ABRAHAM, Edward Penley Vol 1 v2

ABRAHAM_EDWARD_PENLEY_Vol1_v2

Catalogue of the papers and correspondence of Sir Edward Penley Abraham FRS (1913 - 1999) VOLUME | Section A: Biographical Section B: University of Oxford Section D: Publications Section C: Research and development NCUACS catalogue no. 103/2/02 by Simon Coleman and Peter Harper E.P. Abraham NCUACS 103/2/02 Title: Deposited in: Reference code: GB 0161 Compiled by: Simon Coleman and Peter Harper Date of material: ca 1925-2000 Description level: Fonds Catalogue of the papers and correspondence of Sir Edward Penley Abraham FRS (1913-1999), biochemist Extent of material: ca 2450 items Department of Western Manuscripts, Bodleian Library, Oxford © National Cataloguing Unit for the Archives of Contemporary Scientists, University of Bath. NCUACS catalogue no. 103/2/02 E.P. Abraham NCUACS 103/2/02 THE COMPILATION AND PRODUCTION OF THIS CATALOGUE WAS MADE POSSIBLE BY GRANTS FROM THE EDWARD PENLEY ABRAHAM RESEARCH FUND AND THE EDWARD PENLEY ABRAHAM CEPHALOSPORIN FUND. E.P. Abraham NCUACS 103/2/02 NOT ALL THE MATERIAL IN THIS COLLECTION MAY YET BE AVAILABLE FOR CONSULTATION. ENQUIRIES SHOULD BE ADDRESSED IN THE FIRST INSTANCE TO: BODLEIAN LIBRARY KEEPER OF MANUSCRIPTS OXFORD OX1 3BG E.P. Abraham NCUACS 103/2/02 LIST OF CONTENTS GENERAL INTRODUCTION SECTIONA BIOGRAPHICAL A.1-A.115 SECTION B UNIVERSITY OF OXFORD B.1-B.92 SECTION C =RESEARCH AND DEVELOPMENT C.1-C.1114 SECTIOND ~~ PUBLICATIONS D.1-D.288 SECTION E LECTURES AND BROADCASTS E.1-E.63 .SECTION F VISITS AND CONFERENCES F.1-F.89 G.1-G.90 SECTION J J.1-J.43 SECTIONH CORRESPONDENCE H.1-H.563 SECTIONG NON-TEXT MATERIAL SOCIETIES AND ORGANISATIONS INDEX OF CORRESPONDENTS E.P. Abraham NCUACS 103/2/02 GENERAL INTRODUCTION PROVENANCE The papers were received from the Sir William Dunn School of Pathology, University of Oxford, with additional biographical material from Mrs T. Mayes, Sir Edward Abraham’s niece, in summer 2000. OUTLINE OF THE CAREER OF EDWARD PENLEY ABRAHAM Edward Penley Abraham was born at Southampton on 10 June 1913 and educated there at the King Edward VI School. He won an exhibition to Queen’s College Oxford, taking a First in chemistry and acquiring a particular interest in organic chemistry. At the Dyson Perrins Laboratory in Oxford he undertook research on peptides and studied for a D.Phil. under Robert Robinson. His work included an important contribution to the study of lysozyme which was also being investigated by Howard Florey and Ernst Chain at the Sir William Dunn School of Pathology. After taking his doctorate in 1938 Abraham was able to develop his increasing interest in biochemistry at the Biokemiska Institut, Stockholm, which he attended as a Rockefeller Travelling Fellow. He returned to England the following year and in January 1940 took up a post at the Sir William Dunn School of Pathology at Florey’s invitation. During their investigations of naturally occurring antibiotic substances, Florey and Chain had turned value. successful clinical trial of penicillin on humans in February 1941, Abraham played a significant role in the elucidation of its chemical structure and in 1943, with Chain, proposed the novel beta-lactam course of this research he and Chain observed that the antibiotic was destroyed by an enzyme produced in a strain of E-coli. The discovery of this enzyme, named penicillinase, proved to be of their attention to penicillin in 1938. After experiments on mice in the summer of 1940 yielded (henceforth written B-lactam) structure with a fused two ring system. This theory was strongly great importance to future studies of micro-organisms and antibiotic resistance. Following the first encouraging results, Abraham joined the work on the purification and chemistry of penicillin. In the A culture of the cephalosporium fungus, whose antibiotic properties were first discovered in Although the astonishing clinical impact of penicillin would overshadow all subsequent breakthroughs issue was settled in 1945 when X-ray crystallographic study by Dorothy Hodgkin and Barbara Low opposed by Abraham’s former supervisor, Robinson, who favoured an alternative structure. The in antibiotics, the discovery of Cephalosporin C by Abraham and Guy Newton led to the appearance of a new group of B-lactam antibiotics of equal importance to medicine and of greater commercial confirmed the B-lactam structure. E.P. Abraham NCUACS 103/2/02 Sardinia by Giuseppe Brétzu in 1945, reached the Sir William Dunn School of Pathology in September 1948. After initial experiments by N.G. Heatley, the production of culture fluids was turned over to the Medical Research Council’s Antibiotics Research Station at Clevedon in July 1949. Abraham and his colleagues succeeded in isolating a number of antibiotic substances from the culture fluids, the one producing the results originally observed by Brétzu given the name ‘Cephalosporin N’. The discovery of Cephalosporin C, a substance detected in minute quantities in partially purified Cephalosporin N in September 1953, was epoch making. It was active against certain bacteria unaffected by penicillin, while being resistant to penicillinase and of very low toxicity. Cephalosporin N was shown to be a new form of penicillin and was re-named ‘Penicillin N’. Despite the combined efforts of Oxford, Clevedon and the Glaxo Group there proved to be many difficulties with the production of Cephalosporin C by fermentation and it took until 1959 for Abraham and Newton to determine its chemical structure. Later that year they showed that subtle mutations of the Cephalosporin C molecule could lead to the production of more potent antibiotics which would still be resistant to penicillinase. Work aimed at producing higher yields of the nucleus of the molecule (7-aminocephalosporanic acid or 7-ACA) continued during the early 1960s, with Glaxo and other pharmaceutical laboratories licensed by the National Research Development Corporation (NRDC) collaborating with the Dunn School. The successful outcome of this painstaking work enabled studies of semi-synthetic cephalosporins to proceed, with the drugs cephalothin and cephaloridine being introduced into medicine in 1964. The NRDC’s worldwide patenting and biosynthesis and enzyme inactivation of penicillins and cepahlosporins, while also investigating other at the University of Wisconsin (1966-1967) and the Squibb Lecture at Rutgers University (1972). up to support medical, biological and chemical research, especially at Oxford. antibiotics such as bacilysin. He maintained a strong interest in antibiotics research abroad, and After 1964 Abraham continued to conduct research on B-lactam antibiotics, including the licensing scheme covering the cephalosporins eventually yielded huge royalties, for many years the into two trusts, the E.P. Abraham Research Fund and the E.P.A. Cephalosporin Fund, which he set chief source of income for the corporation. Abraham diverted the greater part of his royalty income travelled extensively to visit research laboratories and give lectures such as the Rennebohm Lecture 1980 (an Honorary Fellow from 1980) and as an Honorary Fellow of a number of other colleges. antibiotics field brought him numerous awards, including the Royal Medal of the Royal Society Abraham also contributed to academic life in Oxford as a Fellow of Lincoln College from 1948 to Abraham was elected a Fellow of the Royal Society in 1958 and became Professor of Chemical Pathology in 1964. In addition to his knighthood in 1980, his outstanding contributions in the (1973), a CBE (1973), the Mullard Prize of the Royal Society (1980) and several honorary degrees. E.P. Abraham NCUACS 103/2/02 A man of exceptional modesty, Abraham was affectionately regarded by his colleagues at all levels. He remained on good terms with both Florey and Chain after their acrimonious breach and later wrote well-received articles on both scientists for Biographical Memoirs of Fellows of the Royal Society. He married Absbjérg Harung, a Norwegian, in 1939 and they had a son. Abraham died on 8 May 1999. DESCRIPTION OF THE COLLECTION The papers cover the period 1925 to 2000. The following paragraphs are intended to provide a summary of the collection, by section, and to draw attention to items of particular interest. Further explanatory notes and cross-references are found, where appropriate in the individual sections in the catalogue. Section A, Biographical, includes a variety of material reflecting many aspects of Abraham’s personal and professional life. A number of his school notebooks survive, along with eighteen undergraduate notebooks. There are letters of congratulation on his election to the Fellowship of the Royal Society, 1958, and on his receipt of the Royal Medal of the Royal Society in 1973, and correspondence and papers relating to other honours and awards. Included also are correspondence concerning the history of antibiotics (mostly 1990s), correspondence and papers relating to his support of various charities and appeals later in his life, appointments diaries (1963-1992) and a sequence of personal correspondence, 1974-1998. Section B, University of Oxford, is short. The material includes correspondence and papers relating to the business of Lincoln College (1960-1996), of which Abraham was a Fellow, and building work and administration at the Sir William Dunn School of Pathology (1954-1994). Other papers, chiefly concerning social and fundraising events, reflect his associations with other Oxford colleges and organisations, sometimes through donations by the Abraham Trusts. collaborative research with the Antibiotics Research Station of the Medical Research Council on the Section C, Research, presents extensive and diverse material spanning some sixty years of Abraham's biochemical research. There are notebooks, correspondence, publications and other papers, chiefly relating to research on cephalosporins and related substances by Abraham’s team and other organisations. There are a few of his notebooks dating from his period at the Dyson Perrins Laboratory and his early years at the Sir Willam Dunn School of Pathology; one survives from his year in Stockholm (1938/1939) as a Rockefeller Travelling Fellow. The early Dunn School notebooks include details of experiments on penicillin from 1940. There is significant coverage of the E.P. Abraham NCUACS 103/2/02 cephalosporium culture fluids in the 1950s, the work that led to the isolation of Cephalosporin C and the determination of its chemical structure. A large body of correspondence and papers relates to the involvement, through to the 1990s, of the National Research Development Corporation in the on- going research on the cephalosporin antibiotics and their commercial exploitation, the participation of licensed pharmaceutical companies such as Squibb, and legal cases concerning cephalosporin patents in which Abraham provided expert opinion. Experimental work by Abraham’s team on a range antibiotics and related compounds, including Cephalosporin C, Bacilysin and B-lactamases, is documented by a large group of laboratory notebooks dating from 1946 to 1983. They are mostly the work of Abraham’s research assistants, though a few are A small body of correspondence and papers relates to research on bacilysin from 1957 and there is also some scientific correspondence of a more general nature. his hand. in Section D, Publications, comprises Abraham’s drafts of scientific papers, book reviews and other articles by Abraham, dating from 1956 to 1998, and editorial correspondence. Of particular interest are the drafts and correspondence relating to his Biographical Memoirs of Fellows of the Royal Society for Howard Florey (1971) and Ernst Chain (1983). The correspondence highlights the sensitive issues Abraham had to negotiate in the preparation and drafting of the Memoirs. There are also drafts of other obituaries he wrote for Florey and Chain. Section E, Lectures and broadcasts, principally comprises drafts and correspondence relating to public lectures given by Abraham from ca 1960 to 1993. Most lectures are on the origin and development of B-lactam antibiotics; one given at the National Portrait Gallery in 1993 surveys the discoveries of Sir Alexander Fleming. A small amount of lecture material used by Abraham for teaching is included. The papers relating to broadcasts is slight, chiefly concerning Abraham's contributions to various television and radio programmes on penicillin, the cephalosporins and the work of Howard Florey, dating from 1962 to 1991. British scientific organisations, including the Biochemical Society, the Chemical Society, the Society Section F, Visits and conferences, covers the period 1955 to 1995. The material chiefly covers Abraham’s participation in symposia and conferences on chemotherapy, antibiotics and, in some cases, specifically B-lactam antibiotics. On longer stays abroad he sometimes combined attendance at symposia with lectures at universities and visits to pharmaceutical laboratories. Among the visits and conferences for which significant documentation survives are the International Congresses of Chemotherapy held in Vienna, 1967 and 1983; the Interscience Conferences on Antimicrobial Agents and Chemotherapy held in Chicago, 1967 and 1981; and a visit to India in January 1985 which included the Asian Congress of Pharmacology in New Delhi. Included are drafts of papers given by Abraham at symposia. Section G, Societies and organisations, presents material covering Abraham’s involvement in many E.P. Abraham NCUACS 103/2/02 for General Microbiology and the Royal Society. Overseas organisations are represented by the American Academy for Arts and Sciences and the Australian National University (John Curtin School of Medical Research). Much of the correspondence in this section is general in nature, though there is material relating to lectures and addresses given by Abraham, such as the 5th L.P. Garrod Lecture for the British Society for Antimicrobial Chemotherapy in 1986. Section H, Correspondence, principally consists of scientific correspondence, 1944-1998, arranged by individual or country. The correspondents include some colleagues of Abraham, such as Norman Heatley, Henry Harris and Guy Newton, research assistants and workers in Abraham’s: laboratory and scientists in other institutions. The correspondence arranged by country reflects Abraham’s strong interest in antibiotics research overseas and documents visits to many countries for participation in conferences and meetings. There is also a short sequence of material concerning references and recommendations. Section J, Non-text material, largely consists of photographs of Abraham, with a few of colleagues such as Guy Newton, dating from 1930-1995. Included are school photographs, portraits from Abraham's early career and several showing him with colleagues and fellow scientists taken at conferences or functions. There are also a few lecture slides and videotapes, one recording an event at the Sir William Dunn School of Pathology, at which Abraham spoke, celebrating the 50th There is also an index of correspondents. S. Coleman anniversary of the published paper on the therapeutic application of penicillin. Bath 2002 E.P. Abraham NCUACS 103/2/02 SECTION A BIOGRAPHICAL A.1-A.115 A.1-A.10 AUTOBIOGRAPHICAL AND BIOGRAPHICAL A.11-A.40 CAREER, HONOURS AND AWARDS A.41-A.66 SCHOOL AND UNDERGRADUATE NOTEBOOKS A.67-A.96 DIARIES A.97, A.98 E.P. ABRAHAM TRUSTS A.99-A.101 CHARITIES AND APPEALS A.102, A.103 HISTORY OF SCIENCE A.104, A.105 ARCHIVES AND BOOKS A.106-A.114 A.115 PERSONAL CORRESPONDENCE LIST OF PUBLICATIONS E.P. Abraham NCUACS 103/2/02 Biographical BIOGRAPHICAL AND AUTOBIOGRAPHICAL 1957-1998 ‘Personal reference, 1957. records’ prepared for Royal Society, latest bibliographical Abraham was elected to the Fellowship of the Royal Society in 1958. A.20-A.22. See Autobiographical account for McGraw-Hill Modern Scientists and Engineers, 1980. ‘Sir Edward Abraham and the cephalosporin and penicillin stories’, NRDC [National Research Development Corporation] publication, 1980 or later. The article was written by J.C. Cain, Managing Director, NRDC. ‘Biography’ for Central Office of Information, 1981. ‘Portrait’ of Abraham, Oxford ‘Edward Abraham: A major figure in antibiotics’, The Biochemist, 1990. ‘New antibiotic from another happy accident’. Times, 13 December 1985. ‘Description’ of Abraham’s career at Oxford for the University’s External Relations Office, 1991. Brief biographical details for meeting of Oxford University’s Chancellor's Court of Benefactors, 1998. Record, 1993. ‘Chance favours the prepared mind. A tribute to the work of Sir Edward Abraham and his distinguished colleagues at the Sir William Dunn School of Pathology’. 