KENDREW_JOHN_COWDERY_Vol1
Catalogue of the papers and correspondence of
Sir John Cowdery Kendrew FRS
(b. 1917)
VOLUME |
List of Contents
Foreword
Sections A - F
General Introduction
NCUACS catalogue no. 11/4/89
by Jeannine Alton
J.C. Kendrew
NCUACS 11/4/89
Title:
Compiled by:
Jeannine Alton
Deposited in:
Bodleian Library, Oxford
Date of material:
1927-1988
Reference code:
GB 161
Description level:
Fonds
Extent of material:
ca 2000 items
Catalogue of the papers and correspondence of Sir John Cowdery Kendrew
FRS (b. 1917), molecular biologist
NCUACS catalogue no. 11/4/89
© National Cataloguing Unit for the Archives of Contemporary Scientists, University of Bath.
NCUAGS 11/4/89
J.C. Kendrew
The assembling of the material, and the compilation and production of
this catalogue, have been made possible by a generous subvention from
THE LEVERHULME TRUST
NCUACS 11/4/89
J.C. Kendrew
SOME OF THE MATERIAL IN THE COLLECTION MAY BE SUBJECT
TO RESTRICTED ACCESS.
ENQUIRIES SHOULD BE ADDRESSED IN THE FIRST INSTANCE TO:
The Keeper of Western Manuscripts
The Bodleian Library
Oxford
OX1 3BG
NCUACS 11/4/89
J.C. Kendrew
LIST OF CONTENTS
FOREWORD
GENERAL INTRODUCTION
SECTION A
NOTEBOOKS, NOTES AND ESSAYS
A.1-A.120
INTRODUCTION
NOTEBOOKS
School
War service
University (postwar)
NOTES AND ESSAYS
SECTION B
INTRODUCTION
A.119
A.120
War service
A.28-A.31
School
A.32-A.118
University
SECOND WORLD WAR
Later miscellaneous notes
Correspondence and papers 1941-46
CAREER AND CORRESPONDENCE
Career
NCUACS 11/4/89
J.C. Kendrew
REPORTS
e
o
F
O
h
W
e
a
m
e
W
w
W
“29
29
.30
yee
Coastal Command
Bomber Command
Anti-submarine warfare
Combined Operations
Methodology
.32-B.41
Middle East Command
-42-B.47
South East Asia Command
.48-B.53
Postwar papers
HISTORY OF OPERATIONAL RESEARCH
B.54-B.60
Correspondence, papers, drafts
SECTION C
RESEARCH
C.1-C.308
INTRODUCTION
EARLY RESEARCH
Reaction kinetics
G.2-C.5
CG. 6-Gi 5
Information retrieval
Computation on EDSAC I
INFORMATION RETRIEVAL/DATA PROCESSING
Polypeptide configuration 1953
Controlled shrinkage of protein crystals 1952
Adult and foetal sheep haemoglobin 1946-58
Protein solubility c.1949
PROTEIN ANALYSIS PROJECTS
Procollagen 1951-52
Muscle 1947-54
NCUAGS 11/4/89
Gi22
6:25
C.24
X-ray experiments 1953
Not used.
Material transferred to C.1
Chymotrypsinogen c.1956
Ca25,;-.6726
Correspondence "New proteins" 1947-69
EARLY RESEARCH REPORTS
C.2T
Reports 1946-53
MYOGLOBIN
NOTEBOOKS (Kendrew and collaborators)
C.28-C.40
Preliminary work
C.41-¢.100
Main myoglobin programme
C.101-C.116
Collaborators’ notebooks
C.117-¢C.125
Atomic co-ordinates/amino-acid sequencing
C.170-¢C.189
C.190-C.195
MATERIALS AND APPARATUS
C.196-C.198
Miscellaneous
C.126-C.129
Miscellaneous
C.130-¢C.169
Preliminary work
Main myoglobin programme
Collaborators’ notes and data
NOTES AND DATA (Kendrew and collaborators)
Computer time
.205-C.207
Densitometer
~199-6. 202
Supplies and specimens
2208 ,G.209
. 203
. 204
Optical diffractometer
Microcamera
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J.C. Kendrew
COLLABORATORS AND STAFF
C.210-C.238
Individual files
C.239-C.247
Chronological files
CORRESPONDENCE
-248-C.272
Aspects of myoglobin
wehS-GIZ EL
Atomic co-ordinates/amino-acid sequencing
.278-C.291
Publications
.292
Skeletal model
.293-C.297
Ball-and-spoke model
.298
Science Museum London
.299-C.307
Correspondence
MISCELLANEOUS
Pantographs
INTRODUCTION
SECTION D
D.1-D.39
MRC LABORATORY OF MOLECULAR BIOLOGY CAMBRIDGE
Historical
Research and administration
Apparatus and equipment
Buildings
Staff
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J.C. Kendrew
SECTION E
CAMBRIDGE : UNIVERSITY AND COLLEGE
INTRODUCTION
CAMBRIDGE UNIVERSITY
Wied vel a2
Teaching and curriculum
E.3-E.5
Committees
E.6
Electoral and Advisory Boards
PETERHOUSE
E.7-E.10
Scholarship and entrance examinations
E.11-E.13
Supervision
Pe ade
Prizes
Esb5 BT 6
Mastership elections
SECTION F
F.1-F.232
INTRODUCTION
EARLY HISTORY
EUROPEAN MOLECULAR BIOLOGY:
INTRODUCTION TO SECTIONS F,
G AND H
EUROPEAN MOLECULAR BIOLOGY ORGANISATION (EMBO)
Miscellaneous correspondence
Preliminary meetings and correspondence 1963
Formal constitution and statutes
.16-F.33
Relations with other organisations
.34-F .42
Policy document
cit
.LO-F.15
.43-F.56
Funding
.57-F.60
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J.C. Kendrew
MEMBERSHIP
F.61-F.77
Pi78.F 379
Nominations and elections
1963-82
Circulars and lists
1964-75
COUNCIL
F.80-F.118A
Correspondence and meetings 1964-80
F.119-F.127
Membership and elections
P1288 3129
Minutes and circulars
1963-74
1963-81
COMMITTEE
.130-F.132
Membership
.133-F.140
.141-F.149
Correspondence and papers
Fellowship applications
1965-74
1964-74
1964-74
L530
Minutes
1965-73
COMMITTEE
LABORATORY COMMITTEE
.154-F.167
. 168
Minutes and circulars
1965-74
1965-74
1966-69
VESE-AR 153
Membership
Correspondence and papers
1974-80
Meetings, correspondence and papers 1963-73
General administrative correspondence
Correspondence and papers
1974-81
B20 hts
Finance and accounts
F209 °F 2210
Appointments
F.229
Minutes
F.169-F.208
ADMINISTRATION
F.216-F.220
SYMPOSIUM COMMITTEE
B..221-F.. 228
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J.C. Kendrew
MISCELLANEOUS
F230 ch 258
Press releases, articles, comments 1963-71
2 oe.
Annual reports
1966-81
SECTION G
EUROPEAN MOLECULAR BIOLOGY CONFERENCE (EMBC )
G.1-G.150
INTRODUCTION
EARLY HISTORY
G.1-G.13
"Swiss Initiative" 1964-67
G.14-G.28
Intergovernmental meetings and negotiations
G.29-G.35
Signing and ratification of Agreement 1969-70
1967-69
G.36-G.55
1969-79
MEMBERSHIP
G.56-G.64
1968-76
SUBCOMMITTEES AND WORKING GROUPS
GENERAL CORRESPONDENCE AND PAPERS
"Andres" Working Group on future of Conference
Steering Group of Laboratory Working Groups
Organisation, structure, administration
G.103-G.106
Enlarged legal sub-group
.66-G.73
Laboratory Working Group II
.74-G.87
Laboratory Working Group III
.88-G.91
Laboratory Working Group IV
.92-G.102
.107-G.114
Laboratory Working Group I
Role of the laboratory
Site of the laboratory
Financial aspects
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J.C. Kendrew
CONFERENCE AND COMMITTEE PAPERS
G.115-G.150
1967-81
SECTION H
EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL)
H.1-H.417
INTRODUCTION
AGREEMENTS
H.1-H.6
Te 6
Laboratory Agreement
Headquarters Agreement
THE BUILDING OF THE LABORATORY
poo Mese?
Temporary accommodation in Heidelberg
H.183-H.202
-47-H.49
.50-H.55
Inauguration
.21-H.34
Building Committee
.13-H.20
Early planning and costing
.35-H.46
Architects, tenders, plans
Furnishing and interior design
RESEARCH COMMITTEES AND WORKING GROUPS
Provisional Scientific Advisory Committee (PSAC)
Instrumentation
Scientific Advisory Committee (SAC)
Nuclear Magnetic Resonance (NMR) Working Group
Recombinant DNA (rDNA) Committee
H.178-H.182
Biological Structures
Scientific Purchases Committee
RESEARCH DIVISIONS - HEIDELBERG
Computer Policy Working Group
H.152-Hol77
Cell Biology
.141-H.151
Workshops
.56-H. 68
.69-H.97
.98
oo
.100-H.102
.103-H.140
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J.C. Kendrew
OUTSTATION AT DEUTSCHES ELEKTRONEN SYNCHROTRON (DESY)
- HAMBURG
.203-H.205
Early History
.206-H.210
Relations with DESY
~2ib-B. 213
DESY Committees
.214-H.217
Staff
.218-H.220
Equipment
.221-H. 237
Research
OUTSTATION AT INSTITUT MAX VON LAUE - PAUL LANGEVIN (ILL)
- GRENOBLE
.238-H.246
Early History
261
ILL - EMBL Building
.248-H.254
ILL Scientific Council
3250
/296
Staff
Equipment
»2570-n. 262
Research
H.280
Courses
H.266-H.273
Seminars
H.274-H.279
Lectures
RESEARCH PROGRAMMES
SEMINARS, LECTURES, COURSES
Laboratory Research Programmes 1975-87
Existing, continuing, proposed new membership
H.281-H.291
Visitors
H.292-H.296
Staff
MEMBERSHIP
H.297-H.304
H.263-H.265
VISITORS AND STAFF
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J.C. Kendrew
ADMINISTRATION
.305-H.
pOL2-H.
Organisation and planning
Committees
,SL9-H.
3,
Finance
252 54H.
O27-H,
.334-H.
Staff Association
Miscellaneous
Appointments
DIRECTOR-GENERAL’S NOTES AND CORRESPONDENCE
H.345-H.358
Notes
H.359-H.367
Kendrew’s appointments and career at EMBL
H.368,H.369
Personal correspondence
H.370-H.377
Director-General’s correspondence
FINANCE COMMITTEE AND COUNCIL MINUTES
H.378-H.417
1973-81
SECTION J
SECTION K
INTERNATIONAL SOCIETIES, ORGANISATIONS ,
UK SOCIETIES, ORGANISATIONS, CONSULTANCIES
Addenda : Lectures 1946-87
Correspondence with publishers and editors
SECTION L
LECTURES, PUBLICATIONS, BROADCASTS
L78-L.98
Radio, televison, films
L.f-b.7 7
Lectures, publications, reviews
L.99-L.144
L.145-L.149
CONSULTANCIES
L.1-L.149
INTRODUCTION
NCUAGS 11/4/89
J.C. Kendrew
SECTION M
JOURNAL OF MOLECULAR BIOLOGY
INTRODUCTION
MoT M2
Founding papers 1957-59
M.3-M.19
Correspondence with editors and authors
M.20-M.37
Correspondence with Academic Press
SECTION N
VISITS AND CONFERENCES
INTRODUCTION
SECTION O
CORRESPONDENCE
INTRODUCTION
PotBS
P.18-P.40
BG —P Ey
Appointments and staffing
Poh? fe7
Miscellaneous
SECTION P
REFERENCES AND RECOMMENDATIONS
Theses and higher degrees
Grant applications/research funding
INDEX OF CORRESPONDENTS AND ORGANISATIONS
SECTION R
BIOGRAPHICAL
BIBLIOGRAPHY
NCUACS 11/4/89
J.C. Kendrew
FOREWORD
Kendrew is
The
completion of this Catalogue of the personal papers 6: Siz
John
the
Archives
a significant event in the work of the National Cataloguing Unit for
subject
both in the nature of
of Contemporary Scientists,
its
matter and in the manner of its achievement.
This is not the only occasion on which we have undertaken the task of
is the first time that an
a living scientist.
But it
working on the papers of
opportunity
has
been taken to examine such a large collection at
a time
when
the
subject was retiring from his major scientific and
academic
commitments,
was still available to guide us
and
extremely grateful to Sir John for his ready co-operation in this task.
in our analysis of its contents.
We are
The
project
has also been significant because it
has
provided
an
excellent
opportunity
to engage the experience and expertise of
Mrs Jeannine
the
of
All
Archives
and
like
to
Centre.
It
is
gratitude
Alton,
the
completed
record
our
Mrs Alton.
to the Director,
Sir Rex Richards,
On behalf of NCUACS I
time available to us without the dedication
understanding help of the Leverhulme Trust.
Trustees of the Leverhulme Trust, for their support.
former Executive Director of the Contemporary Scientific
been
difficult to imagine how the task could have
Finally, the project could not have been tackled without the generous
would
within
researchers in the history of molecular biology will be greatly in her debt.
June 1989
Director, NCUACS
R.A. Buchanan
and
the
NCUACS 11/4/89
J.C. Kendrew
GENERAL INTRODUCTION
PROVENANCE
The material was received from Kendrew at various dates April 1987 to
April 1989.
Certain additional papers, chiefly those relating to his personal
life or
to ongoing concerns, remain in his charge during his lifetime.
OUTLINE OF THE LIFE AND CAREER OF SIR JOHN KENDREW
John Cowdery Kendrew was born on 24 March 1917.
His mother,
Evelyn
Sandberg,
was
a distinguished art historian;
she lived in Italy and the boy
photography.
Governor.
In
tutor of St.
Catherine’s
Major
Scholar.
While
his
main
widely
as
possible
as
half-subjects
birds and flowers,
buildings and
(later)
at Bladon near Woodstock;
from the range of subjects
of both of which he
became
a
They lived in Oxford and also
early interests in natural history,
Clifton
College
Bristol (Scholar, 1930-1936),
subject was chemistry he made it his business
1936 he went to Trinity College Cambridge as
a
and Reader in Climatology at Oxford University.
walking and cycling expeditions were frequent, with
was brought up by his father Wilfred George Kendrew,
Kendrew was educated at the Dragon School Oxford (1923-1930) and
attended lectures in physics, mathematics and biochemistry, taking the last two
and then in India and Ceylon with South-East Asia Command where he was
up an undergraduate interest in radio developed in the Signals
and worked first on radar and from 1940 on operational
kinetics in the Department of Physical Chemistry.
photographer and added a growing love of music;
he was appointed as
a Junior Scientific Officer at
special reference to anti-submarine warfare,
remain permanent features of his life.
Most
of his war service was spent abroad,
in
chemistry and
immediately
began
research
In June 1939 he graduated
with
First-Class
Honours
bombing accuracy and
radio
in Cairo with
Middle
East
with architecture and
of
the Cambridge OTC,
By December 1939,
1
of the Tripos.
He kept up
his
to
profit
as
he
studied
and
Air
Ministry
skills
as
a
archaeology,
with
aids.
reaction
following
in
Unit
the
research
available;
these,
in
Part
Command
NCUAGS 11/4/89
J.C. Kendrew
officer in charge of operational research and Scientific Adviser to the
Allied
Air Commander-in-Chief, holding the honorary rank of Wing Commander.
Wartime
travels
and
encounters were to have major effects
on
his
future career.
J.D. Bernal,
met in Cairo, India and Ceylon, persuaded him of
the
importance of research into protein,
and this was reinforced by a meeting
with L.C. Pauling in the course of a roundabout journey home via Australia
and
America in the spring of 1945.
Though he hesitated for some time and explored
the
possibility
of
remaining in Government service to
continue
operational
research
and
planning
for
peacetime
policies,
he
decided
to
return
Cambridge,
and
began a collaboration with M.F. Perutz under the direction
to
of
Sir Lawrence Bragg at the Cavendish Laboratory.
Thus began a heroic period:
in Kendrew's career and in those of his
collaborators,
in the subject of research - X-ray crystallographic analysis of
protein
structure
-
,
in
the Cavendish Laboratory
and
the
University
of
Cambridge.
In October 1947 the Medical Research Council set up a Unit for the
long
oO
oO
quarters
exploring
particular
erystallography;
After
in
Laboratory
of
as.
its
total
staff;
currently
more
in
the
cramped
Molecular
Biology,
Study
of the Molecular Structure of Biological Systems with Perutz and Kendrew
and often tedious haul,
spaciously housed
than
this was the origin of the now
famous
continued
to
work on haemoglobin) in 1962,
requiring much manual experimentation as well as
sperm-whale
myoglobin as the most suitable for analysis
he and his collaborators eventually succeeded in producing a
and huts where such brilliant work was achieved in the 1950s.
many possible problems and materials Kendrew chose myoglobin and
three-dimensional model at a resolution of 6-A in 1957 and 2-A in
was rewarded when he shared the Nobel Prize in Chemistry with Perutz
increasingly sophisticated computing resources to handle large amounts of data,
of Peterhouse, as also of his undergraduate college, Trinity.
Crick and J.D. Watson (both of the MRC Unit) shared the Prize in Physiology
Medicine with M.H.F. Wilkins for the determination of the structure of DNA.
principally through Peterhouse which had welcomed him
during
with responsibility for selection and tuition of undergraduate
members,
He was Director of Studies in Natural Sciences for many
as well as holding several College offices.
Kendrew had maintained his links with
He later became an Honorary Fellow
early
postwar
years
as
a Research Fellow
1947-1953
and
later
as
Alongside the laboratory work,
that annus mirabilis when
F.H.C.
Supernumerary Fellow.
university
life
the
years
or
a
by
X-ray
1959.
This
(who
had
NCUACS 11/4/89
J.C. Kendrew
To
this period also belongs Kendrew's marriage to
Elizabeth
Jarvie
1948
and
subsequent
divorce 1956.
J.D. Watson,
who
was
under
Kendrew’s
supervision
as
a research student,
lodged at their home during his early days
in Cambridge.
From about the late 1950s Kendrew became more involved in
scientific
matters
in
the
wider world.
He was a founding member
and
first
Honorary
Secretary
of
the
British
Biophysical Society;
in 1959
he
undertook
the
Editorship
of
the new Journal of Molecular Biology which
he
retained
until
Lose, ;
he
was Deputy Chief Scientific Adviser Ministry of Defence
1960-1963;
and
he served on committees and advisory boards of the Royal Society where
he
had been elected to the Fellowship in 1960.
With the award of the Nobel Prize
this
involvement
gained
momentum
and
an
altogether
new
dimension
in
international
terms
with
the development of the European
Molecular
Biology
Organisation
(EMBO) and its Laboratory (EMBL) ;
the first
exploratory
talks
seem indeed to have coincided with the journey to Stockholm at the end of 1962.
Here
too
the
way
was_
to be long and hard.
The
formation
of
an
active
international association of scientists working in molecular biology (EMBO) was
in
as
and
Secretary-General,
of EMBC,
project,
agreement
(1973),
(EMBC)
The Laboratory
organisation
did
formal opening (1978).
as
Secretary-General
on the Council of EMBO,
but the formal
funding
and
was even longer in reaching an
first Director-General of the EMBL.
which was especially dear to Kendrew,
as Chairman of its Laboratory Committee and later
its
relatively
easily achieved during 1963 and 1964,
In all these developments Kendrew was closely involved,
a secretariat and research programme in place (1974) and
a
was established by agreement by thirteen West European states.
of such a body required intergovernmental political agreement and
not come until 1969 when the European Molecular Biology Conference
Presidency of the International Union of Pure and Applied Biophysics 1964-1972.
other commitments to national and international science
science and scientific policy can be seen in his appointment
Society
and on other learned societies in particular the
In Britain they include service on the Council for
Weizmann Institute Israel 1964 and the
Vice-Presidency
service on the Defence Scientific Advisory
Council
the Council and other committees of
Examples of increasing involvement
Society
and the Institute of Biology.
also belong to these years.
Policy
and
chairmanship
of some of its
and as Project Leader
and
committees
and
working
1974,
continuing
service
on
British
Biophysical
1969-
the
Royal
international
Governor
of
the
Scientific
parties
1964-1972,
Many
policy
NCUACS 11/4/89
J.C. Kendrew
During
the
1960s
Kendrew
continued
his
research
on
myoglobin,
o
refining the resolution to 1.4-A and determining the co-ordinates of
virtually
all
the
2500
atoms in the molecule.
In the later 1960s however
his
other
commitments increasingly absorbed his time and energy and his official move
to
Heidelberg
as
Director-General
of
EMBL in 1975 marked
the
end
of
active
research.
The
creation of the EMBL as
a physical entity and more importantly
as
an
international
centre of excellence where several
teams
and
research
projects
could
co-exist
and
collaborate
was
a
lasting
achievement.
In
addition, or in consequence, Kendrew’s diplomatic skills, mastery of detail and
experience in chairmanship made him constantly in demand on a wider stage.
served,
often
as chairman,
on the scientific councils or advisory boards
He
of
laboratories or research institutions in Naples,
Basel,
Brussels,
Stockholm,
Heidelberg
and
others,
on various UNESCO committees,
and on many
electoral
boards
for
honours
and
appointments in
Britain
and
abroad.
His
formal
association
with
science
at
the international level may
be
said
to
have
culminated
in his service with the International Council of Scientific
Unions
(ICSU) as Secretary-General 1974-1980 and President 1983-1988.
Cambridge,
Kendrew’s
Research
brought
Since
1987.
his
connections
or
until
1982
lived
in
his
Council
and
then
he
has
of
ICSU,
as
house
near
His last
appointment
maintaining
renewed
twice,
organisations,
notably
as
Past-President
continuing
active
John’s
College
until
and
Member of the Executive
Board
involvement
with
many
him
back to Oxford as President of
St.
when he retired on reaching the age of
65.
appointment as Director-General of the EMBL
was
original contract of secondment from the Medical
Economic Communities, and other international associations.
Chairman of the Board of Governors of the Joint Research Centre of the European
attention to material of particular interest.
sections and many of the sub-sections and individual entries
material is very extensive and provides information not only
Additional explanatory notes or information accompany
aspects of Kendrew's own career but on many of the
The following paragraphs are intended only
to
The papers are presented as shown in the
and organisations connected with it.
DESCRIPTION OF THE COLLECTION
the catalogue.
of Contents.
virtually
all
individuals
the
the
draw
separate
body
of
on
in
The
List
NCUACS 11/4/89
J.C. Kendrew
It
should be said at the outset that the entire collection
reflects
on
almost
every page what are probably the best-known features
of
Kendrew’s
personality:
on
the
one
hand his
methodical
and
analytical
power,
his
meticulous
not
to
say
obsessive insistence on
accuracy
and
comprehensive
documentation,
shown
in
his
lifelong interest
in
record-keeping
and
the
devising
of recondite systems for information storage and retrieval;
on
the
other
hand,
an
aloofness
or elusiveness of temperament which
sets
certain
limits to personal relations.
There are a steadiness and control, a detachment
combined
with
seemingly tireless application which
constitute
a
formidable
intellectual armoury and which are present from the earliest records.
Thus,
Section A (Notebooks, Notes and Essays) though mainly covering
early
school and undergraduate work 1930-39 is remarkable for its maturity and
for
the quantity and quality alike of the content.
It
is classified under
a
system
of
Kendrew’s
own
devising
which,
though
intrinsically
clear
and
flexible,
involved
careful
pagination with at least two
referents,
and
an
appreciable
measure
of cross-referencing in order to
amalgamate
school
and
university
work;
as
there
are some 9000 manuscript
pages
of
notes,
not
have
A modern
the
the
historian
D.D. Woods,
J. Needham,
and essays,
F.G. Mann,
W.J. Pope,
K. Bailey,
I.
Langmuir
E.K. Rideal,
F.P. Bowden,
Second World War
F.W. Aston,
R.G.W. Norrish,
counting
notebooks
identification of lecturers.
scrupulous indexing of topics,
The latter included most of the leading
the degree of labour required would not
the very full notes of lecture courses and
and
some visiting lecturers (J.E. Lemnard-Jones,
J.A. Ratcliffe, W. Cochran, F.G. Hopkins, M.
Dixon,
figures in Cambridge science immediately before and after the
been contemplated, let alone undertaken and carried through, by many.
of intellectual or educational development will be grateful for
aircraft patrol
private reports on his analysis of the war situation at various dates,
available at that time at a well-run school science department and a
and future state of operational research and of his own career
Section
B (Second World War) chronicles Kendrew’s
contributions to operational research,
and contains original reports from
an exceptionally comprehensive
major "science" university.
may
be cited among very
many
others).
by
him and others.
anda punched card,
organisation
of
government
A. Neuberger,
D Keilin,
therefore
provides
It also includes
suggestions
and
proposals
for the postwar
various
commands
designed by him,
picture
of
the
several
letters
or
overseas
service
to be used by
of
the
plans,
sequence
education
The
total
current
his
science,
careful
and
NCUACS 11/4/89
J.C. Kendrew
crews to record incidents.
Section C (Research) is one of the major components of the collection
and
furnishes a very full record of Kendrew’s research,
including some of his
collaborators’
work.
It
is concerned almost entirely with protein
structure
analysis,
beginning in 1946, and includes the devising of computer programs to
handle
and
process data on machines of
progressive sophistication
(EDSAC I,
EDSAC II, Mercury, IBM 7090 and others), the many years of experimentation with
types
of
myoglobin
until in December 1952 sperm-whale emerged
as
the
most
promising
crystal source,
and the ensuing protracted sequence of
diffraction
pictures,
phase
determination,
scaling,
manual
and
computer
calculations
leading up to the establishment of contour maps and the final three-dimensional
picture
at
successive Angstrém resolutions.
There is also material
on
the
concurrent
and subsequent work on amino-acid sequencing by chemical methods in
correlation
with
the
crystallographic analysis.
In addition
to
the
main
sequence of notebooks, notes and data, there is material relating to specimens,
apparatus
and
models,
and correspondence with collaborators
and
colleagues
extending
over more than twenty years.
The progress of the work can thus
be
as_
the
or
on
syntheses
of the text.
and
period,
of
progress,
section,
but
contains
Section
D
(The
MRC
bench
or
in
correspondence
throughout
the
there are reports,
work-allocations
and their publication.
the like written from
the
and covering key points such
the excitement of the eventual
followed
in great technical detail.
On a more immediately accessible
level,
Attention is drawn to these and other items
identification of the best crystalline protein,
project diaries, summaries of experimental findings, charts
of interest in the introduction to Section C and at various points in the
of
entrance and scholarship examinations for Peterhouse and the "King’s Group"
Structural Studies Division from 1969 (no.1) until his secondment to Heidelberg
section
and does not fully reflect Kendrew's work as lecturer and teacher,
minutes and research proposals for Laboratory
correspondence on the new building and
His own extremely
detailed
notes
full record of committee meetings
(Cambridge: University
and
conducted
by
the Director M.F. Perutz,
Laboratory Cambridge) is
There are also agendas,
service
at Cambridge.
on
equipment
and
and some material
Board
meetings,
its
extension
his
committee
of
Kendrew’s
own
a
relatively
is
another
short
body
short
Section
E
College)
staff.
inh.
and
a
NCUACS 11/4/89
J.C. Kendrew
colleges in the 1950s are again of interest for the history of education.
Sections
F,
G
and
H are all devoted to the
history
of
European
molecular
biology
and constitute another major component of
the
collection,
covering twenty years 1962-82.
The extent of the material made it expedient to
present
it
in separate sections for the Organisation EMBO
(Section
F),
the
Conference
EMBC
(Section G) and the Laboratory EMBL (Section H).
A
general
introduction to the topic and to the material has been prepared as well as_
the
specific
introductions
preceding each section.
As has already been
stated,
Kendrew was closely involved in the movement from its earliest inception;
held
high office in its key committees and secretariat and was also active
he
in
several
channels
of the science policy establishment in Britain such
as_
the
Council
for Scientific Policy and the International Relations Committee of the
Royal
Society.
His
unique place at or near the centre of events
makes
his
record
of
special value in several regards.
It
is remarkably
complete
and
contains
the early history or "founding papers" of all three European
bodies,
many
of
them
in the form of manuscript or informal
letters
exchanged
with
distinguished
colleagues
throughout Europe as well as
in
Britain
where
the
of
EMBO,
M.F.
Perutz,
official,
research
for
molecular
and
time
and A. Klug.
In addition,
negotiations,
discussions
and
Cambridge
MRC
Laboratory
agreements at personal,
buildings and staffing;
All aspects
of
the
European
national and international level;
biology movement are thus covered:
itself provided the first Chairman
projects, membership and elections;
incorporation
in the present collection.
the first Secretary-General of EMBO, J. Wyman, has
and many founder members such as
S. Brenner, H.E. Huxley, F.H.C. Crick
global inflation and fluctuating European exchange rates in the 1970s;
at Kendrew’s request made over his own papers and correspondence on the subject
funding - made dangerously unpredictable for the laboratory project by the
note.
all stages are of the greatest interest, especially for the laboratory project;
members to keep the project alive by personal contacts is
and most of the items have a descriptive entry or introductory
advances a proliferation of committees and working parties.
Section H also includes documentation of his own career at EMBL.
unfavourable comment and hostility is not neglected;
concerned respectively
with
UK
Kendrew's own notes of discussions,
Each has an alphabetical list
societies and organisations.
Sections
J
and
K
are
planning and problems
of doubt,
founder
and
with
of
and as
The element
international
contents
budgets, costings
the efforts of
evident
in
at
many contexts.
NCUACS 11/4/89
J.C. Kendrew
Of
special
interest
in Section J are the "founding papers"
of
the
British
Biophysical
Society,
papers
of the Council for Scientific
Policy
including
those of the Working Groups on molecular biology,
on the proposal for EMBL and
on the Dainton and Rothschild reports on the organisation of research,
and the
Council's Standing Committee on International Relations.
There is also a full
record of the High Energy Particle Physics Review Group chaired by Kendrew, and
material
relating
to
various
committees and
sub-committees
of
the
Royal
Society.
