harvard ‘Studies University, 10, 12 and 13 March 1958. Mitchell gave lectures on the ‘Mechanisms of the therapeutic actions of ionising of radiosensitisers’ and ‘Some investigations of practical interest’. The lectures were the basis of Mitchell’s book Studies in radiotherapeutics published in 1960 (E.30-E.36). Whilst in Boston he spoke on ‘Some clinical investigations in radiotherapeutics’ to the New England Roentgen Ray Society, 14 March. etc. ‘Studies in radiotherapeutics’, William Withering Lectures, Birmingham University, 13, 14 and 15 May 1958. These were the same lectures delivered at Harvard in March (E.124-E.126) Schedule for visit; notice of lectures; ‘Synopsis of lectures’; etc. Correspondence re arrangements; synopsis; notice; Correspondence re arrangements. 2 folders. NCUACS 36/4/92 J.S. Mitchell ‘Strahlenschutz in Ooffentlichen Gesundheitsdienst in Grossbritannien’, dated ‘20 Marz 1960’. 10pp typescript. ‘Some aspects of the uses of radioactive isotopes in medical diagnosis and treatment’, Nottingham, 31 October 1962. 2pp typescript summary. E.130-E.133 ‘Attempts to develop a radioactive drug’, Robert Knox Memorial Lecture, 1965. E.130-E.132 50pp manuscript draft plus 1p manuscript summary. 3 folders. Manuscript and typescript tables; legends for figures. Annotated reprint; correspondence re arrangements. ‘New approaches to radiotherapy’, Fison Lecture, Guy’s Hospital, London, 19 May 1970. ‘Applied science and the development of radiotherapy - past, present and future’, British Institute of Radiology Silvanus Thompson Memorial Lecture, Bristol, 8 June 1968. The lecture was published in the British Journal of Radiology (Bibliog. 88). 2 folders. E.137, E.138 ‘Newcastle Lecture & Cambridge 18.3.72’. Contents of Mitchell’s folder so inscribed: incomplete typescript and manuscript draft paginated 19-28; miscellaneous pages of drafts; manuscript notes; etc. 2pp typescript summary; correspondence re arrangements. ‘The heritage of physics and its applications in medicine’, Newcastle-upon- Tyne Regional Medical Physics Department, 13 January 1972. 31pp typescript. NCUACS 36/4/92 J.S. Mitchell E.139-E.142 Miscellaneous lectures correspondence. ‘The medical and biological applications of the recent developments in nuclear physics’, Glasgow University, 1 March 1946. ‘The results and prospects of radiotherapeutics’, Pharmaceutical Society Cambridge and District Branch, 24 April 1947. ‘The application of nuclear physics in medicine’, Middlesex Hospital Students Medical Society, 10 February 1949. ‘The medical applications of recent advances in nuclear physics’, Atomic Scientists Association London Branch, 16 December 1949. ‘Practical Apothecaries of London, 4 December 1950 (Bibliog. 39). aspects of isotopes relation to in medicine’, Society of ‘Medical uses of atomic energy’, Birmingham University Extra-Mural course, Worcester, 12 November, Birmingham, 13 November 1954. Oral Surgery Club, Cambridge, 12 April 1957. BROADCASTS Manchester Medical Society, ? January 1959. ‘Some problems in the study of radio-sensitisers and radioactive drugs’, London University Postgraduate Medical School, 24 May 1962. Cambridge University Scientists Luncheon Club, Michaelmas Term 1962 (declined). Treatment of cancer, Cambridge University Scientists Luncheon Club, 7 March 1974. death. Correspondence 1947 re planned BBC Home Service radio broadcast on ‘Blood’. The programme, in which Mitchell was to have participated with Sir Joseph Barcroft and Sir Lionel Whitby, was abandoned after Barcroft’s Correspondence 1946 with BBC Features Department re radio broadcast on ‘Atomic Energy’. Mitchell advised on the draft of the programme. NCUACS 36/4/92 J.S. Mitchell ‘Radiotherapy Today’, BBC Home Service radio broadcast 9 October 1947. Brief correspondence; transcript of programme. Invitation 1985 to participate in BBC Radio Four broadcast on British nuclear tests in the 1950s (declined). REPRINTS Reprints of Mitchell’s published papers 1932-85. Not a complete set.