5 December 1991. ‘Sir Edward Abraham: An Eightieth Birthday Tribute’, Lincoln College See also A.13. E.P. Abraham NCUACS 103/2/02 Biographical Entries for biographical directories, 1971-1997. 2 folders. A.11-A.40 CAREER, HONOURS AND AWARDS 1925-1999 King Edward VI School, Southampton Abraham attended the school, 1925-1932. benefactor. He was subsequently a major Swimming certificates, 1925-1926 Oxford & Cambridge Schools Examination Board Certificate, 1929. 4 folders. The Queen’s College, Oxford. Correspondence and papers, 1931-1934. Rockefeller Travelling Fellowship, University of Stockholm, 1939. A.13-A.16 Correspondence with Chairman of Governors, Headmaster and others, 1991-1998. Letter of 20 November 1931 from the College informs Abraham of election to an Exhibition. his Abraham was an Exhibitioner of the College, 1932-1936 where he read the Honour School of Chemistry. 1939. Abraham worked at the Biokemiska Institut Stockholm as a Rockefeller Travelling Fellow, 1938-1939. One letter only from the head of the institute, H. von Euler, 18 September E.P. Abraham NCUACS 103/2/02 Biographical Nuffield (Penicillin) Research Fellowship, Lincoln College, Oxford, 1948. Abraham was a Fellow of Lincoln College, Oxford 1948-1980, Honorary Fellow from 1980. See also A.32. Typescript note from the Rector on the terms of the Fellowship. A.20-A.22 Election to the Fellowship of the Royal Society, 1958. Letters of congratulation, 1958. In alphabetical order. Unindexed. A-J. Unidentified and first names only. Certificate only. Certificate only. Rennebohm Lecturer of the University of Wisconsin School of Pharmacy, 1966-1967. Honorary membership American Pharmaceutical Association Academy of Pharmaceutical Sciences, 1967. Unidentified and first names only. Appointed Commander of the Order of the British Empire (C.B.E.), 1973. Official notification and letters of congratulations, 1972-1973. Unindexed. Notification and letters A-H. Letters J-Z. E.P. Abraham NCUACS 103/2/02 Biographical Honorary Fellowship, Queen’s College, Oxford, 1973. Letters from the Provost and others re election to the Honorary Fellowship, 1973. A.27-A.29 Award of Royal Medal of the Royal Society, 1973 A.27 Correspondence with the Royal Society, 1973-1974. Letters of congratulation, 1973. In alphabetical order. Unindexed. A-M. N-W. Unidentified first names only. Knighthood, 1980. Newspaper-cutting only. Honorary degree, University of Exeter, 1980. Correspondence re arrangements, manuscript notes of speech by Abraham. Correspondence with the Royal Society, 1980-1981. Dinner in Abraham’s honour at Lincoln College, Oxford, 1980. Photocopy of manuscript notes for Abraham’s speech. Mullard Award of the Royal Society, 1980. E.P. Abraham NCUACS 103/2/02 Biographical Correspondence re proposed nominations of Abraham for Nobel Prize, 1981, 1983 and 1997. Honorary Fellowships of Oxford Colleges, 1983, 1986. Honorary Fellowship, St Peter’s College, Oxford, 1983. Letter of congratulations only Honorary Fellowship, Keble College, Oxford, 1986 Invitation declined by Abraham: feel embarrassed by the number of my Honorary Fellowships and decided that | should not allow the list to grow if the possibility of its doing so were to arise’. ‘But some time ago | began to Honorary degree, Oxford University, 1984. Letters of congratulation; brief correspondence re arrangements, 1983-1984. Honorary degree, University of Strathclyde, 1989. Correspondence re arrangements, 1988-1989. Honorary degree, Harvard University, 1997. Correspondence and papers, 1996-1997. Opening of the Oxford University Pathology Support Building, 1997. Draft of obituary by L.D. Sabbath. Includes memorial address by H. Harris as published in Oxford Magazine, Nougth Week, Hilary Term, 2000. Abraham officially opened the building to which he had ‘contributed so generously’, 10 October 1997. Funeral and memorial service. 1999. E.P. Abraham NCUACS 103/2/02 Biographical A.41-A.66 SCHOOL AND UNDERGRADUATE NOTEBOOKS 1928-1936 A.41-A.48 King Edward VI School, Southampton, notebooks. A.41 Notebook with label ‘King Edward’s School, Southampton’ on front cover with pupil’s name ‘E. Abraham’, the subject ‘Physics’ and the date ‘Oct. 1928’. Used for experimental work. A list of experiments is on the first lined page at the front. Notebook with label ‘King Edward’s School, Southampton’ on front cover with pupil’s name ‘E. Abraham’ and the subject ‘Physics’. N.d. Used for experimental work. Notebook with label ‘King Edward’s School, Southampton’ on front cover with pupil’s name ‘E. Abraham’ and the subject ‘Physics. Heat & light sound’. N.d. Used for experimental work. N.d. Used for experimental work. Notebook with label ‘King Edward’s School, Southampton’ on front cover with pupil’s name ‘E. Abraham’ and the subject ‘Physics [rest of label torn but probably indicated that the particular areas of the subject covered were magnetism and electricity]’. Used for notes on ‘The Properties of Matter’. ‘Notebook with label ‘King Edward VI. School, Southampton’ on front cover with pupil’s name ‘E.P. Abraham’ and the subject ‘Physics’. N.d. Notebook with label ‘King Edward VI. School, Southampton’ on front cover with pupil’s name ‘E.P. Abraham’ and the subject ‘Physics’. N.d. Used for notes on the ‘Properties of Matter’. E.P. Abraham NCUACS 103/2/02 Biographical ‘Notebook with label ‘King Edward VI. School, Southampton’ on front cover with pupil’s name ‘E.P. Abraham’ and the subject ‘Physics II’. N.d. Used for notes on magnetism and electricity. ‘Notebook with label ‘King Edward VI. School, Southampton’ on front cover with pupil’s name ‘E.P. Abraham’. Used for essays. The first essay on pragmatism is dated at the end ‘Essay Club Winter Term 1930’. A.49-A.66 Undergraduate notebooks, The Queen’s College, Oxford. King Edward VI. School, Southampton notebook with school label on front cover obscured with new blank label inscribed ‘The Phase Rule’. ‘E.P. Abraham’ inscribed inside front cover. N.d. Used for undergraduate notes. Notebook with ‘E.P. Abraham The Queen’s College Oxford’ inscribed inside front cover. First page headed ‘The methods for Notebook with ‘E.P. Abraham Queen’s College Oxford’ inscribed inside front cover. Used for ? essays on chemistry. ‘The composition of water and the relative atomic weights of oxygen and hydrogen’ is dated ‘Nov. 1° 1932’, Used for chemistry notes. the determination of vapour density’. Latest date in the text 1933 (in note on the hydrogen isotope). Used from the front for notes on ‘The kinetic theory of gases’. Notebook with ‘E.P. Abraham The Queen’s College [Oxford] 1934’ inscribed inside front cover. Used from the front for notes on ‘Isomerism’. Notebook with ‘E.P. Abraham The Queen’s College Oxford 1934’ inscribed inside front cover. E.P. Abraham NCUACS 103/2/02 Biographical Notebook with ‘E.P. Abraham 1934’ inscribed on the front cover. Used from the front for notes on ‘The lesser known elements’ and from the back for notes on ‘Inorganic compounds’. Notebook with ‘E.P. Abraham 1934’ inscribed on the front cover. Used from the front for notes on ‘Corrosion, Passivity and the Protection of Metals’. Notebook with ‘E.P. Abraham The Queen’s College [Oxford]’ inscribed inside front cover. Used for notes on ’Oxidation and Reduction in Organic Chemistry’ from the front and on ‘Mechanism of Reactions’ from the back. Latest bibliographical reference 1934. Notebook with ‘E.P. Abraham The Queen’s [College Oxford]’ inscribed inside front cover. Latest date .P. Abraham Notebook with ‘E.P. Abraham’ inscribed inside front cover. Used from the front for notes on ‘Acids and bases (continued)’. in notes 1934. Used for notes on ‘Rubber’, ‘Ketenes’, ‘The basic properties of oxygen’, etc. Latest bibliographical reference 1935. Notebook with ‘E.P. Abraham The Queen’s College [Oxford]’ inscribed inside front cover. bibliographical reference 1932. Used from the front for notes on ‘Relativity’, ‘The Alkaloids’, ‘Structure and Synthesis’, ‘Carbohydrates’ etc. Latest bibliographical reference 1936. Notebook with ‘Essays inscribed inside front cover. The Queen’s [College Oxford] There are essays on ‘Fermentation’, ‘The Constitution of Alcohol and Ether’, ‘Aldehydes’, Latest ‘Nitrification’, Nitrogen’, fixation ‘The etc. of E.P. Abraham NCUACS 103/2/02 Biographical Notebook with ‘E.P. Abraham The Queen’s College [Oxford]’ inscribed inside front cover. First page headed ‘Essays’. However, contents may be summary notes of contents of earlier notebooks perhaps prepared for revision purposes. See A.50 for example. Latest bibliographical reference 1934. Notebook with ‘E.P. Abraham 1934’ inscribed inside front cover. Used for notes re practical work. First page headed ‘Quantitative Analysis’. Notebook with ‘E.P. Abraham The Queen’s College Oxford 1934’ inscribed inside front cover. Used for notes re practical work. etc.’ First page headed ‘Organic Preparations Notebook with ‘E.P. Abraham The Queen’s College [Oxford]’ inscribed inside front cover. N.d. First page headed ‘Points in Physical Used from both ends for notes re practical work. ‘Potassium iodate’. First page at back headed ‘Gas Manipulation’. First page at front headed Used for notes re practical work. Chemistry’. Notebook with ‘E.P. Abraham The Queen’s [College Oxford]’ inscribed inside front cover. N.d. Notebook with ‘E.P. Abraham The Queen’s [College Oxford]’ inscribed inside front cover. N.d. Used for notes re practical work. First page headed ‘Tetrahydrocarbazole’. E.P. Abraham NCUACS 103/2/02 Biographical A.67-A.96 DIARIES 1963-1992 Appointments diaries. The sequence lacks a diary for 1970. There are two diaries for 1978. 1963. E.P. Abraham NCUACS 103/2/02 Biographical E.P. Abraham NCUACS 103/2/02 Biographical A.97, A.98 E.P. ABRAHAM TRUSTS 1979, 1989 Abraham established a number of charitable trusts with funds arising from the development of the cephalosporin antibiotics. A.99-A.101 1975-1997 respect of the 17 March 1967, and Deed of Trust in CHARITIES AND APPEALS Letter from E.P. Abraham re cephalosporin funds in reply to an enquiry from G.Wilkinson, February 1979. Letter from Kidsons chartered accountants, 20 February 1989, enclosing photocopies of Deed of Trust in respect of the E.P. Abraham Research Fund, 17 March 1967, Trust Deed in respect of the Guy Newton Research Fund, E.P.A. Cephalosporin Fund, 18 May 1970. 3 folders. Correspondence and Abraham, 1975-1997. papers re charities and appeals supported by E.P. Abraham NCUACS 103/2/02 Biographical A.102, A.103 HISTORY OF SCIENCE 1976, 1994-1998 Correspondence with historians and others re the history of antibiotics, biographies of scientists etc., 1976,1994-1998. 2 folders. A.104, A.105 ARCHIVES AND BOOKS 1986-2000 Correspondence and papers re arrangements made for Abraham’s archives and books and re related matters, 1986-2000. 1986-1989. 1997-2000. 1974-1998 A.106-A.108 A chronological sequence of correspondence, 1974-1998. A.106-A.114 PERSONAL CORRESPONDENCE Includes replies to Abraham’s letters of congratulation. 2000 item is a list of the books transferred from Abraham’s home to Lincoln College, Oxford. 1995-1998, n.d. 1974-1976. 1979-1993. E.P. Abraham NCUACS 103/2/02 Biographical A.109-A.114 Correspondence and papers with B.L. Parry and others, 1973-1977 and n.d. 6 folders. PUBLICATIONS LIST Typescript chronological list of Abraham’s publications. E.P. Abraham NCUACS 103/2/02 SECTION B UNIVERSITY OF OXFORD B.1-B.19 WILLIAM DUNN SCOOL OF PATHOLOGY B.20-B.61 LINCOLN COLLEGE B.62-B.92 OTHER COLLEGES AND UNIVERSITY ORGANISATIONS E.P. Abraham NCUACS 103/2/02 University of Oxford WILLIAM DUNN SCHOOL OF PATHOLOGY 1954-1994 Invoices etc for equipment and supplies purchased by the William Dunn School, 1954. 19 folders. B.20-B.35 Correspondence and papers re the building of School, 1964-1975, 1980. a major extension to the Contents of 2 files inscribed ‘Pathology - New Building’. 16 folders. Minutes of Departmental Committee Meetings etc, 1992-1994. Miscellaneous correspondence and papers, 1992-1994. B.38-B.61 LINCOLN COLLEGE 1960-1996 Various committee papers and other papers re general College business, 1960-1965, n.d. Abraham was a Fellow of Lincoln College, 1948-1980, and a member of the College’s Finance Committee. 9 folders. The college organised an appeal in 1972 for the conversion of a church into a new library and later sought funds for other projects. B.39-B.47 ‘Lincoln College Appeal’. Contents of a file so inscribed. See A.19 and A.32 for further material relating to Lincoln College. Correspondence etc, 1972-1993. E.P. Abraham NCUACS 103/2/02 University of Oxford B.48-B.57 Correspondence and papers re general business and activities college, 1974-1996, with a few papers 1962-1964. of the Included are invitations to functions and papers relating to college and committee meetings (Abraham was a member of the Finance Committee). Included in B.53 is a 2pp manuscript draft of a speech by Abraham, [?after 1980]. 10 folders. Letter from papers, 1979. National Research Development Corporation, with related Found with papers in B.48-B.54. B.59-B.61 Copies of papers concerning applications for Junior Research Fellowships at Lincoln or proposed research, 1975. including accounts of research projects College, 3 folders. B.62-B.92 1958-1998, n.d. Abraham was a Supernumerary Member. Correspondence, mostly notices for meetings. Ashmolean Club 1990-1998 Arranged alphabetically. Miscellaneous correspondence is at B.91, B.92. OTHER COLLEGES AND UNIVERSITY ORGANISATIONS 2 folders. Correspondence and papers re Advisory Council meetings and various events and functions. Abraham was on the College Advisory Council. B.63, B.64 Green College 1993-1998 E.P. Abraham NCUACS 103/2/02 University of Oxford Keble College 1992-1996 Correspondence etc re appointments of EPA Junior Research Fellows. Lady Margaret Hall 1978-1997 Abraham was elected an Honorary Fellow of the college in 1978. Correspondence etc an Honorary Fellowship, invitations to functions, grants to the college by EPA trusts and other matters, 1978, 1992-1997. re Abraham's election to Linacre College 1983-1996 Abraham was an Honorary Fellow of the college. Fund made a donation towards a new residential building at the college. The EPA Cephalosporin Correspondence etc re invitations to functions and general business. 