Correspondence with W.L. Bragg and others at the
Royal
Institution
provides
useful
links
with Kendrew'’s research career
during
the
myoglobin
project;
material for the Design Research Unit shows him in an unexpected role
in
the
1940s
submitting
ideas for industrial
and
design
applications
of
scientific advances.
On the international scene (Section K) there are records of Kendrew’s
extensive
service
on
the
councils or advisory boards
of
institutions
and
laboratories
and of their research programmes - examples among others are
the
Basel Institute for Immunology,
the Laboratory of Molecular Embryology Naples,
the
Max-Planck-Gesellschaft
Munich,
the Molecular
Biology
Department
Free
one
of
important
by
1974.
at
a
office
from
but chiefly by
Kendrew’s
most
the
International
University
of
Brussels,
begun in 1963, with the
Weizmann Institute Israel.
the
United
Nations
University
Tokyo
- and
good
commitments and in which he held high
Council of Scientific Unions (ICSU) which
remains
The international scientific unions are represented
include his folders of lectures and talks 1946-1987.
documentation for his long and continuing association,
Biochemistry (IUB) and Pure and Applied Biophysics (IUPAB),
Section L (Lectures, Publications, Reviews) was considerably expanded
late stage in the compilation of the catalogue by Kendrew’s decision
and
and miscellaneous material on the fortunes and vicissitudes of the journal
from other publications because of Kendrew’s long involvement with the
lectures than previously available and include substantial courses
M (Journal of Molecular Biology) has been treated separately
in America and Japan, and various special invitation lectures.
and
have been extensively cross-referenced to related
material,
and other events elsewhere in the collection.
Once again there are "founding papers",
careful notes and analyses by Kendrew,
its inception and as
a Director of
Academic
These appear as
addenda
They contain
many
Editor-in-Chief
from
journal
Press.
invitations
more
conferences,
to
given
Section
as
NCUAGS 11/4/89
J.C. Kendrew
its publishers over a time-span of thirty years.
Section
N (Visits and Conferences) is not extensive and is far
from
reflecting
the
extent
of Kendrew’s
travels.
His
notoriously
peripatetic
existence
becomes
apparent by the accumulation throughout the
collection
of
references
to
journeys
in connection for
example
with
European
molecular
biology,
or
on
behalf of ICSU and its constituent unions,
or
the
official
visits
for
the
Council
for Scientific Policy,
or the
regular
visits
and
meetings at other laboratories and institutions.
Sections
0,
P and R are all short sections.
Section 0
(Correspon-
dence) is not extensive since Kendrew kept almost all his correspondence in the
files
or
notebooks to which it related.
One touches here
on
the
reticent
element in his temperament;
the correspondence is open and friendly yet rarely
develops into long-term exchanges.
Section P (References and Recommendations)
covers
a
long
period
and is international in range;
some
is
subject
to
restricted access.
Section R (Biographical) contains some interesting material
on Kendrew’s career and appointments, including many offers of posts in Britain
the
It
will
be
is
and abroad.
catalogue.
myoglobin) and,
seen
that the collection comprises
material
Unsurprisingly, it contains little of a personal nature.
A Bibliography and an extensive index of correspondents complete
the full history of a major scientific discovery as such (the structure
different nature and of potential interest in several fields of enquiry.
and
The material relating to the Journal of Molecular Biology
in the many research proposals put forward by individuals
unions and especially of their central body ICSU;
of one field of European co-operation in the history
The international aspects of science can be studied
an important aspect of the scientific process:
examples of how leading scientists
membership
and
evolving
preoccupations
and the diffusion of changing
a
wider
public awareness through the
subject at a particular time.
EMBO, EMBC and EMBL.
including EMBL,
educational
process
exceptional
coverage
various
levels.
the
evaluation
There is
material
scientific
concepts
developments
in
their
intellectual
training
organisation,
assemblies,
saw the
key
on
by
at
is
of
institutions
of
very
There
of
and
in
of
while there
scientific
reflects
filtering
to
NCUACS 11/4/89
J.C. Kendrew
communication
of
research findings and the criterion
of
peer-judgment.
Of
perhaps
more
specialised
interest
is
the
evidence
of
the
scientific
contribution
to the war effort during the Second World War,
seen here in
the
correspondence
and
reports
on
operational research
in
several
fields
of
hostilities and in the responsibility exercised by people still in their
early
twenties.
It should be recalled that the documents on all these topics include
both
official papers in the shape of minutes,
reports and the like,
and also
Kendrew’s
own meticulous notes,
drafts and comments which greatly
supplement
the
official
material,
and background correspondence and
discussions
which
rarely form any part of them.
Some sections or items in the collection may be subject to restricted
access.
NCUACS 11/4/89
J.C. Kendrew
ACKNOWLEDGEMENTS
Thanks
are due primarily to Sir John Kendrew for initially
allowing
his
papers
to go forward for cataloguing,
and for his continuing
invaluable
interest in the process.
He has made himself freely available for consultation
at
every
stage
and placed his almost total recall at
the
disposal
of
the
compiler.
At his instance,
Dr. R.G. Parrish and Professor J. Wyman have also
made relevant material available from their own records.
Professor Sir David Phillips has kindly given advice and
information
and
helped
to
identify
material
on the joint
Royal Institution - MRC Unit
research.
Dr. R.W.
Members
Manuscripts
sources
of
Hazel Gott
has
Bodleian
Library
and of NCUACS have been
unfailing
information, advice and encouragement.
faced the processing and revising of
Dr.
E.A. Leedham-Green of Cambridge University Archives and
and former members of the staff of the Department of Western
Lovatt of Peterhouse have helped with information on Kendrew’s Cambridge years.
with remarkable resilience and aplomb.
the
catalogue
NCUACS 11/4/89
J.C. Kendrew
SECTION A
NOTEBOOKS, NOTES AND ESSAYS
A.1-A.120
INTRODUCTION
NOTEBOOKS
School
War service
University (postwar)
A.28-A.31
School
War service
NOTES AND ESSAYS
Azi19
AS b20
University
A.32-A.118
Later miscellaneous notes
NCUACS 11/4/89
J.C. Kendrew
INTRODUCTION
This
section includes early school and university
notebooks,
notes
and essays from 1930 to 1939,
and one notebook each from Kendrew's war service
(A.26)
and
his
later Cambridge career (A.27).
There are
also
some
later
miscellaneous research notes and postwar lecture notes (A.120).
The laboratory
notebooks, observations and notes relating to his principal postwar research on
myoglobin and other proteins are in Section C.
The
most
remarkable feature of the material presented here
is
the
diligent
care
with
which Kendrew wrote up his work even
from
the
earliest
stages of his career, culminating in the major indexed series of notes at A.40-
A.117
which
incorporates
material from
lectures,
literature
searches
and
laboratory
experiments,
drawing on school work as well as Cambridge
sources,
all classified under a system of his own devising.
factors
science
all
but
later
paginated,
inscriptions
were
the
essential
bearing
not
historian
of
Although
Kendrew’s
own
talents and diligence
in
building his career,
standard
hardback
type,
The
school
notebooks
are
of
the
work
expected and attained at Clifton.
mention should be made of the high level
only contemporary legends such as "Set 4"
in red ink showing where they fall into the major indexed series.
loose pages of small quarto format from his school sixth form period onwards.
recalls (private communication August 1988) that when he entered the sixth form
No notebooks of this kind survive from Cambridge, Kendrew having come to prefer
Holmyard and for the Headmaster N. Whatley.
Holmyard prescribed not one of his own many textbooks which were widely used in
set had rapidly to acquire a reading knowledge of scientific German.
very thoughtful and marked with critical care,
in the notebooks and in the essays at A.29.
no translation was available and
the
schools
at the time but a German text;
The head of Science 1920-40
was
the
whom Kendrew recalls as
and later scientific
and
other masters can be
particularly
good
The general essays
were written
for
of
physics
was
seen
on
the
Comments
by
these
W.C. Badcock,
editor
E.J.
Holmyard.
A.30,
often
class
at
teacher.
exercises
of
Kendrew
The head
a
NCUACS 11/4/89
J.C. Kendrew
Kendrew did not reach Cambridge until 1936 and the war was to disrupt
his
and many other lives in 1939.
But he had three years of exposure to some
of
the country’s most distinguished scientific minds and used the
opportunity
fully,
offering Chemistry,
Physics,
Biochemistry and Advanced Mathematics in
Part I
of the Natural Sciences Tripos and Chemistry in Part II.
His extensive
reading, assiduous lecture attendance and note-taking are dauntingly documented
in
the
major
indexed series,
and the careful recording
of
lecturers’
and
supervisors’ names is valuable for the history of education.
On his return to
Cambridge
in
1946,
the
focussing
of
his
interest
in
biochemical
and
crystallographic studies can be seen in the continuing meticulous lecture notes
from
1946.
His
own work as lecturer and college supervisor and director
of
studies, for which equally careful records were kept, can be seen in Section E.
NCUACS 11/4/89
J.C. Kendrew
NOTEBOOKS
SCHOOL
Notebook
cover and front page.
"Physics"
with red ink indications for main index
on
Paginated 1-140.
pp.1-56,
pp.58-84,
pp. 66-119; © "Light"
"Electricity" 1930
"Mechanics"
"Hydrostatics", 1931
Notebook "Physics",
cover and front page.
with red ink indications for main index
on
Paginated 1-140.
pp.1-87 used,
"Heat", 1931
1932.
"Physics.
magnetism.
Lecture".
Electricity
and
All pages used.
Notebook "Physics. Mechanics and the properties of matter. Lap:
with red ink indications for main index on cover and front page.
Paginated 2-134.
All pages used.
1932.
Notebook
Paginated 2-70.
for main index on cover and front page.
Notebook "Physics. Electricity and Magnetism. Lab", with red ink
indications
Paginated
1-70.
pp.9-10, 1933
Not all pages used.
Notebook
Lecture".
Paginated 2-50.
Mechanics
and the
properties
of
matter.
pp.2-38 used.
1932.
pp.2-8,
1932
"Physics.
NCUACS 11/4/89
J.C. Kendrew
30
A.7
Notebook "Sound. Lab.",
on cover and front page.
with red ink indications for main index
Paginated 1-10.
pp.1-4 used, 1933.
Notebook "Light. Lab.",
on cover and front page.
main index system 41(b)-90(b).
with red ink indications for main index
Pagination added later to conform with
pp.41(b)-86(b), 1933
Notebook "Heat. Lab.",
on cover and front page.
main index system 61(c)-110(c).
with red ink indications for main index
Pagination added later to conform with
pp.o61(c) 106); 1933
Notebook "Sound. Lec[ture]", paginated 1-30.
pp.1-15 used,
1933
Chemistry
"Chemistry Lecture",
paginated 1-68.
pp.1-53 used, with Index at rear,
1931.
Dated on front
work
Notebook "Chemistry Lecture", paginated 1-68.
Notebook
page 1931 but work continues to 1932 and includes revision
for Clifton internal and School Certificate examinations.
are dated 1932.
Small
school
classification
press cuttings stuck at rear,
with red ink
on cover and front page and index
Notebook
main
later) on front page.
1-97.
probably not part
the
with
but
on latest discoveries in physics,
concerned
Undated,
Mainly
table.
of
indications
(probably
for
added
format
notebook "Chemistry",
"Laboratory notebook",
sequence.
Paginated
of elements and periodic
index
Paginated 1-40.
pp.1-38 used, 1931.
NCUACS 11/4/89
J.C. Kendrew
A.15
Notebook "Chemistry. Extra Lab. 1932", paginated 1-30.
pp.2£-25 used,;.
1932.
Notebook "Inorganic Chemistry Lecture".
on front page).
Undated but 1932 (see A.17).
Paginated 3-139 (index
Notebook "Inorganic Chemistry Lecture II",
all pages used.
1932.
paginated 3-69.
Not
Notebook "Chemistry Organic Lecture", paginated 2-72.
pp.2-62 used,
1932.
Notebook "Chemistry Organic Practical", with red ink indications
for main index on cover and front page.
Paginated 1-60.
pp.1-33,
1932
pp.34-54, 1933.
Paginated 1-64.
1933.
"Inorganic
Lab.",
Paginated 71-137.
"Inorganic Lab.",
for
pp.1-41,
pp.42-60,
pp.61-64,
pp.71-112,
1934
pp.113-137, 1935.
with red ink indications for
main
and index (probably added later)
with red ink indications
main
and index (probably added later)
Analyses, 1933
Volumetric analysis, 1933-34
Qualitative analysis [1933]
Notebook
index on cover and front page,
on front page.
Notebook
index on cover and front page,
on front page.
Analyses, 1935.
with red ink indications for main index
on
and index (probably added
Paginated (probably added later) 241-260.
"Chem. Lab.",
cover and front page,
Notebook
on
front page.
pp.241-259,
later)
NCUACS 11/4/89
J.C. Kendrew
Notebook
handwriting suggests a date 1932-33.
"Inorganic
Analysis",
paginated
2-43.
Undated ;
Notebook
Chemistry".
C9325,
(not
standard
school
sequence
format)
Paginated 2-61.
Not all pages used.
"Organic
Undated but
Analyses, notes on the literature.
undated and probably
Notebook
during Kendrew’s time at the Dragon School, Oxford.
"Geography
Notes",
very
early
maps,
Notes,
in
Climatology, Oxford University and he was attracted to the study
of geography at one time.)
(Kendrew's
mnemonics.
Reader
father
was
A.23
WAR SERVICE
Kendrew’s S.0. Book 135, signed and headed "Summary notes".
runs
notes
of visits to
coastal
their
equipment,
14 March 1941 and
covers
lists of air
22 November 1940 to
UNIVERSITY (POSTWAR)
of circuits and installations,
Binder of "Filofax" pages inscribed "Peterhouse Cambridge", with
index of topics as follows:
Material
a
wide range of topics on radar and coastal air defence, including
diagrams
stations
and
squadrons,
The visits were mainly to
comments on personnel and equipment.
squadrons in Scotland and in Northern Ireland,
and the material
was the basis of Kendrew's reports at B.26.
post 1947.
Mathematical formulae
Mathematics
Physics
Statistics and probability
General biology
Psychology
Sociology
Archaeology
Geography
Botany
Photography
Chronology
and notes on books and articles read.
Own notes,
Undated
NCUACS 11/4/89
J.C. Kendrew
NOTES AND ESSAYS
SCHOOL
Demonstrations and notes on explosives.
Essays and questions on scientific topics,
limits
dated, various dates 1933-35.
or preparation for
revision
as
some written to time
few
examinations.
A
General essays written for E.J. Holmyard and N. Whatley.
Miscellaneous shorter notes.
to
about
Included
reply
omitted
omitted from textbook on organic chemistry.
here are two letters received by Kendrew at Clifton in
word
a _ phenomenon
1935 from J. Read on
from Concise OED;
1932 from
enquiries
K. Sisam
by him:
UNIVERSITY
Essays and questions
"Supervision with Dr Feather 1938".
"Supervision with Dr Mann 1937" (F.G. Mann,
organic chemistry).
"Supervision with Dr Feather 1937, 1938"
University Lecturer in physics).
(N. Feather, Trinity,
Reader in
Trinity,
NCUACS 11/4/89
J.C. Kendrew
A.35
Miscellaneous essays, some for F.G. Mann, most for "Dr Hoar"
[T.P. Hoar], others without attribution.
A.32-A.34
notes.
are
A.35 is
on the small quarto pages used for the main indexed
on the large quarto often used in Cambridge in the 1930s.
series
of
Teaching material
Practical biochemistry, Michaelmas Term 1937.
Material for 24 classes.
Practical biochemistry, Lent Term 1938.
Material for 22 classes.
Practical biochemistry, Easter Term 1938.
Material for 5 classes.
Examinations
Biochemistry,
Physics,
Sciences
Tripos question
papers:
1939 (Chemistry).
Preliminary
1937,
Mathematics),
I 1938 (Chemistry,
Natural
Part
Part II 1936,
Some papers annotated by Kendrew.
NCUACS 11/4/89
J.C. Kendrew
Major indexed series of notes and lectures
The
consists of almost 9,000 manuscript pages of small
This
format.
career
postwar
included
1946-50 (see A.49, A.61, A.91-A.93, A.104-A.107, A.111).
and the Cambridge lectures extend to
school notes and lecture notes
period covered is
Kendrew’s
1936-39,
quarto
undergraduate
also
courses
main
are
but
in
method
the "code-book",
of classification is preserved separately
format
Kendrew's
A.40
loose pages.
topics:
code prefix.
physics lower case letters a-h,
and for mathematics Roman numerals I-IV.
at
on
basic
physics, biology, mathematics, each with a
for
for biology Greek characters a-6
For chemistry this is upper case letters A-D,
also written on the same
is clear and flexible.
There are four
chemistry,
It
Within each topic the organisation is
as follows:
code prefix followed by numbered pages - systematic
and
notes on the literature
eg,
6.1 -Cet72,
notes
numbered pages followed by code prefix - lecture notes eg.
320C.
113¢C-
numbered pages followed by code prefix in brackets -
A
The
laboratory notes eg.
1(C)-70(C).
for
few
thus
total
sequence
included.
identified.
the notes are also
the sequences have an index of contents.
"code-book" contains a detailed subject index of
In addition
Almost all
elements,
the
methods, definitions, apparatus and instruments etc.
compounds,
Cambridge lecturers are always named and some of the main source
invitation
books
are
outside the routine university teaching programme
lectures
an
provides
also
then
exceptionally full conspectus of the intellectual training
though it may be doubted how many took such diligent
available,
advantage of
it.
subject index.
classification
"Code-book",
explaining
including
system
and
NCUACS 11/4/89
J.C. Kendrew
Chemistry
Code-prefix upper case letters, subdivided into:
A.
B.
Systematic inorganic chemistry.
Theoretical and general chemistry.
Physical chemistry.
Organic chemistry.
Systematic inorganic chemistry
Systematic inorganic chemistry notes,
group indexed,
divided.
each
the whole paginated AO-A473 with some pages sub-
arranged by groups,
Part
Lent
page.
B.
I Lecture course "Inorganic chemistry",
and Easter terms 1938,
paginated 0A-33A.
by
H.
McCombie,
Index on first
paginated BO-B165,
index on front page,
Theoretical and general chemistry
General notes and notes on the literature (school and university
material),
some pages
sub-divided.
1939, index on front page, paginated 143B-218B.
Part II lecture course "Theoretical Chemistry" by
Jones,
paginated OB-77B.
Part II lecture course "Crystal Chemistry" by
Part
Michaelmas 1938, index on front page, paginated 78B-142B.
"Thermodynamics"
J.E. Lennard-
page,
front
Michaelmas
1938,
by
J.K. Roberts,
R.C. Evans,
II
lecture
course
Lent
1939,
index
on
Lent
NCUACS 11/4/89
J.C. Kendrew
A.47
Part
index on front page, paginated 219B-243B.
lecture course "Valency" by W.C. Price,
II
7
Easter
1939,
Chemical
paginated 244B-247B.
Society
lecture
"Fireworks"
by
Dr R.E.D. Clark,
"Theories
Lent
and Easter terms 1950, index on front page, paginated 248B-412B.
of molecular structure" by
J.E. Lennard-Jones,
Laboratory notes,
little earlier school work, paginated 1(B)-202(B).
mainly Cambridge work 1937-39 but includes
a
C.
Physical chemistry
R.G.W. Norrish,
I
II
some pages sub-divided.
Part
Michaelmas 1937, index on front page, paginated 0C-111C.
lecture course "Physical chemistry" by
Part II lecture course "General physical chemistry",
Michaelmas
1938 (by F.P. Bowden) Lent 1939 (by E.K. Rideal), index on front
pages, paginated 113C-320C.
General notes and notes on the literature, mainly university but
some school material, indexes on pp.C0, C60, C160, paginated CO-
C187,
E.K. Rideal, index on front page, paginated 375C-432C.
Part II lecture course "Surface reactions",
Part
Rideal, index on front page, paginated 321C-374C.
lecture course "Colloids",
Michaelmas 1938, by
Michaelmas 1938,
by
E.K.
NCUACS 11/4/89
J.C. Kendrew
38
A.56
Part II lecture course "Some aspects of biocolloids", Michaelmas
1938, by E.K. Rideal, index on front page, paginated 433C-475¢c.
Part II lecture course "Electrochemistry",
1939, index on front page, paginated 476C-530C.
by F.P. Bowden, Lent
Part
Allsopp, Lent 1939, index on front page, paginated 531C-582C.
lecture course "The structure of
molecules"
by
II
C.B.
Part II lecture course "Reactions in solution"
Hughes, Easter 1939, index on front page, paginated 583C-615C.
by E.A. Moelwyn-
"Recent
Lecture
Langmuir
paginated 616C-617C.
the
of
developments
in the study of
films.
GEC"
[Irving
Langmuir],
13
October
By
Dr
1937,
"Modern
Eirich, paginated 618C-636C.
theoretical aspects (polymers)",
Summer
1946,
by
F.
1939,
compounds,
front pages,
paginated D1-D335,
D.
Organic chemistry
notes and experiments October 1937 - February
Laboratory
paginated 1(C)-169(C).
index
mainly university but includes a little school
some re-
Systematic organic chemistry notes on acrylic
on
material,
numbered and a jump in numeration at D130.
paginated D700-D947 with a jump in numeration at D812.
Systematic
compounds
(quinonoid rings), alicyclic, and others, indexes on D700, D760,
Systematic
(benzenoid
school material, paginated D400-D698.
on
on front pages,
many pages sub-divided,
compounds
little
a
chemistry
notes
chemistry
notes
rings),
index
on
cyclic
cyclic
includes
organic
organic
NCUACS 11/4/89
J.C. Kendrew
A.66
chemistry
"Organic
the
literature, school and university material, index on first page,
paginated D1000-D1147.
- general",
notes
notes
and
on
I
three-term
Part
W.J. Pope,
Easter
paginated 1D-5D, pages much sub-divided.
index on front pages,
Michaelmas 1936,
lecture
1937,
course
"Organic
by
Lent and Easter 1937, P. Maitland,
only,
notes for Lent 1937
chemistry"
II
three-term
Part
by
F.G. Mann, Michaelmas 1938, Lent and Easter 1939, index on front
page, lectures all dated, very full notes paginated 6D-351D.
chemistry"
"Organic
lecture
course
Part II
by
1939, index on front page, paginated 352D-397D.
lecture course "Stereochemistry",
W.J. Pope,
Lent
"Some
October 1937 by F.B. Kipping, paginated 398D-404D.
compounds",
aromatic
lecture
Chemical
to
Society
22
notes,
Laboratory
LCD) -179(D).
analyses and experiments 1936-39,
paginated
Pp.78(D)-92(D) are "Report of work carried out at
ICI Laboratory, Blackley, Manchester August 1938".
NCUACS 11/4/89
J.C. Kendrew
Physics
Code-prefix lower case letters, sub-divided into:
Electricity
Light
Heat
Mechanics:
properties of matter
Sound
Atomic physics:
general
Crystal physics
Philosophy and scientific method
a__Electricity
by
experiments
b.
Light
1935-36,
earlier
and notes on the literature,
Notes
but
paginated a0-al58, several pages sub-divided.
includes a little school material,
mainly university (to 1939)
a115,
indexes
a0,
on
I
lecture
course
Easter 1938,
electricity,
"Electricity"
index on front pages,
J.A. Ratcliffe,
paginated
laboratory
notes
some initialled W.C.B.
Part
Michaelmas 1937,
Oa-204a.
Practical
Clifton,
131(a)-239(a);
ALA. 3
and
at
[Badcock], paginated
pages to be supplied from notebooks at
b152, paginated b0-b234.
Practical
Cambridge 1937-38, paginated 241(a)-404(a).
General notes, school and university material, indexes on b0 and
laboratory
notes
and
electricity,
experiments,
NCUACS 11/4/89
J.C. Kendrew
41
A.77
Part I lecture course,
on front pages, paginated 1b-114b.
by A. Wood,
Lent and Easter 1937, index
light,
Practical
1935
notebooks at A.1,
117(b)-222(b).
paginated 91(b)-110(b),
A.8,
A.2,
laboratory notes and experiments,
school
earlier pages to be supplied from
and university 1937-38
paginated
at _
General notes, school and university material, indexes on cO and
c36, paginated c0-c97, several pages much sub-divided.
Part I lecture course "Heat",
index on front page, paginated Oc-112c.
by
Dr H. Carmichael,
Lent 1938,
Practical heat, laboratory notes and experiments, at school 1935
paginated
from
notebooks at A.2,
and university 1936-37 paginated 141(c)-
TICE) |
111(c)-134(c),
supplied
earlier
pages
to be
A.9,
d
front
index on
Mechanics:
properties of matter
school and university material,
General notes,
page, paginated d0-d125.
Part I lecture course "Mechanics"
index on front pages, paginated 1d-100d.
204(d).
Practical mechanics, laboratory notes and experiments, at school
1935
earlier pages to be supplied from
and university 1936-38 paginated 101(d)-
notebooks at A.1,
paginated 71(d)-100(d),
Michaelmas 1936,
by A. Wood,
A.4,
NCUACS 11/4/89
J.C. Kendrew
General notes, index on front page, paginated e0-e22.
Part I lecture course "Sound", by A. Wood, Lent and Easter 1937,
index on front page, paginated le-39e.
Practical sound, laboratory notes and experiments 1936 paginated
11(e)-23(e);
be
pp.l(e)-10(e),
supplied from notebook at A.7
referring to school work,
to _
£
Atomic physics
General notes and notes on the literature,
school
sub-divided.
and university material,
paginated f£0-f£103,
index on front page,
some pages
I
Michaelmas
by
F.W. Aston,
g
Crystal physics
Most of this material is postwar.
Part
1936, index on front page, paginated Of-22f.
lecture course "Isotopes",
Notes on the literature, index on front page, paginated g0-g5l.
W. Cochran, Lent 1950, paginated 148g-179¢.
Lectures on "Crystal Physics:
Lent and Easter 1946, index on front pages, paginated Og-10lg.
Lectures on "Fourier methods" by H.D. Megaw, Lent 1948,
front page, paginated 102g-147g.
"Some properties of the
reciprocal
lattice",
selected topics"
by W.H. Taylor,
Lectures
on
index on
by
NCUACS 11/4/89
J.C. Kendrew
h_
Philosophy and scientific method
Notes
paginated hl-h23.
on
the literature (made in last terms
at
school
1936)
Code-prefix Greek characters, sub-divided into:
Biochemistry
Zoology
Botany
Physiology
a
Biochemistry
Much of this material is postgraduate or postwar.
sub-
Part
1937,
series
F.G. Hopkins,
E. Holmes, T.R. Parsons, E.H.F. Baldwin, D. Needham,
M. Dixon,
some
divided.
Michaelmas
Given by a
Dodie pelt,
J. Needhan,
pages
Notes on the literature,
page, paginated a0-a/5.
I
three-term lecture
Lent and Easter 1938,
university and postwar, index on front
course
"Biochemistry",
of lecturers;
names include
D.D. Woods.
Paginated
Oa-353a,
index on front pages.
NCUACS 11/4/89
J.C. Kendrew
44
A.97
"Cell
Michaelmas 1939, index on front page, paginated 354a-417a.
oxidations",
respiration
biological
and
by
M. Dixon,
"Some
Michaelmas 1939, index on front page, paginated 418a-432a.
intermediary
metabolism",
aspects
by
Dr
of
Holmes,
"Biochemistry of carbohydrates",
index on front page, paginated 433a-483a.
by D.J. Bell, Michaelmas 1939,
"Enzymes",
paginated 484a-535a.
by
M. Dixon,
Michaelmas 1939, index on front page,
"Plant biochemistry",
front page, paginated 536a-587a.
by
N.F. Hill,
Michaelmas 1939, index on
"Organisation
proteins",
page, paginated 587a-620a.
and
physical
A. Neuberger,
by
chemistry
Michaelmas 1939,
of
amino-acids
index on
and
front
aspects
of
protein
by
by
Professor
chemistry",
23 November 1937,
Ferry
paginated
lecturer from Harvard),
"Some
(visiting
621a-623a.
of X-ray analysis and their application to
"Methods
problems",
paginated 670a-699a.
"Respiration and respiratory carriers", by D. Keilin, Lent 1946,
index on front page, paginated 624a-669a.
paginated 737a-766a (last note reads "course abandoned").
"Protein and enzyme kinetics",
on front page, paginated 700a-736a.
by K. Bailey, Michaelmas 1946, index on front page,
by P. George, Easter 1946, index
biological
page,
M.F. Perutz,
"Proteins",
Lent 1946,
index on
front
NCUACS 11/4/89
J.C. Kendrew
biochemistry,
1937,
Lent 1938,
laboratory
notes
index on front
and
pages,
experiments,
paginated
A.108
Practical
Michaelmas
O(a)-151(a@).
B__Zoology
at
Clifton
1936,
index
on
front
page,
at
Clifton
1936,
index
on
front
page,
Notes
paginated 08-1188.
lectures
on
y__
Botany
Notes
paginated 07-1457.
lectures
on
6
Physiology
Part II lecture course "Cell Physiology" by
Hodgkin, D.K. Hill,
Michaelmas 1946, Lent 1947,
E.N. Willmer,
A.L.
index on front
page, paginated 06-1296.
NCUACS 11/4/89
J.C. Kendrew
Mathematics
Code-prefix Roman numerals, sub-divided into:
General notes
II
Analysis
III
Vectors and statistics
IV
Differential equations
I
General notes
Miscellaneous
calculus, mechanics, index on front pages, paginated I O-I 74.
mathematical
trigonometry,
algebra,
notes,
II_
Analysis
by
H.M. Taylor,
Lent 1937,
index on front pages,
III
Vectors and statistics
"Analysis",
paginated II 1-II 151.
"Vectors, tensors, numerical methods, interpolation statistics",
by R.S. Stoneley,
index on front
pages, paginated III O-III 172.
Michaelmas 1937, Easter 1938,
page, paginated III 174-III 232.
Statistics.
during war
[LP
comparison of loss rates" dated 1 November 1944.
undated but probably done
Includes on pp.III 225-
the
Index on front
Unpaginated notes and calculations on tensors.
“Summary. of ORS (B.C: Reporte. LTS
(on poorer quality paper).
Notes and calculations,
232.
,a
Note
on _
NCUACS 11/4/89
J.C. Kendrew
IV
Differential equations
I
lecture
Part
special
functions, integrals", by F.C. Powell, Lent 1938, index on front
pages, paginated IV 0-IV 133.
"Differential
equations,
course
Other University notes
Notes,
literature, July 1939 - January 1940,
first research work with E.A. Moelwyn-Hughes.
experiments, laboratory work, abstracts and notes on the
on mutarotation, Kendrew's
See also C.1.
Includes:
Malvern)
February - June
1940
literature.
scientific
subjects
Establishment,
of small format "Filofax" notes on
Made on same format as main university
Notes on the literature (proteins, X-ray diffraction).
Bundle
but miscellaneous content and date.
Notes on radar research carried out with TRE (Telecommunications
Research
on
Also notes on
Barkhausen-Kurz oscillators, aerials, valves etc.
the
notes
but not paginated.
Material extends. to 1962.
Notes
visits
wisits to USA 1951,
taken at visits and conferences,
research
laboratories and
papers and discussions,
including
progress,
Notes
1946-49.
taken at lectures,
mainly special lectures at
Cambridge
to
in
1953.
NCUACS 11/4/89
J.C. Kendrew
SECTION B
SECOND WORLD WAR
INTRODUCTION
CAREER AND CORRESPONDENCE
Bit
Career
B.2-B.24
Correspondence and papers 1941-46
REPORTS
B.
We
5B:
B.
B..
B.
B.
B.
B.54-B.60
Methodology
Postwar papers
Bomber Command
Coastal Command
Combined Operations
Middle East Command
South East Asia Command
Anti-submarine warfare
Correspondence, papers, drafts
HISTORY OF OPERATIONAL RESEARCH
NCUACS 11/4/89
J.C. Kendrew
INTRODUCTION
Kendrew (private communication July 1988) describes how he came to
be
involved with radio research in prewar Cambridge as follows:
"Being
a
contrary
character,
at my public school
where
almost
everyone joined the OTC I refused to do
so;
at Cambridge, where almost
no one joined,
I proceeded to do
it.
I joined the Signals
Unit,
of
which W.B.
Lewis was -
I think - Commanding Officer.
Having joined, a
friend
(Jim
Wilkins) and I discovered that Lewis had a contract
with
the
War Office to develop ultra-shortwave two-way radio,
and that
needed spare-time help with this.
The work was non-secret and had
he
no
connexion with radar;
the wavelengths involved were 3m and 66cm - very
short by the standards of those days;
but it meant that we could evade
some
uniformed
parades
and
various
tedious
chores
by
enrolling
ourselves with him in what I think was known as the Research Section
-
a
I
was
headline
of
it.
As
and
as
far
as
When the War came
my academic research,
I remember we were the only
members
I had no idea about radar but
read ‘Meet the walking wireless man’).
friends going off to the armed services.
I
had heard a rumour that Lewis was involved in something
which I did not find very satisfying with all my
and I wrote to him with the result that I was recruited into TRE."
track
to the scoreboard at an athletic meeting at the White City
(the
consequence I had my picture in the newspaper relaying results from the
interviewed by the Cambridge Recruiting Board and told to continue
East,
Junior Scientific Officer at the Air Ministry and he remained a Temporary Civil
in October and December to instruct aircrew and controllers in the use of
posted with the rank of Squadron Leader to Middle East Command,
Command to study and advise on the installation and operation
from
December 1941 he was stationed in Cairo at Headquarters RAF Middle
Servant with Honorary commissioned rank throughout.
(Air
Detection of Surface Vessel) equipment (B.26).
career began in December 1939 when he was
appointed
a
(see A.119) and in the autumn of that year
During the early months of 1940 he worked
Research
(OR)
with
special
reference
to
anti-submarine
warfare,
He worked on
Operational
In September 1941 he was
visiting Malta
officer
of
TRE
accuracy
and
radio
aids.
His
wartime
was
seconded
interesting
Coastal
ASV;
bombing
as
an
to
of
ASV
NCUACS 11/4/89
J.C. Kendrew
concerned
with
coastal,
bomber and army co-operation matters.
During
this
period
he produced a very successful "Handbook for aircrews and
controllers",
often
referred to as
a "Bible" (B.35).
In December 1943,
after a period
of
home
leave,
his rank was raised to Wing Commander on his move to
South
East
Asia
Command
where he served in India and Ceylon as officer in charge
of
OR
and, from June 1944, as Scientific Adviser to the Allied Air Commander -in-Chief
His long period of overseas service ended when he handed over
South East Asia.
his command in February 1945 and returned via Australia, the South West Pacific
After
London where he rejoined the Air Ministry in
1945.
June
to
USA
and
considerable
thought about the prospects of remaining in
government
service,
Kendrew
accepted
a
Senior Department of Scientific and
Industrial
Research
grant
to
continue
his academic career at Cambridge
and
resigned
from
the
Ministry with effect from 10 January 1946.
The
essential
requirement
of detailed and accurate
data
for
the
compilation
of
official
OR
reports chimed well
with
Kendrew’s
meticulous
temperament and fostered,
if
it did not inspire,
a continuing interest in the
indexing and organisation of information (B.25, Bw36; 8.375. 8.92).
3368,
The
and
of
London
account
Kendrew’s
operational
research in the RAF
An
contributions can be found in Air Ministry Air Publication
wartime
Origins and Development of Operational Research in the Royal Air Force,
1963.
of
HMSO,
NCUACS 11/4/89
J.C. Kendrew
CAREER AND CORRESPONDENCE
documents
Miscellaneous
appointment
1939,
1941, Wing Commander December 1943.
notification
as Junior Scientific Officer Air Ministry
career:
December
of commissions as Squadron Leader September
Kendrew’s
wartime
on
Correspondence
and Papers 1941-46
The documents had been numbered and
are the contents of Kendrew’s "Personal" or "D/O"
These
(Demi-
Official) files and consist of letters, carbon copies, memoranda
and shorter communications sent or received by him,
principally
during his overseas service at HQ RAF Middle East and with South
East Asia Command.
tagged
by him, a new file being opened when the total reached about one
hundred
poor
condition, and have been replaced with the contents divided into
more manageable units while retaining their original order;
it
should be noted that this numerical order does not correspond to
and
the
administrative
letters
themselves.
The files thus created were bulky and in
chronological order of writing,
reflecting the postal
referred
delays
items.
often
the _
in
to
there
service
documents
Kendrew’s
visits to
colleagues,
preparation
and circulation
cover all aspects of
this extensive period:-
news of friends serving elsewhere,
has been no attempt to calendar the
is delays and inadequacy of supplies and
indication is given in the entries of material of
career
postings and promotions of self
reports,
with
or
A
personnel.
special
full
The
during
and
personal
Kendrew by others, testing of equipment, data collection etc.
leit-motif
Some
interest,
range of the correspondence.
Kendrew to R.A. Watson-Watt on OR matters.
Setting up OR in Cairo;
Bes5)
OR
shortage of personnel in Cairo);
Kendrew's manual for pilots (R.17, see
proposal (July) to transfer him to India to initiate an
and
includes several letters from
(strongly resisted because of pressure of work
11 September 1942 (numbered 1-25).
15 December 1941 -
15 December 1941 -
19 May 1943
Section
of
OR
but
NCUAGS 11/4/89
J.C. Kendrew
6 June -
23 August 1944
6-25 June (numbered 1-25).
17-30 June (numbered 26-50).
N.B. Letters go up to
17 July.
Kendrew’s
situation
theatre,
and
subsequently.
letter
in South East Asia,
of
17
July is
a full analysis
of
the future of OR in the
his own career for the remainder of the
the
war
Pacific
and
war
20 July -
7 August (numbered 51-75).
3-23 August (numbered 76-100).
22 August -
5 December 1944
N.B.
21 October.
22 August -
5 September (numbered 1-25).
Letters go up
22 September -
Reports and information on SEAC and Pacific theatre, move of ORS
to
by
A.C, Menzies.
by J.D. Bernal,
proposed
Ceylon,
Kandy,
visit
visit
28 August -
to
8 November (numbered 51-75).
16 September (numbered 26-50).
been so reduced that the posting was not attractive to him.
Kendrew's
Visits by J.D. Bernal, A.C. Menzies, C.H. Waddington.
letter of
78) refers to the opportunity offered
him to return to UK as Officer in charge of ORS Fighter Command,
and
then
Work
J.D. Bernal, A.C. Menzies.
view that the commitments of the Command had
5 December (numbered 76-100).
17 November (no.
acclimatisation,
15 November -
on
night
vision,
reports,
visit
by
his
by
NCUACS 11/4/89
J.C. Kendrew
23 November 1944 -
27 February 1945
23 November -
up to
5 January 1945.
20 December 1944 (numbered 1-30).
N.B. Letters go
2-16 January 1945
January.
(numbered 31-60).
N.B.
Letters go up to 29
29 January -
27 February (numbered 61-90).
handed over OR Section to his successor,
Kendrew
on
to
Australia, New Guinea, the Philippines, USA and Canada.
4 March..to.
February,
leaving.
return
on
2/7.
G.A. Roberts,
‘via
UK
Arrangements for tour of Australia,
USA, January-April 1945.
South West Pacific Area and
are
Mainly official signals, passes etc.
Shorter
4 March 1946.
correspondence
the unnumbered contents of a "D/O" file and
Miscellaneous correspondence December 1944 -
These
include
continuing correspondence on Kendrew’s Pacific and American tour
before returning to UK, exchanges with staff members, continuing
work on OR and on postwar career plans,
testimonials for former
serving officers.
overseas service in SEAC, December 1943 - October 1945.
allowances,
taxation
during
on
pay,
NCUACS 11/4/89
J.C. Kendrew
Miscellaneous manuscript notes.
is
an assemblage of tightly written notes on a series
This
of
small format (17mm x 9mm) early "Filofax" lined and graph pages,
alphabetical
with
order
devised
by
Kendrew and laid out on the first two pages of the sequence.
follow the coded "Arrangement of notes"
They are not in chronological or
dividers.
but
It
contains,
"Operational"
often
in
very
condensed
material is divided into two main areas
on a wide variety of topics relating to air
and
The
form,
"Technical".
information
power,
allied and hostile, in all theatres of war, radar and navigation
aids,
equipment,
bombing
analyses of performance in defence and
anti-submarine
official
attack
in
documents
operational
or
policy
coverage
being
but there are sections under "TRE"
and "RDF Hist." which incorporate material going back to 1930.
and detection devices,
warfare,
research and visits to air stations,
of
activity
committee
derives variously from a
Most entries are dated,
July 1939 - May 1945,
It
published
reports,
Kendrew'’s
study
own
the main
circuits and
etc.
or
decisions.
A.26
See
his
A.119 for Kendrew’s notes on radar research February-June 1940,
S.0O.
for
Book of notes on radar and coastal air defence November 1940 - March
L94) A: 116 for notes. on: OR;
NCUACS 11/4/89
J.C. Kendrew
REPORTS
of these bear the wartime classification "Secret" or "Most
Several are by Kendrew, or by members of his OR units
interest
B.28
P.M.S.
H.M. Barkla (private
Most
Secret".
who feature in the correspondence files.
in bearing notes by Kendrew about their history (see B.27,
and
Blackett (B.31) described as "classics" by
communication November 1987).
and there are copies of two papers
Some are of
8.60)
also
by
The material is duplicated typescript, sometimes with manuscript
additions or corrections.
Coastal Command
Kendrew on arrangements for ASV (Air
by
Reports
Surface
squadrons,
Various dates January-September 1941.
installation
inspections
Vessel)
visits,
and
of
Command
and flights to test equipment.
Detection
Coastal
use
in
(not
52,
125,
210,
135,
142,
181,
186,
127,
128,
150,
160
March
1943,
with
June
212A,
(undated
diagrams
report and
unnumbered,
Bomber Command
folder
1941
143, unnumbered, 144,
Kendrew’s
set),
ORS/CC.
a _ complete
running classification
of Coastal Command reports
-
Nos.
133,
carried out off Ireland),
146,
Kendrew),
204,
unpublished ORS/CC Report No. 218"), 222.
130.-(Cby, Kendrew),, 1S1:(by Kendrew) ; 132,
134 (undated report and diagrams by Kendrew on U-boat hunts
145,
by
192 (with manuscript diagrams by Kendrew),
218 (with manuscript note by Kendrew "Draft of
Miscellaneous reports and manuals 1941-42, 1944.
ORS (B.C.) Reports nos.
note
1944 and an undated report.
S.176 (with a manuscript
1942,
reports dated
by Kendrew "Officially destroyed") ;
Anti-Submarine
Warfare
14,
40,
NCUACS 11/4/89
J.C. Kendrew
Combined Operations
Miscellaneous papers 1942.
OR Methodology
P.M.S. Blackett October 1941,
Two papers by
"Scientists at the
Operational Level" (ORS/CC 154), and "Note on certain aspects of
the
dated
October 1942).
Operational Research"
(incorrectly
methodology
of
Middle East Command
Kendrew’s binder inscribed "ORS/ME Routine Reports on A/S [anti-
submarine]
manuscript
index.
and anti-shipping operations",
with his
run
Reports
numerical or chronological order,
S30
EO 620, 22 29.
December
28° oS hee
1941 - July
oe
eo sk
1943,
not
as follows:
necessarily
in
R4 (missing), 5,
papers
V [Visit]
Defensive
operations.
are
variously
classified
ground RDF"
Ri 36>
Ro39). R43.
Close-
Direction
operations February-July
M [Memorandum] ,
or
and are not necessarily in numerical
Bomber
R415, R230 54.32)
The
R [Report],
chronological order.
Kendrew's binder inscribed "ORS (ME) Bomber operations.
[Radio
support
Finding], with his manuscript indexes for each topic.
continued
Kendrew’s
J.C.K.
his manuscript index.
Defensive
M18; Bi29, M27 M18. R21, Milly, B25, 9.5) M20 RAE,
ground RDF February 1942 - August 1943:
by
There are four sections each with
inscribed "ORS (ME) Miscellaneous
Close-support
R.40, R.48.
December 1942 - August
and Coastal Section".
Via
Vee
Moe:
Mozt,
R345
oM23-32 ,
Mo
R16.
binder
papers
as
1943:
1943:
NCUAGS 11/4/89
J.C. Kendrew
Miscellaneous
1943:
M.25, unnumbered, M.33, R.42.
unnumbered: = Mola!
reports
on
sea operations January 1941 - August
M3. MS) MLS R24. OR. 26 eemissirio )
Miscellaneous
without official numbers, March 1942 - June 1943.
on sea operations
reports
short
(by
Kendrew),
Papers on close-support and radio aids,
M.6,
correspondence and memoranda about R.7.
unnumbered,
M.7,
R.7,
M.9,
January-September 1942:
for
See B.40
unnumbered.
Miscellaneous
March-November 1942.
papers
(by Kendrew),
without official
numbers,
Paper listed for 12 September is missing.
"The
aircrews and controllers."
operational
employment
of ASV
Mk.II:
a
handbook
for
was
originally ORS
which
It
This
Kendrew,
separately.
Kendrew's
issued,
RAAF Headquarters Melbourne n.d.
is referred to
"Bible".
Folder
very
was
(ME) Report no.17 of
1 July
favourably
received
and
in the correspondence,
R.1/7
copy of
includes
revised edition of 1 August 1943 and version issued
1942,
by
issued
often as
first
by
as
Miscellaneous
1943.
reports part or all by Kendrew March,
May,
June
of
to
to
by
but
ORS
(ME)
those
reports
additional
Education Publication
Instruction
and reports),
abbreviations),
and
See B.60 for a historical report by ORS ME.
no.34
preparation and design of log
(Operational
Includes R.49,
technical terms and
in
no.1l
mainly
intelligence
sheets,
Miscellaneous
Kendrew's binders.
(Glossary
related
summaries
card indexes (some annotations by Kendrew and others).
13, 20-23, °25-29,°31-35,; \41,.44-46, 49, 50,54, 57-59.
Coastal Command Tactical Instructions (CCTI),
RAF, ME but not produced by them.
Coastal
RAF, ME but not produced by them.
Command Tactical Memoranda (CCTM),
Nos;7 10 5.18).22-27 5295.30)
Not a complete set.
Not a complete set.
circulated by HQ,
32-37, 4.
circulated
Nos.
HQ,
by
2,
NCUAGS 11/4/89
J.C. Kendrew
B.39A
Miscellaneous naval reports and memoranda.
Correspondence
aspects
aids
RDF system.
thereto"
of
and memoranda 1942 about Kendrew’s report
possible
air co-operation with the army and
(R.7 at B.34) suggesting wider use of
"Some
radio
"Rebecca"
Small
Tobruk
November 1942 (3) and tank hit in Western desert April 1943 (2).
photographs of Italian submarine hit
format
off
South-East Asia Command
Progress
January-December 1944.
reports of ORS Air
Command,
by
Kendrew,
nos.
4-7,
"Miscellaneous papers produced by self",
1944
miscellaneous notes, calculations, graphs.
("Pacific
Report"
n.d.
and
November 1943, October
few
- incomplete),
a
Air
6-11,
and
includes
photographs
of
him
on
Command Memoranda nos.
13-21 February-December 1944
on bomb and depth charge trials in Ceylon jungle, is
ORS Air Command Reports nos.
(no.6 by Kendrew and others).
9-12, January-December 1944
by
after
ORS Air Command Memoranda nos.
(no.
12,
Kendrew
explosions).
ORS
unnumbered
Research Unit February 1945 on bomb and napalm trials.
correspondence files.
Folder
American
continuation of hostilities in Pacific theatre April 1944
L945:
flame-thrower
Some are referred to
fatigue in tropical conditions etc.
and
for
- May
fuel,
in the
assembled by Kendrew
on
various
two papers from Jungle
report April 1944;
1944;
Targets
requirements,
Australian
and
weapons
preparation
topics
in
of
reports
sources
NB 16,
17 April,
June
radar
N./7,
site
from
NCUACS 11/4/89
J.C. Kendrew
Postwar Papers
Reports, suggestions and plans by Kendrew on specific OR matters
and on the organisation of government science.
Operational research
on
“of - bombing,
"Notes
Manual
Kendrew’s
correspondence August 1945.
visit to Washington on his way back from
a _ project for the compilation
of
a
datay.-*..°",
16 May 1945
comprehensive
written ~ during
with
SEAC,
"Operational
note
ciation of Scientific Workers].
"written for the Joint Sciences Committee,
research in RAF Commands",
December 1945
a
A.Sc.W" [Asso-
with
Organisation of Science
to
the
application
of
systems
September
C. Gordon (Air Ministry) August 1945.
mechanical indexing
manpower)
"Notes on the national organization of science" August 1945.
Register"
is
designed by Kendrew,
(of
an example of a punched
scientific
"On
Central
here
Included
patrol report,
of his war service.
the
1945.
aircraft
probably at an early stage
Ideas on government science, and on own career, in the form of a
letter to
research generally" n.d.
defence
and its relation to post-war staffing of government
post-war
"The
ministries,
of scientific staffs
card
for
strength
in
the
NCUACS 11/4/89
J.C. Kendrew
HISTORY OF OPERATIONAL RESEARCH
Correspondence, Papers, Drafts
Correspondence
including
work in Coastal Command and Middle East.
1948
Kendrew'’s
with
recollections and comments on his
historian
official
of
early
ASV,
OR
own
"Wise.
short-hand which Kendrew taught himself during the war, n.d.
-notes for a ‘talk-or
C.63;.
C.77,
¢-:117,
C.126, C.127, C.169 and also in some of the informal talks at L.145.
It may be appropriate here to point out
that for all the stress laid
on
mechanical
computation,
and
indeed
the
presence
of
EDSAC
and
other
printouts,
the notebooks are remarkable for the sheer quantity of calculations
and tabulations, phase diagrams, electron density maps and the rest laboriously
The
letter
W.L.
own
(C.288)
is
2-A
and
worked
by hand,
by Kendrew as well as his collaborators,
not to mention
the
to
his
of
thanks
and
careful
Bragg
contributes
excitement
collaborators
congratulation
characteristically warm-hearted letters and
Kendrew’s
personal charge.
of the final complete syntheses at 6-A and
their publication is well captured in the correspondence at C.288, C.289.
logging and summaries of experimental programmes which were always his
enthusiastic as well as informative.
NCUACS 11/4/89
J.C. Kendrew
EARLY RESEARCH
Reaction kinetics
Material
1939
collaborative
in Proc. Roy.
=
relating
to research with
E.A. Moelwyn-Hughes,
paper "The kinetics of mutarotation in
Soc.
1/6;
F940:
January
“1940;
the
results
were
published
July
a
solution"
as
certain enzyme reactions
of
enzymic hydrolysis of non-reducing
Material includes brief statement of research, "the experimental
investigation
first
disaccharides
instance
the
the technique employed will be the polymetric one, using the
[Physical
very sensitive instrument equipped in this Department
Chemistry, Cambridge]
charts and
graphs of mutarotation and heat reactions of arabinose, lactose,
maltose, mannose, xylose.
by the late Professor Lowry",
the
...
in
paper
on "The mechanism of unimolecular
included here are two manuscript and typescript drafts for
Also
a
by
Kendrew and M.H.J. Webb (a research student of Kendrew), one set
the other April 1954, with brief calculations
dated April 1953,
in the hand of J.M. Bennett and a letter from I.F. Trotter.
No
(Material
paper
originally
and
transferred here on Kendrew's advice.)
of this title is listed in the
Bibliography.
reactions"
"Protein
gas
with
found
Analysis
Projects"
See also A.118.
NCUACS 11/4/89
J.C. Kendrew
INFORMATION RETRIEVAL/DATA PROCESSING
Information Retrieval
Correspondence
methods,
EGGS :
with
classification
with special reference to punched cards 1946-49, 1951,
colleagues on sorting
and
Includes letter December 1946 to
Cavendish
electronic
project,
systems
USA.
Laboratory)
searching device and on his own electronic
the
on
computer
and correspondence 1947-51 on abstracting and indexing
in
E. Orowan (then working at’
research’
American Chemical Society and elsewhere
J. von Neumann
at UNESCO,
from
on
1946-52
card
Correspondence
17
systems on supply of cards to Kendrew's design (his letter of
April 1950 also
mentions J.M. Mitchison as involved in design).
A little correspondence with colleagues interested in the system
is also included.
manufacturers
punched
with
of
by
punched
to
diagrams
schemes",
diagrams
Kendrew,
"Punching
Kendrew’s
on
card
notes and
some annotated
design (drawings and
manuscript
schemes",
Specimens of punched cards for various purposes,
Miscellaneous
"Classification
applications, topics to be referenced etc.
Correspondence 1949-50 with manufacturers on supply of punch for
cards
included);
also included is letter 1973 from a colleague still using one of
the punches.
or designed by Kendrew.
NCUACS 11/4/89
J.C. Kendrew
Computation on EDSAC I
of
the
using
2- and
methods
Storage
concerns
material
Automatic
Delay
of
The
(Electronic
computation
syntheses.
Bennett
later worked at Ferranti;
Acta crystallogr.,
the Inaugural Conference of the Manchester University
L951 %
machine
the
for
Patterson
J.W.
and _ who
they published papers on the topic in
and in the official publication of
Computer,
Kendrew's early collaborator on this work was
he met at Cambridge through H.E. Huxley
3-dimensional
Computer)
Fourier
EDSAC
whom
1952
and
5,
.€.196
See
replacement by EDSAC II,
for.
the
end of
the: work
on
EDSAC
~I
before
its
and also C.80, €.208, C.209.
Notes and calculations
"Miscellaneous programming ideas", n.d. c.1949
contribution to Barcroft volume published 1949.
some on verso of
"Two-dimensional
sheets, some on verso of 1948, 1949 publications.
low symmetry",
n.d.,
some on EDSAC programme
1952
1954,
undated
2-dimensional
EDSAC sheets dated 1953,
"EDSAC 3-D programme",
notes.
"EDSAG
calculations,
and another, some sheets dated 1954,
"EDSAC 2-dimensional Patterson programme", some dated 1950,
and later "modification" by D.W. Green 1955.
Beh Go Crick,
Miscellaneous notes, graphs, narratives on Patterson peaks,
dated 1952 and referring to work on Pauling helix calculated
and narratives by Kendrew,
Notes,
D.M. Blow
programmes".
1956, 1957.
programmes
Patterson
some
by
Fourier
NCUACS 11/4/89
J.C. Kendrew
Work with J.W. Bennett
Notes
Bennett on "EDSAC Crystallographic Computations".
and calculations (some by H.E.
Huxley),
short report by
"Fourier methods",
note by another on "probable error in synthesis
calculations,
notes,
letter from
Bennett,
drafts
etc.
for
arrangements,
and publications.
Group,
"Some
on
Includes Institute of Physics
Correspondence,
papers
Analysis
paper
on
Symposium
Stockholm
July
"Crystallographic
electronic
they
University
and calculations are included.
conferences,
X-ray
November 1950 (Kendrew and Bennett presented a
crystallographic
EDSAC"),
Determination
paper
digital
whether
Manchester
notes
is not clear
of
Digital Computer July 1951.
was accepted but it
Some additional
Techniques in
computations
calculations
Conference
attended),
high-speed
Inaugural
Structure
195
(Kendrew
and
Bennett's
Advanced
computer"
with
a
with
the
See L.145 for texts of papers.
for
for
X-ray
Crystal
proposal
Computer
Related material
"The Anisograph", correspondence and information 1950.
Analogue
Research
Structure Analysis, Pennsylvania 1949-50.
EDSAC order codes.
NCUACS 11/4/89
J.C. Kendrew
PROTEIN ANALYSIS PROJECTS
are
These
titles or descriptions.
which feature in the notebooks at C.30-C.34.
in chronological
Kendrew's
Many refer to materials or experiments
presented
order,
with
Adult and foetal sheep haemoglobin
1946-58
Correspondence
publications,
August 1947 from
paper
Perutz later published in Proc. Roy.
supplies,
some addressed to M.F. Perutz including letter 18
draft
and
D.C. Hodgkin commenting critically on a
haemoglobin (the joint paper by
Soc.,
194, 1948).
research
results,
Kendrew
foetal
on
on
Muscle
the
on
(see
of
170,
at
MIT
Fund
Much
of
with
1947,
letter
Fellow
results
1952-54
1950-54
material
colleagues
Protein solubility
etc.
work with
23 December 1952 announces the
See C.20 for other collaborative work with Huxley.
relates
H.E. Huxley and includes reference
methods,
Correspondence
to
materials,
to
collaborative
1952 and to Huxley’s work as
their joint paper in Nature,
also C.220).
Commonwealth
Kendrew’s
successful
crystallisation of "the most marvellous myoglobin crystals, from
sperm whale of all odd places" (see also C.25).
Brief correspondence 1951-52.
Graphs and diagrams, n.d., c.1949.
Procollagen
NCUACS 11/4/89
J.C. Kendrew
Controlled shrinkage of protein crystals
1952,
Mainly
Includes
Huxley.
Society Symposium,
haemoglobin crystals",
"Discontinuous
final
Acta crystallogr.,.
is also included.
agreed
relating to collaborative papers by
Kendrew
manuscript draft of paper given to
7 February,
and
Chemical
on "Stepwise lattice changes in
Huxley’s heavily-corrected manuscript on
and
in
A later letter (1965) on the work
in haemoglobin
crystals"
61953.
changes
title
draft for version published under that
lattice
See also C.17.
Polypeptide chain configuration
Brief correspondence 1953,
1973.
X-ray experiments
1953
Not used.
for
Kendrew
to
take
X-ray
on
request
calculations,
Chymotrypsinogen
Material transferred to C.l.
Correspondence
pictures of bacterial spores.
Data
collaborative
Acta, 20.1956.
to
paper with Kendrew published in Biochim. biophys.
attention.
Kendrew’s own description on the folder is "New proteins".
material
proteins
particularly
search
for
diffraction
The
various
some,
the
X-ray
some sent by others for his interest or
on
for
analysis,
initiated by Kendrew
the
is correspondence 1947-69 with colleagues
and
suitability
in the early years,
suitable
programme,
Correspondence
"New proteins"
crystalline
M.M. Bluhn,
materials
mainly
by
related
X-ray
and
their
in
for
NCUACS 11/4/89
J.C. Kendrew
Cre
1947.
writing
enthusiastically
LOS2.
1952,
recently
myoglobins of various species.
one of the most favourable protein crystals yet
GPT).
Includes a letter to H. Neurath from Kendrew 22 December
"we
whale
is
(See also
whale
an absolute gold-mine in the
One form - from sperm whale -
myoglobin:
shape
of
struck
about
...
"
1953-69.
EARLY RESEARCH
REPORTS
Reports
1946-53.
by Kendrew on his research,
teaching and
publications
crystallographic
out
addressed from Cavendish and Molteno Laboratories
January
of protein
carried
studies
report,
annual
perhaps intended for departmental
on
"Report
during 1946",
and
1947.
to
Master
of
of
an
first
year
on
foetal
member",
research
haemoglobin,
August 1948.
Peterhouse on
M.F. Perutz as Director and myself as
Molteno Institute report June 1947 - June 1948.
Report
Fellowship July 1947 - June 1948;
Unit
with
part-time
myoglobin etc.
Research
refers to "formation of MRC's
for the Study of the Fine Structure of Biological Systems,
Dr
independent
horse
to exploit it.")
Reports to Master of Peterhouse 1948-49, 1949-50 (refers to work
on
H.E.
Huxley,
crystals),
1952-53
Fellowship,
granting of “unlimited tenure" by MRC, successful identification
of
that
remains is
continuing difficulty in obtaining suitable
(final
"a very wide choice of experimental material,
report on termination of
1951-52 (papers with
J.M. Bennett,
Research
and all
1950-51,
EDSAC),
NCUACS 11/4/89
J.C. Kendrew
MYOGLOBIN
NOTEBOOKS (Kendrew and collaborators)
Preliminary work
Binder of "Filofax" pages inscribed "Peterhouse Cambridge" (same
format as A.27) with index of topics as follows:
Mathematics
Physics
Photography
Chemistry
Biochemistry
Crystallography
EDSAC
Protein structure
Current research
Haemoglobin
Myoglobin
c.1946-53 and includes own notes,
notes on
Physical methods of investigation
runs
Material
literature,
(Huxley, Crick, Perutz) etc.
motes
and
Structure of other biological macromolecules
and a little later (1970) material.