2 folders. 1969-1988 Abraham was a member. 3 folders. B.69-B.71 Natural Sciences Club Papers and correspondence re meetings, functions and general business. Correspondence etc re invitations to functions and general business. Abraham was a Friend of Pembroke. One or both of the Abraham Trusts donated money to the college. Pembroke College 1988-1995 E.P. Abraham NCUACS 103/2/02 University of Oxford B.73, B.74 The Queen's College 1977-1996 Abraham was an Honorary Fellow. Correspondence re functions and general business. 2 folders. St Cross College 1983-1990 One or more of the Abraham trusts appears to have been a benefactor of the college. Correspondence etc re invitations to functions and other business. St Hilda’s College 1984-1994 Both Abraham trusts were benefactors of the college. Correspondence etc re functions and general business. At least one of the Abraham trusts was a benefactor of St Hugh’s College. Correspondence, mostly re invitations to functions. St Peter’s College 1987-1997 St Hugh’s College / St Anne’s College 1995, 1997 Correspondence etc mostly re funding of academic posts and functions, 1984-1994. 2 folders. Abraham was an Honorary Fellow. The EPA Cephalosporin Fund made a donation to the college to help endow an existing Biological Sciences Fellowship. E.P. Abraham NCUACS 103/2/02 University of Oxford B.80-B.88 University Registry and other offices 1958-1998, n.d. B.80-B.85 Contents of file inscribed ‘University Offices’. Correspondence etc with the Registrar and other offices and individuals within the University, 1958-1998, n.d. of Topics covered include Pathology, Abraham’s receipt of an honorary Doctor of Science degree from the University in June 1983, and various events and functions, 1958-1998. Sir William Dunn School funding the for 6 folders. Contents of a file inscribed ‘University Registry’. Correspondence re fundraising, events and general matters, 1977-1988. 2 folders. Contents of a file entitled ‘Safety’. 1982-1995 B.89, B.90 Wolfson College Correspondence, mostly re fundraising and functions. Abraham was an Honorary Fellow of the college and a Patron of its Appeal. The EPA Cephalosporin Fund made a donation to the college. Papers and correspondence, mostly with the University of Oxford Safety Office, re safety procedures associated with work with micro-organisms, 1989-1992. 2 folders. Correspondence with various Oxford colleges, including Linacre College, and individuals re fundraising, donations by the EPA Cephalosporin Fund and other matters. This material was found in one original file. 2 folders. B.91, B.92 Miscellaneous correspondence 1993-1997 E.P. Abraham NCUACS 103/2/02 SECTION C RESEARCH AND DEVELOPMENT C.1-C.1114 This section documents a variety of research by Abraham and his colleagues at the Sir William Dunn School of Pathology and by a number of other organisations. The greater part of the material relates to the work on Cephalosporin C and related compounds and the development of marketable cephalosporin antibiotics, though research on penicillin (from 1940), bacilysin and other antibiotics is also covered. Papers relating to the cephalosporins is dispersed through most of the sub-sections listed below. The correspondence covering the stages of the collaborative research from the late 1940s to the introduction of the first cephalosporin drug in 1964 is chiefly found in the sub-sections ‘Medical Research Council’, ‘National Research Development Corporation’ and ‘Other Organisations’. C.1-C.206 EARLY RESEARCH AND RESEARCH ON PENICILLIN C.207-286 LABORATORY NOTEBOOKS AND PAPERS C.287-C.357 C.358-C.605 C.964-C.989 C.1068-C.1114_ C.606-C.963 OTHER ORGANISATIONS MEDICAL RESEARCH COUNCIL C.990-C.1016 | BACILYSIN RESEARCH SCIENTIFIC CORRESPONDENCE NATIONAL RESEARCH DEVELOPMENT CORPORATION (NRDC) (BRITISH TECHNOLOGY GROUP (BTG)) MISCELLANEOUS PAPERS C.1038-C.1067 ‘CEPHALOSPORIN C HISTORY’ C.1017-C.1037_ LEGAL CASES E.P. Abraham NCUACS 103/2/02 Research and development C.1-C.206 EARLY RESEARCH AND RESEARCH ON PENICILLIN 1935-ca 1949 C.1-C.4 Dyson Perrins Laboratory notebooks C.5 Rockefeller Travelling Fellowship (Stockholm) C.6-C.14 Early William Dunn School of Pathology notebooks C.15-C.206 Penicillin reports Dyson Perrins Laboratory notebooks 1935-1938 Abraham worked at peptides. the Laboratory from 1936-1938, researching on Hardback notebooks containing manuscript notes by Abraham mostly relating to experiments, including tables and graphs of experimental results. All are inscribed ‘Dyson Perrins Laboratory’ except C.4 which probably belongs in this set, being of very similar physical appearance to C.1-C.3 and dated 1938. Records of particular experiments are often dated. Mostly re experiments involving Undecylenic acid, October 1935-ca June 1936. From front notes on various experiments; from back notes on experiments involving lysozyme. Undated. front cover. Abstracts from papers on various experiments with references at end, undated. General notes on various compounds and reactions. Inscribed ‘1938’ inside E.P. Abraham NCUACS 103/2/02 Research and development Rockefeller Foundation Travelling Fellowship (Stockholm) 1938-ca 1949 Notebook inscribed inside front cover ‘Biokemiska Institutet...Stockholm’ (crossed out) and ‘Sir William Dunn School of Pathology’. notes The cover Abraham’s period Foundation travelling fellow, 1938, 1939. in Stockholm as a Rockefeller Re experiments involving various enzymes, October 1938-August 1939. Paginated 1-150 (pages 1-147 used), with further notes at back. See also A.18. Early Sir William Dunn School of Pathology notebooks 1940-ca 1949 The notebooks vary considerably in physical appearance. Some include loose pages of notes. Re experiments involving various substances, including enzymes and intestinal mucosa, and early experiments on penicillin (June-ca October 1940). January-October 1940. This notebook appears to be a continuation of C.7. Re various experiments on penicillin and its purification, November 1940-ca August 1942. Re various experiments on penicillin and related compounds (including penicillanimine), and experiments unrelated to penicillin, August 1942-ca November 1947. including cephalosporins, ca October 1949. Notebook with heading ‘Penicillin Analyses’ on first page. front: on From various compounds, May 1941-ca 1943; from back: similar notes on compounds, experimental relating results notes brief to E.P. Abraham NCUACS 103/2/02 Research and development From front: notes on ‘Penicillin Purifications’, September 1941-ca February 1943 (some later notes may not relate to the heading); from back: notes re experiments on penicillin and related compounds, ca November 1941-ca July 1942; notes following heading ‘Penicillin: Mode of Action etc... 10.1.45’, January-April April- September 1945; 1 further page of notes, January [71946]. ‘Proactinomycin’, following heading 1945; notes Notebook inscribed ‘Spiraca and Arctium’ on cover. hand, partly in another's hand. Partly in Abraham’s Notes on various experiments, July 1944-ca May 1945. Notebook inscribed ‘Abstracts’ inside cover. Notes on various compounds, ca 1945-ca 1949. General notes headed ‘Use of moulds in primitive medicine’, ca 1945-ca 1949. C.15-C.206 1944-1946 Penicillin reports Notebook (cover missing) entitled ‘Penicillin Abstracts’. Included at back is a letter to Abraham re arrangements for his lecture on ‘Penicillin Chemistry’, Oslo, 9 April 1946. Notes on penicillin and on various other compounds and processes, ca 1948-ca 1950. been maintained or reconstructed where identification was possible. Copies of by various organisations in the UK and the USA detailing the progress of chemical research on penicillin, with related papers and correspondence. There are a number of different series of reports; these sequences have reports (many are entitled ‘Progress Reports’) E.P. Abraham NCUACS 103/2/02 Research and development C.15-C.146 Committee for Penicillin Synthesis (CPS) reports, 1944-1946. Copies of typescript reports by various organisations, including the Sir William Dunn School of Pathology, ICI Ltd (Dyestuffs Division), Imperial College London, Merck & Co. Inc., Glaxo and the Squibb Institute of Medical Research. The reports are in a numbered sequence, ‘CPS 1-698’. A few are missing. Mostly progress reports and studies penicillin annotations by Abraham. related compounds. and on A few particular processes involving reports contain manuscript 3 copies of the index to the series. 2 copies include manuscript annotations. 2 folders. C.17-C.26 Reports: nos CPS 1-106, January-June 1944 (a few dated 1943). 10 folders. 11 folders. 19 folders. 21 folders. 22 folders. C.27-C.37 C.38-C.56 C.57-C.77 Reports: nos CPS 300-399, September 1944-February 1945. Reports: nos CPS 107-207, January-June 1944 (a few dated 1943). Reports: nos CPS 208-299, March-October 1944 (mostly June-October). 22 folders. Reports: nos CPS 400-502, December 1944-May 1945 (with a few possibly earlier). Reports: nos CPS 503-599, April-August 1945 (with a few earlier). C.100-C.121 C.78-C.99 E.P. Abraham NCUACS 103/2/02 Research and development C.122-C.146 Reports nos CPS 600-698, July 1945-May 1946. 25 folders. Papers relating to meetings of November 1944-September 1945. the Committee for Penicillin Research, With a few other papers found with this material. C.148-C.168 Copies of reports by various organisations, including Glaxo Laboratories Ltd, Boots Pure Drug Co. Ltd and Imperial College of Science and Technology, 1941-1945. Many reports are inscribed ‘Professor Sir R[obert]. Robinson’. E.P. Abraham NCUACS 103/2/02 C.148-C.161 Research and development Incomplete series of reports numbered PEN.1 - PEN.150, January 1941-July 1945. The series was found unevenly distributed in 2 parts, one group of reports being tied together with a label, ‘Dr Abraham’. The larger group is referred to below as the ‘main part of the series’. Some later reports are stamped ‘property of the Therapeutic Research Corporation of Great Britain Ltd’. C.148-C.157 Main part of the series. 10 folders. C.158-C.161 Reports labelled ‘Dr Abraham’. 4 folders. C.162-C.168 Incomplete series of reports numbered PEN.X. 1 March 1945. - PEN.X. 54, July 1942- 7 folders. 9 folders. Some reports Corporation of Great Britain’. C.148-C.161, the reports being very similar in structure and content. Research This series appears to be related to that in Therapeutic ‘property stamped are the of C.169-C.177 - PEN.C. 107, See C.202-C.206 for further reports from this series. Incomplete series of reports (copies), numbered PEN.C. 3 May 1943-September 1945. Reports are mostly by official bodies, such as the National Research Council and include conference reports. se The material includes various different series of reports which were found in a mostly disarranged state. Sequences have been re-constructed where identification was possible. Copies Control... Technical Papers Received from USA’, 1942-1945. C.178-C.183 ‘Ministry of Production of reports entitled Supply, Penicillin E.P. Abraham NCUACS 103/2/02 Research and development Included at C.179 is a carbon copy of a typescript by Ernst Chain entitled ‘Brief account of to the discovery of the chemotherapeutic properties of penicillin at the Sir William Dunn School of Pathology, Oxford’. the circumstances which led 6 folders. C.184, C.185 Typescript papers, mostly minutes etc, Penicillin Committee, 1942-1944. re the business of the General With a few related reports found with this material. 2 folders. Correspondence between Therapeutic Research Corporation of Great Britain, October 1942-December 1943; papers re meetings on penicillin research, 1942-1943. Robinson Robert and the Sir Contents of a file. of a file History..Pen 16 folders. C.186-C.201 C.202-C.206 Contents University’. Copies of typescript reports, 1942-1944. ‘Penicillin inscribed There was no indication of any original organisation of these papers and no attempt at re-arrangement has been made. The material is mostly typescript, with manuscript papers in an unidentified hand. At C.197 is a letter (1943) from Sir Robert Robinson to Ernst Chain. Miscellaneous reports and other papers, with brief correspondence, 1942- 1945. 5 folders. Most of the reports are from the ‘PEN.C’ series (see C.169-C.177) and appear to fill some gaps in the numbered sequence. Included at C.205 is brief correspondence between Sir Sir Edward Mellanby, 1943. Robert Robinson and Reports..Oxford E.P. Abraham NCUACS 103/2/02 Research and development C.207-C.286 LABORATORY NOTEBOOKS AND PAPERS 1946-1983, n.d. Binders and notebooks containing manuscript notes etc by Abraham and his research assistants at the Sir William Dunn School of Pathology. The material principally documents experiments relating to the development of the cephalosporins and other antibiotics and includes tables of results, graphs, and photographs. The notes are chiefly by research assistants, though many of the binders and notebooks contain notes in more than one hand. Arranged chronologically, though material has been kept together where identified as the work, or chiefly the work, of a particular individual. ‘Cephalosporin’ is abbreviated to ‘Ceph’ on the dividers found in the binders. Notebook, January 1946-July 1948. Notes in an unidentified hand. Mostly re experiments involving B. Subtilis and ayfivin; a few other notes from back re experiments on an antibiotic produced by Staphaur[?eus]. Paginated 1-185. Notebook, July-December 1948. Notes in same hand as C.207. Paginated 186-230, of which 186-220 have been used. Large binder, December 1948-November 1953. Notes mostly in Abraham’s hand; the remainder in an unidentified hand. Mostly re experiments involving ayfivin, continued from C.207; a few other notes from back; 1 loose page of notes at front dated June 1946. (December 1949-1952, 1957); ‘Nonin’ (February 1957). Separated into sections by dividers labelled as follows: ‘Alvein’ (one page dated February 1949); ‘Bacilysin’ ([ca April]-May 1949); ‘Ayfivin’ (December 1948-November 1953); ‘Pu[?ml]ulin’ (February 1951); ‘Ageritin’ (December 1952); ‘Nisin’ (June 1950-January 1952); ‘Micrococcin’ (October [?1951]- January 1952); ‘Techniques’ (pages dated September 1949, February- March 1950). Separated into sections by dividers labelled as follows: ‘Cephalosporin’ (June-October 1949); N’ (November 1949-June 1954); ‘Methionine C.14’ (June-August 1954); ‘Synnematin B’ (October 1954); / C14’ (September 1955); ‘Ceph P’ ‘Bacitracin’ (1955, 1956); ‘Ceph N ‘Cephalosporin Large binder, June 1949-February 1957. and partly in an unidentified hand. Notes partly in Abraham’s hand E.P. Abraham NCUACS 103/2/02 Research and development Notebook inscribed ‘Margaret Ann Keren Pill’, June 1949-March 1950. Re experiments on various compounds including ayfavin, penicillin and cephalosporins, with index and further notes from back. Paginated 1-159. Notebook inscribed ‘Ann Pill’, 1950-1951. Mostly re experiments on Cephalosporin N, with index from opposite end. Paginated 1-156. 