Similar
house at Linton,
on
Nature of life),
meeting" 1946 etc.
but material is mainly 1940s.
books and articles read (extensive notes on
Kendrew'’s
Includes notes
Szent-Gy&rgyi's
"Haemoglobin
lectures and conference
papers,
"Filofax" binder,
inscribed with address of
information from
colleagues’
the
research
NCUACS 11/4/89
J.C. Kendrew
76
C230
main
notebook of small quarto pages (same format as
Loose-leaf
The
indexed series of earlier university notes at A.40-A.117).
material,
1946-53;
there is an index listing the "Research notes - project numbers"
which
The
projects are:
each with a numbered thumb index
covers various dates
extensive,
run 10-25,
which
card.
is
10
Adult sheep methaemoglobin
Experiments,
1947.
data,
crystallisation
November
1946
- "Summer"
ll
Foetal sheep methaemoglobin
Experiments,
1947.
crystallisation,
dialysis
November
1946
- July
12
Horse myoglobin
Removed for extended treatment in separate notebooks.
CxiS2:.
See C.31,
13.
Foetal human methaemoglobin
Crystallisation
January-July 1948.
of
various
samples
November-December
1946,
index
14
15
16
iF
November-
measurements,
Whale myoglobin
crystal preparation
Horse methaemoglobin - shrinkage
Refractive
December 1946.
Removed for extended treatment in separate notebooks.
C.34.
calculations of absorption coefficients, April-June 1947.
Experiments January-July 1947, February-March 1951.
January 1947, January 1948, August 1949.
Miscellaneous X-ray experiments
Ox myoglobin
adjustments,
to
take
fibre
photographs,
18
Microcamera
See C.33,
Attempts
camera
NCUACS 11/4/89
J.C. Kendrew
19
Theoretical calculations - chain configurations
July 1949 - February 1950.
20
Miscellaneous biochemical work
Tests on rat haemoglobin July 1949, gelatin November 1951.
21
Chymotrypsinogen
Removed and kept with work on whale myoglobin.
See C.34.
22
Lamprey haemoglobin
Experiments November-December 1951.
23
Muscle
are
These
Calculations and diagram June-July 1952, with a "Note
g5Z :
published and is the best source of information."
is
Lotmar-Picken material from dried muscle",
See C.17.
the joint paper with H.E. Huxley "Extractability of
: November
now
The reference
the
1952.
However the paper
very bad notes.
Nature,
170,
to
is
24
25
Penguin myoglobin
Sea-lion myoglobin
Brief notes only, March 1953.
Brief notes only, March 1953.
the crucial experiment!".
Preceding
"Notes from January 1946 - August 1946"
numbers, presumably because they antedate the system.
with work on adult and foetal sheep methaemoglobin (nos.
the main list) and are given a separate index of
11
references.
"Identity
methaemoglobin -
the "project numbers" as listed above is
which have
of
project
They deal
10 and
cross-
Among the experiments is one dated July 1946 on the
foetal
orthorhombic
monoclinic
a series
forms
and
no
of
of
of
NCUACS 11/4/89
J.C. Kendrew
Grad
Horse myoglobin
12
This is no.
into a major research topic.
to
GC. 32.
12-34,
12-40,
of the projects listed in €.30,
developed
It has its own index running 12-1
of which 12-29 to 12-34 appear separately at
which
is
on
work
sources,
The
crystallisation,
Fourier
projections, phase calculations etc. mainly October 1946 - March
1949, re-examined November 1952.
received
examinations,
specimens
X-ray
Patterson
various
from
and
Horse myoglobin
Continuation of C.31, index numbers 12-29 to 12-34.
Preparation
using
collaborators (including J.D. Watson).
crystallisation February 1950
methods
apparatus,
various
and
and
and
- January
with
1952
various
Whale myoglobin
the
work
There is
whale
its
own
a
15
further
etc.
analysed
Institute
Cambridge),
15-1 to 15-59.
the sperm whale.
The notebook has
finback
to
crystallisation,
elsewhere in the notebooks
of the projects listed in C.30.
At rear of book are notes on preparations and methods.
narrowing down of various types of
This is no.
became eventually the material of choice for the main
after
whale,
notes)
running
only,
notebook (C.34).
Whale myoglobin
programme
(blue
and
index
Work in this book covers 15-1 to 15-29
separate
continuation having been transferred to
in
diffraction
December 1946 - October 1952, with an occasional
Experiments on specimens prepared by J. Keilin (then working
Molteno
pictures etc.,
later note 1953, 1954.
List: insC:30);
Continuation of C.33 with index running 15-30 to 15-55 (and some
a separate list of references
further
and
to
the
other
than whale:
porpoise, seal, dolphin, penguin, tortoise, carp,
and some mixed crystals.
work is mainly the "1952 Programme" for "Crystallisation of
beginning
on the sperm whale material (the eventual choice)
The
whale
October 1952.
book also includes tests on many types of
chymotrypsinogen
21
1953 (project no.
September-October
numbered
in
with M.M. Bluhm and R.G. Parrish,
Entries continue to August 1954.
rear of book is work on
September-October
subdivisions).
myoglobin",
At
1951,
myoglobin
the
NCUACS 11/4/89
J.C. Kendrew
79
Note
is
and
The
the
pages.
following notebooks C.35
last of the early notebooks to use
quarto
C.34
the
format
leaf
preliminary
Most have labelled divider cards to separate sequences
binders.
and many have an outline index at the front or for
of material,
a system of pagination with a code
each sub-division.
of letters and/or numbers but no explanatory codebook appears to
survive.
main series are all large
There is
et seq.
quarto
small
loose
in
the
dates
material
problems
suitable
of years,
when initial
from 1953 i.e.
crystals were largely solved and
heavy atoms and the final selection of "Type A" sperm
of
The
obtaining
main
concern was with the determination of ligands for the attachment
of
whale
Within each notebook the material may extend over a
myoglobin.
period
including
notes and calculations,
charts, graphs, printouts, densitometer
diagrams, electron density contour maps, narratives or summaries
great
of
work
majority
hand,
there
members
colleagues elsewhere.
matters of special interest wherever possible.
letters and memoranda
or
Attention is drawn to these and to other
Cambridge and Royal Institution
While
in Kendrew’s
in progress,
of
and is also diverse in
work continues to be
are also notes,
correspondence.
calculations,
character,
the
own
teams
the
and
the
of
Pleochroism of monoclinic and sperm whale crystals.
the
at
is
on
and
and
note
with
whom
1-11,
pages
front,
notes,
topics
graphs
listing
Kendrew
Topic 11
Extensive
published
See also 0:16.
calculations,
"Paramagnetic
D.J.E. Ingram
resonance results"
myoglobin and haemoglobin of sperm and finback
Work
and of horse, subdivided into:
numbered
Index”.
accordingly.
and
diagrams, ideas and critiques in pencil and ink with corrections
and comments in red ink, March 1953 - May 1957.
in the
index
material
results and collaborative research
incorporates correspondence,
a
with
on
"Electron spin resonance in myoglobin and haemoglobin",
Nature,
178;.1956..
course of lectures by J. Griffith, Lent term 1958.
"Intensity distribution",
notes
abso 0. (7 -Vie Luzzath.
"Fourier theory",
Cochran, Michaelmas term 1957.
"Rotary dispersion", charts, correspondence P. Doty 1957.
"Finback 3-D", Pattersons, notes, progress sheets 1954.
Kendrew’s notes on a course of lectures by J.
calculations,
(see
properties of haem proteins",
Kendrew’s notes
correspondence
observations,
F.H.C. Crick
J. Donohue,
"Magnetic
1954-56,
charts,
whale,
on
a
NCUACS 11/4/89
J.C. Kendrew
CG. 37
of
analyses,
diagrams,
photographs
Included in the section on "Type D"
Data,
of myoglobin, identified as Type A through to Type L,
with dates 1953-56.
whale) is
work
myoglobins.
for
these.
whales", 3 August 1953.
types
some pages
(blue
a manuscript draft perhaps for an outline programme of
whale
looking
correlating
blue
titled "Rod directions in sperm monoclinic and blue
An attempt to establish the directions by
comparison between sperm monoclinic
rods in Patterson projections,
projected
various
Also
and
and
a
At rear of book, brief note on chymotrypsinogen.
Miscellaneous work, subdivided into:
-
chemical work", including "Imidazole
"Heavy atom
programme"
(undated notes), "Isocyanide programme" (Kendrew’s narrative and
notes
programme"
(narrative and notes 1955),
by Dintzis and Bodo,
re-examined 1959).
"Nitroso-compound
"Dyes" (1955,
1954-55),
progress
on
"Standard
whale myoglobin.
intensities",
charts
and calculations
for
finback
"Experimental", mainly on camera settings, correspondence, 1956.
"X-ray
various types of myoglobin and ligands.
pictures",
detailed charts and observations 1954-57
on
C
which
by
but
choice
includes
finback
Material
penguin,
Kendrew
runner-up
Laboratory
including
to
final
heavy-atom".
of sperm whale.
contributions
Work on seal myoglobin,
notes on preparation of king
in his 1963 Science article as a close
who continued to work on seal myoglobin
"Preparations",
and sperm whale, 1955.
H. Scouloudi
years at the Royal Institution and later at the
"Type
refers
the
calculations,
etc.,
most
correspondence from
from
many
Biophysics
work, February-November 1956, May-July 1958.
Kendrew
to
notes,
data, EDSAC sheets, electron density contour maps
and/or
R. Hart and R.E. Dickerson at Cambridge and
for
Molecular
periods of
Only one page dated (January 1957).
Work on type D;
various exposures, X-ray precession camera photographs.
in Kendrew's hand.
heavy atom attachment, densitometer diagrams at
Not all
There are two main
See also J.121.
Oxford.
NCUACS 11/4/89
J.C. Kendrew
Main myoglobin programme
begin on 5 May 1954 with the attachment of heavy atoms
This is
a sequence of stiff-backed looseleaf binders, all with a
number and (from C.63 onwards) a descriptive title on the spine.
They
to
and continue to November 1963, covering the X-
type A crystals,
Kendrew
ray analysis programme at 6-K,
numbered
XXXIX
these
and
are
contains
presented
they
include a much higher proportion of collaborators’ work.
and 1.b-k.
first 39 books in Roman numerals from I
order is preserved (C.41-C.79);
chronological
order as far
Subsequent
possible;
the last
October
dated
books
1959.
to
of
work
1.5-%
2-8,
this
the
in
as_
With very few exceptions,
labelled sub-dividers,
pagination
proportion
and,
when
usually been checked through by him.
with code letters and figures.
of
in Kendrew’s
collaborators’ work or data are included,
the books are meticulously kept, with
usually an index or list of contents and
substantial
own
hand
they have
the work (up to C.79) is
A very
research record assembled by Kendrew.
notebooks are here presented as a separate sequence
archival convenience and partly because they represent
mainly
The
the
for
final
on
the same topics, antedating or concurrent with these but kept in
a
collaborators’
notebooks (C.101-C.116) and the notes and data (C.170-C.195) and
should be consulted as supplementary documentation.
are preserved
Other records
different
format,
among
the
on
it
is
I).
the
for
and
atom
(Book
heavy
these
which
Narratives,
in each book,
contour maps, printouts.
numerals used as pagination;
some of the contour maps and EDSAC
catalogue entries attempt to give dates
the chronology of the multiple projects
Type
calculations,
work by Bodo.
scaling,
May 1954 - September 1957.
the
Although
work
these can be no more than an approximation.
In fact few dates are used except in Kendrew’s narrative logs of
experiments,
printouts,
the main identification lies in the code
and in correspondence;
which
letters
constitute
were
going forward simultaneously.
July 1955 - April 1957.
standard
Measurements, calculations, scaling and rescaling,
Narrative at front of book runs July 1955
Type
Includes some work by Dintzis and others.
factors, contour maps, printouts.
Type
intensities.
radial distribution.
- June 1956.
front.
Measurements, scaling
observations,
Includes some
Work on met-myoglobin
heavy atom (Book II).
(Book III).
Index of
topics
heavy
atom
A
A
A
at
NCUACS 11/4/89
J.C. Kendrew
82
C.44
A
atom
heavy
(Book IV).
Type
Includes
calculations,
temperature and scaling factors,
June 1957.
some work by Dintzis,
maps,
contour
index.of
‘topics
Bodo and
others.
radial
printouts.
distribution
September 1955
“at.
front.
Narratives,
charts .
-
work
Type A heavy atom (Book V).
some
by Dintzis and
tables
scaling,
1958:.
of signs,
Index of topics at front.
others.
Narratives,
contour maps.
October 1955
Includes
calculations,
- May
A
Type
Includes
scaling,
graphs, printouts.
heavy
some
structure factors,
atom
work
(Book VI).
by
Dintzis
sign determination,
June 1956 - Decmber 1957.
Index.
and
others.
cf
topics.
iat
-front.
Calculations,
contour maps,
Type A heavy atom (Book VII).
¢
projection with ligands at
work.
graphs, contour map.
Summaries,
a and
collaborators’
charts of observations, scaling, Pattersons,
Index of topics at front:
Includes
2.7 &.
Few pages dated, July 1956 - June 1957.
work.
work.
bak:
Index
A
(Book
data,
Lorenz
Fouriers,
Summaries,
IX).
at front.
difference Fouriers,
Three-dimensional data 6-A.
scaling,
D.C. Phillips.
Few pages dated, May-September 1956.
Three-dimensional data
Includes
collaborators’
Includes some
corrections,
scaling, contour maps,
Type A (Book VIII).
collaborators’
radiation effects,
graphs.
Type
summaries
calculations,
and data from
LOD
and
Charts,
contour maps, correspondence
Few pages dated, June 1956 - May
O57.
h/a
Relative
Includes
derivatives (Book X).
Divider card 23.6 "Theory" includes notes
collaborators’ work.
by H. Wyckoff (a principal collaborator in this work) and F.H.C.
charts,
Crick.
June-
phase circles,
November 1956.
Type A heavy atom (Book XI).
summary
and
Calculations,
Calculations of .D,:
Includes
Index
work.
Few pages dated, February-June
Index and summaries at front.
Few pages dated,
collaborators
contour maps.
Calculations,
co-ordinate
involving
printouts,
structure
-
methods
results,
graphs.
at
front.
factors,
graphs,
single
D.,
ao
b
NCUACS 11/4/89
J.C. Kendrew
Cc. 52
A
derivatives.
heavy atom (Book XII).
Index
Type
diammine
Includes work by
structure factors,
dated, May 1956 - May 1958.
printouts,
Wyckoff and others.
Work on H_
and
summary
succinate
for
both
Calculations,
contour maps, graphs.
83
H
and
topics®
Fouriers,
Few pages
heavy atom (Book XIII).
A
H. Wyckoff,
Type
summary at front.
by
history of the computations.
Pattersons,
distribution,
printouts, contour maps.
also
who
LA
Includes collaborators’ work,
contributed a note on
MOtK ION
He
Intensity data,
scaling,
repeat
computations,
One printout dated November 1956.
Index
and
in particular
previous
the
radial
graphs,
Type A heavy atom (Book XIV).
(main collaborator
summary,
contour maps,
Fouriers,
index
contour maps, summary dated January 1957.
and structure factors,
Work on porpoise and sperm whale
index and
Aistribution,
PCMA:
distribution,
graphs January-December 1956;
J. Kraut) 1956;
printouts,
PCMS and H_
scaling,
summary,
scaling
radial
radifl
am,:
and
A heavy atom (Book XV).
Type
each topic.
intensities,
b projections, scaling, contour maps.
May 1957.
Index for
a and c projections,
calculations, Pattersons, printouts, contour maps,
Few pages dated January-
Includes collaborators’ work.
Work on PCMS and Au.
A
a
and
Data,
Includes
printouts,
for each topic.
Work on Au/PCMS
Index
scaling,
structure factors,
Index for each topic.
Work with various heavy
heavy atom (Book XVI).
A heavy atom (Book XVII).
Few pages dated, March-May 1957.
c
b,
collaborators’
contour
Data, calculations, Fouriers, contour maps, graphs.
Type
and projections.
work.
one page dated May 1957.
Type
projections.
work.
maps, Pattersons, graphs.
Only one page dated May 1957.
Work with various heavy atoms
work.
Includes collaborators’
for
Type
in
Intensities,
specific crystals.
atoms
Includes collaborators’
Only
Index for each topic.
contour
A heavy atom (Book XVIII).
scaling,
tables
maps,
data
23D"
of
3D
NCUACS 11/4/89
J.C. Kendrew
84
C.59
Type A heavy atom (Book XIX).
Includes
including
Index for each topic as follows:
collaborators’
or
summaries
Work on 6-& 3D Fourier synthesis.
himself
results.
work
reflections on
but much is by
methods
Kendrew
and
on
21
out
his
part
letter
various
related
Kendrew
factors,
structure
to Bragg of
"Relative y". Notes, diagrams, graphs, calculations, reflections
by
to
included.
suggestions by W.L. Bragg with whom correspondence is
"Phase
In
very
determination
pleased with the way this has gone, and think there will be very
While I am away phase
few major ambiguities of phase indeed ...
reflexions,
diagrams out to 2.8-R will be drawn for hkO and Okl
the
extend
to
just
present
isomorphous
phase
April-July
methods."
diagrams referred to.)
is practical politics
technique
is virtually complete ...
C.61A for the
replacement
whether it
(See C.61,
Kendrew
writes:
1957.
with
July
I am
3-R
our
see
to
to
to
6-A
"Structure factors".
various heavy atoms.
Notes, calculations, tables and charts for
Only one page dated March 1957.
"F values".
for checking.
Data, calculations, phase angles, Kendrew’s queries
"Scaling”™.
from
investigations" April 1957.
W.L. Bragg February 1957,
Calculations,
correspondence
"Scaling
radial distribution,
summary by Kendrew of
N.B.
Work continues in next book.
of
by
note
(many
topic
later
phase
C.59).
Notes,
circles,
Book XIX,
Kendrew),
revisions
printouts.
calculations,
Index for each
on "Testing of
A heavy atom (Book XX).
Some pages dated, March 1956 - June 1957.
Type
(continuation
follows:
"Zz Fourier projection".
printouts.
Work on 6-4 3D Fourier synthesis
as
Tables, calculations
Includes
Various dates July 1957 - October 1958 and
computer]
"3D Fourier synthesis of myoglobin - 6-8".
and
collaborators’ work.
a
Fourier routine" by C.L Coulter, October 1961.
See C.59)).
"Fourier synthesis including heavy atoms".
charts,
January 1958.
Phase circle determinations,
61957,
Extensive tables and
-
on heavy atom peaks November
Book
coded...
myoglobin
Kendrew’s
colour-
heavy
notes
atoms
1957
7090
[IBM
XxXI.
n.d.
NCUACS 11/4/89
J.C. Kendrew
85
C.61A
Unnumbered Book XXII.
by W. Hoppe, M.M. Bluhm, n.d.,
laboriously drawn by hand,
introduced.
a and c projection phase circles.
Work
All these were
before computerised methods had been
(1957 see C.59).
Book XXIII.
front.
printouts, contour maps, refinement programme.
Co-ordinates of heavy atoms.
collaborators’ work.
Includes
Index and summary at
calculations,
Tables,
May-August
58:
The remainder of the sequence bears a title as well as
on the spine, and these are used in the entries.
a
number
data processing" (Book XXIV).
Data sheets and printouts,
Includes work by Dickerson and others,
at front of book, charts on "State of project" March, April
"2-R
calculations and graphs.
and,
1959.
cover.
"2-8 hol refinement" (Book XXV), with Dickerson’s name on inside
including
front
notes,
summaries
Various dates November 1958, March-July
calculations,
1959.
the work is
descriptions
Of < GWORK;
graphs.
programs,
hand,
Much
his
of
in
of
Gold.
diff F.
Work
mainly
XXVII).
January 1958,
(Book
graphs,
program"
program,
radiation" (Book XXVI).
"Comparison
Statement
various heavy atoms.
by
Graphs, calculations, data, contour maps, printout
"radiation damage" is
the
The last section on
January 1959 and includes a letter on
"2-R
Dickerson.
(dated April 1958).
dated
subject from Kendrew to D.C. Phillips June 1960.
June 1959.
by
XXVIIT).
comparison of 6-R and 2-8 data, most work
"Scaling - met" (Book
Dickerson and others,
checked by Kendrew.
"Scaling
graphs, by Dickers6n 4nd others.
Work
calculations,
Printouts, calculations,
Dickerson.
for
June-July 1959.
May-June 1959.
calculations,
H am," (Book
Printouts,
printouts
by
of
PCMS
XXIX).
NCUACS 11/4/89
J.C. Kendrew
C.69
"Scaling Au Double" (Book XXX).
by Dickerson and others,
a graph by Kendrew.
May-June 1959.
Printouts, calculations, graphs
with extensive checks and comments and
"Scaling
nea.
-
corrections" (Book XXXI).
Calculations and graph,
"Correlation
program),
maps, by Dickerson and others n.d.
results" (Book XXXII).
calculations,
(M. Rossmann’s
extensive electron density and contour
Printouts
"Correlation
diagrams,
dated, July 1959.
in
results" (Book XXXIII).
Extensive
several hands including Dickerson’s.
calculations,
pages
Few
"2-8 - Least squares" (Book XXXIV).
program),
diagrams, scaling tests, charts, graphs.
calculations
by Dickerson and
Printouts,
others,
(M. Rossmann’s
densitometer
March-August 1959.
See C.75).
mainly
by
printouts,
August 1959.
Myoglobin Phases 5 Int.
"2-8
Book XXXVI.
August 1959.
Phase Refinements 3/8/59" (Book XXXVI).
Printouts, data, calculations,
Strandberg.
program routine by
for
calculations, mainly by Dickerson,
Programming
"Phase refinement" (Book XXXV).
Dickerson,
graphs,
July 1959.
"2-8
random sampling,
some checking by Kendrew.
Run (1) 1959" (Numbered in
error
Mainly printouts with a very few notes.
n.d. (August 195892
"2-8
Rossmann's
At
finer
names of those involved,
August 1959.
Mainly printouts (M.
achieve
progress,
Royal Institution,
front of book are charts
work being done at
beek annotations,
Similar material,
" (Book XXXVII).
(Book XXXVIII).
on attempt
to
Fourier
F
Fy
"2-8
Fourier
ay sharp"
program)
resolution.
of
NCUACS 11/4/89
J.C. Kendrew
87
G19
"6 and 5.5-& Fourier (2-8 data)" (Book XXXIX).
(M. Rossmann's program) with some annotations.
Mainly printouts
October 1959.
is
Kendrew’s
the last book in
This
remaining
looseleaf
are presented in chronological order as far as_
contain
numbered
with each other.
The
books C.80-C.100,
in the same format of stiff-backed
binders and bearing a descriptive title on the spine,
Some
Kendrew's
and may overlap chronologically with it and
similar or closely related to that
possible.
sequence.
sequence,
numbered
work
in
for
and
scaling
checking
non current".
Programs, tests, notes and calculations,
"EDSAC:
Lorenz
printouts
corrections to be run on EDSAC II.
Almost all the routines were
written by R. Hart who was a principal collaborator in this work
Calculations and
until
notes by Dickerson and others,
of
lectures
book
"Programming for EDSAC II" by H.P.F. Swinnerton-Dyer
September-
October 1957:
he left the laboratory in August 1958.
January-July 1958.
course
Kendrew on
factors
At rear
notes
42pp.
and _
are
by
of
a
determination,
some
Programs and routines for refine-
Lorenz-polarisation
and
Also included are
calculating
revisions by
Dickerson
of
programme ,
Roger Hart".
"EDSAC program
ment
correction,
others.
notes
Lorenz corrections, March 1958.
by A.L.
Hart,
phase
with
by
by
all
some by
routines,
Dickerson,
Strandberg
Instructions,
Input program".
March-May 1959.
Patterson on alternative method
printouts, tests,
and
Some printouts dated February 1958.
"Correlation function
Dickerson and Strandberg.
"Scaling Program".
checking,
almost
others.
See C.73-C.78 and also correspondence at C.234.
This
programme, when several important aspects were coming to
and Dickerson (a principal collaborator)
America.
"7-10 August 1959".
using
printouts, corrections and checking.
little by Strandberg.
random sampling
graphs,
notes,
Almost all by Dickerson, a
research
a point
was about to return to
Work on phase refinement,
Calculations,
program.
Routines and tests, by
M. Rossmann’s
particularly
July 1959.
critical
period
was
the
of
a
NCUACS 11/4/89
J.C. Kendrew
88
c.85
"2-8 Myoglobin Phases 5 Int.
printouts,
comments by Kendrew.
n.d. (August 1959).
all checked,
Run (2) 1959" (See C.76).
Mainly
Some graphs, notes,
Some annotations by Dickerson and others,
with a few notes.
"M.T. Load Program.
for EDSAC II,
Dickerson,
dated, June-September 1959.
2-R Phase Program 1959".
test printouts and checks, graphs.
a few later additions or revisions.
Detailed routines
Almost all by
Few pages only
1959.
Myoglobin
"2-8
printouts,
August-November
modified
1960 to allow for phase output by Strandberg and others.
Routines,
Routines devised and used
August
1959 by Dickerson and others,
checks, notes, revisions.
Program".
Fourier
Input
60
Heavy atom adjustments".
proced-
routines for phase runs, printouts, checks, calculations,
August
some
by
"Dickerson Aug.
ures,
density
1960, with reference back to "2-8 Phase Program Aug 1959";
notes
Rossmann.
Routines by Dickerson
and calculations by
programs
contour
charts,
Loading
Fourier
Watson,
maps.
H.C.
1961
bao).
but
This
work
in
Sa0,
This was
Myoglobin
Absorption
corrections".
D.C. Phillips at the
Absorption corrections".
collaborative work between
December 1960 - June 1961.
includes correspondence and data exchanged.
"15-2
material,
mainly on myoglobin crystal no.
on
Watson, but a little in other hands.
Similar
with correspondence and data from Phillips to Watson,
but includes a little work
and
Phillips
July 1961 - May 1962.
mainly
by the need to interchange EDSAC and Mercury
"15-2 Myoglobin 1960.
printouts,
(lo?
Watson in Cambridge and
and
1960,
complicated
(see also C.90, C.92).
Detailed data,
diagrams, charts, calibrations for myoglobin crystal
H.C.
Royal Institution
Begins August
was
tapes
February-May 1961.
data".
"15-8
Continuing
Watson,
including extensive comparisons, tests and merging between EDSAC
and Mercury tapes.
seal myoglobin and lysozyme.
5 Int. Run (4) Jan 1961".
"o-R Myoglobin phases.
Work mainly by
collaborative
1961.
work
Printouts.
Myoglobin
Phillips
merging
between
Scaling
March
and
and
145,
NCUACS 11/4/89
J.C. Kendrew
89
C.93
"15-8 Myoglobin 1961.
tables,
C.L. Coulter.
Graphs and plots,
calculations, notes, in several hands including Watson,
Refinement details".
Various dates August 1961 - November 1963.
"Refinement
Notes,
by Watson.
sic) ;
calculations, routines, printouts, data runs, almost all
Atom Parameters 1961
Heavy
of
and’
1961">
October 1960 - December 1962.
"2-R Myoglobin Phases
5 Int. Run (5)
Feb '62".
Printouts.
Phases
"2-R
printouts, a few notes.
Myoglobin
5
Int.
Run
(3)
Aug
'62".
Checked
"oR
printouts
maps.
Myoglobin Special Sections
program)
(Rossmann’s
(1)".
electron density
Calculations,
and
tables,
contour
Few pages dated, December 1960, January 1961.
"9-8 Myoglobin Special Sections (2)".
Earliest work November
on
1960.
helices.
Similar material, mainly
April-July
mainly
1959,
Printouts.
Block Layout".
Block layout".
"2-R Myoglobin Data
"1.5-R Myoglobin Data
Printouts.
NCUACS 11/4/89
J.C. Kendrew
Collaborators’
notebooks
(not
These are laboratory notebooks, presented in alphabetical order,
some
of
myoglobin
or concurrent
research.
with,
or
kept as notes and data at C.190-C.195.
in
The work is sometimes preliminary to,
the material later incorporated in the main sequence,
collaborators
all)
the
the
of
Information
duration
"Staff" folders at C¢,210-C. 238%
about
and
of their participation in the work can be found in the
the members of the team and the
nature
M.M. Bluhm
"Bluhm - chemical work".
of
various types of myoglobin (horse, seal, blue, finback and sperm
whale), chrymotrypsinogen.
16 February 1955.
7 October 1952 -
crystallisation
Preparation and
"Bluhm - diary".
later more sporadically).
Laboratory diary 1953 (kept daily to
8 June,
and
entry is
entries
November
Detailed
notes,
"Spectra etc.".
Few pages used.
Calculations and graphs.
Entries run 3 May 1955 -
some annotations and identifications by
on various types of myoglobin and attachment of
10 October 1957;
1955 - January 1956 in the
"Bodo - xtal growing 300-539".
diagrams
atoms.
few
Kraut,
Last
re-working some of the material.
of material received from Royal Institution 11 March 1958.
"TI
Entries run 21 February -
the
Dintzis 1955-57 with comments, diagrams etc.
calculations,
heavy
there are a
J.
Dickerson.
was
LE POMS".
re-working of
by
and
and a note on cover
10 March 1958 and are a_
heavy atoms Au and PCMS made
a note by Dickerson 18 February 1958 when he
(See next book C.105.)
R.E. Dickerson
and
Dintzis)
crystals
with
Register
of
gold
tubes
hand
of
n.d.
(Bodo
Bodo
NCUACS 11/4/89
J.C. Kendrew
91
C.106
"Photography
Indexes
diagrams, calculations etc.
of material received,
Book I".
Both ends of book used and paginated.
Tables,
numbering conventions.
3 January -
26 September 1958.
"2-R
indexed and paginated.
Photography
of Myoglobin
II".
26 September 1958 -
Book
Similar
material,
14 July 1959.
HM s Dintzrs
Tables and calculations of photographs of myoglobin crystals and
heavy
is
inscribed "Book I" but no later books survive.
September 1955 -
1 July
atoms
1956.
book
The
19
J... Kraut
"Blue - porpoise".
and porpoise myoglobin.