29, with a few unpaginated pages. Included at the front is a loose set of notes paginated 1- Notebook in the hand of Ann Pill, undated. Headed ‘Methods and preparations’ on first page. reference purposes. Brief notes, probably for Large binder, 1951-1962. Notes mostly in Abraham’s hand; the remainder in an unidentified hand. Separated into sections by dividers labelled as follows: ‘Ceph C’ (July 1954- February 1961); ‘Desacetyl Ceph C’ (February 1960-March 1961); ‘Ceph C,’ (January 1958-July 1960); ‘["'*C] Ceph C Acetate’ (June 1959-October 1961); ‘Rydon Smith Comp[ound] (Cephalosporidine)’ (May 1961-March 1962); ‘Penicillinase on C, Ca & Cc’ (January 1958); ‘Penicillinase’ (January 1960-ca February 1962); ‘Ceph C Nuchar Expts’ (January-February 1958); ‘Ca pyridine production’ (January 1958-March 1960); ‘Ca Nicotinamide’ (February-June 1958); ‘Ca Sulphapyridine Sulphathiazole’ (June-July 1958); ‘Ca Glyoxaline’ (December 1961); ‘Ceph C conc HCI’ (June 1958-December 1959); ‘Mixed crystalline acid from Ceph C spots 1+2+3’ (October-November 2 & 3’ (November 1958-November 1961); 1958); ‘Separated cryst. acids 1, ‘Ceph product’ (November 1958-March 1959); ‘Benzoyl Ceph C’ (March 1959); ‘Thiazole acylation etc’ (October 1958-April 1959); ‘Ceph C Nucleus’ (July-September 1959); ‘Secretin’ (October 1955- October 1957); ‘Pancreozymin’ (March-April structural considerations’ (March-April 1959); ‘Techniques’ (one page dated May 1962); ‘Polyacetylene Dr [?Landor]’ (February-March 1962); Unlabelled (possibly a continuation of ‘Techniques’), includes 2 graphs dated January 1951, and 1962. given) and general notes on chemistry and human anatomy. Contains experimental data (details of the nature of experiments are not Paperback notebook inscribed ‘M. Read’ on cover, ca May-ca October 1953. C performic oxidation 1959); ‘Ceph C_ E.P. Abraham NCUACS 103/2/02 Research and development Notebook inscribed ‘M.L. Read’ on cover, July 1954-September 1955. Re experiments synnematin and Cephalosporins C and N. involving various compounds including penicillinase, Notebook inscribed ‘M.L. Read’ on cover, October 1955-October 1956. Re experiments involving various compounds including penicillinase and Cephalosporins C and N. Notebook inscribed ‘Mary L. Read’ on cover, October 1956-January 1958. experiments Re Cephalosporin C, bacitracin and penicillinase. involving various compounds including — secretin, Notebook inscribed ‘Mary L. Read’ on cover, January 1958-December 1958. Mostly re experiments involving Cephalosporin C. Mostly re experiments involving Cephalosporin C. Mostly re experiments involving Cephalosporin C. Notebook in the hand of Mary L. Read, December 1958-March 1960. Notebook inscribed ‘M. Loveridge’ inside cover (in the same hand as C.214- C.219), March 1960-November 1961. Notebook inscribed ‘M. Loveridge’ inside cover (in the same hand as C.214- C.220), November 1961-February 1962. Mostly re experiments involving penicillin and Cephalosporins C and N. Large binder, June 1955-February 1958. Notes in unidentified hand. Mostly re Cephalosporins C and G. E.P. Abraham NCUACS 103/2/02 Research and development Large binder labelled ‘Ceph C D[ ? ]s 1961’, October 1960-July 1962. Notes in unidentified hand. At beginning: notes re experiments involving various compounds including a-aminoadipic acid and Cephalosporin C, October 1960- ‘January | 1961. Then separated into sections by dividers labelled as follows: ‘Run 8 ['"4C] - valine (January 1961- ‘March 1962); ‘Run a1 C] — acetate 24hr (February- April 1961); ‘Run 16 [''* C] acetate 24 hrs’ (May-July 1961); ‘["""“C] - acetate 48 hrs’ (June 1961); ‘Compound P [?] Run 17 48 hr Ac’ (October, November 1961); ‘*"“C] - (July 1961); °C] - cystine Run 19° (September 1961-May 1962); TC) a Aad R.24’ (November 1961-July 1962); ‘Run 28 a - oxo - glutarate 5 “C’ (April-December 1961); ‘Media and washed mycelium expts’ (October 1961-February 1962); ‘Synthesis of A a - aminoadipic acid’ (March-May 1961); ‘Synthetic [?wash] Cephalosporidine etc’ (March-July 1962); ‘Radioactivity standards and backgrounds’ (April 1961-February 1962). a Aad Run 18’ Notebook inscribed M.L.R. Sharp, September 1961-April 1962. Re experiments on various compounds including acetic acid, carboxylic acids and Cephalosporin C. E.P. Abraham NCUACS 103/2/02 Research and development Large binder inscribed ‘M.L.R. Sharp’ on spine, March 1962-December 1963. 1962); 1962); experiments’ (July-September Separated into sections by dividers labelled as follows: ‘D, L Valine uptake’ (December 1963); ‘Benzyl penicillin prepn’ (November, December 1963); ‘Est. of cpds [?compounds] 1&2 from ceph C’ (March-May 1962); ‘a - Aad — (April-May 1962); ‘Penicillaminic acid’ (May 1962); ‘Lysine . Arginine’ (May- June ‘Cephalosporidine synthesis spectra etc’ (April-September 1962); ‘Imidazole 1-acetic acid spectra’ (May-June 1962, with a few pages dated October 1960); ‘Dimethoxybenzoyl 7ACA’ (September 1960, June 1962); ‘DMB2 7ACA’ (June-October 1962); ‘7ACA’ (July 1962); ‘Hydrolysed mycelium saccharopine’ (September 1962); ‘p-nitro-phenolchloracetate’ (October 1962-November 1963); ‘Acetyl methionine’ (December 1962); ‘Hog acylase |’ (December 1962); ‘N-chloracetic DL-a-NH[?]’ (December 1962-Dec 1963, with one page dated April 1960); ‘y-OH valine, y-OH valine lactone’ (April 1963); ‘Rotation of a.a. (a—Aad) ex fermentation + “peptides” [?] (glutathione, saccharopine)’ (April-July 1963); ‘Uptake of D & L a Aad by washed [?susp]’ (July-October 1963); ‘Ceph N degreda” products (maps)’ (February-April 1963); ‘Ceph C est. by elution’ (February, March 1963); ‘Disintegrated cells homogeniser’ (October, November 1963); ‘N-ethy! [?morpheline] [?] buffer’ (January 1963); ‘Ceph C stand[ard]’ (November 1962); ‘Add” of C’* cystine to anaerobic resuspension’ (November 1963); ‘C'* NaOAc’ (October, November 1960, October 1962); ‘Instruments Hilger’ (May-October 1962); ‘Instruments N. Chicago counter’ (May 1962-June 1963); ‘X-press Expt. [?] (Miriam)’ (November 1963); ‘Background IDL counter’ (April, May 1962); ‘M.Wts [Molecular Weights]’ (undated). ‘L -— 2 Notebook in unidentified hand, May-August 1963. Mostly re ‘Pyo Enzyme Experiment’ and ‘X-Press Experiment’. Large binder inscribed ‘JMT’ on spine, October 1963-August 1965. Vs Separated into sections by dividers ‘Uptake after sonication’ (November, December 1964); sonicator’ (January 1964); ‘Demaine’s and Aida’s buffers’ (January 1964-August 1965); ‘p-Fluorophenylalanine’ SH measurement’ (May 1965); ‘Measurement of SH DTNB’ (March-May 1965); ‘N-chloracetate expts sonication’ (October 1964-January 1965); ‘Model expts a - ketoadiplic]’ (January 1965); ‘Pimafucin’ (November, Decmber 1964); ‘Assays Ceph C and Ceph N’ (September 1964); ‘X-Press’ (July-October 1964); ‘Isolation D- valine from Cephalosporium’ (May 1964); ‘X-Press 3 experiment’ (January 1964); ‘Cell-free system homogeniser (February 1964); ‘Disintegration of mycelium’ (homogeniser)’ (October, November 1963); ‘Nessler’s solution’ (June-September 1964); ‘Nessler’s model experiment’ (September 1964); ‘Conway vessels’ (July 1964); ‘Optical configuration D and L Alanine D and L Tyrosine’ (April, May 1964); ‘a-Amino-adipic acid’ (June 1964); ‘70% ECOH extractions MSE homogeniser (February 1964); tL. Benzyl penicillin potassium salt’ (January 1964); acid’ (September-December 1964); ‘Cell-free system. labelled follows: extract a - Aad ‘Glaxo (May, June 1965); as -— ‘A E.P. Abraham NCUACS 103/2/02 Research and development ‘Bacilysin — chromatogram (Mrs Lomakina)’ (January 1964-March 1965); ‘Bacilysin’ (February-July 1964); ‘Dowex column alanine & tyrosine’ (June 1964); ‘Ceph C absorption measured (Hilger)’ (October 1963-July 1964); ‘Assay For Prof. Jones (D.P.)’ (October 1963); ‘Production curve of Ceph N & Ceph C’ (November 1963); ‘Nuclear Chicago plateau’ (November 1963); ‘Calibration of Warburg manometers’ (April 1964); ‘Colony counts sonicator’ (January-April 1965). Large binder inscribed ‘GFN Peptides’ and ‘Takano-san’ on cover and ‘G.F. Newton’ inside cover. The label ‘Paul’ appears on the spine. October 1964- December 1968. ‘TCB+PB Separated into sections by dividers labelled as follows: ‘2pBWA 1’ (January 1967); ‘2pBWA 2’ (January 1967-November 1968); ‘PBG2/3[?] G/C5, G.10 col’ (July [?1967]); ‘PBG2/3 G10 GC3 G10 G/C4 G10’ (June, July 1967); ‘PBG2&3 Ac [?Els] G10’ (January-September 1967); ‘PB G1’ (January 1969); ‘PBG2’ (undated); ‘PBG3’ (undated); ‘PBG4’ (one page dated March 1968); ‘GCB+PB Separation of GSO3H & Taurine on G10 — HOAc’ (March, April 1968); ‘TCB+PB 2¢BWA|[?]’ (April 1968); ‘TCB+PB2¢BWA POOL P,’ (May-August 1968); ‘POOL P2 2BWA 2’ (May 1968); ‘POOL P; 26BWA3’ (May-June 1968); ‘Analysis of pools from 2¢BWA col[?]’ (June 1968); ‘P2 middle ex. 2>BWA 2 [?] 26BWA 4’ (June 1968); ‘TCB+PB Pool “GSO.H” 26BWA 5’ (October 1964-December 1968). (February-April G25-70% 1968); PYR’ by dividers ‘A-H’. labelled C.229-C.232 [etc]’ (December 1964-January 1965); Loose pages of notes, originally from a binder, 1964-1965. Contents of a file inscribed ‘Joan Roscoe’. Separated into sections Included among numerous topics and experiments are the following: Section A: Contents [index to sections A-G only]; B: ‘Medium of H.J.O. Rogers, record of B. subtilis A14 culture’ (January-June 1965); C: ‘Test run on Rogers’ medium, investigation of inocula’ (September, October 1964); D: ‘Bacilysin production [etc]’ (October-December 1964); E: ‘Expt. To see if [?chloramphenicol] can be extracted ‘Treatment of bacilysin sample & freeze-drying, preparation of large quantities of acetone extract’ (February-May 1965); G: & bacilysin pro[?dn], further attempts to establish the identity of the radioactive & postulated bacilysin spot’ (April-July 1965); ‘Shikimic acid’ (July, August 1965); H: ‘Comparison of zones given by Cephalosporin C and bacilysin 208’ (August 1965). 4 folders. ‘Expt. To follow glucose utilization Paginated 1-275. F: E.P. Abraham NCUACS 103/2/02 Research and development Notebook inscribed ‘LDS [Leon D. Sabath] Rabbit Expts’ on cover, February 1965-January 1966. Re the study of penicillin antibodies in rabbits. Large binder, January 1965-April 1972, with one page dated 1964. 2 pages in the index (see below) headed ‘Bronwen Loder’. Cu cpds ‘C-L-V [?compounds]’ Separated into sections by dividers labelled as follows: ‘Index’; ‘GA, GC, CV’ (January 1968-July 1969); ‘L-C-D-V’ (July 1969-September 1969); ‘L-C-L-Y’ (June-September 1969); precipitate’ (July-September 1969); cysteine’ ‘Trityl (January-March (February-December 1965, February 1969); (March- December 1965); ‘Mycelium expts AC-ACV’ (May 1965-January 1966); ‘Mycelium expts GC’ (April 1968-November 1969); ‘HS-‘ (May 1965-January 1966, November 1968-February 1970); ‘Sonication expts’ (November 1965); ‘Enzymes’ (June 1965, March-June 1968); ‘Actinonin’ (January-November M. Jago’ (June 1962); 1965, one page dated October 1964); ‘Actinonin ‘Misc’ 1969-June 1970); Rhozities gargylophera’ (January 1971-April 1972) ; ‘DMB’ (October 1970-September 1971). Loose material at front. 1965); ‘Hydrazide - (September 1965, ‘S-benzyl February ‘Atta AC’ 1972); acids’ 1971); Glu.Ala ‘Cuprous ‘Hydroxamic ‘Photoplasts’ (February-May (May-December Large binder labelled ‘P.B.[Bronwen] Loder’ on spine, 1968-1972. Separated into sections by dividers labelled as follows: Unlabelled pages at beginning re experiments involving Park nucleotides, Cephalosporin N and other compounds (October 1969-June 1971); ‘Ceph N’ (September 1969- May 1970); ‘Methods’ (January 1968-September 1969, November 1971); ‘ACV’ (November 1971-July 1972); ‘“C-D-Val + a KIV’ (November 1971); ‘Resolution of a Aad‘ (June- Cy SO3H.Gly’ (January 1969-February October 1970); ‘Glu.Gly 1972); mercaptides’ (September 1969-July 1972); ‘CFS Ceph. Sp’ (May 1970-March 1972); ‘CFS Penicillium’ (May 1969-June 1972); ‘Ceph sp. Sonicates’ (May 1970-July 1970); ‘P4 Complex’ (June 1970-January 1971); ‘7-ACA’ (February 1968- July 1972, one page dated November 1965); ‘PS and slow spot’ (November 1970-February 1971); ‘Glaxo copper precipitate’ (June 1969-July 1970); ‘Cuprous mercaptides’ (August-December 1970); ‘Esters’ (March 1969- August 1970); ‘Model mixture a[?m]ino acids’ (March, April 1969); ‘ORD’ (March-September 1969); markers’ (September-November 1969); ‘Phenylacetyl Ceph C & penicillin) N’ (March-June 1970); ‘Ceph October uptake expts’ (October 1969-December 1971). fas Separated into sections by dividers labelled as follows: ‘P. chrysogenum SC 6140’; ‘Ceph C standards’ (November 1975); Large binder labelled ‘T.J.B.’ on spine, 1965-1982. hand. Notes in Abraham’s ‘Amino acid E.P. Abraham NCUACS 103/2/02 Research and development ‘Steptomyces’ (January 1972, July 1974-October 1975); ‘B.subtilis 6633 Rapid assay’ (March 1972); ‘Pen'[icillinJase Pseudomonas’ (October 1972- October 1974); ‘Pen’[icillinlase B. cereus 569 H’ (July 1968, March-June 1974); ‘D-amino acid oxidase - Aspergillas’ (February 1968-February 1959, July 1973); ‘Q176 / C21 P. chrysogenum’ (January 1968-May 1973, June 1979); penicillin acylase’ (February-March 1974, January 1982); ‘Ceph CW 19’ (July 1973-October 1974); ‘Acremonium’ (January-February 1973); ‘Cephalosporium C91’ (November 1965-November 1971). ‘E.coli Paginated in part from back 1-128. Large binder labelled purification expts’ on spine. 1966-1969. ‘J. Walker _Bacilysin. Production expts. Early ‘Mass 1968); spectra’ November (May-November Separated into sections by dividers labelled as follows: ‘Protease’ (February, March 1967); ‘NMR’ (September 1968-March 1969); ‘Bacilysin hydrolysis’ (October, 1968); ‘Crystallization’ (September, October 1968); ‘Terreic acid’ (October 1968); ‘.R. spectrum bacilysin’ (September 1968); ‘Bacilysin detection’ (March 1969); ‘O.R.D.’ [no notes]; ‘LAP’ (February 1969); ‘Action on fungi & yeasts’ (June 1966-April 1969); ‘Bioautography bacilysin lactone [?]’ (May 1969); ‘cbz bacilysin’ (March, April 1969); ‘Effect of bacilysin on B. subtilis’ (June 1969); ‘N- (March acetylglucosamine bacillin’ (January 1966-January 1969); ‘Phenylacetyl bacilysin’ (May 1969); ‘B. subtilis mutants’ (December 1966-July 1969); ‘B. subtilis intracellular’ (August, September 1969); ‘Bacillin N-acetylglucosamine’ (December 1968- June 1969); ‘Agar AB’ (December 1966-April 1969). extracellular supernatant’ ‘Production Warburg’ bacilysin 1966); by of July ‘A14_ (June, 1969); Large scale C.239, C.240 Large binder labelled ‘J.E. Walker purificat”. Compounds P1, P2, P3. Tyrosine. CrCl. red”. 1968, 1969. Bacilysin. Sephadex A25. Separated into topics by dividers labelled as follows: ‘Purification (cont)’ (January-December 1968); ‘P1, P2, P3’ (September 1968-October 1969); ‘p- nitrophenol TFA’ (June 1968); ‘t-BOC Ala.Ala-‘ (November 1968); ‘CrCl. reduction’ (September, October 1968). 2 folders. Chromatogram graphs from experiments by accompanying data sheets, 1968, 1969. ‘Amino acid analyses — bacilysin J.E. Walker’, contents of a file so inscribed. J.E. Walker, with few a E.P. Abraham NCUACS 103/2/02 Research and development Large binder labelled ‘Sylvia Main Book |’ on spine, 1966-1968, with a few notes dated 1965. expts’ resin’ (January, ‘Mycelium Separated into sections by dividers labelled as follows: ‘Fungal luciferin’ (January-February 1966); (January 1966-May 1968); ‘Glaxo compounds’ (January 1966-February 1967); ‘Glaxo ceparin [appears as ‘ceporin’ in the notes] (May-July 1967); ‘7ACA’ (July 1967); ‘7ACA tosylate’ (February, March 1968); ‘ACV and GSH’ (January 1966-May 1967); 1966- ‘Ethylene November ‘N- phenylmaleimide exchange cellulose Amino Ethyl AE11’ (August 1966); ‘Anion exchange cellulose cellex PAB’ (September 1966); ‘B-Lactamase’ (May 1966-April 1968); ‘Actinomycin D’ (June 1966); ‘Spectra of tyrosine & tryptophan’ (July 1966); ‘Desacetoxy cephaloglycin & cephaloglycin’ (January, February 1967); ‘Miscellaneous’ (March 1967-December 1968, with a few pages December 1965); ‘Safety’ (undated). (July-December 1966); ‘Whatman ion ‘Polyamino (June-July (February February ‘Assays’ styrene 1968); 1966); imine’ 1967); [?] Loose notes at front. Large binder labelled ‘Sylvia Main Book II’ on spine, 1967, 1968. a Contents of a C.243-C.250 (October 1968-[?November] 1970); Loose pages of notes, originally from a binder, 1968-1970. box labelled ‘Jeremy and Anne’. Separated into sections by dividers labelled as follows: ‘Index’; ‘7ACA’ (June 1967-April 1968); ‘Ceph C + ENHp2 cap:’ (February-May 1967); ‘Ceph C + cysteine’ (April, May 1967); ‘Ceph C + & B- ala’ (July-October 1967); ‘Ceph C + Lys[sine] & polylys’ (July-September 1967); ‘Ceph C + NH3’ (July- October 1967); ‘Reactions with B-lactamase’ (February-October 1967); ‘3- methyl Ceph C’ (August, September 1967); ‘Deacetyl Ceph C’ (October 1967); ‘Ceph C + heavy metals’ (October, November 1967); ‘Ceph C + NaBH,’ (September-November 1967); ‘Misc’ (February-November 1967). 8 folders. Separated into sections by dividers labelled as follows: ‘Antibodies to B- lactamase’ G’ (October 1968-July 1969); ‘Antibodies to de + [?dyl] c’ (June-September 1969); “b assay’ (December 1968-March 1970); ‘Antibodies to rabbit RBC’ (November 1968-April 1970); ‘Animal log’ (May-September 1969); ‘Reaction pen G etc ERBC BGG’ (November 1968-May 1970); ‘B-lactam conjugates’ (October 1968-June 1970); ‘Haemagglutinate of pools v.s. various cells’ (October 1969-June 1970); ‘Hapten inhibition’ (September 1969-April 1970); ‘Purification of antibodies’ (August-October 1969); ‘Ouchterlony’ (September, October 1969); ‘Quant. ppts’ (September-December 1969); ‘7ACA A? [ ? ] A” (October 1969-May 1970). Antibodies to C & E.P. Abraham NCUACS 103/2/02 Research and development C.251-C.268 Notes etc (1 original binder, the remainder loose pages from binders), 1978- 1983. Numerous references indicate that this material was the work of Dr J.S. Jayatilake. The notes are all in the same hand. The loose notes in C.251-C.267 were found together. C.251-C.254 Loose notes, October 1978-November 1980. file inscribed ‘Synthesis of ISON and conversion of ISON [arrow] Penficillin] N by an [?epimerase]’. Contents of a Paginated 1-78. 4 folders. C.255-C.264 Loose notes, 1979, 1980. These notes appear to be a continuation of the material in C.251-C.254. C.265-C.267 10 folders. 3 folders. 1979); ‘(DLD) ACV’ April 1980); ‘(LLD) (July, August sulfone (hot and ‘Penicillinic acid Paginated 78-161 (some material is unpaginated). Separated into sections by dividers labelled as follows: Labelled 6-APA’ (October, November 1979); cold)’ (January-[ca June] 1979); ‘(LLD) ACV’ (March 1979-May 1980); ‘(LLD) ABV’ (ca (LLD) GCV’ ( September ‘(LLD) CCV’ (September 1979-September 1980); ‘(LLD) ACB’ (March-December 1980); (LD) — [?Decanboxy] ACV (UCV)’ (September, October 1980); ‘“(LD) Adipyl CV’ (November 1980); ‘Adipyl-L-cystein dipept.’ (January 1981); (LD) CV- dipeptide’ (April [?1980)). ASV’ (March-September 1980); 1980); Loose notes, October 1982-February 1983. Contents of ‘Synthesis of “cold” & “hot” ACG Attempted labelling expts’. fans Separated into sections by dividers labelled as follows: ‘P. Chrysogenum ext. G25/S/N & G25[?]N’ (April Chry: G25 NS/N CV dipep Activ[ity] / Inhi[bition]’ (March, April 1981); ‘P. Chryso: Assay of ASO-50, 50- 65, 65-80, 80+’ (April, May 1981); ‘P. Chrys: protein fraction DEAE seph[?] A50’ (May 1981); Large binder labelled ‘GSJ 4 experiments’. 1981, 1982. In the same hand as C.251-C.264. Penicillin chrysogenum. Prep” of extract & a file inscribed 1981); ‘P. E.P. Abraham NCUACS 103/2/02 Research and development Il [?] ‘P/C R1221/5 DEAE/AS G100’ (July 1981); ‘ACV activity’ / DEAE — [?sol]’ (May 1981); ‘R.1221 P/C ‘P. Chrysogenum Dyno mill harvest[?]’ (May 1981); ‘Gel-electro phoresis’ ([?May or June 1981] ); ‘P/C R1221/1 Dyno mill large scale’ (June 1981); ‘P. Chrysogenum Dyno mill small scale’ (June 1981); ‘P/C Dyno mill 0-80% DEAE-seph R1221/2’ (June 1981); ‘Dyno-mill R1221/3’ (June, July 1981); ‘Dyno-mill R1221/4’ (July 1981); ‘P/C R1221/2 DEAE/AS/0.5[?7]0.2’ (July 1981); ‘G100 calibration’ (July 1981); (July, August 1981); ‘ACV activity 1,2&3% ACV [?]’ (August 1981); ‘R1221/6 extract G100 / mol wt.’ (August 1981); ‘Effect of catalase triton x-100 G100 extract’ (August 1981); ‘ACV [?dimer] / P. Chrys & acrem.’ (August 1981); ‘Km ACV — IN [?lsopenicillin N] in P.C.’ (August 1981); ‘G100 column’ (September 1981); ‘P,; value’ (September 1981); ‘Km — Deter[mination]’ (September 1981); C. acremonium’ (September 1981); ‘R1223 / harvest time antibiotics production’ (September 1981); ‘Effect of co-factors’ (October 1981); ‘1. Effect of a-ketoglu[tinate] 2. DEAE in MOPS’ (October 1981); ‘Dyno mill R1225/1’ (October 1981); ‘Stability in various buffers’ (October 1981) ‘R1225/2 Extract prep':- ‘TRIS’ 7 Bacilysin samples’ (December 1981); & ‘R1225/3 1981); (December 1981); ‘R1225/5’ (January 1982); ‘R1225/6’ (February 1982); ‘R1225/7’ (March 1982); ‘Prep — Gel expts’ (March 1982) ; ‘Harvest of in “old” & “new” media of chromatofocussing phenylsepharase columns’ (April 1982); ‘Ps in “old” — large scale Dyno mill’ of (April ‘Use phenylsepharase at 35% AS conc” (May 1982); ‘1. Harvest of P» in old media in fermentor 2. P2/new/ shake flasks’ (May 1982); Pz (850g) — Dyno ‘Activity (December 8’ (December 1981); ‘Chromatofocussing ‘R1225/4’ ‘ACV [?dimer] activit / also with 1982); 1982); Dyno mill extracts’ (April dyno mill’ 2nd expt’ (May 1982); Ps» ‘Use mill extract’ (May-July 1982). E.P. Abraham NCUACS 103/2/02 Research and development C.269-C.282 Loose notes, originally from a binder, 1979. Separated into sections by dividers labelled as follows: Untitled notes at front (September 1979); ‘Dialysis in Fe etc [?1h]’ (September 1979); ‘Dialysis 68 [?1h]’ (August, September 1979); ‘Ph 66’ (August 1979); ‘Co-factors 64 65’ (August 1979); ’50,000g 61’ (July 1979); ’20,000g 50,000g 60’ (July 1979); ‘+ - DTT 20,000g 59’ (June, July 1979); ‘GSJ — ACV 20,000g 58’ (June, July 1979); ‘diffr[erential] assay 55’ (June 1979); ‘ACV: time’ (April 1979); ‘ACV / PL conc” (February-May 1979); A[encircled C]V + ACV 76’ (October 1979); ‘A[encircled C]V’ (October 1979); ‘A[encircled CV, ACV 75’ (October 1979); ‘ACV / CP’ (May 1979); EB / ACV /°H’ °H/ 'C ACV ex JEB’ (July- September 1979); “H — isopen N’ (February-April 1979); ‘N purif™ (June-July 1979); ‘1153 N — C [?]’ (January-July 1979); ‘C91 / 5H caad’ (February, March 1979); ‘dialysis DTT 1h asc 72’ (September 1979). 14 folders. Binder inscribed ‘Henry Chmara Amidotransfer’ on cover, 1979 (with a few notes dated 1978 near back). of of E. Isopenicillin N PAGE Notebook syn[?e]thetase’, June 1982-November 1983. inscribed Pang ‘C.P. Analytical Loose notes at back. Topics covered include ‘Purification of amidotransferase from E-coli ESS 22- 31’ (October 1979); ‘Action of Bacilysin in vivo inhibition of amidotransferase’ (August 1979); ‘Purification of amidotransferase from C[?oryne]bacterium 168’ (July 1979); ‘Purification of amidotransferase from Sup. 105000g’ (May 1979); ‘Purification of amidotransferase from E-coli MRE 600’ (March 1979); ‘Purification coli MRE 600 and some aspects of interaction with bacilysin and anticapsin’ (February 1979). a new part Title on first page is ‘Gel electrophoresis’. This topic appears to cover all the notes in the book. Found loose in unmarked file. From front: notes re visits to universities and institutions in the USA and re various chemical processes. From back: notes on atomic physics, isotopes and various biochemical processes. References to published sources indicate a possible date ca 1948. Manuscript numerical data, possibly relating to experiments, n.d. Notebook in Abraham’s hand. E.P. Abraham NCUACS 103/2/02 Research and development C.287-C.357 MEDICAL RESEARCH COUNCIL 1949-1987 In July 1949 the MRC’s Antibiotics Research Station at Clevedon began to produce culture fluids from the cephalosporium fungus for study by the Sir William Dunn School of Pathology. In early 1952 Abraham’s colleague Guy Newton was sent to Clevedon to help speed up the supply of Cephalosporin The improved supply enabled Abraham’s team to isolate almost pure N. CephalosporinN. producing sufficient quantities of Cephalosporin C for the Dunn School’s requirements, Clevedon workers discovered a mutant strain of the fungus which gave significantly higher yields. difficulties following Glaxo’s 1957, In in Abraham served on the Scientific Steering Committee to oversee the work of the Antibiotics Research Station, Clevedon. The majority of the papers relate to the work of the Antibiotics Research Station and its collaboration with the Sir William Dunn School of Pathology. See C.1042-C.1048 for further correspondence re the work at Clevedon. C.287-C.292 Correspondence between Abraham and C.W. Antibiotics Research Station, re research on cephalosporin, October 1949-December 1952. Hale the of 6 folders. C.293-C.308 C.293-C.296 Contents of a file inscribed ‘EPA corresp. Clevedon — Oxford - NRDC’. Included are copies of typescript reports by scientists at the Antibiotics Research Station and the Sir William Dunn School of Pathology. Correspondence, mostly carbon copies of letters from Abraham to B.K. Kelly and G.W. Hale at Clevedon; included also is correspondence between Abraham, the National Research Development Corporation and Glaxo Laboratories Ltd. 1949-1961. 4 folders. C.297-C.300 1949-1954. 1955-1958. 4 folders. E.P. Abraham NCUACS 103/2/02 Research and development C.301-C.307 1959-1961. 7 folders. Letters by Guy Newton to Abraham, ca [March- May] 1952. C.309-C.317 Drafts of papers co-authored by Abraham, with related material. Publication details given where known. 1p copy of typescript abstract of a paper entitled ‘Properties of some derivatives of cephalosporin C and heterocyclic tertiary bases’, by C.W. Hale, Abraham and G.G.F. Newton, Supplement to International Abstracts of Biological Sciences (\V International Congress of Biochemistry, Vienna, September 1958); letter from Hale, 1958. ‘The Influence of Methionine on the Biosynthesis of Cephalosporin N’, by C.W. Hale, Abraham and G.G.F. Newton. letters re the 18pp copy of typescript draft with manuscript revisions; 2 content and possible publication of the paper, December 1958. 13pp copy of typescript, with draft figures etc, with the first of the above titles and authors. ‘The Cephalosporin C Nucleus (7-Aminocephalosporanic acid)’, by G.G.F. Probably published under this title followed by the Newton and Abraham. additional words ‘and some of its derivatives’, by Bronwen Loder, G.G.F. Newton and Abraham, in Biochemical Journal 79, 1961. fete 2pp copy entitled ‘Appendix into Cephalosporin C” ’, by C.W. Hale, G.A. Miller, Abraham and G.G.F. Newton (possibly part of the paper published under this title, with the name P.W. Trown added to the authors, in Biochemical Journal 84, 1962). ‘Formation of the cephalosporin C nucleus (7-ACA) by enzymic hydrolysis of an N-acyl derivative of 7-ACA’ by G.G.F. Newton and Abraham. 5pp copy of typescript draft with manuscript revisions. Copies of typescript appendices, possibly to the papers in C.309 and C.310. 1. “Incorporation of 1-'*C Acetate E.P. Abraham NCUACS 103/2/02 Research and development 6pp copy entitled ‘Appendix 2. “Cephalosporin C,” ’, by G.G.F. Newton and Abraham. Spp copy, with manuscript revisions, entitled ‘ Appendix 3. “Cephalosporin Ca (pyridine)” ’, by Abraham, G.G.F. Newton and C.W. Hale. ‘The Separation of Cephalosporin N and Cephalosporin C’, Newton and Abraham. by G.G.F. 8pp copy of typescript draft with manuscript corrections. C.315, C.316 Copies Cephalosporin C, with manuscript revisions and annotations. typescripts detailing various experiments, of 5 mostly re Found with the draft in C.314; one typescript is inscribed ‘separation paper’. 2 folders. Typescript report by C.W. Hale, December 1956; data and photographic prints (some mounted onto cards). C.319, C.320 2 folders. C.318-C.320 Various reports, 1957-1959, 1961, n.d. Found with the material in C.314-C.316. Copies of typescript reports of experimental results by scientists at the Antibiotics Research Station. Reports by C.W. Hale entitled ‘The Extraction of antibiotics produced by Malayan actinomycete’, January-March 1951. act as an advisory body to the Antibiotics Research Station. Correspondence and committee papers re the setting up and business of the Scientific Steering Committee for the work of the Antibiotics Research Station, April 1956-October 1957. Abraham was a member of the Committee which was formed in May 1956 to E.P. Abraham NCUACS 103/2/02 Research and development Miscellaneous correspondence and papers re the work of the Antibiotics Research Station, 1956-1958. C.323-C.333 Correspondence with the National Institute for Medical Research, 1950- 1973. Re various research on publication. Correspondents include Martin Pollock. antibiotics and the preparation of papers for Contents of a file inscribed ‘NIMR’. C.323-C.327 1950-1957. 5 folders. C.328-C.333 1958-1968, 1972, 1973, 1978. 6 folders. scientists C.335-C.341 1953-1970. 7 folders. C.335-C.357 manuscript notes and diagrams typescripts and Inscriptions on some of the pages indicate collaboration with Glaxo Ltd. Included is correspondence with research topics, found with this material and probably related to assessments by Abraham of applications by others for MRC grants. other organisations and Correspondence and papers re applications for research grants by Abraham to the Medical Research Council and correspondence arising, 1953-1985. re Miscellaneous experiments, some possibly for use in the preparation of publications, 1965, 1968, n.d. 7 folders. re it; and C.342-C.348 1971-1973. E.P. Abraham NCUACS 103/2/02 Research and development C.349-C.354 1974-1978. 6 folders. C.355-C.357 1979-1985. 3 folders. C.358-C.605 NATIONAL RESEARCH DEVELOPMENT CORPORATION (NRDC) (BRITISH TECHNOLOGY GROUP (BTG)) 1952-1995, n.d. In 1949 the NRDC became involved in the research on Cephalosporin, helping to coordinate the results of the work done at Oxford and Clevedon. Following the isolation of Cephalosporin C in 1953, the NRDC persuaded Glaxo Research Laboratories to join the collaboration. After the elucidation of the chemical structure of Cephalosporin C in 1959 the NRDC took steps to exploit the commercial value of the antibiotic by devising a worldwide patenting and licensing strategy. With the subsequent granting of extensions to some of sales of cephalosporin antibiotics earned the corporation a royalties which was shared with inventors. of £152 million the patents, total in enabling a number of ring system, cephalosporin In 1958 Abraham accepted a consultancy position with the NRDC. In order to find methods of producing the Cephalosporin C nucleus (7-ACA) in quantity, the NRDC granted options on licences to the pharmaceutical companies Glaxo, Eli Lilly, Squibb, Smith Kline and French, Merck and Pfizer (USA), Ciba and Farmitalia (Europe) and, later, Fujisawa (Japan). With funding from the Corporation new methods were discovered for the large-scale production of 7-ACA and for the conversion of the penicillin to the different cephalosporins to be produced. Te Correspondence, with related papers, re patenting; the progress of, and the funding of, research on antibiotics (mostly cephalosporins) carried out by Abraham’s team and the pharmaceutical companies; the development of marketable drugs by some of the companies; the publication of papers; and matters arising, 1952-1995. The principal correspondents are NRDC executives and managers, in particular James C. Cain and R.S. Crespi. The NRDC later combined with the National Enterprise Board to form the British Technology Group. See also C.1042-C.1053. C.358-C.519 E.P. Abraham NCUACS 103/2/02 Research and development six separate groups of files. The correspondence was found arranged in This arrangement has been maintained, though there appears to be no obvious differentiation between these groups in terms of content. C.358-C.372 Correspondence, mostly letters to Abraham from the NRDC and patent agents, 1952-1960. Contents of 2 files. Included is correspondence re Abraham’s acceptance of the consultancy position. C.358-C.362 1952-1955. 