Preparations and experiments on blue whale
Few pages used.
June-July (1956).
in
whale
heavy
October
Anyway,
to
R.G. Parrish
isomorphous
various
are
covered
in
collection.
of
iodine
and
other
experiments
ClELO, G6. FEL
"although the
not mentioned.
crystallization
Also covered are
the resultant effect on
©C.110) Parrish writes:
In an accompanying note of
books,
is
insertion
heavy
the period covered is Sept.
notebooks sent by Parrish to Kendrew at his request for the
Two
1986
present
imidazole
(attached
the
derivative
intensity
present
efforts
changes
none
toward
successful.
May
1954 during which time we did the species survey, identified the
sperm
isomorphous
derivatization
produce
significant intensity changes and began the program to get heavy
atoms into the structure."
1955.
Parrish
on "Species specificity of myoglobin",
paper with Kendrew on "Imidazole complexes of myoglobin and _
position of the haem group", Nature, 175,
published a collaborative paper with Kendrew and others
1954, and a
the
as preferred,
without
crystals
(even
showed
atoms)
atoms,
1952
that
could
Nature, 174,
NCUACS 11/4/89
J.C. Kendrew
P.J. Pauling
looseleaf
Bulky
finback
crystal
PLOG. “ROY. SOC. 4. 231, LIOb.
whale
structure
myoglobin,
binder of collaborative work with
to their joint
whale
myoglobin II Finback
related
of
on
Kendrew
"The
paper
myoglobin",
Data, graphs, contour maps, electron density charts, sub-divided
into:
projection Fourier
projection Fourier
projection Fourier
Intensity data
ce
b-
a
Origins and scaling
Error in film measurement
There are notes, revisions and checking by Kendrew, interspersed
to
with Pauling’s work;
topic and are not in numerical order.
20
August 1954 -
they are paginated but are allocated as
The period covered is
12 December 1955, not in chronological order.
B. Strandberg
(1958).
H. Wyckoff
Unidentified
April-July.
Similar material.
(1959).
Relates to work with
"Photography. Book I".
"Wyckoff X-ray notes 1956".
Records, diagrams, graphs, n.d.
"Photography. Book II".
Dickerson n.d.
Various dates January 1956 - 1958.
Notes on 3-D planes. Some notes in German. August-November 1957.
Miscellaneous
and
scaling
analysis.
some related to
haemoglobin
notes and records,
mainly on smoothing,
structure factors,
NCUACS 11/4/89
J.C. Kendrew
Atomic co-ordinates/amino-acid sequencing
in
to
of
the
but
the
and
with
Moore
using
is
for
organic
Stanford
programme,
unnumbered
conjunction
main myoglobin
crystallography.
for Medical Research New York (C.273),
of the amino-acid sequence of myoglobin had
a timely research project by Kendrew as
a series of stiff-backed looseleaf binders like
Edmundson pursued this research first in America and
those
This
and
used
They relate to a two-pronged analysis of the
usually untitled.
chemical
myoglobin molecule
structure
The
X-ray
methods
been
determination
as
suggested
as
Rockefeller
1955
and from 1956
Institute
then
A.B.
For the
from 1961 to 1964 at the MRC Unit in Cambridge (C.219).
crystallographers,
resolution
and later the even finer 1.4-& made it possible to identify many
more
co-
By the time of
ordinates to many of the atoms in the molecule.
"From the results of
his Nobel Lecture Kendrew was able to say:
acid
the
residues
of
probability"
the
(Science, art cit. 1963).
are known with almost complete certainty and
30 are known with a fair degree of
achievement of the high 2-8
chemical studies,
than previously,
today some 120
and to assign
side-chains
W.B. Stein
remaining
spatial
amino =
X-ray
early
many
and
the
the
at
1.4-8
of
1970.
the
With
Rome,
Union
an
were
not
16,
1963.
The
full
with
the
atomic
(1962).
sequence
courtesy
Congress
1963 and
of:
9-18
published;
co-ordinate
H.C. Watson,
interactions
of sequences
collaborated
on
lists,
(C.274
1.4-
determination,
International
analyses,
paper
however,
"Progress
successively revised,
= the
September
of
side-
chief
he
in papers on the amino-acid
were in constant demand (C.275-C.277).
Acta crystallogr.,
is included by
structure" was delivered by H.C. Watson at the
material covers a long period of time from June
a
resolution
Sixth
of
abstract
A
D.C.
Kendrew
myoglobin (1961) and haemoglobin (1965) and also wrote on
chain
his
collaborator
circulated
which
resolution
collaborative
myoglobin
International
Crystallography,
appears in the supplement to
photocopy
the
abstract
Phitlips at ¢C.289°.
C225.
when
and Edmundson began work on the project to 1967 and the
a
The content and timespan of each
sub-
They include correspondence and work or results from
and
and
in Kendrew'’s own hand
his
C.120-C.123,
The
Kendrew
circulation
little later work 1968,
binder
dividers.
colleagues
Watson.
and
careful
may also be very diverse even within the
considerable detailed work undertaken
checking at all stages.
lists of co-ordinates;
A high proportion,
collaborators,
especially
particular
Edmundson
labelled
there is
however,
of
the
shows
the
of
1956
in
See
is
also
and
NCUACS 11/4/89
J.C. Kendrew
94
Gully
"Myoglobin
sub-divided as follows:
structure
old material".
Miscellaneous
material,
Tables and notes by
"Chemical data".
with A.B. Edmundson on peptide analysis;
record
sometimes "booming success",
1960 - May 1964.
work in progress at the bench sometimes "bad
on one occasion "paydirt".
correspondence
this is an interesting
news",
March
Kendrew,
of
"S/C [side-chain] identification".
drafts and revisions for lists.
Detailed notes and
March 1960 - July 1964.
tables,
"Interactions etc.".
May 1962.
Tables, diagrams, notes.
December 1960 -
"Sequence data".
from
data from R. Hill March-August 1962.
conferences December 1960,
Annotated material and sequence data received
correspondence and
June 1961,
Notes,
correspondence
of haemoglobin and myoglobin and
on
"Homology".
homology
to
collaborative paper "Comparison between the amino-acid sequences
of sperm whale myoglobin and of human haemoglobin" Nature,
190,
1961.
mainly
probably related
December 1960 - July 1963.
Watson,
with
"Notes pre 6-& Fourier".
in type A and also types B,
January 1958.
Early notes on heavy atom
D,
C,
F
myoglobins.
attachment
-
1956
June
sub-
Few pages
tables,
features".
"Interpretation of 6-8 Fourier".
Notes and diagrams n.d.
Notes
and diagrams,
Miscellaneous
material,
some by Watson
and
"Chemical data".
Notes and charts.
"General
others.
structure current".
Notes, charts, colour codes.
May 1960 - September 1964.
"Myoglobin
divided as follows:
"Bond lengths, models".
dated, 1961.
1968".
"S/G.
February 1962 to "Final allocation November 1964 153 residues".
"Interactions etc".
and
colleagues on configurations 1962.
data on leucines from D.C. Phillips
correspondence
other
Detailed notes and revision of
Detailed notes and charts,
"Sequence
1963.
Miscellaneous charts,
May 1964 - March
October 1962
- March
correspondence.
identification".
1961,
and from
"Homology".
Charts,
data,
data".
NCUAGS 11/4/89
J.C. Kendrew
C.LT9
"H.C. Watson. Myoglobin notebook".
divided as follows:
Miscellaneous material, sub-
At front of book, untitled - miscellaneous notes, data, electron
density charts, contour maps, December 1959 - April 1960.
"Least
all by Watson and includes printout by Dickerson June 1959).
Notes and printouts June-September 1960 (not
squares".
"Holes in Fourier".
Notes and charts.
q
"Sequence
Edmundson.
data".
Notes and charts,
includin
&
material from
"Myoglobin co-ords".
Charts (not by Watson).
"Complete
charts.
myoglobin co-ordinates".
Tables,
electron
density
Untitled.
amino-acids in myoglobin, n.d., c.1961.
Notes by Kendrew for the 3-D co-ordinates of the 153
The notes were originally made in a small format notebook unlike
according to Kendrew (private
any elsewhere in the collection;
communication
a
was
direct sight of the 2-R model in the laboratory.
subsequently
separate
sheet to fit into a standard looseleaf binder.
July 1987) they were probably jotted down from
apart and each page stuck on to a
The book
taken
the
helices
(numbered A-H)
of
2-8
setting out co-ordinates
pp.1-53
p2
p3
pp.1-30
p4 = pp. 1-13
The
pls
on
molecule.
"2-8 Side-chains co-ordinates".
as follows:
notes are in three sections,
povand. pa
eight
for
Within each section the co-ordinates are based
myoglobin
the
Each section is separately paginated:
Tables and calculations.
"Notes
Notes on each amino-acid and likely identification,
with some later notes and corroboration by Watson.
"Summary
amino-acids in helices A-H.
Tables for
All in Kendrew's hand.
Three sets of work, sub-divided
Probably preliminary work for
identification
of
151
above.
by Kendrew,
notes
on S/Cs".
on side-chains".
"Co-ordinates".
NCUACS 11/4/89
J.C. Kendrew
C7122
"1.5-R Side-chains".
is
This
group,
dividers.
a detailed examination of 152 amino-acids and the
haem
the helices A-H being separated by sub-
toa page,
one
The top half of each page gives the chemical identification, and
and
the lower half has notes on the X-ray findings first at 2-R
then
final
A few notes have dates
identification is
in April, May 1962.
reworkings and modifications at
in upper right corner.
1 5-%:
with
The
rear
At
15pp. list and comments dated October 1965.
"p4 co-ordinates plotted
book
of
on
2-R
Fourier".
Untitled.
by
ordinates for Coulter least squares program" 1 March 1962.
Printouts of co-ordinates, many checked and annotated
"Proposed changes in co-
Kendrew and with a front page list
rear
At
14pp.
revisions" 25 April 1962.
book
of
charts
and
notes
of
"Co-ordinate
Printouts of co-ordinates on EDSAC,
with notes
Untitled.
checking
hands but
density charts and contour maps.
several
in
mainly
Few pages only dated 1962-64.
Watson.
by
and
Electron
also
Also
are
the
Later
letter
Watson.
related
undoubtedly
work 1966-67,
from R. Diamond
almost all in Kendrew's
version 8 October 1967 is also
to preparation and circulation of
co-ordinates and a little work by
warning that "further revisions will
a manuscript note of material to be listed dated
manuscript lists and tables of factors in myoglobin
July 1966 on his listings
Work
and the present set should not be regarded as
revised
hand;
Untitled.
of
includes
is
myoglobin
co-
mainly
ordinates
Kendrew's
and Watson’s "Myoglobin orthogonal coordinate and dihedral angle
listing dated 1 April 1967" which was circulated 18 August
1967
be
with
final".
required
and
A
later
1970.
there is
lists
(See
of
pro jected
"Tabulations
publications on co-ordinates.
C.274).
for
manuscript
included
included
papers",
perhaps
for
other
NCUACS 11/4/89
J.C. Kendrew
Miscellaneous
so
are
because
notebooks
designated
These
more
heterogeneous in content than those of the main myoglobin series
or
CG TZ F
nevertheless are part of the myoglobin research and include some
of
the most accessible explanatory material and correspondence.
C.128, C.129 have more general reference.
because
timespan.
C.126;
wider
they
cover
they
are
a
Kendrew and several collaborators relating to the
Miscellaneous notes, data, correspondence etc.
myoglobin
sub-divided
but mainly 1957-58,
earliest date 1955
"General notes".
by
programme,
as follows:
"Exp."
densitometer
annotated
Institution results,
Pauling, T. Deeley, D.C. Phillips, Dickerson.
Notes and diagrams for camera settings for 3-D pictures,
several series of wedge tests (1958)
Royal
P.J.
correspondence or notes by
and
Dintzis,
data (1955),
comparison
Cambridge
Kendrew,
by
of
and
Notes
"Theo."
reflections
required at various Angstrém resolutions (1958), phases, scaling
by Wyckoff (1956) and others,
contour
maps, phase determination (1957 by D.M. Blow).
electron density charts,
calculations
number
on
of
Of
a
by
27
of
at
in
on _
the
are
his
and
Din,
April
"Notes
special
written
interest
obtained
division
project".
equipment
programme"
required and
the method of
for W.L. Bragg
rear of book,
the probable timespan,
project diary by Kendrew 24
to collaborators and various charts on
will be a synthesis going as far out
III
as we can - probably to 16k. 3 preferably by the
3-dimensional Fourier synthesis with
isomorphous
Untitled,
1957 -
and notes from or
of
myoglobin
These outline the future programme,
methods
between Cambridge and the Royal Institution.
II will be
or
Stage
space
April
10 December 1958 intercalated with related correspondence
"State
the
1958.
the
labour
He writes: "Stage
resolution 3
replacement.
reciprocal
heavy-
atom method."
NCUACS 11/4/89
J.C. Kendrew
98
Gel27
Untitled.
Kendrew and collaborators.
61, sub-divided but not always labelled, as follows:
by
Earliest date 1958 but mainly 1960-
Miscellaneous notes,
correspondence etc.
data,
Untitled.
lectures",
computer programs from C.L. Coulter 1961.
Kendrew’s
manuscript
notes October
"Cochran's
1961,
notes
on
Fourier
correspondence
Transform
on
Untitled.
Brief note on visitors to Unit September 1962.
Untitled.
Fourier transform,
by Brenner, Antonini, and on Fortran 1960-61.
on
notes on "American trip" by Perutz, lectures
correspondence
Fourier,
for 6-8
Contour
maps
Photographs
of Fourier syntheses,
"Structure",
1960",
charts,
from Watson on side-chains January 1961,
Kendrew some dated 1958.
haem
of
"Myoglobin 2-R
and of helices.
R1 model
April
Electron density
letter
miscellaneous notes by
group and special section diagrams with a_
"Amino
sequences 1958-61.
acid
comp."
Notes
and
tables
of
various
protein
3
Project
February 1959
diary
correspondence
1961,
"Journal".
with
to
intercalated
and various charts on "State of project" (similar
collaborators
final
material
stages
(Nature,
185, 1960), but also includes from 1 August 1960 plans to refine
the
Includes data or correspondence from
Coulter, Dickerson, Phillips, L.H. Jensen.
of work and publication of paper on 2-R
to project diary at C.126).
resolution to 1.5-8.
Mainly related to
-
notes
model
July
from
and
10
or
is
all
papers,
1959-71,
Laboratory.
discussions
scientific
at meetings
hand,
and
attended by him
programme of the
consisting of his notes of
"Conference notes and lectures".
a chronological sequence of material
talks and seminars given in
by visitors or by staff members during its Open Days,
in
This
lectures,
Kendrew’s
or by
questions
the
other members of the MRC Unit,
Unit
and
also of the papers given at the 1969 EMBO meeting at Konstanz on
the
Molecular
though primarily on protein
Biology
structure, is thus not exclusively on myoglobin.
The work is sub-divided as follows:
This
kept
complement to Sections D (MRC Unit),
N (Visits and conferences).
was a late addition to the collection and
though its contents are often an
has _ been
essential
F (EMBO), L (Lectures) and
item
as an entity,
The content,
European
proposed
NCUACS 11/4/89
J.C. Kendrew
1959-62
D. Davies
Polynucleotides
30 October 1959
Gierer
TMV
20 January 1960
Anfinsen
no title
tr. d:.
International
First
polypeptides,
participants, notes).
Madison
Symposium
on _ poly-a-amino
Wisconsin,
19-23 June 1961
acids
and
(programme,
See L.147
Gordon
(programme, participants, 12pp.notes).
on proteins,
Conference
New Hampshire 26-30 June
1961
See L.147, N.14.
Gurd
Chemical Studies of myoglobin
11 July 1960
Brenner
Replicon
n.d.
Krimm
Feather
O'Brien
no title
18 February 1963
25 February 1963
Brandén
no title
25 March 1963
Green
Lactoglobulin
13 May 1963
Luzzati
Synthetic polypeptides
11 February 1963
1963-65
See L.147, N.17.
7 October 1963
24 January 1964
D. Blow
Chymotrypsin
28 May 1963
Crickday
Bonner
Weizmann Conference, June 1963.
Regulation of chromosome
activity
Holland visit to laboratories,
see also L.148
12 October 1965
Conformation workshop,
24-25 June 1965 (7 pp. notes).
Molecular interpretation of
Bohr effect
Structural Studies Division,
account of work in hand
Gordon
1965 (3lpp. notes).
National Institutes of Health, Bethesda,
Conference on proteins,
New Hampshire
28 June -
2 July
Crick
Talk to lab.
12-13 October 1964
See L.148, N.20.
Klug
Turnip crinkle virus
25 February 1965
See L.148, N.19.
Perutz
4 February 1965
February 1964
NCUACS 11/4/89
J.C. Kendrew
1967-68
Blow
Travels in USA
17 August 1967
Perutz
no title
23 May 1968
McLachlan
Gordon Conference 1968
L9 July. £968
Symposium on symmetry and function of biological
Nobel
systems
at the macromolecular level, Stockholm, 26-29 August 1968 (23pp.
notes).
See L.148, N.29.
1969
Diamond
Real space refinement of
myoglobin
8 July 1969
Clark
tRNA crystals
29 September 1969
EMBO
scientific part) (9pp. notes).
discussion
Konstanz
27-29
November
1969
(notes
on
See F.190-F.194.
Crick
Chromosome structure
19 October 1971
Notes on the literature, mainly 1961-68, sub-divided as follows:
Indexing
Proteins - general
Proteins - part[icular]
Haemoglobin
DNA
Miscellaneous
NCUACS 11/4/89
J.C. Kendrew
NOTES AND DATA (Kendrew and collaborators)
the
and
than
paginated
documentation
are more miscellaneous in character,
and less rigorously
These
dated
for
preservation in the "official" sequence of notebooks, though the
work
is often concurrent and therefore follows a similar order.
C.130-C.169 deal with research methods and
species
and the quest for the material best suited to X-ray
specificity
C.170-C.187 relate to the main myoglobin
diffraction analysis;
programme.
C.190-C.195
also
not
exclusively so
contain material relative to the main programme,
The "collaborators’ notes and data" at
in topic or date.
techniques,
selected
but
Preliminary work
Horse haemoglobin and myoglobin
Brief notes, electron density charts on haemoglobin.
(EDSAC)".
shape".
Papers
n.d.
Diagrams,
on
molecular
myoglobin.
resolution
3D Patterson
calculations.
"Horse
lattices,
February 1949.
Diagrams,
Includes a note from W.L. Bragg,
"Haemoglobin - Low
calculations, printouts, December 1950 - January 1951.
Horse myoglobin.
headed "Pseudo-orthorhombic" and perhaps related to joint
with
myoglobin", Acta crystallogr., 7,
photographs of myoglobin Fourier syntheses by R. Pepinski.
lattices, ideas on structure, some
paper
horse
pseudo-orthorhombic
Correspondence
myoglobin.
machine".
Pepinsky
Le.
“Veorter
"A
1954.
form
of
"Horse
and
NCUACS 11/4/89
J.C. Kendrew
Blue whale
"Blue
Edsac
Kendrew May 1952.
whale myoglobin
sheets,
in
(NH
do so,",
a.0
b,-
calculations,
defisity charts,
ce pro jections ,
by
checked
all
Blue whale in phosphate,
December 1952.
a,
b,
c
Patterson.
Similar material
Penguin
"Penguin imidazole orthorhombic".
contour maps, intensity calculations October 1953.
Printouts,
density
charts,
Penguin a,
b,
c Patterson.
Similar material n.d.
b,
ec
projection.
Diagram
of "Intensity
strip
Printouts, density charts,
Some dated July, September 1954.
Early X-ray diffraction picture.
Carp myoglobin a,
lattices.
"Carp non-principal projection".
November 1952".
Similar material October 1953.
"Centred seal b,
diagram October 1954.
Printouts, density charts,
Lattices A2,
B’ diagrams.
c face diagonals".
"Wash seal a,
c".
"Centred seal".
NCUAGS 11/4/89
J.C. Kendrew
C.144
"Wash seal b".
Similar material October 1953.
"Wash seal monoclinic a".
Similar material October 1953.
"Monoclinic seal Lattice A".
1954.
Similar material
February,
June
"Seal myoglobin Lattice A’
b patterson".
Similar material n.d.
"Seal
scaling charts, using above data.
‘Nodes and loops’
".
Graphs,
radial
distribution
and
Finback whale
was the subject of extensive study 1950-54.
This
work (C.149-C.160) is
Bluhm (C.161-C.164) and P.J. Pauling (C.165, C.166).
the
in Kendrew's own hand, and some is by M.M.
Much of
Work by Kendrew
Manchester
1952".
"Fly's eye work
photographs,
methods developed by H.S. Lipson.
Printouts, contour maps, density sheets, calculations, lattices,
graphs, ideas for structure etc.,
some dated November 1950, July
LISE.
Includes 9pp. summary of results.
"Inequalities.
graphs,
one
relation between the signs of structure factors" 1952,
of which is enclosed.
"EDSAC Finback whale May 1953".
Cochran's rule.
‘Manual’ application of Cochran's rule".
adaptation for EDSAC program etc.
Notes,
(only
"A
draft
lattices,
diffraction
set
dated 25 April 1953)
based on paper by W. Cochran
Routines and tables,
dated
May
1952 using
optical
Notes,
graphs,
(See also C.203.)
a
applying
some
calculations,
NCUACS 11/4/89
J.C. Kendrew
104
c,153
"Fouriers of Finback.
material, continues to June 1953.
(EDSAC inequalities)
May 1953".
Similar
whale 3-dimensional Patterson".
"Finback
density
February, April, July 1954.
charts,
contour maps,
calculations etc.,
Printouts (checked),
dated
some
paginated and with a summary of contents,
organisation as the stiff-backed binders
and
This is
"Type F Inequalities".
punched,
format
instead as loose papers in a folder.
L953
to
Cochran's
for finback whale.
and
a substantial file of material,
of the same
kept
The material runs December
using
Fouriers
attempts
but
December
methods and other programmes to obtain good
various
covers
1954
C.156-C.160
folders
Five
finback,. 1954 ;1955..
of
contour maps and printouts
for
Fouriers
of
Work by M.M. Bluhm
scaling
Few dates.
folders
of
Cit6E: €. 162
G.163,;.C,.164
intensities etc.
Work by P.J. Pauling
calculations and charts for
Two folders of density sheets and contour maps.
Two
camera setting,
finback whale.
factors,
for 3-dimensional structure of
dates August 1954 - March 1955.
This is work similar to that at C.111A on salt water changes
finback
ROY +500.
related to the joint paper in
projections, November 1954 -
myoglobin,
UG56:,
Calculations and notes on
Miscellaneous notes,
contour maps etc.,
whale
,°237',
calculations,
in
Proc.
March 1955.
a,
b,
c
various
NCUACS 11/4/89
J.C. Kendrew
Whale - Structure factors
Notes, calculations and diagrams, all by Kendrew.
whale
finally
attempt to explore research techniques and results.
the "type A"
crystals
(not
all
Early work on
selected)
in
Patterson fitting".
"Whale
crystals at different angles, early contour maps.
dated
EO S2
Various diagrams
1948-49
but one of the sets of drawings is dated
graphs
of
The folder is
May
and
3
of structure factors for various models.
a note by Kendrew summarising the results e.g.
"Whale
graphs,
have
enough
improvement was obtained",
sets of notes bear dates in February, March, May 1952.
Structure Factors and Fouriers". Detailed calculations,
tables
Most
good
decisive
Some
"this looks pretty good" etc.
absolutely
Fourier",
justify
"not
"no
to
a
"Whale
Similar
project diary of work 13 June -
Series a-n,
material,
IVC,
in
D.
9 July,
no year given.
calculations".
a
Perhaps
includes
Structure factor
the order described.
Also
19528
NCUACS 11/4/89
J.C. Kendrew
Main Myoglobin programme
Orthorhombic sperm whale
and diagrams by Kendrew on "packing" and crystal lattices
March
A and B orthorhombic sperm whale,
dated
some
Types
Notes
of
ESS3.
orthorhombic
"Sperm
sheets, contour maps, a,
by R.G. Parrish, related to joint paper in Nature, 175,
density
c projections, some by Kendrew, some
met-imidazole".
graphs,
Notes,
1955.
b,
"Sperm
Kendrew n.d.
orthorhombic ‘end-on' Fouriers".
Work by
Parrish
and
"Sperm orthorhombic a Patterson", November 1952, January 1953.
n.d.
have
maps,
some
dated
June 1954.
of
the
Printouts,
in order."
orthorhombic b
b projection
from
computation of the
in the > origins I
Monoclinic sperm whale
inconsistencies
whole
"Sperm monoclinic met-imidazole".
contour
Kendrew.
Patterson".
calculations,
With a later note 21 May 1955 by Kendrew
checked
the
Everything seems
"Sperm
density sheets,
"Because
through
photographs to the check totals of the Edsac.
to be
and calculations by Bluhm, only one page dated October 1953.
"Reflections on Wissenberg Patterns".
February-April 1953.
Calculations, density sheets,
and
"Sections through 3-dim. Patterson of sperm monoclinic".
Charts and notes by Bluhm
Work
by
Parrish
Notes
NCUACS 11/4/89
J.C. Kendrew
C.L78
Scaling factors and checks by Bluhm.
myoglobin.
graphs,
"Sperm
whale
calculations,
including note on "Reconciliation of 3-dimensional results
2-dimensional
little by Bluhm.
3-dimensional
projections".
synthesis".
almost all
printouts
dated
July
Work
(one
by
16
Notes,
1953),
with
a
Kendrew,
Fourier".
"End-on
Notes
Kendrew, a little by Bluhm.
1953.
calculations,
and
by
June 1953 and a later note November
almost
all
.181-¢C.183
Three
checks for Pattersons.
folders of calculations,
density charts,
printouts
and
"Sperm whale myoglobin.
Large
and some additional, of values to be used on EDSAC tapes.
3-dimensional Patterson. EDSAC sheets".
1-12
scale charts by Bluhm checked by Kendrew,
numbered
Bluhn,
checks’
and
and
data
on
on
radial
some
with
Includes
Kendrew’s
(see C.36),
contour maps
distribution.
Printouts and
3-D Patterson".
density sheets,
calculations,
by
"Sperm monoclinic EDSAC outputs.
calculations, all checked and corrected by Kendrew.
Miscellaneous
projections,
corrections dated October 1954.
Work
intensity
distribution for haemoglobin, myoglobin and ribonuclease sent by
V. Luzzati 1954
notes and calculations by
Bluhm.
diagrams, including haem group n.d.
Later work
various hands n.d.
on radial distribution,
sections".
diagrams
Contour
Fourier
special
maps
and
etc.
in
charts,
"3-D
a
and
graphs,
NCUACS 11/4/89
J.C. Kendrew
Collaborators’
notes and data
In alphabetical order
R.E. Dickerson and others
calculations,
Notes,
Dickerson
with Royal Institution;
Phillips
Kendrew
Dickerson to V. Shore.
preparation
by
but also by others and relating to collaborative work
includes notes on verso of letter from
from
12 May 1958
undated
methods
mainly
etc.,
note
and
December 1957 - December 1958.
an
to
H.M. Dintzis
"Hel
charts, densitometer readings etc.
syntheses".
Difference
Notes,
1955.
calculations,
density
Notes,
scaling
is
in
on
haem
group.
1955-56".
maps etc.
The material
D.C. Phillips
on Type D and Type F.
"Type F
tables,
Kraut’s
standard
pages.
Joe Kraut’s work
contour
work
Work
graphs,
printouts etc., paginated 1-121 but not in numerical order, some
dated 1960.
factors,
Includes brief notes by Kendrew on
the
format of the loose-leaf binders but was kept as loose
3M CsCl densitometer tests.
"H. Wyckoff
tests, irradiation tests,
miscellaneous
densitometer
narratives,
Extensive
H. Wyckoff
Includes
notes".
notes,
-
NCUACS 11/4/89
J.C. Kendrew
Unidentified
Work on isocyanide spectra 1954-55.
"Interesting
note
combination of myoglobin with isocyanide".
unidentified
hand
in
File cover has a manuscript
the
early
work
on
NCUACS 11/4/89
J.C. Kendrew
Miscellaneous
data,
relating to checking 6-&
Correspondence,
1957,
obtained on EDSAC I against DEUCE computer at National
Laboratory.
Includes
correspondence with J.S.
analysis,
dimensional
the air permanently any time now
small pieces".
printouts, density sheets, contour maps,
3-dimensional Fourier synthesis
Physical
D.W. Green,
on 3-dimensional
2-
analysis explaining that "EDSAC 1 will be going off
in
from Kendrew 7 December
Rollett July-October
is at present
programs
EDSAC 2
letter
EDSAG
1957
and
...
on
by
a
"An examination of the helices in myoglobin".
for a paper so titled,
of H.C. Watson, n.d.
Manuscript draft
with 6 tables and 3 figures, in the hand
but 1960 or later.
included is
Also
a brief outline by Kendrew for the paper under
the title "The helical segments of polypeptide in myoglobin" and
a note of two major collaborative papers intended for the series
on "Structure of myoglobin" in Proc. Roy. Soc.
of which I-V had
been published 1950-59.
The two mentioned in the note are "VII
a three-dimensional Fourier synthesis of sperm whale crystals at
2-& resolution by Kendrew,
Strandberg, Phillips and
Kendrew,
Shore"
Phillips,
These
papers did not in fact appear and the work was published only in
the shorter form of communications in Nature.
"VIII Interpretation of a 2-R Fourier
Dickerson, Shore".
Strandberg,
Watson and
Dickerson,
and
by
?
of
of
to
on
for
1965,
"Aids
proposal
research
interpretation
interpretation
computer generated models
Material
three-dimensional syntheses.
on
crystallography"
renewal
of
Mainly exchanges with M.O. Dayhoff
protein
1962 (with comments by Watson and Branden) and
publication
Atlas of Protein Sequence &
Structure, later correspondence on probability research 1971.
NCUACS 11/4/89
J.C. Kendrew
MATERIALS AND APPARATUS
Supplies and specimens
on
and
and
with
whaling
shippers,
stations,
the supply
individuals
1952 when Kendrew and his team discovered the
Correspondence
colleagues
suitable samples of myoglobin,
also of various other species.