5 folders. C.363-C.368 1956-1958. 6 folders. C.369-C.372 1959-January 1960. 4 folders. C.373-C.392 C.373-C.377 1952-1959. C.378-C.382 Correspondence etc, mostly carbon copies of letters by Abraham, 1952- 1967. Contents of 4 files. 5 folders. C.383-C.387 1962, 1963. C.388-C.392 1964-1967. 5 folders. 1960, 1961. 5 folders. 5 folders. E.P. Abraham NCUACS 103/2/02 Research and development C.393-C.413 Correspondence, 1968-1972. Contents of 3 files. Included is correspondence re the patent extension granted to the NRDC in 1972. Included are a few letters to, or by, other individuals and companies, and draft affadavits by Abraham, mostly in connection with the patent extension referred to above. C.393-C.399 1968-1970. 7 folders. C.400-C.413 1971; 1972: 14 folders. C.414-C.464 Correspondence etc, 1973-1995. Contents of 5 files. Included are reports on various research topics. 15 folders. 1978-1980. 11 folders. 10 folders. C.414-C.423 1973-1975. C.424-C.438 1976, 1977. C.439-C.449 11 folders. Included at C.448 is material relating to a dinner held in honour of Abraham on the occasion of his retirement. C.450-C.460 1981-1983. E.P. Abraham NCUACS 103/2/02 Research and development C.461-C.464 1985-1992, 1995. 4 folders. C.465-C.493 Correspondence, December 1958-1966. Contents of 3 files. C.465-C.472 December 1958-1960. 8 folders. C.473-C.480 1961. 8 folders. C.481-C.493 1962-1964, 1966. Very few letters are post 1962. 13 folders. C.494-C.519 10 folders. 9 folders. 7 folders. C.513-C.519 1967-1969. Mostly 1967, 1968. C.494-C.503 1963, 1964. With a few letters 1965. C.504-C.512 1965, 1966. Correspondence, 1963-1969. Contents of 4 files. 4 folders. Miscellaneous correspondence etc with BTG, 1983-1985, 1988. C.520-C.523 E.P. Abraham NCUACS 103/2/02 Research and development C.524-C.532 Copies of assignments and agreements (involving Abraham, Guy Newton, the NRDC and others), with related papers and correspondence, 1954-1967. 9 folders. C.533, C.534 Accounts produced in accordance with the cephalosporin revenue sharing agreements, with related papers and correspondence, 1959-1963. Found with the papers in C.524-C.532. 2 folders. C.535-C.540 Copies of draft patent specifications for applications filed by Abraham, Guy Newton and the NRDC, 1959-1962. 6 folders. C.541-C.545 typescript Copies on developments in Cephalosporin C research, with other papers concerning patents, 1959-1962. co-authored by Abraham, of reports, some 5 folders. E.P. Abraham NCUACS 103/2/02 Research and development C.546-C.569 Contents of file labelled ‘Cephalosporin C Dossier’. Copies of numbered typescript reports by scientists at the Sir William Dunn School the MRC’s Antibiotics Research Station, 1959-ca 1965. Pathology (including Abraham) and of Some of the reports are also drafts of papers for publication. 24 folders. C.570-C.574 C.575-C.583 Copies of typescript ‘Reports to the NRDC on Biochemical Studies Relating to Cephalosporins and Penicillins’ Sir William Dunn School of Pathology, one with manuscript revisions by Abraham, 1969-1973. the by 5 folders. Copies of lactamases by Abraham others, 1969. typescript research reports on the cephalosporins and B- 9 folders. 3 folders. 17 folders. C.585-C.587 C.588-C.604 Miscellaneous papers and correspondence, mostly re patents, 1953-1985, 1992, n.d. Schedules of patents and patent applications concerning Cephalosporin C, 1960-1971. Copy of legal brief relating to a dispute over patents between Dr H.S. Burton and his ex-colleagues at the Sir William Dunn School of Pathology, 1961. Containing detailed experimental results and technical information. ‘Cephalosporin Analogue 87/4’, produced by Glaxo Group Ltd, ca 1964-1970. printed document so a large entitled E.P. Abraham NCUACS 103/2/02 Research and development C.606-C.963 OTHER ORGANISATIONS 1946-1994, n.d. Correspondence and papers, mostly relating to the various stages in the research on Cephalosporin C and other work on B-lactam antibiotics. The organisations are mostly pharmaceutical companies. Arranged alphabetically by organisation. C.606-C.614 Beecham Group plc 1970-1991, n.d. Beecham was a manufacturer of semi-synthetic penicillins. company succeeded in isolating the penicillin nucleus ‘6-APA’. In 1959 the Correspondence, mostly re requests for chemical samples for research and exchanges of information. C.611-C.614 5 folders. 4 folders. C.606-C.610 1970-1977. 1978-1983, 1987, 1988, 1991, n.d. Included are correspondence and papers re the Beecham Colloquium (September 1981): at C.612 are a copy of a transcript of a discussion at the colloquium ‘The Control of Antibiotic-resistant bacteria’, in which Abraham participated; and a proof, with manuscript corrections, of a paper ‘The Design of New Antibiotics and Bacterial Resistance’ by Abraham, probably given at the colloquium. Also included at C.614 is correspondence re Abraham’s assistance to Beecham in patent litigation. Correspondence re studies on B-lactam antibiotics. Bristol-Myers Company (USA) 1973, 1978-1987 E.P. Abraham NCUACS 103/2/02 Research and development C.616-C.620 CIBA Ltd 1961-1966, 1973-1975 CIBA was one of the companies granted a licence by the NRDC in the 1960s to research methods of producing the Cephalosporin C nucleus. Abraham gave a lecture at CIBA, Basle, Switzerland, September 1962. Correspondence and papers. Included at C.618, C.619 are manuscript and typescript drafts (some incomplete) of Abraham’s lecture entitled, ‘Preliminary Experiments on the Biosynthesis of Cephalosporin C’, with related correspondence. Also at C.619 is a copy of a 3pp typescript of a talk by Abraham entitled ‘Gordon Conference’. 5 folders. C.621-C.624 The Distillers Company Ltd 1949, 1953-1963 In the 1950s Distillers produced quantities of cephalosporin for use by the Sir William Dunn School of Pathology. The company reached an agreement with the NRDC (1959) for research into Cephalosporin C. 4 folders. C.625-C.632 1971, 1978-1991 Correspondence etc. Dyson Perrins Laboratory (Oxford) Included is material relating to a patent dispute between Beecham Research Laboratories Ltd and Distillers. The 1970s and 1980s saw various collaborative projects on the biosynthesis of penicillins and cephalosporins involving the Dyson Perrins Laboratory, the Sir William Dunn School of Pathology and Eli Lilly (see C.633-C.881). ise Included is correspondence with Jack Baldwin re research on biosynthesis of Some to appointments to research and other posts, correspondence relates including refereeing. Correspondence and papers. At C.628-C.630 are manuscript and typescript drafts by Abraham and Baldwin ‘The Biosynthesis of Penicillins and Cephalosporins’, with Natural Products Reports 5 (Royal Society of Chemistry), correspondence re publication. article 1988, an of and _ related articles. penicillins and cephalosporins E.P. Abraham NCUACS 103/2/02 Research and development At C.631 are unidentified manuscript and typescript drafts found with the material in C.628-C.630. 8 folders. C.633-C.881 Eli Lilly and Company 1954-1994 Eli Lilly signed an agreement with the NRDC in January 1959 for a research programme aimed at producing substances related to Cephalosporin C (including its nucleus). This project was unsuccessful, but in early 1960 the NRDC granted the company an option on a licence allowing it to research processes of converting Cephalosporin C to its nucleus (7-ACA). It was the only licensee to achieve a breakthrough in this area, paving the way for large-scale the first cephalosporin antibiotic in 1964. production introduced nucleus. Lilly Eli its of In the following years Eli Lilly funded collaborative research projects on the biosynthesis of penicillins and cephalosporins involving the Sir William Dunn School of Pathology and the Dyson Perrins Laboratory (see C.625-C.632). C.633-C.694 C.633-C.642 C.643-C.662 1965-1971. 1954, 1957-1962. the preparation of crude Correspondence, with related papers, mostly re research on cephalosporins, 1954-1990. Some correspondence 1957-1959 relates secretin. The correspondence covers a number of divisions of the company in the USA and the UK. 15 folders. Included incomplete and disarranged (with proof at C.661), of ‘Cephalosporin C’ Penicillins: Chemistry and Biology, ed. Related correspondence is at C.649-652 and C.660-C.662. drafts, some a paper entitled by Abraham and P.B. Loder in Cephalosporins and Flynn, New York 1972. at C.653-C.659 are manuscript and C.663-C.677 1972-1976. typescript by E.H. to 10 folders. 20 folders. E.P. Abraham NCUACS 103/2/02 Research and development C.678-C.686 1977-1985. At C.683 is a copy of a typescript of Abraham’s introduction to Chemistry and Biology of B-lactam Antibiotics (Volume 1), edited by Robert B. Morin and Marvin Gorman, New York and London, 1982. At C.684 is a proof with corrections of ‘Biosynthesis of Penicillins and Cephalosporins’, a chapter by Abraham in Beta-Lactam Antibiotics for Clinical Use, Clinical Pharmacology 4, edited by Sherry F. Queener et a/., New York 1986. 9 folders. C.687-C.694 1986-1990. 8 folders. C.695-C.697 Drafts and copy of an agreement, December 1985, between Eli Lilly, the University of Oxford, Abraham and Jack Baldwin relating to co-operation on the the agreement and related matters, 1985, 1986. with correspondence etc Biosynthesis B-lactam Project, re 3 folders. C.698-C.833 Found with the remainder of the Eli Lilly papers and correspondence in this sub-section. Experimental notes, originally in a large ring binder, by one of Abraham’s research workers. Included are graphs, tables of results, photographs, a few letters and other related papers. The notes are similar in appearance and content to those in C.207-C.286 which are in, or taken from, ring binders. Contents of 4 boxes labelled ‘1’ to ‘4’. Notes on pieces of card found in the boxes are inscribed ‘JAH’, probably indicating that these notes were the The notes work of Joyce A. Huddleston, a junior colleague of Abraham. appear to relate to some of the collaborative work between Eli Lilly and Oxford University referred to above. hee Separated by dividers labelled as follows: ‘aap: DS,T,ESS’, November 1979; ‘time course substrates cent” [centrifugation]’, October, November 1979; ‘cofactors undia / dialysed’, October 1979; ‘D-M 0 myc[elium] 73/2’, October 1979; ‘D-M/2 73’, September 1979; ‘D-M 70’, September 1979; ‘Dr Young’s cpd’, PS’, September-November 1980; ‘Feroceryl deriv[atives]’, June-September 1976; Listed as two groups of folders for ease of reference. Notes, contents of ‘Box 1’. C.698-C.734 July 1977; ‘Lu43, 44 C.698-C.714 E.P. Abraham NCUACS 103/2/02 Research and development July, August 1976; ‘GL cpds’, June-September 1976; ‘clav[ulanic] acid’, ‘SGW_ Bioassays’, March-October 1976, April 1978; ‘Proto: C’, April, May 1978; ‘Proto: N, C 120, 250’, May 1978; ‘Proto stabilisers’, June 1978; ‘Pen N: ESS’, June 1976-October 1977; ‘Pen N: T’, November 1976, July 1979; ‘C, N+ BI’, February, March 1978; ‘BI: cephs’, January 1978; ‘IN N bioassay’, February, May 1979; ‘PL control’, July 1978; ‘Separations N, C etc’, January 1977-December 1978; ‘10% NaCl’, July 1975; ‘ACUSOsH elp.’, October 1975, February 1976; December 1977; ‘analyser: cephs cephs oxidised’, November 1977; ‘u-NHp Lilly solv 1’, June, July 1978; ‘ODS — 2’, March-July 1978. / 17 folders. C.715-C.734 [?], Porasil (Continued from C.698-C.714). ‘Cig April 1975-May 1979; ‘Liposomes’, April 1978-January 1979; ‘REV’, February, March 1979; ‘GSH, ACVSH [?]’, July, 1975-February 1976; ‘ox. stds’, May 1975; ‘XAD-2’, July 1978; ‘Lilly: N sulphoxides’, March 1976; ‘Axcorasil [?]’, February 1975- March 1977; ‘Purif" of Pen N by [7]; Sep” 7-[?] Ceph C & Pen N by acid”, March 1975; ‘Pen N [to] penillic acid’, March-September 1975; ‘Pen purif” — [7], June 1974-May 1976; ‘TP-1 TP-2’, April, May 1977; ‘Det” of efficiency of counting’, July 1975-July 1977; ‘Streptomyces lipmanii’, February-October 1975; ‘C91 growth expr, May 1977-April 1978; ‘G25 Pen purif" 1’, July, acid’, September, August 1975; ‘2’, September, October 1977; October cuprous mercaptide’, January-December 1975; ‘Pen N [to] aaad [?Pen] SOsH’, June, August 1977; ‘aaadgly’, October 1975-May 1977; ‘A. nidulans TCA extract’, January, May 1975. May-September 1976; peptides’, ‘penillic 1977; ‘C91 ‘C91 20 folders. C.735-C.757 C.735-C.778 This box was also inscribed ‘Lilly / SWQ 3H / Listed as two groups of folders for ease of reference. Notes, contents of ‘Box 2’. 14C’. 23 folders. Separated by dividers labelled as follows: ‘L — 2, 33H[?]val 10/1’, November 1975-January ‘C. acremonium mutants (Lilly)’, April-July 1975; ‘ACV: intra and extracellular’, August-October 1975; ‘Lilly: '*C val [to] ACV’, June 1975; ‘L-3H-val 3H / “C = 7/1’, September-December 1976. February-October ‘L-3-3H 1976; 1976; val 8/1’, E.P. Abraham NCUACS 103/2/02 C.758-C.778 Research and development ‘L-2-3Hval’, C.735-C.757). (Continued from 1977 (included at C.758 are a few letters to Abraham from Douglas Young of Sussex University, 1975-1977; included at C.759 is copy of a 9pp draft of paper entitled ‘The Stereochemistry of B-lactam Formation in Cephalosporin Biosynthesis’, by Abraham, Joyce A. Huddleston et al, Biochemical Journal 169, 1978); ‘3H / a cysteines expr 1’, February-April 1977; ‘Expr 2’, June- September 1977; ‘[?] cys XAD’, July 1976-April 1977. February January, 21 folders. C.779-C.811 Notes, contents of ‘Box 3’. Listed as two groups of folders for ease of reference. C.779-C.793 dividers Separated by at beginning): ‘LLD - ACV(1)’, August 1978-January 1979; ‘LLD - ACV(2)’, November 1976-January 1979 (chiefly 1978); ‘Ceph C ex [?]’, February 1976-October 1977. page of contents labelled follows (with as 15 folders. 18 folders. C.794-C.811 C.812-C.833 Notes, contents of ‘Box 4’. ‘DTT, cys: [?]’, August, September 1977; (Continued from C.779-C.793). ‘C91 ceph C resusp" [resuspension], February 1976-July 1977; ‘ACV content’, March 1976; ‘toxy content’, March, April 1976; ‘glass wool’, January 1977; ‘Radioactive cpds’, January-November 1975; ‘C91 Protoplast exprs “Cval’, January 1975; ‘CV’, February-October 1975; ‘DLD-ACV’, March-July 1975; ‘CV(2)’, February-November 1975; ‘Toxin 1’, January, February 1978; ‘N acetyl ceph C’, May-February 1976; ‘N acetyl Pen N’, May, June 1975; ‘G10 s[?]pn acids’, July 1975-November 1976. 22 folders. at Separated by beginning): ‘mo198’, October 1978; ‘°N / MIT’, November 1978-January 1979; ‘[?lysate] Demain Oxford’, July 1978; ‘Pen N expr 3’, April, May 1978; ‘Demain ESS’, February 1978; ‘effect of Demain buffer, February, March 1978; ‘Demain 3H Pen N’, January, February 1978; ‘3H Pen N 2 tube 3’, January-March 1978; ‘evap" bioassay’, January-March 1978; ‘tris / mops’, January 1978; ‘3H Pen N [pH] 7.5, 6.5, 4.5’, December 1977; ‘1078 ESS tris / mops’, December 1977; ‘3H Pen N 2’, October-January 1978; ‘ESS cof[actors] +/- AccoA’, October 1977; ‘3H 1 Pen N’, September-November 1977; [?], September 1977; ‘250 rpm [?]’, August, September 1977; ‘Demain expr’, August 1977; ‘250 rpm ESS’, August 1977. bio’, September 1977; ‘250 rpm ESS co page of contents ‘250 ESS [?] as follows f. dividers labelled (with E.P. Abraham NCUACS 103/2/02 C.834-C.881 C.835-C.865 Research and development Contents of Pathology — Dyson Perrins] collaboration 1984-". a file entitled ‘SWDSOP — DP [Sir William Dunn School of Papers and correspondence, 1985-1994, with a few papers, 1961, 1962. Mostly copies of reports re the collaborative research carried out by Eli Lilly and Oxford University. There is also material relating to published papers and correspondence, 1985-1994. For related material see C.1071-C.1077. ‘Isolation, sequence determination and expression in Escherichia coli of the Isopenicillin N-synthetase gene from Cephalosporium acremonium’, by Abraham et al., Nature 318, 1985. copies 2 revisions, the other headed ‘final copy’; letter re publication. one headed ‘working typescripts, copy’ of with manuscript Further correspondence etc relating to this paper is in C.836, C.837. Drafts and copies of various reports etc, and papers re the exchange of information between Eli Lilly and Oxford, 1985-1989. 31 folders. C.867-C.874 6pp copy of typescript of paper. by Abraham, though his manuscript None of the reports appear to be revisions are found on some. ‘Acyl coenzyme A: 6-aminopenicillanic acid acyltransferase from penicillin chrysogenum and aspergillus nidulans’, by Abraham et al., FEBS Letters 262, 1990. 5 folders. of ‘Isolation C penicillium chrysogenum transformants: a new fungal biosynthetic pathway’, by Abraham et al., Proceedings of the Royal Society B 248, 1992. Correspondence re preparation and publication of the paper, September 1991-December 1992. Included are typescript drafts, some with manuscript revisions by Abraham. construction of of deacetoxycephalosporin from fermentation broths C.867-C.871 E.P. Abraham NCUACS 103/2/02 Research and development Further typescript Abraham. drafts, some incomplete, with manuscript notes by C.873, C.874 Material printed out from a floppy disc found with the papers in C.867-C.872. 2 further drafts of the paper, with other pages of text probably related to the paper. 2 folders. The original discs are included at C.873. draft manuscript of 2pp Production an Cephalosporins by a Transformant of Penicillium chrysogenum’, of introduction for a paper, with revised typescript version and further 1p typescript draft. Abraham, entitled ‘The by transformants Possibly early drafts of the paper ‘Production of deacetoxycephalosporin C by pathway engineering, by Abraham et Industrial Microorganisms (possibly a publication by the American Society of Microbiology), [71993]. chrysogenum: Penicillium antibiotic al., of 3 folders. C.877-C.879 C.880, C.881 Miscellaneous correspondence, with reports, re progress of research, 1988- 1991, 1994. 8pp copy of typescript for unidentified publication entitled ‘Production of deacetoxycephalosporin C by introduction of modified bacterial isopenicillin N epimerase and penicillin N expandase genes in Penicillium chrysogenum’. Mees In on Cephalosporin C, chiefly to find ways of increasing the yields of the antibiotic from strains of the cephalosporium fungus. This was achieved after much painstaking work involving repeated mutations of the mould. Miscellaneous typescript reports etc by the Lilly Research Laboratories, 1961, 1962, 1971. 1956 the NRDC arranged for Glaxo to Glaxo Group Ltd C.882-C.913 1957-1985 research 2 folders. join in the E.P. Abraham NCUACS 103/2/02 Research and development Glaxo’s huge investment in introduction of its drug ‘Ceporin’ (‘cephaloridine’) into medicine. the research bore fruit in 1964, with the Correspondence etc mostly re research on Cephalosporin C, the progress of ‘cephaloridine’, publications and matters arising. C.882-C.889 1957-1964. Included is correspondence re cephalosporin nomenclature. 8 folders. C.890-C.897 1965-1968. Included at C.891, C.892 are a draft and a later copy of the script of a Glaxo film entitled ‘Antibiotic from the sea’. Abraham assisted in the production of the script and appeared in the film, though not as a speaker. Included also is correspondence etc re the Conference on Cephalosporidine at New College Oxford, 13-16 March 1967, which Abraham attended; at C.895 is a copy of a typescript of an introductory talk given by Abraham at the conference entitled ‘Cephaloridine. Historical Remarks’. 8 folders. E.P. Abraham NCUACS 103/2/02 Research and development C.898-C.905 1969-1972. is correspondence Included Conference. on Cephalosporins, Brighton, 11-13 May 1970, in which Abraham participated. At C.901 is a review of the conference by Abraham and P.B. Loder: ‘Cephalosporins’, Postgraduate Medical Journal, Supplement vol. 46, October 1970. a copy of a typescript draft of International the etc re 8 folders. C.906-C.913 1973-1985. is correspondence re Included a collaborative research project (which the company would finance) with the Sir William Dunn School of Pathology. by Glaxo to a proposal enter into C.914-C.921 Imperial Chemical Industries Ltd (ICI) 1953-1988 Abraham held a consultancy position with ICI, 1955-1958. 8 folders. 7 folders. 1950-1981 C.922-C.928 Merck & Co. Inc. Scientific correspondence re research on the cephalosporins and other antibiotics, 1953-1963, 1970, 1981-1988. Mostly 1953-1963. Correspondence re research on Cephalosporin C and other antibiotics, 1950, 1953, 1958-1981. Merck was one of the companies licensed by the NRDC in the early 1960s to work on the production of the Cephalosporin C nucleus. lactamases, 1948, 1950, 1956-1978, 1992. Mostly 1959-1978. The station supplied microorganisms and microbial products to research workers. In 1961 it began a Cephalosporin C production project to assist with the research programme overseen by the NRDC. Correspondence, with copies of reports, re work on Cephalosporin C and B- Microbiological Research Station (Porton Down) C.929-C.940 1948-1992 E.P. Abraham NCUACS 103/2/02 Research and development C.941-C.943 Pfizer Inc. (Chas. Pfizer & Co. Inc.) 1960-1986 Pfizer was one of the companies licensed by the NRDC in the early 1960s to work on the production of the Cephalosporin nucleus. Correspondence re research on Cephalosporin C and other antibiotics, 1960-1962, 1977, 1978, 1985, 1986. Mostly 1960-1962. 3 folders. C.944, C.945 Smith, Kline & French Laboratories 1960-1975 Smith Kline & French was one of the companies licensed by the NRDC in the early 1960s to work on the production of the Cephalosporin C nucleus. Correspondence etc, mostly re research on Cephalosporin C, 1960-1962, 1972-1975. 2 folders. C.946-C.949 C.950, C.951 4 folders. C.946-C.962 1946-1983 Sixth Interscience Conference on Antimicrobial Agents Squibb Institute of Medical Research (E.R. Squibb & Sons Inc.) Correspondence and papers re Cephalosporin C and proposed visits and conferences etc, 1946, 1957-1966. Squibb was one of the companies licensed by the NRDC in the early 1960s to work on the production of the Cephalosporin C nucleus. Included is correspondence re arrangements for Abraham’s participation in the and Chemotherapy (ICAAC), Philidelphia, USA, October 1966. 2 folders. Correspondence etc, chiefly re a legal case involving E.R. Squibb and Sons Inc, 1971. Included is a draft of an affadavit by Abraham in connection with this case. E.P. Abraham NCUACS 103/2/02 Research and development C.952-C.960 Lectures by Abraham: the Squibb Lectures for 1972 at Rutgers University, New Jersey, 20, 21 September; and at the annual meeting of the Infectious Diseases Society of America, Atlantic City, 25-27 September 1972. Correspondence re arrangements for both events and correspondence arising, 1971, 1972. C.953-C.957 Drafts etc of the Squibb Lectures. Abraham delivered 2 lectures which were published as ‘Biosynthesis and Enzymic Hydrolysis of Penicillins and Cephalosporins’, University of Tokyo Press, 1973. ‘Biosynthesis of Penicillins and Cephalosporins’, first Squibb lecture. In the published version the title of the lecture is ‘Aspects of the Biosynthesis of Penicillins and Cephalosporins’. 26pp manuscript draft with revisions; copy of revised typescript version with addenda. 58pp typescript draft, with manuscript revisions, and figures etc. 3 folders. Copy of proof with corrections. C.954-C.956 ‘B-lactamases and their Role in Resistance to B-lactam Antibiotics’, second Squibb Lecture. 2 folders. 47pp manuscript draft with revisions entitled ‘Enzymic Degradations of the Penicillins and Cephalosporins’, with of another draft version; typescript tables and data etc, probably relating to the lecture. Lecture given at the annual meeting of the Infectious Diseases Society of America as a contribution to the topic ‘Enzymic Degradation of Antibiotics’. C.959, C.960 Correspondence arising from the lectures, chiefly re the publication of the Squibb Lectures, October 1972-March 1974. 4 further pages, possibly part E.P. Abraham NCUACS 103/2/02 Research and development C.961, C.962 Correspondence etc re general matters, 1974-1983. 2 folders. Upjohn Co. 1954-1973 Correspondence in connection with the company’s research on antibiotics, 1954, 1959-1968, 1973. C.964-C.989 SCIENTIFIC CORRESPONDENCE 1955-1983 Correspondence, and related material, between Abraham and scientists in British universities re research on B-lactamases and various antibiotics. Included is correspondence of a more general nature including some re appointments etc. Contents of files inscribed with the name of the relevant university. Arranged alphabetically by university. 1955-1981 C.964, C.965 The principal correspondent is Ernest F. Gale. 2 folders. C.964-C.967 University of Cambridge Correspondence with scientists, chiefly in the School of Biochemistry and the Medical Research Council Unit for Chemical Microbiology, re various research on antibiotics, 1955-1965. 2 folders. Included is correspondence re arrangements for the Roche Symposium on ‘Aspects of Peptides and Protein Chemistry’, 29 November 1971, attended by Abraham. C.966, C.967 General and scientific correspondence, 1971-1981. E.P. Abraham NCUACS 103/2/02 Research and development C.968-C.972 University of Edinburgh 1965-1981 Correspondence re research on B-lactamases, The principal correspondent is Martin Pollock. included. General correspondence is 5 folders. C.973-C.976 University of Newcastle-upon-Tyne 1974-1983 Correspondence etc, chiefly with R.J. Stoodley of the School of Chemistry, re research on B-lactamases. Includes correspondence re arrangements for a lecture by Abraham at the University, November 1974, and a B-lactamase workshop, April 1979. 4 folders. 10 folders. C.987, C.988 University of Surrey 1972-1981 C.977-C.986 University of Sheffield 1962-1974 Correspondence and papers re research on actinonin, 1962-1968, 1974. Almost all the material is 1962-1968. The NRDC funded work on actinonin undertaken jointly by Abraham's department and chemists at the University of Sheffield working under David Ollis, Professor of Organic Chemistry. 2 folders. The principal correspondent is Robert Thomas. Included is a typescript draft with manuscript corrections (in a paper entitled ‘The Interaction of Nocardicins with B-Lactamase II’, by Abraham et al (publication details unknown). Correspondence re biosynthesis of penicillins and other research on B- lactam antibiotics, 1972, 1973, 1979-1981. a hand other than Abraham’s) of E.P. Abraham NCUACS 103/2/02 Research and development University of Sussex 1973-1982 Correspondence mostly re research involving chiral cysteines. The principal correspondent is Douglas Young of the School of Molecular Sciences. C.990-C.1016 BACILYSIN RESEARCH 1957-1991 The antibiotic bacilysin, produced by a number of strains of Bacilus subtilis, was first encountered by Abraham and his co-workers in 1946. Preliminary work on the production and purification of bacilysin was carried out by Abraham and Guy Newton, but the work ended in 1948 due to insufficient resources and the Dunn School’s increasing interest in cephalosporins. Abraham and his colleagues returned to research on this antibiotic in the early 1960s. This material was found in a number of files which were tied together. 6 folders. C.996-C.1009 Published papers, 1965-1970 or [after]. C.996, C.997 Proof with manuscript corrections; re-print with manuscript annotations. C.990-C.995 file. The correspondents comprise Abraham’s colleagues and other scientists working in various countries. ‘Production and Purification of Bacilysin’, by Abraham, G.G.F. Newton and H.J. Rogers, Biochemical Journal 97, 1965. Correspondence etc re research on bacilysin and related substances, 1957, 1962-1975, 1981-1991. Contents of a Journal 97, 1965. 13pp manuscript draft with revisions; later typescript draft with manuscript revisions (including draft figures). C.998, C.999 ‘Observations on the Structure of Bacilysin’ by Abraham et al, Biochemical E.P. Abraham NCUACS 103/2/02 Research and development 24pp typescript draft, with manuscript revisions, and draft figures. ‘Experiments relating to the Biosynthesis of Bacilysin’, by Abraham and J. Roscoe, Biochemical Journal 99, 1966. 21pp manuscript draft with revisions; later incomplete 2pp typescript draft with manuscript revisions; re-print. of Bacilysin and a New Amino Acid from Culture Filtrates ‘Isolation of Bacillus subtilis’, by Abraham and J.E. Walker, Biochemical Journal 118, 1970. Copy of 11pp typescript and figures etc; proof. C.1002, C.1003 ‘The Structure of Bacilysin and Other Products of Bacillus subtilis’, Abraham and J.E. Walker, Biochemical Journal 118, 1970. by 15pp typescript draft, with manuscript revisions, and legends for figures etc. Copy of revised typescript and proof. 7pp typescript draft with manuscript revisions. ‘Antibiotic Production and Sporulation in Walker, [71970 or after]. Publication details unknown. B. subtilis, by Abraham and J.E. Copy of 2pp typescript and photographs for figures. ‘Carbobenzoxy Derivative of Bacilysin’, by Abraham and J.E. Walker, [71970 or after]. Publication details unknown. ‘Effect of Bacilysin on Certain Fungi and Yeasts’, by Abraham and J.E. Walker, [?1970 or after]. Publication details unknown. 2pp typescript draft, possibly incomplete, with manuscript revisions; copy of typescript revised version, with photographs for figures. E.P. Abraham NCUACS 103/2/02 Research and development 25pp untitled manuscript draft of paper re experiments on bacilysin, with revisions, [?1970 or later]. C.1008, C.1009 Untitled drafts of paper re experiments on bacilysin, [71970 or after]. C.1008 35pp typescript draft of main text with manuscript revisions. Part of another typescript draft of the paper with manuscript revisions; copy of typescript draft, with manuscript revisions, of captions for figures etc, with photographs. C.1010, C.1011 Correspondence with various scientists and organisations re research on bacilysin, 1962-1965. A few letters relate to the preparation of some of the papers in C.996- C.1009. 