December
suitability
to locate supplies;
to
sea
various
fish trains and airports.
fisheries,
of
particularly of sperm whale
but
The earliest exchanges date from
special
trying
Perutz joined the initial quest by writing
to and from ships at
were
at
overnight
cables were sent
members of the laboratory
of sperm whale meat and no time was lost in
times to collect specimens from cold stores,
a colleague in Peru,
despatched
transport
other
and
1952-53.
1955-58.
porpoise
Optical diffractometer
(much of this relates to the investigation of
1960-65
myoglobin by R.H. Kretsinger), 1972.
See also C.150.
Correspondence,
lamp,
related to optical apparatus devised by H.S. Lipson whom Kendrew
approached
Also
includes
high
correspondence
intensity light sources.
masks and "pantographs" on optical
Examples
of
are at C.308.
the matter on the advice
notes on the "Fly’s
diffractometer
W.L. Bragg.
commercial
suppliers
drawings
Eye"
with
and
of
on
of
NCUACS 11/4/89
J.C. Kendrew
Microcamera
Densitometer
Drawings and diagrams by Kendrew and others.
densitometers design
suppliers,
"Scanning
correspondence
"flying-spot" densitometer,
19575 A.C.0- North 1958;
with
paper (no author or
correspondence with
data".
Drawings,
blueprints,
on
M.H.F. Wilkins
date)
"Bluhm
notes,
information on photometer from F.H.C. Crick.
Densitometer".
calculations,
Correspondence with
graphs
Bluhm
by
commercial
firms,
October-December 1953,
Correspondence with supplier and colleagues on microdensitometer
1957-59.
Miscellaneous rules and scales for use on densitometer
in Kendrew's laboratory.
AWRE
routines
Computer time
Aldermaston.
correspondence
of time on IBM 7090 at
on use/hire of computer
Use
1959-61,
C.L. Coulter 1960-62.
Correspondence
and information on myoglobin work on 7090 by
Miscellaneous
on
various machines and at various institutions 1959-67, especially
1960-61 when EDSAC 2 was no longer capable of the fast computing
required.
time
NCUACS 11/4/89
J.C. Kendrew
COLLABORATORS AND STAFF
posts
research
Correspondence and papers relating to doctoral, postdoctoral and
team.
other
Applications
USA,
foundations;
funded
there
or _ short-term
are
contracts.
from various grant-giving institutions and
some MRC staff members on long
from UK and Europe,
with the protein
crystallography
mainly
from
also
come
but
publications,
material may include applications and
The
for
work in team, arrangements for funding, supply or importation of
equipment,
visits of varying
duration, research proposals, progress and results, exchanges of
information,
etc.
considerable
Some
period and include news of subsequent career.
related correspondence with other colleagues
others extend over
brief exchanges,
recommendations
advanced
degrees,
are
a
Individual files
Banaszak, L.J.
1962-66
the
and
had
been
hoped
1951-60
Work on guanidated myoglobin and GPDH.
and others
Bluhm, M.M.
appointment,
Bodo, G and others
working as Scientific
Assistant
Includes a little correspondence 1951 when
to make
Kendrew's
Bluhm was an MRC staff member,
to Kendrew 1952-55.
it
analysis and material for 1952 appointment.
1973
conducted after Bodo had left MRC laboratory and
atom
Brdndén
correspondence only, on arrangements.
Correspondence
returned
attachment etc.
a temporary MRC staff
Bretscher, P.A.
Brdndén, C-I
myoglobin
and others
research,
a year as
Austria,
1957-60
member.
Brief
to
on
spent
heavy
1962
1968,
NCUACS 11/4/89
J.C. Kendrew
Co2Z15
Coulter, C.L.
and others
1959-66
funded
worked 1960-62 on the 1.5-& Fourier synthesis
7090,
Coulter
on
IBM
Includes
Crystallographic
on
protein structures" which discuss the work at 1.4-R.
of myoglobin" and
Institutes
structure
abstracts
Association meeting June 1962 on "Recent
"Refinement _ methods
computed
Health.
American
work
for
National
given by
Coulter
papers
by US
the
of
of
at
Creighton, T.E.
and others
1965-68
Dickerson, R.E.
and others
1957-68
at
worked
Dickerson
Science Foundation,
a
joint
myoglobin co-ordinates etc.
other
and
shorter visit July-August 1960.
the laboratory,
from January 1958 to
publications,
research
US
by
funded
National
21 August 1959 and for
funding,
results,
Correspondence on
and
plans
Dintzis, H.M.
and others
1955-63
worked at the laboratory as
a Rockefeller Fellow
important
contributions
to
the
1954-
isomorphous
Dintzis
595
replacement work.
making
to
by US
about
funded
1959-71
National
and others
returning
Foundation,
Institutes
sequencing,
to America,
some delays,
Edmundson, A.B.
and subsequently (February 1965)
special equipment provided for the work by
After
attributed
methyl-cellosolve)
protein chemistry.
Edmundson came to work in the laboratory on
of
Correspondence and
the
made
After
amino-acid
Health, from October 1960 to September 1964.
material
Rockefeller
over indefinitely to the laboratory, are also included.
projects.
illness
particular
on
prolonged contact with solvents
phase circles,
discontinue
Edmundson
developed
equipment,
Structure
Hoppe, W.
research
factors,
obliged
1958-64
1957-58
and
was
an
(in
other
work
to
NCUACS 11/4/89
J.C. Kendrew
C222
Huxley, H.E.
and others
1950"55
mainly related to Huxley’s period
Research and recommendations,
at M.I.T. as Commonwealth Research Fellow, his return to the MRC
Unit and provision of an electron microscope for his research.
Jensen, L.H.
and others
1959-62
Helices in 2-8 and 1.5-8 resolutions.
See also C.127.
Kraut, J.
and others
1954-59
Kretsinger, R.H. and others
1963-73
Research and joint publication, draft paper on "The structure of
porpoise myoglobin".
Levitt, M.
and others
1967-70
Levitt
1968 until the award of
held an MRC Training Scholarship at the laboratory
from
a Fellowship at Caius in 1970.
1963-71
1951-56
correspondence is
Pauling, P.J.
and others
Parrish, R.G.
and others
Parrish
54;
and results.
was a Merck postdoctoral fellow at the laboratory 1952-
on funding and career, research programme
Research, publications.
Schoenborn, B.P.
and others
Pinkerton, M.
1955-61, 1969
1951-56
1964-69, 1974
NCUACS 11/4/89
J.C. Kendrew
C.232
Steinrauf, L.K.
and others
1958-63, 1967
Stockell, A.
Work on papain.
1958-59
Strandberg, B.E.
1959-65
Correspondence
resolution
and
C.84).
Strandberg
July
1959
refers
to
crucial
work and pressure to complete before
finished
their stay at
laboratory
stage
of
2-8
R.E. Dickerson
also
(see
Stryer, L.
and others
1961-64
Watson, Hod:
1959, 1964-68
Watson
1959 - June 1968.
had an MRC staff appointment at the laboratory
December
1959-62
letter of
myoglobin
Wheeler, J.
Wyckoff, H.W.
and others
programme.
1954-57, 1963
Kendrew's
of
the
current state of the
summary
Wyckoff's
17 July 1955 includes a very clear
Part time MRC staff member, working on EDSAC programming.
reports on his research are also included.
NCUACS 11/4/89
J.C. Kendrew
Chronological files
Shorter correspondence relating to applications to vist or
Similar material to C.210-C.238 above,
at the laboratory.
work
but
less extensive.
1952-54.
1955-56.
1958-59.
1965,
1964,
1966.
NCUACS 11/4/89
J.C. Kendrew
CORRESPONDENCE
Aspects of myoglobin
years,
ease of reference,
below are the contents of Kendrew’s bulky
for
folders,
C.248-C.272
descriptive
sub-divided
The material for each topic, which may extend over very
titles.
The content
many
elsewhere
may
e.g.
and
results, comments on publications, but Kendrew’s arrangement has
been respected.
is presented in chronological order.
have some degree of overlap with
correspondence
preparation,
on
methods
with his
own
of
exchange of
specimens
Myoglobin - biochemistry 1947-81
1950-54.
L950 297 .
1960-62.
1958-59.
Looe.
BOT 2. LORI e
NCUACS 11/4/89
J.C. Kendrew
Myoglobin - Theory 1949-68
1949-53.
1956-1965; 96s
Myoglobin - electrical - magnetic 1953-70
LOSS,
L958.
1960-63.
1964,
1968,
1970.
LOS 1958, £96) 962.65.
Myoglobin - helix content 1955-62
Includes samples of micrographs.
Myoglobin - electron microscopy 1954-63
1966.
$955, 1957-56, 1962,
Heavy atoms 1957-66
1957-60, 1965,
NCUACS 11/4/89
J.C. Kendrew
Myoglobin - physical chemistry general 1958-77
1958, 1961-63.
1964-65.
E970.
LOTS,
297 7.
Myoglobin - oxygen reaction 1960-74
1960-62, 1966-67, 1970;.1972,21974.
Myoglobin - 2-R Fourier 1960-67
1967.
Porphyrin structure 1961-66
1960-62,
of haem group.
1965,
Correspondence and data 1961-66.
Mainly on helical structure and position
supplies, specimens, preparation methods, equipment etc.
requests for information
on
Shorter
correspondence
1954-75;
NCUACS 11/4/89
J.C. Kendrew
Atomic co-ordinates/amino-acid sequencing
by
Kendrew
work
Correspondence 1955-59 with US colleagues on collaborative
chemical
suggested
determination
be
undertaken by the Rockefeller Institute for Medical Research New
York alongside the X-ray diffraction analysis in progress at the
MRC Laboratory.
of the amino-acid sequence of
myoglobin,
November
1955
for
the
to
2
The correspondence is mainly with S. Moore and W.H. Stein at the
Rockefeller Institute, and with A.B. Edmundson who was the first
to
graduate
the
a
Rockefeller Institute,
postdoctoral
Laboratory
research
(C.219).
Some correspondence with other colleagues is included.
later at Brookhaven and eventually as
fellow
work on the
at the MRC
initially
project,
student
at
exchanges
The
progress of the myoglobin project at a critical time.
are of particular interest
in
chronicling
the
Kendrew’s
1967,
lists of requests for tables,
74.
August 1967,
and Watson’s tables of co-ordinates circulated
revised October 1967.
April
miscellaneous
and chart of those supplied 1967-
With
of
on
from
by
of
to
to
tables
letter
thanks,
Kendrew
research,
sequencing
reluctance
colleagues on
Cr2765 Cuz
15 February 1965
compiled
letters
and Watson
information
explains
co-ordinates
C. Levinthal of
the
distribute
Kendrew'’s
his
prematurely.
co-
(C.274).
or
myoglobin model-building, requests to use
some
Correspondence
simple requests for Kendrew's results, others with more detailed
exchanges on work in progress, publications, 1960-67.
Shorter correspondence distributing or requesting tables of
ordinates
Includes
educational projects,
or quote material.
1970-78.
1967-69.
research
C.276
SVT
in
1967
NCUACS 11/4/89
J.C. Kendrew
Publications
General correspondence
Kendrew
and
correspondence
1958-68 arising
General
myoglobin
colleagues,
of
permission
and
published results and continuing work on myoglobin.
from
collaborators,
editors and publishers.
reprints
to quote or reproduce material,
congratulation,
scientific
exchanges
requests
related
authors,
to
or
received
publications
on
from
Includes letters
photographs,
thanks,
from
arising
and
letters of
by
some
for
January-May.
January-May.
June -December.
June -December.
1968.
June -December.
January-May.
1964,
NCUACS 11/4/89
J.C. Kendrew
Myoglobin papers
Correspondence
(with
synthesis
Wyckoff and Phillips) in Nature, 181,
and its publication
August 1957 - January 1958 on the 6-R resolution
Parrish,
Dintzis;
1958.
Bodo,
Kendrew’s letter of
Bodo, Wyckoff and Kraut,
interest, summary of the work and future plans:
sent to Parrish, Bluhm, Dintzis,
is reproduced below for its historical
20 August,
CAVENDISH LABORATORY,
CAMBRIDGE
20 August, 1957
To save repeating myself, this is
a circular letter to
tell you that we finally managed to do a 3-dimensional Fourier
synthesis of myoglobin the other day, with a resolution of 6
A.
The phases were determined using 5 different isomorphous
derivatives - mercury diammine, gold, PCMBS, mercury diammine +
PCMBS, and gold + PCMBS - with an accuracy which I should
estimate as + 20°;
and therefore real.
minutes using a 2-dimensional program of David Green’s modified
for the purpose;
repeated on DEUCE, the big machine at the National Physical
Laboratory.
and as a double check it has since been
The calculation was done on EDSAC in 76
of which 100 were h0l’s
400 terms in all,
and so
The general shape of the
Its position checks up exactly with
The Fourier shows much more than I personally ever
All the main features of the 2-dimensional Fourier of
First of all the main parts of the polypeptide
is the iron atom, which gives a
is definitely on the
hoped it would.
chains are quite clear;
peak 50% higher than the chains and is the most prominent
feature in the pattern.
that of the iodine peak in the 2-dimensional difference Fourier
of p-iodo-phenylhydroxylamine.
molecule corresponds pretty well with what we have said in
earlier papers, and its position in the unit cell is precisely
what was suggested by Howard Dintzis's salt-water difference-
Fourier.
the protein are now interpretable, and its highest peak,
incidentally, turns out to be the iron atom.
the chains is complicated and our old term "quasi-parallel" is
an over-simplification!
the average electron density of the chains drops to near average
so that at this resolution they nearly fade out,
or at least the
turns are not distinguishable from salt bridges, etc.:
the
consequence is that it may not be possible at this stage to
string together the various segments into a unique sequence.
Several of the segments are essentially parallel (though not
straight), but others run at right angles and so to speak tie
the bundle together round the outside.
The haem group is not
in one sense it
inside the molecule -
Unfortunately when they turn corners
The arrangement of
NCUACS 11/4/89
J.C. Kendrew
124
outside, though in another one might say that it was buried in a
cleft, though there is clear access for oxygen and other
molecules.
Our plan is
to extend the resolution to
A. using the
same techniques as hitherto, though the phase determination will
not be
years.
should clear up a lot of the doubtful points.
resolution!
(3,000 reflexions per derivative this time!).
Maybe we can do this in 18 months or
After that atomic
so accurate.
2
This
3
I thought you might like to have this advance
information about the latest results which, it goes without
saying, would not have been possible to achieve without the
efforts you made when you were in the Unit.
from everyone here.
All good wishes
Why not come back for a while and help with the 3A
stage?
All the best -
"
also
dated 17 August
includes a generous letter of congratulation
Folder
W.L. Bragg
thrill it was to see your structure yesterday
...
appreciate your coming over so quickly to show it
suggests
synthesis was actually completed, was 16 August.
from
("I feel I must write to say what a
I did deeply
to me"), which
the
"the other day" of Kendrew’s
letter,
when
that
and
Bragg
included
1960
on _
the
and
brief
colleagues,
2-R
again
publication.
in
early January and
January-February
includes a little
a pity to cut any
manuscripts
issue.
are letters to and from
Nature published the papers very rapidly,
fascinating and meaty that it would be
Also
correspondence with Nature about publication.
Correspondence
its
synthesis
enthusiastically
("I
with a real thrill ...
so
Ee out):
the
February
collaborators and colleagues.
resolution
writes
have been reading your paper and
Perutz’
the paper describing these results is all
of
receiving
13
with
written-up record of the 1.4-% work.
the
Included
Watson,
1.4-R
presented
at
Kendrew,
International
Sixth
(photocopy
Union of Crystallography,
kindly
of
provided:
presented
papers on the research in 1962 (see C.215) but there is no fully
Phillips and Blake,
International Congress and Symposia of the
resolution myoglobin structure determination" by
here is the abstract of the paper "Progress
supplement to Acta crystallogr.,
Rome, 9-18 September 1963
correspondence
publishing
in
the
Coulter
also
1963,
A
81,
Coulter,
Brdndén,
by.
Dic.
Phillips).
C.L.
Also
with
16,
NCUACS 11/4/89
J.C. Kendrew
Les
c.290
(a)-(h) and caption for Figure 18 pp.94-95
"Crystal
Series
structure of myoglobin V", with Bodo, Dintzis and Wyckoff, Proc.
ROY 150C'.
L959.
20357
of
Miscellaneous captions for exhibits.
Circulation list for Kendrew’s publications c.1954-58.
In July 1986 Current Contents,
no.29 featured the 2-8 paper
(Nature, 185) as "This Week’s Citation Classic" by which date it
The 6-8 paper (Nature, 181)
had been cited in 475 publications.
had
paper
(Nature, 190) had been cited 405 times at the same date.
cited 140 times and the amino-acid
sequencing
been
29
NCUACS 11/4/89
J.C. Kendrew
MODELS
Skeletal model
By
were
originally designed by Kendrew and made up
These
Cavendish
workshops.
Repetition
laboratories
unofficially,
and
information on the matter.
the
workshops and later (from 1958) in the MRC Unit's own
Cambridge
other
though
Correspondence with MRC
historical
known as Kendrew models.
to
frequently,
August 1963 - December
1960
Engineers
they
Ltd.,
US.
manufactured
by
sold
provides
several
others
mainly
1965,
being
were
They
were
in
in
Correspondence with colleagues,
MRC and others on supply of models 1960-70.
Cambridge Repetition Engineers,
Ball-and-spoke model
to
many
kind.
small
approached
MRC in May 1965 with a view
requests for models of the myoglobin
correspondence and negotiations with MRC and
Cambridge Engineering Laboratories who had a
Barker should be formally licensed by NRDC to produce
of the
Research Development Corporation (NRDC) it was
Preliminary
circular letters to colleagues May 1965 - May 1966.
Following
Kendrew
manufacture and sale.
of
business
National
that
models.
in May 1966;
established, by Kendrew and passed on to Barker.
molecule,
commercial
He suggested the services of A.A. Barker
private
After various discussions with MRC and
agreed
the
Letters to colleagues about the scheme were circulated
orders were received and processed, and priorities
4 Folders.
Correspondence
and
priorities 1966-71.
C.294-C.297
periodical
orders,
orders
lists
NRDC,
and
of
NCUACS 11/4/89
J.C. Kendrew
Science Museum London
Correspondence
models, advice on captions etc.
with museum staff about loan or gift of
Various dates 1958-77.
various
Correspondence
Correspondence
costs etc.
methods,
of atomic model-building and scientific illustration.
colleagues and manufacturers
with
on
1953-58.
models", often referred to elsewhere in the correspondence.
"Pauling-Corey
R.B. Corey,
With
on
space-filling
1957.
With manufacturers of expanded polystyrene/plastics.
1957-59:
of
1960)
Models,
1961-62.
Molecular
Exhibition
and molecular models of the Biophysics
report of the Conference of the committee
Includes catalogue of British Biophysical Society Winter
1965;
earlier
Meeting
on
(September
atomic
Biophysical
Chemistry Study Section of the US National Institutes of Health.
Printed/duplicated information on model-building.
1966-67.
and
an
and
NCUACS 11/4/89
J.C. Kendrew
MISCELLANEOUS
Pantographs
and
"pantographs"
(End
Masks
on)
taken 1952 with the so-called "fly's eye" optical diffractometer
based on the work of H.S. Lipson.
of finback whale myoglobin
See C.203.
NCUACS 11/4/89
J.C. Kendrew
SECTION D
MRC LABORATORY OF MOLECULAR BIOLOGY, CAMBRIDGE
INTRODUCTION
BUILDINGS
APPARATUS AND EQUIPMENT
RESEARCH AND ADMINISTRATION
HISTORICAL
NCUACS 11/4/89
J.C. Kendrew
INTRODUCTION
This
is the last and current title of the famous
institution
where
most
of
the
brilliant early research was conducted which
gave
Britain
its
historical
lead in protein crystallography and molecular biology.
Under
its
original
name
of Unit for the Study of the Molecular Structure of
Biological
Systems
it
was
set up in Cambridge by the Medical Research
Council
from
1
October 1947 with a staff of two,
M.F. Perutz and J.C. Kendrew,
housed in the
old Cavendish Laboratory in Free School Lane.
The Unit expanded rapidly
-
by
1950
F.H.C. Crick
and H.E. Huxley were already working there and
J.D. Watson
arrived
in
Michaelmas 1951 - and was renamed the Molecular
Biology
Research
Undt in’ 1956,.
Although plans were put forward by Perutz,
and accepted by the
MRC,
in 1958 for its expansion into a Laboratory of Molecular Biology with its
own
building,
the
work continued at the Cavendish
in
increasingly
cramped
conditions
until
1962,
when
new quarters were opened by the
Queen
in _
the
University
Postgraduate Medical School on the New Addenbrooke's Hospital site.
by
A. Klug.
of
the
M.F. Perutz
in
1979,
various
gatherings,
until
he
reached
(until
1986)
and
was
Chairman
of
Deputy
Chairman
the
Laboratory
Kendrew
was
retirement
age
Division
of
and
Director
celebrations,
The records of his
his successors being S. Brenner
A further major extension was agreed in 1964.
own research in Cambridge constitute Section C.
Structural Studies until 1974 when he was seconded to EMBL.
The fortieth anniversary of the first MRC Unit was marked in 1987
about some of these is at D.39.
articles and TV
programmes;
information
NCUACS 11/4/89
J.C. Kendrew
BUILDINGS
Architects’
plans
Addenbrooke's site.
January,
March
1960
for
laboratory
on
Architects’ plans June 1966 for extension.
Correspondence
Correspondence,
laboratory,
including
little later material.
mainly
memoranda,
negotiations
on
conducted by Perutz 1963-64 with
extension
MRC,
research notes and ideas from colleagues and
also
to
but
a
1967,
and
for
EMBL,
or
possible
material
1965,
accommodation
for
memoranda
Miscellaneous
correspondence
European scientists, 1968.
later
on
is documented in Section C.
Much of the material deals with the laboratory's later needs for
computer hard or software.
Equipment for Kendrew'’s own research
APPARATUS AND EQUIPMENT
NCUACS 11/4/89
J.C. Kendrew
Computers
Conferences
MRC
facilities for staff of MRC Units, 1958,
computer
needs and
on
access
to
computing
1962.
General
correspondence,
memoranda,
estimates,
notes
of
discussions,
Cambridge
officials,
requirements,
1961-69.
meetings
University,
covering
and committees,
with computer firms,
all
aspects
of
in MRC
computer
purchase,
hire or collaborative use of
laboratory
and
colleagues and MRC
and
machines
policy
memoranda and notes from other members of
Includes
in
reports received from colleagues working elsewhere.
particular D.M. Blow,
U.W. Arndt,
laboratory,
and also information and
Correspondence,
Cambridge University Titan machine.
memoranda,
discussion
notes etc.
1963-69
on
at
Computer
discussions
(to
a cost of
1966
memoranda,
Correspondence,
1963-66
process
£140,000.
complaining of poor performance of machine.
on purchase by MRC of Ferranti Argus 304
data from X-ray diffractometer,
of letter by
Includes
notes
copy
of meetings and
see D.11) at
Perutz
and
time
November
papers 1963-67 on use of computer
Correspondence
Atlas Computer Laboratory.
processing camera for slide making.
Correspondence, memoranda, discussion notes, costings etc.
66
apparatus.
performance of Ferranti apparatus.
1959-
diffractometer
poor
of
Includes
Watts/Ferranti
Hilger
copy
correspondence
Miscellaneous
See also D.9.
purchase
complaint
Polaroid
1957-61
Perutz
rapid
on
&
of
on
by
on
NCUACS 11/4/89
J.C. Kendrew
Computing Staff
Tabulated information by Kendrew and others on requirements
computing staff for various members of laboratory.
on those engaged.
for
A few notes
Correspondence
work
Kendrew’s notes.
as
computing
with successful applicants for full or part time
Includes
laboratory
1957-62.
staff
in
Research Staff
earliest
Applications
mainly
vitae,
1962
but
to
1969-73.
curricula
recommendations and a log of correspondence (compiled in
work in laboratory,
Material includes
date
correspondence,
laboratory).
NCUACS 11/4/89
J.C. Kendrew
RESEARCH AND ADMINISTRATION
and minutes of laboratory Board meetings,
administrative papers
Miscellaneous
agendas
equipment,
new
laboratory, finance, a little correspondence.
space allocation,
proposals
1961,
lists of personnel and
research projects or sub-divisions
1964-74.
for
Includes
requests for
visitors,
the
in _
Miscellaneous
laboratory:
research
reports
and proposals
by
members
of
TMV
1964
K.C. Holmes, A. Klug
X-ray diffraction
n.d.
unsigned
Nucleic acid
Chymotrypsin
Mass spectrometry
F. Sanger
D.M. Blow
F. Sanger
NMR
A.D. McLachlan
for
MRC
to
of
visit
Division
(Chairman) ,
synopses
Subcommittee
talks accompanying demonstrations
for symposia and study courses on the
A.S.V. Burgen,
R.D. Preston and P.M.B. Walker.
Notices, applications etc.
work of the laboratory 1967-73 and undated.
of
Arrangements
Members of the Subcommittee were
Structural Studies 9 May 1973.
A.F. Huxley,
Pe:
J.A.B. Gray
Includes programme,
Phillips,
timetable,
and
other background information supplied to Subcommittee, report on
visit and comments.
other business trips for 1975.
Brief notes by Kendrew on various matters related to laboratory,
including a breakdown of time spent in UK,
at EMBL, on ICSU and
NCUACS 11/4/89
J.C. Kendrew
135
D238
Structural Studies Committee Meetings 1-118,
3 March 1975.
10 February 1969 -
agendas,
Includes
correspondence,
allocation,
financial
Structural Studies Division.
and
space
visitors,
estimates and allocations relating to the work of the
requirements,
dealing
with all aspects
background
papers
staffing,
apparatus
and
equipment
minutes
and
some
of
N.B.
For meetings 1-7 only the agendas survive.
HISTORICAL
Miscellaneous
the laboratory in 1987.
items commemorating the fortieth
anniversary
of
NCUACS 11/4/89
J.C. Kendrew
SECTION E
CAMBRIDGE : UNIVERSITY AND COLLEGE
INTRODUCTION
CAMBRIDGE UNIVERSITY
Bee ee
E.3°=E.5
Teaching and curriculum
Committees
E.6
Electoral and Advisory Boards
E.14
Prizes
Bed5), EG
E.7 -E.10
E.11-E.13
Supervision
PETERHOUSE
Scholarship and entrance examinations
Mastership elections
NCUACS 11/4/89
J.C. Kendrew
INTRODUCTION
The
material in this section deals with Kendrew’s postwar career
at
Cambridge.
Though by no means a complete record, it gives some picture of his
involvement in university and college life.
For virtually the whole of this period, that is from the start of the
MRC
Unit
on 1 October 1947,
Kendrew was a full-time salaried member
of
the
staff
of
the
Medical
Research
Council and indeed
remained
so
until
his
retirement
from EMBL in 1982.
His own position,
like that of the
MRC
Unit
itself,
was
thus
somewhat
ambivalent
vis-a-vis
the
organisation
of
the
university
and its collegiate life,
but like many of his colleagues he made a
full contribution to the requirements of research,
teaching and administration
at
university level,
while his connection with Peterhouse gave him
a _ valued
link with college life.
Sciences
Sciences
he
an
own
to
1953,
and
July
1947
he
was
elected
1953
until
1950-56
and
a
resigned
in
organised
the
Kendrew
was
College Lecturer in
Natural
research
during the 1950s,
accustomed efficiency;
he continued to be actively
involved
Honorary
Fellow
in November 1975.
Despite the intense pressure of
his
He was Director of Studies in Natural
to
a Supernumerary Fellowship from
crystallography section of the MRC Unit,
with many aspects of life at Peterhouse.
elected to a Research Fellowship at Peterhouse
July 1975 on his secondment to Heidelberg;
Governing Body served on various committees.
together with his responsibilities for the protein
selection and tuition of scholars and undergraduates
R.8,
of his developing research and of the early growth of the
he was Steward from 1955 to 1959 and as
a member of the
latter is held in the College Archives.
Information
about
Kendrew’s appointments at Peterhouse is
Official material relating to the
of
his
Research
Fellowship 1947-53
give
They are included at C.27.
succinct
and
interesting
to the Master of
Peterhouse
during
the
with
his
1956-67
and
Kendrew’s
annual
MRC
Unit.
tenure
accounts
from
1
at
reports
NCUACS 11/4/89
J.C. Kendrew
CAMBRIDGE UNIVERSITY
Teaching and curriculum
record.
Notes of graduate supervision fees paid to Kendrew 1950-68, kept
J2D.: Watson; oR Gs
as
Parrish,
Poe.
Bretscher.
R.A. Crowther,
Py Paueine,
C.L. Nobbs,
H.E. Huxley,
include
Names
correspondence
Brief
subject
suggested by J.W.S. Pringle and J.A. Ramsay.
papers
in Part I
biology"
1959-60
of Natural
cell
and
on
proposed
Sciences
"Half
Tripos,
Committees
Deer
and
of
the
General
report
Board on
the
1968-70
on
Committee
and
brief
long-term
Department.
needs
and _
departments;
correspondence
J.B. Hutchinson
were E.C. Bullard,
Copy of published report.
Chairman of the Committee
to administer the funding,
of
the
J.C. Kendrew.
December
Committee
scientific
members
The
1965 as no.4485 of the Cambridge University Reporter.
was submitted in October and published in
the Chairman was W.A.
the discontinuation of the Department of Colloid
Papers
of
Management for Biophysical Chemistry and Colloid Science, set up
after
Science
staff and research of
in July 1968,
the
G.B.B.M.
Sutherland.
but nominated Kendrew.
Correspondence and material prepared by the "Professorial Group"
discussion
(Chairman A.S.V. Burgen,
with
group,
Biological Sciences Sub-Committee,
Visit of U.G.C.
January
1970
the
departments of biology and to discuss problems that may exist at
Cambridge."
"to learn as much as possible about the activities of
M.F. Perutz was asked to join the
Secretary D.F. Barton) for
Sub-Committee.
The
was
21
NCUACS 11/4/89
J.C. Kendrew
Electoral and Advisory Boards
Material relating to the following, on which Kendrew served, has
been passed to Cambridge University Archives, University Library
Cambridge (Ref: KEN. A-F):
1969
Advisory
Biophysics
Committee
on the Plummer
Professorship
of
Elector
Computing Service
to
the
Directorship
of
the
University
Elector
Biochemistry
to
the
Sir William
Dunn
Professorship
of
Elector
Genetics
Advisory
Physics
to
the
Arthur
Balfour
Professorship
of
Committee
on the Plummer
Professorship
of
NCUACS 11/4/89
J.C. Kendrew
PETERHOUSE
Scholarship and Entrance Examinations
the
time
in
at
a
held
for
at
aiming
separately
candidates
entrance as a commoner were held in March.
These
were
Examinations
exhibition were held in December;
for
their
and marked in common;
"King’s
Pembroke,
Entrance
colleges.
question.
or
examinations for those aiming
held
set
the relevant group here was known as the
Peterhouse,
Colleges.
individual
scholarship examinations in small groups with papers
examinations were usually organised by the
and consisted of
scholarship
and Corpus
Colleges
Gonville
College,
Christi
King’s
group"
and
Caius,
scholarship
1959,
group
Entrance
1951,
the
standard of questions set and analyses of performance, some with
preliminary correspondence and drafts.
and exhibition papers
comments by Kendrew
1953-57,
King’s
with
most
for
on
1963.
1956m.
1958;
Full
Sh L909
with notes and analyses
performance tables of all candidates in King’s group 1954-
Peterhouse entrance examination papers,
of performance, 1950-59, 1962,
Kendrew’s notes on interviews with Scholarship candidates
19535;
71959.
1952,
NCUACS 11/4/89
J.C. Kendrew
Supervision
Kendrew’s notes on undergraduates supervised 1947-50.
Miscellaneous
Peterhouse undergraduates 1962-67.
reading
lists,
correspondence
with
or
about
Correspondence on the supervision system at Cambridge, with W.B.
Harland 1964, H. Butterfield (then Master of Peterhouse) 1965.
Correspondence,
for college prizes,
(Tait Prize 1949, Sohan Lal Bhatia Prize in Physiology 1963-66).
suggestions for titles etc.
Prizes
Mastership
Correspondence and papers 1967-68.
Correspondence and papers 1972-73.
NCUACS 11/4/89
J.C. Kendrew
EUROPEAN MOLECULAR BIOLOGY
INTRODUCTION TO SECTIONS F,
G AND H
European
collaboration in research and teaching in molecular biology
was
a cause to which many scientists devoted themselves from the early
1960s.
Kendrew
was
closely
involved with the movement
from
its
first
inception,
holding major offices in committees,
advisory boards and working groups,
and,
through
his
participation in many of the similar bodies of the UK
scientific
consultative
establishment,
playing
some part in the direction
of
official
opinion.
Though
the detailed history of the movement is exceedingly
complex,
its
outline is simple.
It began with the formation of the European Molecular
Biology Organisation
(EMBO),
set up after various preliminaries
in
February
1964.
This was,
and remains, a private organisation of scientists working in
(EMBC);
The
proven
of
courses,
success
aiming
to
fellowships,
promote
research
meetings
and
eventually
led to
a
series
to an agreement
the
field,
with
Statutes,
shown
from
the
by
thirteen
West
intergovernmental
admissions to seventeen.
Funds for these purposes
and the
helpful
initiative
a Council and an elected
membership,
European Molecular Biology Conference
of
the EMBO programme over this period,
earliest days by the Swiss Government,
summer schools, and collaborative research.
and teaching in Europe by long- and short-term
grant from the Volkswagen Foundation for the three years 1966-68.
were provided by small grants, and, from December 1965, by a major pump-priming
always
comparatively simple low-cost means such as fellowships and courses had not met
the establishment of a major research institute or laboratory had
fostering of European excellence in molecular biology
with the administration and implementation thereof.
for the scientific programme drawn up by EMBO which is
The members of the Conference are representatives of
it
is clear from the very earliest
and its principal role is
to agree a
is
achieved
relatively
free
from
the agreement was
reached
in
In this way the primacy of
really serious opposition,
not
individual scientists,
European states,
increased
by
later
to
establish
a
scientific
aims
then
entrusted
their
number
bureaucracy.
international
governments,
budget
by
documents
While
the
1969
EMBO's
with
that
NCUACS 11/4/89
J.C. Kendrew
been
part
of the plan and that this project was especially
dear
to
Kendrew
himself.
It
was written into all the manifestos and proposals,
a Laboratory
Committee with Kendrew as chairman was in being from 1964,
a proportion of the
Volkswagen
grant
was earmarked for feasibility studies and
the
EMBC
budget
included
from
the
first a provison for
laboratory
working-groups.
it
29s
equally clear that the laboratory project was regarded as highly controversial,
by
governments
because
of
its
high and
continuing
costs
(especially
as
presented in its first and grandiose form),
and by many scientists and members
of
EMBO
itself who disliked and saw no necessity for the concept of
a
large
international
institution
which
might
cream
off
gifted
researchers
from
national
centres
of
excellence.
The Laboratory proposal had
to
be _
soft-
pedalled
at the intergovernmental meetings,
the plans themselves were
scaled
down,
in Britain many high-level debates continued to show reluctance to admit
the
necessity for such an institution,
and not all the members of
EMBC
were
able
to afford a contribution to the cost.
Nevertheless the tenacity of
the
proponents of the laboratory scheme was rewarded when in May 1973 the Agreement
was
signed
by
ten
of the thirteen EMBC
states
establishing
the
European
roof.
The
memoranda,
for
In
Molecular Biology Laboratory
(EMBL).
By that date a site had been agreed
at
special
facilities
Heidelberg
where
Scientific
Advisory
The
laboratory
was
consists of letters,
formally opened in 1978.
were well advanced and a Provisional
they
maintain
separate
offices
under the same
1974 the Secretariat of EMBO as well as
of EMBL moved to
material relating to all these organisations which is
here is
of historical interest for its content and also for its provenance.
Heidelberg, with temporary accommodation at other institutes in the town, plans
collaboration with the “outstations" at Hamburg and Grenoble which offered
Committee had been set up in October 1971 to establish a programme of research.
There is also a considerable
uniquely placed at
or near the centre of the developing project.
service as the first Director-General of the EMBL came
informal discussions by groups of molecular biologists
staple is Kendrew's own carefully-preserved accumulation of
correspondence on the subject for incorporation.
reports and drafts covering twenty years from
he was Secretary-General of the EMBC 1970-74
served on its Council 1963-71 and 1975-77 and
and
Project-Leader
1971-74 then Director-General of the EMBL.
as its Secretary-General 1969-74;
also a founder member of EMBO,
he was a founder member of EMBO,
its Deputy Chairman
Professor
Jeffries Wyman,
Secretary-General
own
papers
and
has
made
over
his
when
Kendrew’s
the
earliest
to
1982
to
an
files:
He
was’
thus
In addition,
preserved
It
and
first
1963-69,
end.
The
NCUACS 11/4/89
J.C. Kendrew
amount of material of Max Perutz,
the first Chairman of EMBO and a prime mover
in
the early meetings and the negotiations for the vital Volkswagen grant
and
the intergovernmental meetings;
and there are letters, carbons or photocopies
exchanged
between
most
of the founder members of EMBO who were
all
leading
scientists working for the encouragement of European collaborative research
in
the intervals of active laboratory life.
The
early
history
of EMBO and of the
"Swiss
Initiative"
leading
eventually
to
EMBC
are thus very well documented in almost every
aspect
by
original material.
The records of the early history of EMBL are unique because
of Kendrew's special commitment to the project;
they include the
preparatory
studies
carried
out
under
EMBO and EMBC and
also
the
building,
research
programmes and administration of the laboratory itself.
Some of the political
dimension of the project as
it affected Britain can be traced in the papers
of
the
Royal
Society's
International
Relations
Committee,
the
Council
for
Scientific
Policy
and
less
extensively of
the
Medical
Research
Council.
Developments
in
other
European
member
states
can
only
be
glimpsed
in
correspondence
with
colleagues
and there is
no
official
intergovernmental
earliest
The
separate
and
remain
material
-
there
(Section
G)
interlinked
in
a
careful
material as such.
present
it
in
the Conference
EMBC
each of which has
its
own
introduction
and list of contents.
and the Laboratory EMBL (Section H),
abundance
of material has made it expedient to
It
is
of course acknowledged that this is
sections for the Organisation EMBO (Section F),
is some overlap when correspondence may range
Nevertheless it has a justification both in chronology and,
in some ways an artificial distinction and that - especially with the
topics and when meetings and membership of committees were arranged to coincide
Committee
scientists and scientific administrators in Switzerland leading to the
Both these organisations were obviously continuously involved with
The EMBO material remains primarily the continuing story of
a private scientific organisation traceable from 1963;
was set up to decide a research programme and a
project and it
is much more difficult to
the first surviving document here is
of
Kendrew
was
appointed
Project
Leader,
political decision to establish EMBC:
The choice has been made of 1971,
political and administrative
considerations
a
Provisional
Scientific
Advisory
for
EMBL when scientific,
there is some
overlap
later, in separate
sometimes uneasily,
legal identities.
and _
balances.
system
of
checks
over several
July 1964.
the
laboratory
assign
a
"starting
Committee
combined.
date"
were,
through
when
Building
NCUACS 11/4/89
J.C. Kendrew
was established to determine site, specifications and choice of architect.
Every
effort
has been made throughout to avoid or minimise
overlap
and cross-references have been provided whenever they seemed useful.
The
success
of EMBO in weathering
financial
storms,
bureaucratic
takeovers and political indifference over so long a period, maintaining its own
entity
and
developing
to
play a significant role
in
an
intergovernmental
institution
such
as EMBC and a major international facility such as
EMBL
is
generally
agreed
to
be largely due to the
close
network
of
distinguished
scientists
who
knew and trusted each other as colleagues and friends.
On:
a
practical
level
this
means that many of the early
documents
in
all_
three
sections
are letters exchanged with varying degrees of informality.
Many are
in
longhand,
or
have manuscript additions and afterthoughts.
Not
all
are
dated, including many from J. Wyman;
not all are signed, including many of the
carbon
copies
from
M.F. Perutz;
these
have been
assigned
a
place
and
provenance from their content.
It should also be remembered that the MRC Unit
at
Cambridge was Kendrew’s base until 1974 and that much of the work of
EMBO,
members
of
Perutz
and
Hoh. Huxley,
Bo HeG. Grick,
EMBO
and
its
its Staff (S,. Brenner,
A. Klus in addition «to
EMBC and EMBL emanated from there,
as well as letters on the unmistakable pink
Kendrew) who were founder or very early members of
copy paper apparently favoured there during the 1960s from the leading
committees.
NCUACS 11/4/89
J.C. Kendrew
SECTION F
EUROPEAN MOLECULAR BIOLOGY ORGANIZATION (EMBO)
Pel-h 239
INTRODUCTION
EARLY HISTORY
ol beg
Preliminary meetings and correspondence 1963
iLO=Be15
Formal constitution and statutes
~ 16-833
Relations with other organisations
.34-F.42
Policy document
.43-F.56
Funding
.97-F.60
Miscellaneous correspondence
MEMBERSHIP
COUNCIL
Circulars and lists
1964-75
Minutes and circulars
1963-81
Membership and elections
1963-74
Nominations and elections
1963-82
Correspondence and meetings 1964-80
1965-73
Correspondence and papers
Fellowship applications
1964-74
1965-74
1964-74
FUND COMMITTEE
F.130-F.
P.133-F*
F.141-F.
Membership
He 150
Minutes
NCUACS 11/4/89
. Kendrew
COURSE COMMITTEE
Lobb 53
Membership
1965-74
F.154-F.167
Correspondence and papers
1965-74
F.168
Minutes and circulars
1966-69
LABORATORY COMMITTEE
F.169-F.208
Meetings, correspondence and papers 1963-73
ADMINISTRATION
P2209 -P: 210
Appointments
Pozilen 215
Finance and accounts
FeZLG6=F 220
General administrative correspondence
MISCELLANEOUS
Pio2s07k 231.
Re252
1974-80
Peg
Minutes
F.221-F.228
Correspondence and papers
1974-81
SYMPOSIUM COMMITTEE
1966-81
Press releases, articles, comments 1963-71
Annual reports
NCGUACS 11/4/89
J.C. Kendrew
INTRODUCTION
The
earliest
surviving
documents
(F.1) are
dated
January
1963.
References in the correspondence,
and Kendrew's later letter of 1971
included
in
the same folder,
mention informal discussions in Geneva and Washington
at
the end of 1962 in which Kendrew, J.D. Watson, and V.F. Weisskopf took part and
L. Szilard
played
a leading role.
(Szilard's early involvement and
strong
encouragement
of
the project were subsequently commemorated
in
the
Szilard
Library
at
EMBL.
See:
Pr4h.>
8.46.
Ho b4s “He 312)...
At this
early
stage,
throughout and indeed considerably later than 1963,
the possible establishment
of a central organisation and institute in Switzerland on the model of CERN was
envisaged.
The
project
was
often
referred
to
as
CERB
(the
biological
equivalent
of
CERN);
other
names and acronyms
were
European
Fundamental
Biology Organisation (EFBO) and European Biological Organisation (EBO).
The
crucial
preliminary meeting,
and the first attended by
Perutz
much
close
through
personal
F.61) and _
the
(F.4-F.7).
Here
relationships
with
scientists
This, like most
(F.8,
F.9),
suggestions
notably the
two
was held at CERN;
research
institute.
of
the early meetings,
links with
Switzerland
continued
for membership were requested (F.60,
of the future shape of the organisation was determined,
A provisional executive committee was appointed and
met
(later first Chairman of EMBO) was at Ravello in August 1963
constituent Council meeting was held in February 1964 (F.80).
E. Kellenberger and others) and the encouragement of the Swiss government.
purposes of funding research fellowships and courses and the establishment of a
In
aide-memoires and notes of meetings or discussions for private circulation.
The first Council meeting ushered in a period of great activity,
the drafting of a constitution (F.10-F.15), the formalisation
aims (F.34-F.42) and the assuring of funds - EMBO is
bound up with the problem of EMBO's relations with,
no subscription or entrance fee.
correspondence and reports and
of international bureaucracy.
were too narrowly confined
or
UNESCO
entailed
the
slower
pace
and
The funding problem
was
national
boundaries
or
limited scientific aims,
Some of these
negotiations
while others
such
as_
the
or independence of,
it was thought,
well documented:
organisations,
some of which,
documented
(F.16-F.33)
through
also
through
elective
and
ramifications
Council
of
Europe
other
by
of
EMBO'’s
there
is
political
are
(Weisskopf ,
all
closely
NCUACS 11/4/89
J.C. Kendrew
the
event
EMBO kept its independence and launched
its
scientific
programme
thanks
to
a three-year grant from the Volkswagen Foundation (F.43-F.49) which,
together with the diplomatic efforts of the Swiss government, saw it through to
the signing of the intergovernmental agreement to provide financial support.
All
these administrative and financial matters,
and the
continuing
negotiations
with
the
Swiss
government,
necessitated
relatively
frequent
meetings
of
Council
in
1964
and 1965 as well
as
private
discussions
or
attendance
at
meetings
which
were reported to
Council
members
by
postal
circular.
The
papers
and
correspondence for these early
meetings
are
of
considerable
interest
in tracing the growth of EMBO through the
efforts
and
personal connections of its founder members.
Although
the
rules of EMBO prescribe that the Council
should
meet
"not less than once a year, normally in January or February", this steady state
was rarely achieved.
The movement towards the establishment of the Conference
and the protracted negotiations for the existence,
scope,
site and funding of
the Laboratory all required special meetings,
the setting-up of working groups
and
the
Council
EMBO's
Committee
Fund
May
which
1964.
1965;
the
Course
fellowships
papers
should
be
to
the
EMBC
Full
records
From 1966
the
material in Section G.
short- and
long-term
implemented
through
the
scientific
programme
was
and the Laboratory Committee
founding documents up to 1974.
preparation of reports and position papers.
and
which met for the first time in November
which received and evaluated applications for
consulted in conjunction with those relating
Committee which first met formally in July 1966;
had its first meeting jointly with the World Health Organisation in
the
the second intergovernmental meeting of January 1968
of Kendrew's special involvement with it
(he was its chairman from its
inception
until 1969) and because of the lukewarm and even
hostile
project encountered from scientists and politicians.
records of the Laboratory Committee are of
the intergovernmental meetings and to the
other EMBO committees and its main task
of
all these committees are preserved here
submission
to
EMBO
members,
European
Molecular
proposals
and
costs
for
to
the
Volkswagen
(F.171-F.182)
It met
less
regularly
than
Foundation,
devised in
1967
Biology
Conference.
from
their
submitted
to
A
major
proposal
to
prepare
particular
was
where
interest
reception
The
because
the
to
which
the
was
NCUACS 11/4/89
J.C. Kendrew
agreement was reached to provide,
initially for five years,
resources for the
EMBO
programme.
The
cost
of this first laboratory
scheme
was
considered
excessive
and
an important meeting of EMBO members and other
scientists
was
held in November 1969 at Konstanz;
here the scientific programme was
revised
and
working parties were set up for each of the specific activities agreed
as
most
appropriate for an international laboratory (F.190-F.194).
The
revised
proposal
(F.195,
F.196)
was published in February 1970 and discussed at
the
first plenary session of EMBC in April 1970.
It was accepted in principle and
the
Conference
set up its own working parties in November
1970
to
consider
specific aspects of the laboratory;
these are documented in Section G.
In
addition
to
these
three
original
committees,
special
EMBO
committees were set up from time to time.
Of these, the Symposium Committee is
documented (F.221-F.229) from its inception in 1974 until its absorption in the
Course
Committee
in 1980.
The ad hoc Committee on rDNA which was set up
Council
in
January 1975 was established as
a
Standing Advisory Committee
by
in
January 1976.
Its recommendation at its first meeting in February 1976 that a
set up within the framework of
EMBL
led
to _
the
containment
laboratory
be
laboratory,
development of the "P4" facility.
All the material relating to the containment
including papers preceding and relative to the EMBO Committee, are
in Section H.
NCUACS 11/4/89
J.C. Kendrew
EARLY HISTORY
PRELIMINARY MEETINGS AND CORRESPONDENCE
Geneva 28 March
laboratory
Correspondence and papers, January - March, on plans for proposed
international
by
Weisskopf.
scientists to
be
No agenda or note of discussions are included;
those invited included J. Monod, C.H. Waddington, A. Engstrém, H.
Friedrich-Freksa,
M. Delbruck, E. Amaldi, A.A. Buzzati-Traverso,
L. Cavalli-Sforza.
Includes Kendrew’s notes of costings,
and meeting held at
approached.
chaired
CERN
Waddington’s
C.H.
objections
continued to be made throughout the ensuing decade.
March outlines
centralised
letter
idea
the
of
to
of
11
a
many
of
the
which
laboratory
included
Also
Szilard
Szilard's part in them.
which
in
here is correspondence 1971 with a biographer
Kendrew outlines the
early
discussions
of
and
Geneva 28 June
for
choice
at
meeting
Europe"
meeting,
"Proposal
presented
(Kendrew’'s
"European Biological
Ravello 16-17 September
laboratory of molecular biology in
",
an
CERB,
Organisation"
Correspondence April - June on arrangements for
of participants, matters for discussion.
Draft and final "Record of Discussion on Molecular Biology ...
papers
international
Waddington’s non-centralised
EBO), comments by M. Delbruck.
Organization Subcommittee" (Chairman: Buzzati-Traverso).
meeting was held at the invitation of the
The
Society
papers were further discussed and the EMBO was set
with
Laboratory
Physical
Waddington
together
a
"Federal
provisional executive committee
(Chairman:
and
Perutz),
a
its summer course.
The Kendrew and
subcommittee
(Chairman:
Kendrew)
Italian
during
a
up,
NCUACS 11/4/89
J.C. Kendrew
bSZ
Correspondence February - August with organisers of meeting
colleagues;
discussions of proposals.
and
participants,
invitation,
proposed
includes
Correspondence July
draft proposals, and French representation at meeting.
with Szilard and
August
-
Waddington
re
Correspondence
meeting.
October
on
Kendrew’s
draft
summary
of _
the
of
Summary
annotated agenda of meeting,
proposals, ms. notes by Kendrew.
proceedings of meeting,
October,
lists of participants, comments on
Kendrew,
by
29
Provisional Executive Committee, Brussels 12 December
meeting
This
chairman
by EURATOM.
was organised by Buzzati-Traverso
as
The expenses were defrayed
acted
who
in the absence of Perutz.
meeting,
no
-
for
research
WHO
Wyman,
French
December
1963
proposal,
continuing
correspondence
Participation in
October - December.
EMBO
of
proposal,
of
minutes),
Wyman's account of meeting (there were
Agenda
formal
January 1964.
Correspondence
Js
cancer
invitations and nominations.
February 1964 the EMBO Council had its first meeting.
In
papers and correspondence for that and subsequent meetings 1964-80.
Correspondence on choice of lawyer.
Drafts
Kendrew,
first
lawyers
drafts
meeting in July 1964.
by
and presented to the
international
further
Council
in Belgium and Switzerland were approached and
the
Swiss firm was chosen at
FORMAL CONSTITUTION AND STATUTES
EMBO Council in February 1964.
constitution and regulations
Kellenberger and Wyman,
See F.80-F.118
drawn
up.
prepared
Firms
of
for
a
Perutz,
were
The
NCUACS 11/4/89
J.C. Kendrew
E53
FB. ld:
Manuscript notes and drafts, some dated January 1964, by Kendrew
and others.
Draft submitted by Belgian lawyers, with a little correspondence
and comments, April - June 1964.
Drafts drawn up by Swiss lawyers,
by Kendrew and Perutz, June - September 1964.
with annotations and comments
Final versions of Rules and Statutes (English and French).
Correspondence
registration of EMBO in Switzerland (12 July 1964),
drafts
amendments of constitution, February 1964 - September 1965.
members of EMBO and with Swiss lawyers
with
re
and
RELATIONS WITH
OTHER ORGANISATIONS
of
some private or
by
the
to
set
up
K.118 and K.119),
F.16-F.26
1963-68
movement
towards
EMBO was involved
UNESCO, ICRO,
ILSI
varying
degrees
numerous
initiatives,
World
Health Organisation
They are presented,
scientific
co-operation
in
the
national and some international.
these which are documented in
The
produced
some
several
detail.
order
forward concurrently, making the story a complex one.
1960s
semi-private,
with
of
for convenience, in chronological
though in fact meetings and negotiations were often going
to a similar
Attention is also drawn (F.169,
initiative
an
international health research centre, to which reference is made
in the correspondence.
in November 1963 (F.17).
the International Life Sciences Institute, was set up by a
of
P.B. Medawar
whose scope and
Its first meeting was
ILSI,
group
the Princesse Liliane Foundation.
were
aims were very similar to those of EMBO.
ICRO,
in
programme
proposed
Control Processes" (F.16).
the International Cell Research Organization, was founded
Biology
was
and
Kendrew
Molecular Biology
Belgian and foreign scientists under the auspices
among those closely involved in the plan,
consultant
as
supported by
as "convenor" on its "Panel 1,
UNESCO's
funds.
serve
was
and
to
UNESCO
Cell
J. Brachet and
1962
to
of
NCUACS 11/4/89
J.C. Kendrew
154
held,
similarity
in many respects between EMBO and ILSI
The
to
consideration of a merger of interests via UNESCO which provided
Several meetings
some administrative and financial assistance.
were
a
"Study on the present needs for international cooperation in the
basic biological sciences" (F.25).
not
and
to
to
for
intergovernmental support.
EMBO however preferred
become absorbed into a global institution of such scale
an "Expert Committee" was set up to prepare
"European"
maintain
search
links
and
led
the
its
in
May, September - December 1963.
Information
programme, budget etc.
about
ILSI,
constitution,
governing
board,
December 1963 - February 1964.
March - April 1964
Includes aproach to UNESCO,
London (April).
notes of discussions in Belgium and
and
28
of
UNESCO
draft
document
by UNESCO,
London
group
May - June 1964
meeting of working
July - September 1964
notes of meetings Brussels 3 May,
Arrangements
May,
"UNESCO Experts" in London 5 June.
arising.
Includes extract from EMBO Council meeting (financed by
UNESCO)
affirming Council's "intention to maintain complete independence
both
of
of
policy
(Perutz,
Kendrew) and ILSI (Medawar, Theorell, de Duve) London 22 July at
which
Medawar reported readiness of ILSI to negotiate agreement
with
up;
UNESCO
EMBO,
correspondence, minutes etc.
and other similar organisations in matters
EMBO
of UNESCO Expert Committee 19 October (official
two separate private accounts by Wyman) and
Minute
correspondence
November 1964 - January 1965
administration",
Meeting
and
Expert
Committee
meeting
with
and
of
and
was
set
NCUACS 11/4/89
J.C. Kendrew
B23
March 1965
sets
out clearly the objections both to
letter
to
Correspondence of Perutz with Brachet and with MRC;
clinically
a
Brachet
oriented scheme and to a broad international scheme;
the letter
to MRC on general aims of EMBO was written for MRC Sub-committee
meeting.
meeting
(hostile to the laboratory) for EMBO Council members.
Perutz's report
included
Also
the
on
is
April - October 1965
Meeting of UNESCO Expert Committee 17 September and its report.
of . report,
correspondence
and
comments
from
1966
Final
colleagues.
copy
CERN
1964
1964
1964-66
See also
Council’s
COUNCIL OF EUROPE
French Cancer Research Proposal
Committee for Higher Education and Research
Miscellaneous correspondence with F. Jacob, V.F. Weisskopf.
Miscellaneous correspondence with F. Jacob, A. Haddow.
B.8.
January 1965 - January 1966
had
The
been
research.
Its Study Group included molecular biology for discussion at its
Strasbourg
meetings at The Hague June and Aarhus October
March
deemed
unnecessary
in view of the negotiations by the Swiss Government
to convene an intergovernmental conference.
April - November 1964,
discussions at The Hague and Aarhus.
concerned since 1963 with projects for combined
correspondence and papers,
See memo. at F.32.
meetings and
Further
action
was
1965
and
March
1966.
1964,
NCUACS 11/4/89
J.C. Kendrew
156
Hd Ou
Interim
January - June 1965 between Perutz and
Correspondence
A. Frank
on
"International
Cooperation in Biology", including comments on meetings and EMBO
affairs.
Committee
discuss
Science
on
to
Council of Europe "Note on Council of Europe action in the field
of molecular biology" summarising negotiations.
Reports
Biology".
of Interim Committee on "International
Cooperation
in
EUROPEAN CELL BIOLOGY ORGANIZATION (ECBO)
1968-72
representatives at meetings
Correspondence and papers re setting-up of ECBO,
EMBO
foundation
plans.
(J. Brachet,
statutes,
meeting,
comments by ECBO on
nominations of
M.G.P. Stoker),
Laboratory
G.113
for later discussions on relations between EMBO
and
See
ECBO.
POLICY DOCUMENT
history,
timed
name
generally
Drafts
but
in
the
French and
programme,
and
a 36pp.
booklet.
philosophy
advanced
courses
and
booklet
was
study
sessions,
fellowship
and teaching
in April 1966 as
and _ scientific
publication of the
It set
programme
three-year
Foundation
made available in English,
booklet was an important element - hence the
1965
with the formal announcement of the
December 1965) from the Volkswagen
The
"Policy
Document"
Government's
initiative to launch an intergovernmental meeting leading to the
establishment of the European Molecular Biology Conference.
German,
The "Document",
out
was
published
of
EMBO’s
fellowships,
research
grants, the case for a European laboratory of molecular biology,
and financial estimates;
the EMBO Statutes and Rules were also
of the material had been prepared and agreed
included.
to
by
June
grant
coincide
(made
which
enabled
further
studies of the laboratory project, to go ahead.
printing.
The document,
a corporate version agreed by members of the EMBO
Council, drew very largely on the early "Proposal for a European
Cit.
Organisation
the
Waddington
"Draft
of
EMBO
March 1965 by A.A. Buzzati-Traverso (F.34) and "Policy for
drafts
Research
were assembled and circulated by J. Wyman and the final
version
to Kendrew who supervised arrangements for translation and
sent
Biology"
other source materials
for Operation and Activities of EMBO Fund"
of May 1965 by J. Monod (F.35).
August 1963;
applied to
it
-
in the Swiss
Fundamental
by
Kendrew
and
of
of
Proposal
Grants"
were
The
NCUACS 11/4/89
J.C. Kendrew
E57
Be 34
and
Waddington'’s
Kendrew's
Traverso’s paper March 1965 (Perutz'’s copy with ms.
and comments) ;
heavily rewritten by him.
revised version by Wyman;
August
paper,
Buzzati-
corrections
Kendrew'’s copy, very
1963;
Manuscript
mainly
by
contribution on policy on research grants.
and typescript drafts for sections of the
Wyman and Kendrew,
but including
J. Monod’s
document,
draft
Later heavily corrected manuscript and typescript draft.
duplicated
Two
(one in Perutz’s hand).
typescript drafts with
manuscript
corrections
and
Papers
draft
and correspondence arising.
correspondence May - July 1965
on
by Wyman to EMBO Council members 20 May,
circulation
their
of
comments
draft
July
1966
on
to be
French
as
of
a
with manuscript note by Wyman "Final
document
This (with version C.
With
printed".
Final
sent to JCK end of June for printing.
Ch.4)
was translated by Jacob and is
covering letter by Wyman, June 1965.
1965 - May
Kendrew's letter to
his letter to Wyman 4 May
Correspondence
booklet.
June 1965 - July 1966 re design and printing
translation,
Jacob
request
1966
10 August refers to the delay in publication at the
the Volkswagen Foundation;
Correspondence
circulation of printed version etc.
of
of
mentions a possible site at Nice for the EMBO laboratory.
Copy of booklet.
of
NCUACS 11/4/89
J.C. Kendrew
FUNDING
EMBO
formal
Several
after
the
successful
Volkswagen
December
programme
negotiations
papers at F.43-F.49.
initiatives in the search for funding were made in 1964
first
most
of these approaches in quantitative terms was to the
Foundation which agreed a grant of
in
EMBO
The
the
This enabled the
for fellowships and courses to prove its value.
and terms of the grant are well documented in
1965 for three years 1966-68.
DM.2,748,000
meeting.
Council
The
came
Although the VW grant was crucial, there were other smaller sums
which
to
survive administratively and start its fellowship programme on a
small _
of
individual members of EMBO and are presented at F.50-F.54.
These usually resulted from the good offices
in betimes in 1964 and helped the
infant
scale.
EMBO
F.43-F.49
Volkswagen Foundation
February - March 1964
H. Friedrich-Freksa with first suggestion of
Perutz’s
circular
giving
includes letter (photocopy)
to
approach
by
replies
Mainly
estimates to put to VW Foundation;
from
VW.
EMBO Council to
of
copy
Includes
O65.
March - September 1965
March - September 1964
original grant application sent to
Includes note of meeting 22 March with VW representatives.
Continuing negotiations, amended application.
October - November 1965
June
VW
NCUACS 11/4/89
J.C. Kendrew
F.47
November - December 1965
3 December.
Papers and correspondence for special meeting with VW to discuss
Includes Wyman's memorandum
terms of application,
VW
meeting and his annotated papers and copy of letter from
on
December
heads
10
of
four
2. Fellowships;
expenditure:
and
3. Courses
planning
the
setting-up of
a basis for a decision in principle
1. Administrative costs;
4. Costs relating to
a central laboratory.
studies
on
This covered
confirming
workshops;
grant.
work
and
as
N.B.
Wyman'’s memorandum refers to information from R. Kerschner
of VW that "Volkswagen's interest in EMBO was originally aroused
by a telephone call from Szilard just after the Ravello meeting.
It
to
Us.
this which led to the original Volkswagen
approach
was
1966
Mainly arrangements for administering grant.
1969-72
correspondence on final spending of VW
grant.
Later
here
A report
Volkswagen Foundation on the utilisation of the grant."
a copy of "EMBO Activities 1966-68.
is
Included
the
to _
fund
at _
the
made
were
1964-66
donations
Interpharma
E. Katchalski.
to the fellowship
Research Council of Israel
Various
request of
A
E. Kellenberger.
donation of S.Fr.42,000 was made through the good offices
Support for two fellowships, arranged by A.A. Buzzati-Traverso.
International Laboratory of Genetics and Biophysics
Amis de 1'Université de Strasbourg
A
C. Sadron.
was made through
donation
offices
$1000
good
1964
of
of
of
the
1964
1964
NCUACS 11/4/89
J.C. Kendrew
F.54
Sweden
1965
Support
for
A. Engstrém.
two
EMBO
fellowships
1966)
arranged
by
Other miscellaneous approaches
Ford Foundation
National Institutes of Health, Bethesda
1966-69
MISCELLANEOUS CORRESPONDENCE
every effort has been made to assign a specific place
While
correspondence
because
occasionally
They are retained here in chronological order.
they deal with several topics in the affairs
because they are peripheral to its main
to
a few escape classification usually
of
EMBO,
concerns.
and papers,
from scientists,
for information about EMBO,
Requests
science
journalists and editors, some with suggestions for collaborative
research or for projects to be undertaken by EMBO.
EMBO.
1964.
Science etc. following Council meeting of February 1964.
Mainly arising from press release and articles in Nature,
but referring to EMBL as well
1965-73.
Similar
material,
as
NCUACS 11/4/89
J.C. Kendrew
MEMBERSHIP
NOMINATIONS AND ELECTIONS
to
and
the
of
EMBO.
(F.61).
meeting
Committee
Executive
Provisional
Perutz
asked
become members
biologists
of
These were presented for consideration
After
European
Chairman
suggestions for membership from the founder members and
scientists
the
Council
(F.62-F.68).
of Statutes and Rules,
associate
The
constitutes
Should
the
consulted
in the early years of the circulars preserved at F.78.
the Ravello meeting it was decided to invite some 100-200
4s
for
leading
at
issued
With the formalisation of EMBO and the drawing-up
the procedures for election of ordinary,
established.
and
EMBO.
are
hence the importance especially
Assembly
by post by Council;
General Assembly and supreme
Council members were more
in February 1964 and
the
General
invitations
nomination
membership
convened,
election
members
closely
powers
organ
not
has
of
and
be
of
sent
from
with
after
members,
F. Jacob,
F.63-F.67
G.N. Cohen,
membership,
A. EngstrSm,
A.M. Liquori,
E. Kellenberger,
OGC.H. Waddington,
of invitation to
copy of
first
H. Friedrich-Freksa,
Perutz's circular letter 1 November 1963 requesting
for
Katchalski,
Sadron,
Maaloe,
Chantrenne and others.
suggestions
E.
Gi,
F. Lipmann, A.A. Buzzati-Traverso, 0.
H
replies
L:L. Gavalli-Sforza,
some with comments on EMBO
(several hostile to laboratory) or including personal
Letters of acceptance of membership,
programme
or scientific news.
Final lists of original membership compiled by Kendrew;
Perutz’s
letter
Council meeting.
Letters 1964 declining membership.
F.63
.64
oo
.67
. 66
NCUACS 11/4/89
J.C. Kendrew
F.69
Election of Associate Members 1965-74.
P./O-F.72
General correspondence on nominations,
and elections for membership 1964-82.
recommendations, ballots
F.70
1964, 1966-68
BT
1969-70
F.72
L97L- 75, L98E-82
Letters of acceptance of membership, 1969-74.
Papers and correspondence 1972-74 re new procedure for
aimed
membership
scientists working in new fields.
enlarging
EMBO
include
at
to
of
election
younger
Correspondence
for
discussion at Council meeting November 1972, circular to members
and selected comments by them.
procedure
prepared
drafts
new
and
on
be
on
work
of
1974
with
F. Jacob,
M. Eigen,
scientists requesting their consent to
Correspondence
with
nominated 1974, 1975.
The final membership
G. Klein, M. Sela and the
Correspondence
Committee and other EMBO affairs.
Election of Nominating Committee 1972-73.
was S. Brenner,
Chairman was N.K. Jerne.
Membership lists.
Miscellaneous circulars to EMBO members 1964-75.
CIRCULARS AND LISTS
Nominating
N.K. Jerne
NCUACS 11/4/89
J.C. Kendrew
COUNCIL
CORRESPONDENCE
AND MEETINGS
1964-80
2 February 1964, Geneva
This was the first formal meeting of Council.
included
relations with other organisations, registration.
membership,
elections
to
Matters discussed
funding,
constitution,
Folder
press releases, minutes.
discusses
and
" 'Fundamental
and
Biology’ might be better from that point of view".
includes correspondence preceding and following meeting,
28 January
feels
that
" ‘Molecular
Perutz’s circular letter of
organisation
presumptuous"
proposed
Biology’
name
of
is
12 July 1964
Comment by Council members April-May on proposal transmitted
F. Jacob
that part of French Government's Cancer Fund might
channelled via EMBO to support research in French laboratories.
by
be
2 February 1965
Agenda, circulars, memoranda, minutes.
Correspondence with members June-July.
Agenda, circulars, arrangements, memoranda, minutes.
in their countries.
Reports by Council members on developments in molecular biology,
and attitudes to EMBO,
Correspondence,
September 1964 - February 1965.
correspondence with
discussion notes,
8-10 May 1965
members
NCUACS 11/4/89
J.C. Kendrew
164
F.87
Circulars,
draft
minister Burckhardt).
note
on
memoranda, minutes, heavily-corrected draft minutes,
Swiss
developments"
"Further
(meeting
with
Correspondence with members March-April,
15 January 1966
Agenda, memoranda, circulars, minutes.
Correspondence with members and others July 1965 - January 1966.
14 January 1967
Agenda,
minutes.
arrangements, Perutz’s notes, Wyman’s notes of meeting,
Correspondence
Laboratory project, intergovernmental meeting).
May 1967
June
1966
(elections
~-
to
Council,
for
and
circular
Conference,
21 January 1968
on Draft Arrangements
Agenda, memoranda, circulars, minutes.
Correspondence December 1967 - March 1968.
Perutz’s
Council members’ replies.
Correspondence October 1968 - February 1969.
Agenda, circulars, minutes and correspondence re minutes.
Invitations, acceptances and arrangements.
12 January 1969
NCUACS 11/4/89
J.C. Kendrew
Mogg
Invitations, travel arrangements.
Perutz and Wyman resigned
as
President
being
replaced
by
M. Eigen
and
and
Kendrew
this
At
meeting
Secretary-General ,
respectively.
1 June 1969
Meeting
European Molecular Biology at CERN on 2 and 3 June.
preparation for
Interim
held
the
in
Conference
of
Agenda, papers, minutes, correspondence, travel arrangements.
26 November 1969
Meeting
Konstanz
meeting on laboratory plans.
held
at
immediately
preceding
(See also F.190-F.194.)
discussion
Agenda, papers, minutes, correspondence, Israel membership.
B LO24. b . OS
17 January 1970
F.102
Agenda, papers (revised laboratory proposal, indicative scheme).
5 April 1970
28 September 1970
Correspondence, travel arrangements.
Agenda, minutes, correspondence.
Meeting held at CERN preceding meeting of EMBC 6-8 April.
et seq.)
circulars, minutes, travel arrangements, correspondence
G.65
Joint meeting with Laboratory Committee.
up of Laboratory Working Groups.
Agenda,
Fos)
Agenda,
on
25
&
28 November 1970
travel
arrangements.
circulars,
minutes,
(See
also
(See also
setting
NCUACS 11/4/89
J.C. Kendrew
F107
26 April 1971
Emergency meeting of Council and Laboratory Committee to discuss
choice of site.
Agenda,
arrangements.
circulars,
memoranda,
minutes, correspondence, travel
11 October 1971
Agenda,
for laboratory, papers and proposals, correspondence.
circular re setting-up of Scientific Advisory Committee
3 December 1971
Agenda, circular, correspondence, travel arrangements.
ES-20;Aprel £972
A
joint
Committee,
laboratory.
meeting
with
discuss
Provisional
the
reductions
to
in
budget
estimates
Scientific
Advisory
for
programme
circulars,
papers
F.111-F.113
and
proposals
4 November 1972
(See F.205-F.207.)
Meeting
laboratory.
preceding "Haarlass meeting" on research
Agenda, circulars, memoranda, papers, correspondence, minutes of
meeting and of informal meeting 28 April 1972.
Agenda,
Katchalski memorials), correspondence, minutes.
party, and replies April 1973
Working party on programme and activities of EMBO after 1974 set
up
A.
Engstrém, J. Wyman, R.K. Appleyard.
to EMBO members on draft report of
Drafts November 1972 - May 1973 by several working party members
(includes
became
final text), correspondence re meetings and drafts.
heavily-corrected by
version
Kendrew
which
at
November
meeting;
the
members
were
N.K. Jerne,
(A. Tiselius,
Kendrew's
circular
working
NCUACS 11/4/89
J.C. Kendrew
F.114
12 January 1973
Agenda, minutes, correspondence, travel arrangements.
4 May 1973
Agenda,
arrangements.
papers and proposals,
correspondence,
minutes, travel
PelLiGi oP tis
12 February 1974
R- LEG
Agenda, memoranda, minutes of meeting and of informal meeting 20
October 1973, correspondence.
Travel arrangements and correspondence.
10 January 1975
was the last meeting which Kendrew attended as
This
General, his successor being N.O. Kjeldgaard.
set of papers (some annotated),
and
and to retiring members of EMBO Committees.
on elections as officers of EMBO,
Secretary-
Material includes
items
Kendrew's letters to new
correspondence on agenda
At
hybrid
to
and _
later
Council
biohazards.
See
the
possible
correspondence and notes on
EMBO
MEMBERSHIP AND
ELECTIONS
modifications
research,
DNA
the
the
the
H.100-
Miscellaneous
matters 1975-80.
biohazards,
design
to
of an ad hoc Committee on
permit
this meeting the Council discussed under Item 14
Nae:
matter
of
Laboratory
setting-up
HelOZ, H.156-H wy.
(1963) and original Council.
Lists
Kendrew,
indicating duration of service on Council and type of membership
(original member ;
invited) and extending
1963-90.
of Council membership compiled
compiled by Wyman of
Early
lists
"EFBO
Executive
elected;
co-opted;
and
charts
by
Committee"
NCUACS 11/4/89
J.C. Kendrew
F.120-F.127
Nominations,
membership of Council.
recommendations
and
general
correspondence
on
FoL20%
066
BotZe
1967
F122
1968
Ba f23
1969
F245
21970
F.125
LOL
F.126
1973
Fid27
1974
MINUTES AND CIRCULARS
Circulars sent to Council members July 1964 - July 1974.
Minutes of Council 1963-81.
NCUACS 11/4/89
J.C. Kendrew
FUND COMMITTEE
MEMBERSHIP
1965-74
Correspondence
H. Chantrenne (Chairman),
Hayes,
member.
H.T. Witt,
1965-66 on orignal membership of Fund Committee:
A.A. Buzzati-Traverso, J.A. Cohen, W.
C.H. Waddington was a co-opted
A. Engstrém.
Membership 1969-70.
Membership 1971-74.
CORRES PONDENCE
AND PAPERS
1964-74
policy
salary
scales,
his
fellowships
at
on
fellowships,
December 1964 - June 1965
Correspondence re appropriate salary scales.
material consists of correspondence between members of
Correspondence
and
EMBO
proposal for operation and activities of EMBO fund".
mainly with A.A. Buzzati-Traverso re support for
"Draft
his laboratory (Naples)
the
The
draft reports, budgets
Fund Committee and the EMBO Secretariat,
and financial estimates, memoranda and papers on meetings of the
Committee,
press
notifications.
minutes and memoranda, notes on salary scales.
Papers
held in Cambridge 8 November 1965.
meeting
Includes policy paper, draft
August and December 1965
and
correspondence for and arising from
first
NCUACS 11/4/89
J.C. Kendrew
F.136
1969-70
1972-74
FELLOWSHIP APPLICATIONS
Includes
documents, interview reports, recommendations.
application
letters
and
of
enquiry,
1964-74
supporting
1964-65
1966
1970
OTE
oi
1967
1969
1968
MINUTES
1973-74
1965-73.
Minutes
NCUACS 11/4/89
J.C. Kendrew
COURSE COMMITTEE
The committee was sometimes known in early correspondence as the
The
"Summer
Schools Committee" or the "Committee on Courses".
it as
EMBO "Policy Document" published in April 1966 referred to
"Committee on Courses" and "Course Committee",
the latter
form
being preferred as from the first formal meeting in July 1966.
MEMBERSHIP
1965-74
Correspondence
Committee.
period of service 1964-71
1965-66
Included here is Kendrew's chart of membership
on
original
membership
of
Course
and
Membership 1969-71.
Membership 1972-74.
of FEBS.
Includes co-operation with Course Committee
on
15
for
EMBO
1965-74
with
other
CORRESPONDENCE
AND PAPERS
March - December 1965
material deals with the organisation of EMBO summer schools
notes,
NATO),
and
(ICRO,
courses organised
policy
FEBS,
by
organisations
international
applications
support,
The
and
courses,
collaboration
information
others.
Includes information on course.
EMBO
Arrangements
policy
Council
drawn up by A. Tiselius (2 copies respectively annotated by M.F.
Perutz and Kendrew), and note of meeting.
EMBO support for "Course on Genetics and Physiology of Bacterial
Viruses",
from
Naples
Interpharma grant.
"ad hoc
January 1966;
includes draft proposals on
July - December 1965
Buzzati-Traverso) met
(Director:
for
Meeting on
Courses"
held
by
A.A.
NCUACS 11/4/89
J.C. Kendrew
B56
January - September 1966
and
Relations
Organisation
Societies (FEBS), Experimental Biology and Medicine.
co-operation with
International
Federation
European
(ICRO),
of
Cell
Research
Biochemical
March - December 1966
Policy,
paper on "The problem of EMBO courses".
course proposals.
meetings,
Includes R.K. Appleyard’s
June - September 1966
Proposed conference on spores.
March 1966 - January 1967
support for Oxford University Summer School
EMBO
Biology and Biophysics.
on
Molecular
January - October 1967
June 1968 - June 1969
May 1968 - January 1969
November 1968 - July 1969
Immunology workshop by J. Oudin (cancelled).
Course held in Greece (some political objections were raised).
1970-71
EMBO
Council January 1969.
by W. Hayes
Lecturers
proposed
scheme,
and
agreed
by
NCUACGS 11/4/89
J.C. Kendrew
F165
December 1971 - October 1972
Includes
from 1975 and renewal of EMBC Agreement.
letter from J. Wyman on future policy for EMBO courses
October - November 1972
EMBO support for Aharon Katzir-Katchalsky Memorial Conference.
1974
EEC Sponsored Courses.
MINUTES
Minutes and circulars
1966-69.
NCUACS 11/4/89
J.C. Kendrew
LABORATORY COMMITTEE
MEETINGS, CORRESPONDENCE AND PAPERS
L963-73
1963-64
and papers.
Includes Kendrew’s "Notes for
on an International Laboratory of Molecular Biology
the
Correspondence
meeting
to
be held in Geneva under the sponsorship of WHO 1-2 May 1964" and
Committee
his
membership was
L.L. Cavalli-Sforza, H. Chantrenne, A. Tissieres
and Kendrew (Chairman).
See also K.118, K.119.
the meeting.
Laboratory
The EMBO
minutes
of
1965
for
case
a European Laboratory
"The
Biology".
Kendrew's draft 29 April 1965 prepared for committee and Council
at request of Swiss government,
with a few manuscript revisions
by M.F. Perutz and J. Wyman.
Molecular
of
which
BF D7E-F ek82
Laboratory Proposal Document 1967
PUL LS
on 23 September.
was
project
drafts and memoranda,
document was prepared,
after consultation with members
Several
seconded from EURATOM as an assistant on the laboratory
in 1967.
the notes and documents are by M. Delauche who
The
of
EMBO, for discussion at a meeting of the Laboratory Committee at
The material includes correspondence on
Nice
the role of the laboratory,
notes of the
meeting and of the preparation of the final version,
was
submitted to the EMBC meeting in January 1968.
draft prepared by R.K. Appleyard.
Correspondence with colleagues on research projects
to
replies,
discussions
committee meeting.
appropriate
notes
of
preceding
early drafts and comments
notes of meetings and
Research proposals.
discussions,
and meetings,
laboratory,
analysis
of
June.
Includes
suggested
of
a
central
April, May.
NCUAGS 11/4/89
J.C. Kendrew
EES
BLS
July, August.
Continuing correspondence, drafts and comments.
draft
quoted extensively from the
drawn up by Wyman and Kendrew for discussion at
meeting.
Draft
"Policy
The
document"
and envisaged a series of appendices to be written by
individual scientists in support of the case for the laboratory.
Three
F.H.C. Crick and J.
See also F.177, F.178, F.184.
Monod are included in the folder.
of these appendices,
by J.A. Cohen,
original
EMBO
"Summary" of Nice meeting,
drafts, comments, September.
J. Wyman’s notes on meeting,
notes,
Information
budgets
various European laboratories sent to
colleagues in preparation for final draft proposal.
research programmes,
laboratory
for
on
costings
Kendrew
and
by
Tk LS
Correspondence
included.
October 1967 - January 1968.
re appendices for document,
some of
which
are
systems"),
as
of
of
B. Hartley,
at Cambridge
Antibody
Problem"),
conversations
H.C. Longuet-Higgins
Notes
costings, November.
(Appendix on "Organisms
V.F. Weisskopf ("The experience
M. Eigen and N.K. Jerne (Appendix on "The complete
the
F. Jacob
M. Delbruck,
solution
to
(Appendix on "Control Systems").
C. Levinthal,
self-organising
CERN and the proposal for a European biology laboratory").
by A. Katchalsky. )
10 "Annexes" are listed, but
a further unlisted Annex
11
Correspondence November - December, mainly comments on draft.
Version submitted to EMBC.
only
Amended draft proposal for laboratory, 69pp, November.
6-10 are present and there is
on
research
space
and
(N.B.
NCUACS 11/4/89
J.C. Kendrew
F.183
1968
correspondence on laboratory matters;
J. Wyman
to
O. Maalge inviting him to become Chairman
in
view of Kendrew’s move to
office
includes letter
of
Secretary-
of
General
from
committee
General.
.184-F.188
Committee meeting at Linton, Cambridge (Kendrew's home),
16 March 1969
Correspondence January - March.
the
Appendix to proposal document.
Laboratory"
EMBO
by
Includes note on "Teaching
intended
A.A. Buzzati-Traverso
at
as
Papers
R.K. Appleyard,
proposal.
circulated
for
0. Maalge
meeting,
by
and Kendrew,
Buzzati-Traverso,
laboratory
on revised
Memorandum and minutes of meeting,
June,
laboratory presented at Interim Conference, June.
drafts and circulars March -
proposed
delegation note on the
copy of U.K.
including
of
assembled
European
countries,
as
a result
Arrangements for meetings in March and June.
Royal Society Discussion meeting, 21 October 1969
Information on present and future plans for molecular biology in
various
March
meeting.
in Nature, 224.
This was a special meeting to discuss "greater participation
Dak.
particularly in its proposed laboratory or
material
signals
concern in the scientific world at the laboratory proposal,
immediately
which
scientific
some of the papers.
includes invitation,
by
Folder
Kendrew,
by
Kendrew, note by C.H. Waddington, Kendrew's note of speakers and
their opinions, report (apparently pirated) of meeting published
papers
contribution
included in this sequence because it
was debated and which is referred
by
and
The
the
and
the
in
laboratories".
M.G.P. Stoker,
Organisation
participants,
S. Brenner,
Molecular
"Konstanz
meeting"
precedes
the
programme
in
the
European
Biology
list of
at
to
draft
is
NCUACS 11/4/89
J.C. Kendrew
F.190-F.194
The "Konstanz" meeting
at
a
to
was
by
was
with
special
biology
held
Konstanz
invitation and was
This symposium "to discuss the present and future development of
European
molecular
1969.
laboratory",
Attendance
EMBO
The Laboratory Committee met twice during the meeting,
members.
on
groups
genetics,
were
appointed
instrumentation
more _ specific
scientific programme for a revised laboratory proposal document.
At the same meeting Kendrew agreed "to take on the directorship,
if the project proved to be good".
27 and 30 November and at the second meeting working
reference
27-30
not
subcellular
computation)
to
November
to prepare a
structures,
confined
(on
and
cell
success of the "Konstanz" meeting was such that it became a
the
was
plans
The
generic term for intensive research meetings of this kind;
similar
referred to as "Konstanz II" (F.205-F.207) and there were
for a “Konstanz (019°(H.147)..
Heidelberg
occasion
Haarlass
near
1971
at
in
See C.128, H.345 for Kendrew'’s notes on the meeting.
Circulars,
circulated to participants, photograph taken at meeting.
lists of participants,
invitations,
agenda, papers
Circulars only.
S. Brenner (Convenor).
Working group on cell genetics.
including comments on working group's
Working group on subcellular structures.
Correspondence and notes,
report sent to
"Notes on Embo meeting
"including the two meetings of the Laboratory committee,
Kendrew's notes for his opening remarks;
eS
unsigned but by J. Wyman.
Correspondence, notes, draft report by H.E. Huxley (Convenor).
Working group on instrumentation.
NCUACS 11/4/89
J.C. Kendrew
POD. ots 196
Revised Laboratory Proposal
Correspondence
circulation of document December 1969 - May 1970.
circulars
meetings,
and
on
preparation
and
of
revised
to
Copy
Conference as CEBM 70/12E, 76pp., and also of Kendrew’s "Summary
of
1
January 1970.
new proposals for an
international
laboratory",
submitted
February
proposal
EMBO's
1970,
16
Correspondence and circulars June - September 1970 re meeting of
The
Laboratory
Hague,
28
this
meeting
was
set up.
Committee as part of joint EMBO/EMBC meeting at
September -
the Sites Subcommittee of the Laboratory Committee
(See also F.105.)
1 October.
At
F.198-F.204
Sites Subcommittee
Heidelberg,
by
1971
Hamburg
-
as
of
as_
secretary.
November
1970,
conducted
its
in
Germany",
A. Tissieres
the members
H.E. Huxley,
February 1971).
and in its report
(January
Sites
Its.,.$Report
22
February
of visits January - July 1971,
consultants and M. Delauche
(November) and additional sites at
also recommended the Heidelberg
were
with D.C. Phillips,
its meeting at The Hague in September 1970 the EMBO
Council
At
a sites subcommittee of the Laboratory Committee with
appointed
K.C.
as
QO. Maalge
Chairman;
and
Holmes and C. Weissmann,
The
H. Zachau
subcommittee met and visited possible sites at Munich (October),
Karlsruhe
CERN
on.
and
a
Selection
1971,
"that the case for the Heidelberg site is by far the
considered
Meanwhile the official Sites Committee of EMBC, set
strongest".
own
up
the
Conference in
programme
of
July
G.74-
G.87.)
See also G.78.
sites
Also included is correspondence on various other possible
a
for
considerable
near
Geneva like that of CERN had been an early favourite and was not
easily
by
Italy and Austria, nor of a possible French site at Nice (though
see F. Jacob’s letter at F.202 and also F.40).
Sites subcommittee:
correspondence,
arrangements for meetings, notes and memoranda on sites visited,
report.
See G.87 for other, later suggestions.
No records survive here of offers
September 1970 - March 1971.
the idea of a
In
particular,
appointment,
laboratory
which
had
been
mooted,
often
for
site.
(See
site
made
the
time.
abandoned.
dated
membership,
NCUACS 11/4/89
J.C. Kendrew
F.199-F.204
Other possible sites for laboratory
Greece 1966-70, 1976.
Offer
made in 1966 and renewed in 1970 of accommodation in part
of the "Greek Institute of Basic Biological Research - Alexander
Fleming"
correspondence
with members of EMBO Council,
Greek colleagues and Lady Fleming
(also a later letter 1976).
founded by Amalia
Includes
Fleming.
He 99
1966
F.200
19;20;;..1976
Cambridge, 1967-68.
Correspondence and memoranda.
Geneva/CERN, 1969-70.
Correspondence and memorandum.
Edinburgh, 1970.
F.205-F.207
Culham, 1970-71
successful
first
meeting
(see
F.190-F.194).
"Second Konstanz meeting", 4-7 November 1972.
was generally referred to as "Second Konstanz"
very
was another meeting to discuss the scientific programme of
it was held at the Hotel Haarlass, Heidelberg,
of
The
was financed from $15,000 remaining from the Volkswagen
It was larger than the previous meeting, and
This
the Laboratory;
but
the
meeting
Foundation grant.
like it included invited guests as well as EMBO members.
Arrangements, travel claims, accounts for meeting.
Programme,
notes on scientific sessions (18pp.
meeting in unidentified hand.
Correspondence,
and final lists.
suggestions for participants, draft
December 1971 - November 1972.
correspondence with speakers,
ms.),
manuscript notes
Kendrew's
on
because
circulars,
circulars,
NCUACS 11/4/89
J.C. Kendrew
F.208
Membership of Laboratory Committee
Miscellaneous
1967-73.
brief
correspondence,
lists
of
members
etc.,
NCUACS 11/4/89
J.C. Kendrew
ADMINISTRATION
APPOINTMENTS -
EXECUTIVE SECRETARY
Appointment of R.K. Appleyard
with effect from 1 August 1965.
(seconded part-time from EURATOM)
Correspondence and negotiations July 1964 - August 1965.
Appointment of
J. Tooze with effect from 1 June 1973.
Correspondence and negotiations, Kendrew’s notes November 1972 -
June 1973.
FINANCE AND ACCOUNTS
Bank accounts in Brussels and Geneva 1964-68.
draft as submitted to EMBO Council,
with comments
and
of first EMBC meeting (April 1967)
by
estimates
for EMBO activities 1969-71,
prepared
at
R.K. Appleyard,
Revised
replies, June-July 1967.
Miscellaneous material on financial situation of EMBO, September
1967 - October 1968.
Financial
request
with correspondence arising with M.F. Perutz April-May 1967.
EMBO Accounts 1964, 1966-70, 1973-80.
NCUACS 11/4/89
J.C. Kendrew
GENERAL ADMINISTRATIVE CORRESPONDENCE
The correspondence consists mainly of exchanges 1965-73
R.K. Appleyard and J. Wyman, M.F. Perutz and Kendrew.
between
1965.
Price, Waterhouse as accountants.
Setting-up
of EMBO office at Brussels,
1967-68
1969-70
LOTT 7 Se
resignation as Executive Secretary.
Includes
brief
correspondence
appointment
of
on
Appleyard’s
NCUACS 11/4/89
J.C. Kendrew
SYMPOSIUM COMMITTEE
as
Heidelberg
was to help to establish the reputation of the
This was set up by Council in February 1974 to organise a series
One of the
of EMBO Symposia to be held annually in Heidelberg.
laboratory
aims
at
the
dissemination of leading research ideas.
at
first organised privately by EMBO outside its general scientific
programme under EMBC and therefore relied on independent finance
and
the
first in the laboratory itself,
in May 1978, coincided with its
formal opening.
The first symposium was held in 1975,
The symposia were
research
centre
major
fees.
and _
and_
for
on
a
At its meeting in January 1980 the EMBO Council agreed that
Symposium
and
responsibilities assumed by the Course Committee;
were
thus incorporated in the general programme
through EMBC.
the
its
the symposia
supported
dissolved
Committee
Standing
should
and
be
CORRESPONDENCE
AND PAPERS
1974-81
Lot?
1975
1976
iists’
of
Pie 22
#225
notes
Organising
programmes,
of symposia,
F.222-F.228
fund-raising,
participants,
Setting-up and membership of Committee 1974.
Committee
and
Developmental Genetics
Molecular Aspects of Gene Function
The Structure and Function of
Biological Membranes
Organisation
meetings,
correspondence, press releases or articles.
Minutes of Standing Symposium Committee 1974-80.
Molecular Biologists Look at Green Plants
Nucleic Acid - Protein Interactions
Ribosome Structure and Function
Molecular Neurobiology
MINUTES
1978
1979
1980
1981
NCUAGCS 11/4/89
J.C. Kendrew
MISCELLANEOUS
Correspondence
information
transcripts and manuscripts.
mainly
with
about
EMBO,
press
EMBC
and
1963-71
EMBL.
on
articles
Includes
and
some
Press cuttings, releases, comments 1964-71.
EMBO Annual Reports 1966-81.