2 folders. C.1012-C.1014 C.1015, C.1016 C.1017-C.1031 Mostly typescript, some with manuscript annotations. 3 folders. 2 folders. Reports, experimental results and research programmes etc re studies on bacilysin compiled by Abraham and his co-workers, 1962-1965, ca 1966. Miscellaneous notes and data, mostly manuscript, some possibly relating to the preparation of the papers in C.996-C.1009. Eli Lilly and Company v Premo Pharmaceutical Laboratories, 1978-1980. Papers and correspondence relating to Abraham’s involvement in cases between pharmaceutical companies in concerned patents for cephalosporin antibiotics. the USA. legal The disputes C.1017-C.1037 LEGAL CASES 1978-1989 E.P. Abraham NCUACS 103/2/02 Research and development The dispute was over an alleged infringement of an Eli Lilly patent relating to cephalexin. Abraham appeared in court as an expert witness for Eli Lilly. C.1017-C.1030 Correspondence and copies of documents relating to the case, 1978-1980. Documents include affadavits by Abraham and a copy of his testimony. 14 folders. Material for draft of unidentified paper: mostly photographs mounted onto pieces of paper, with captions, and loose photographs. Found with the papers in C.1017-C.1030. E.P. Abraham NCUACS 103/2/02 Research and development C.1032-C.1037 Correspondence and papers re legal disputes concerning a patent for crystalline cefadroxil monohydrate belonging to the Bristol-Myers Company, 1986-1989. The material chiefly relates to the case Bristol-Myers Company v Biocroft Laboratories Inc., 1987. Abraham sent a declaration on behalf of Bristol- Myers. At C.1036, C.1037 are two the Declaration of Sir Edward P. Abraham’ and ‘Exhibits to the Declaration of Jack E. Baldwin’. of documents: ‘Exhibits to large files 6 folders. C.1038-C.1067 ‘CEPHALOSPORIN C HISTORY’ 1948-1995, n.d. Contents of a box so inscribed. 4 folders. between Abraham and various C.1038-C.1041 C.1042-C.1048 Contents of a folder: correspondence and papers mostly relating to the early years of the Sir William Dunn School of Pathology’s research on antibiotics from the cephalosporium fungus, 1948-1949, 1952, 1961. Correspondence and individuals covering the different stages of the research on Cephalosporin C, with related papers, 1952-1964. Included is correspondence between Howard Florey and Dr Blythe Brooke, who in 1948 was asked by Professor Giuseppe Brdétzu to notify scientists in Britain of the latter's work on cultures from cephalosporium; correspondence between Florey and Brétzu; and detailed report and summary of work done by the Dunn School from December 1948-March 1949. 7 folders. Correspondents include Guy Newton, the NRDC and Research Station of the Medical Research Council. the Antibiotics organisations E.P. Abraham NCUACS 103/2/02 Research and development C.1049-C.1053 Papers relating to a petition by the NRDC, ca 1958-1960, to the Comptroller of Patents for him to require Dr H.S. Burton to join other inventors in assigning the Cephalosporin N patent to the NRDC. Burton was formerly a junior colleague of Abraham who worked on Cephalosporin P and during the early research on Cephalosporin N. He subsequently claimed that his contribution to the work on Cephalosporin N should have entitled him to inclusion in patents other than Letters Patent Number 745208. C.1049, C.1050 Contents of behalf of Sir Howard Florey and others’. a file labelled ‘Statement, counterstatement and evidence on Copies of declarations, statements etc, reference, 1952-1959. with other documents used for 2 folders. C.1051, C.1052 Contents of a file inscribed ‘Evidence in reply on behalf of Sir Howard Florey and others’, 1949-1960. 2 folders. C.1054-C.1059 ‘Cephalosporin N history’, contents of a file so inscribed. C.1054 3pp typescript draft of the paper with manuscript revisions. ‘A New Type of Penicillin from a Species of Cephalosporium’, by Abraham and Guy Newton, VI International Congress of Microbiology, Rome 1953, Riassunti delle Communicazioni, Vol. 1. Copy of ‘Comptroller Report on the application of NRDC to direct H.S Burton to join with others in assigning the Cephalosporin N (Penicillin N) patent to NRDC’, 1962; newspaper cutting relating to this application or a case closely connected with it. Proof of article, n.d. ‘Isolation of Penicillamic Acid and D-a-aminoadipic acid from Cephalosporin N’, by Abraham and Guy Newton, Nature 172, 1953. ‘Cephalosporin N: a New Type of Penicillin’, by Abraham et a/, Nature 629. E.P. Abraham NCUACS 103/2/02 Research and development 2 typescript reports on Cephalosporin N research at the Sir William Dunn School and the Antibiotics Research Station, with manuscript annotations or corrections, 1952-ca 1958. Brief correspondence re Abraham’s requests for chemical samples from overseas universities, 1953. Typescript lecture programme on Bacteriology and Immunity at the William Dunn School of Pathology, Trinity Term, 1959. Sir C.1060-C.1062 Correspondence and papers, including copy of affadavit by Abraham (and copy of his affadavit for an earlier petition), re the petition of the NRDC to extend the term of a patent (Letters Patent No. 953695), 1976. The patent concerned the Cephalosporin C nucleus (7-ACA). was successful, the term being extended for four years. The petition 3 folders. the Cephalosporins’, a speech by Copy of 19pp typescript of speech. C.1065-C.1067 C.1063 Royal Society Conversazione 23 June 1977. C.1063-C.1067 Miscellaneous papers and correspondence, 1962-1995. ‘A Glimpse of Abraham at the Harvard Club dinner, May 1978. Early History of the 3pp typescript by Abraham and S.G. Waley entitled ‘The Development of the Cephalosporin Family of Antibiotics’ for exhibit at the Conversazione. 3 folders. Included at C.1066 is a script for a BBC External Services radio programme ‘Report from Britain no. 151’, 1965, which mentions Abraham’s work and includes a quote by him. Miscellaneous correspondence re cephalosporin research and the history of Cephalosporin C, 1962-1979, 1995. E.P. Abraham NCUACS 103/2/02 Research and development C.1068-C.1114 MISCELLANEOUS PAPERS 1945-1991, n.d. Abraham’s ‘Report to the Rockefeller Foundation on activities in the USA during the tenure of a Fellowship from April to October 1948’. Copy of 19pp typescript draft with manuscript corrections. ‘The X-ray analysis Crowfoot Hodgkin and E.N. Maslen, ca 1961. of the structure of Cephalosporin C’, by Dorothy Copy of 16pp typescript draft with manuscript revisions referee’s comments and response; data found with the article. by Abraham; ‘Broadcast for Australia’ by Howard Florey, ca 1962-1964. Copy of 9pp incomplete typescript draft of script inscribed ‘HWF’ (Florey’s initials) on first page. C.1071-C.1088 C.1071-C.1074 D. Perry. also C.834-C.881). 4 folders. See H.213-H.226 for related material. Reports etc re work on isopenicillin N synthesase, 1983-1985. Typescript reports, with some manuscript notes, on experiments by some of Abraham’s research workers, 1984-1990. The reports appear to relate to work carried out in collaboration with Eli Lilly and Company (see Some have annotations and revisions by Abraham. See H.85-H.91 for related material. Reports re work on penicillin acylase etc, 1984-1990. C.1075-C.1082 P.A. Whiteman (neé Fawcett). 8 folders. E.P. Abraham NCUACS 103/2/02 Research and development C.1083-C.1088 M.S. Thorniley. Reports re work on E-coli and C. acremonium etc, 1985, 1986. 6 folders. See H.254, H.255 for related material. C.1089-C.1114 Miscellaneous papers, 1945-1985, 1991, n.d. Included are reports, manuscript notes, experimental data; at C.1114 is laboratory manual. a C.1089-C.1100 1945-1985, 1991. 12 folders. C.1101-C.1114 N.d. 14 folders. E.P. Abraham NCUACS 103/2/02 SECTION D PUBLICATIONS D.1-D.288 D.1-D.270 DRAFTS D.271-D.288 EDITORIAL CORRESPONDENCE E.P. Abraham NCUACS 103/2/02 Publications 1956-1998, n.d. Arranged chronologically. Undated drafts are at D.253-D.270. ‘Some Chemical and Biological Properties of New Antibiotics of the Penicillin Group’, co-authored with G.G.F. Newton, Chemical Science and Industry USSR I, 1956. 40pp photocopy of a typescript, with manuscript corrections and additions; 1p manuscript notes by another. Articles and book reviews by Abraham for Endeavour, contents of a file. ‘The Antibiotics in Microbiology’, Endeavour 18, October 1959. Correspondence re publication with corrected proofs of article. 2 folders. Review: ‘Antibiotics in Medicine’, British Medical Bulletin 1960 16, No.1. Letter with 1p photocopy of typescript of review. Review: Recent Progress in Microbiology, edited by G. Tunevall, Oxford 1959. Correspondence re publication; 1p photocopy of typescript draft of review and cutting of printed version. Letters re review request with 1p photocopy of printed version of review. Correspondence re publication of an article ‘New Penicillins, Cephalosporin C and Penicillinase’, with G.G.F. Newton, Endeavour 20, 1961. The Molecular Basis of Antibiotic Action, by E.F. Gale et al, Chichester 1972. E.P. Abraham NCUACS 103/2/02 Publications Review: Fifty Years of Antimicrobials: Past Perspectives and Future Trends, edited by P.A. Hunter et a/., The Society for General Microbiology, 1995. Correspondence re publication; 1p manuscript and 1p typescript drafts of review, with corrected version. Correspondence re unidentified article by Abraham re Cephalosporin C, February-December 1960; letter requesting review of a book, 1955. Correspondence with Endeavour re orders for binding cases, 1958-1968. ‘Antibiotics’, Enciclopedia Medica Italiana, 1959 or later. Correspondence re publication, 1959; 26pp copy of typescript draft (with bibliography) with manuscript corrections. ‘The Chemistry and Classification of Antibiotics’, with G.G.F. Newton, British Medical Bulletin 16, 1960. 20pp copy of typescript draft (with tables and references) with manuscript corrections and additions. ‘Derivatives of Cephalosporin C formed with certain Heterocyclic Tertiary Bases’, with C.W. Hale and G.G.F. Newton, Biochemical Journal 79, 1961. Letter re preparation, 1960; 15pp copy of typescript draft (with references etc) with manuscript corrections; 3 typescript pages of other drafts and figures, probably related to the article. revisions, etc and copy of revised version with figure. ‘New Penicillins, Cephalosporin C and Penicillinase, with G.G.F. Newton, Endeavour 20, 1961. 17pp copy of typescript draft (with references and figures) with manuscript corrections and additions. ‘The Cephalosporins: history and scientific background’, Medical News 48, 1963. Correspondence re publication; 7pp copy of typescript draft, with manuscript E.P. Abraham NCUACS 103/2/02 Publications Copy of published version of the article, with extensive manuscript revisions and copy of revised version with figure etc, n.d. ‘Production of M.Jago and A. Migliacci, Nature 199, 1963. a Cephalosporinase by Pseudomonas pyocyanea’, with 4pp copy of with manuscript corrections; reprint; copy of typescript, with figures, describing experimental results, probably related to the article. with manuscript corrections; typescript proof draft D.18-D.20 Reviews for Nature, contents of a file. D.18 Joint review article by Abraham covering a number of publications on antimicrobial agents and chemotherapy (mostly published in 1963), including Antimicrobial Agents and Chemotherapy - Proceedings of the Second and Chemotherapy, Chicago, Illinois, October 31-Novermber 2 1962, American Society for Microbiology 1963. Antimicrobial Interscience Conference Agents 1962. on 3pp draft of with review typescript publication; Correspondence re review requests; 8pp photocopy of review article; corrected proof. Correspondence re manuscript corrections and copy of later typescript draft; corrected proof. Antimicrobial Agents and Chemotherapy — 1964. Proceedings of the Fourth Interscience Conference on Antimicrobial Agents and Chemotherapy, New York, October 26-28 1964, American Society for Microbiology, [71965]. Antimicrobial Agents and Chemotherapy — 1963. Proceedings of the Third Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington DC, October 18-30 1963, American Society for Microbiology 1963. 2pp copy of typescript obituary and cutting from off-print. 4pp copy of typescript draft of review; proof; copy of typescript probably relating to one of the reviews in D.18-D.20. Obituary for Professor Donald Devereux Woods, British Medical Journal 2, 1964. E.P. Abraham NCUACS 103/2/02 Publications ‘The Cephalosporin Story’, New Scientist 24, No. 217, 1964. 6pp copy of typescript draft, with manuscript corrections, and figures; letter re publication. ‘The Chemistry of New Antibiotics’, The American Journal of Medicine 39, 1965. 21pp copy of typescript draft (with references and figures) with manuscript corrections; letter re publication. D.24-D.26 ‘Enzymic Behaviour of the Cephalosporins’, with L.D. Sabath, Enzymologia 29 (memorial volume to Professor H. von Euler), 1965. Correspondence re an article which Abraham contributed to a 1963 volume dedicated to von Euler on the occasion of his 90th birthday (apparently later published in the Biochemical Journal), October-November 1962. of ‘Enzymic Behaviour of 2 folders. re _ publication Proof with publication. manuscript corrections and revisions; correspondence re See C.562, C.563 for a draft of this paper. ‘The Cephalosporins’, with G.G.F. Newton, Advances in Chemotherapy 2, 1965. Correspondence the Cephalosporins’, with 1p copy of typescript ‘summary’ of the article and copy of typescript of article for the 1963 volume (see D.24). 1965, 1966. Biochemical Journal 99, 1966. Review for Nature (published in 1965): Advances in Drug Research, London 1964. ‘Experiments relating to the Biosynthesis of Bacilysin’, with J. Roscoe, Letters re publication; 2pp copy of typescript of review and proof. E.P. Abraham NCUACS 103/2/02 Publications 21pp copy of typescript draft (with references and figures) with manuscript revisions. Later copy of typescript draft with manuscript corrections. Review for British Medical Journak Biochemical Studies of Antimicrobial Drugs, Cambridge University Press 1966. Correspondence re publication and 2pp copy of typescript of review with manuscript corrections. ‘The Cephalosporin C Group’, Chemical Society Quarterly Reviews 21, No. 2, 1967. Proof with manuscript corrections. See C.567 for typescript [?draft] of paper. Letter of thanks; 1p of typescript message of appreciation; off-print. Appreciation of Florey in obituary notice by various writers, British Medical Journal, 2 March 1968. D.33-D.114 Articles and radio broadcasts by Abraham on Howard Florey arising from the latter's death in February 1968, with related material. Appreciation of Florey in obituary notice by various writers, The Lancet, 2 March 1968. corrections. Correspondence re obituary for Oxford Magazine, with corrected proof and copy of re-print with manuscript revisions; 2 copies of typescript drafts (8pp of obituary for [?Lincoln College Magazine] with manuscript and 9pp) 1p copy of typescript message of appreciation with manuscript corrections; photocopy of off-print; letter of thanks. Obituaries for Oxford Magazine, 31 Magazine]. May 1968, and [?Lincoln College Abraham’s obituary for [?7Lincoln College Magazine] was a revised version of the one he wrote for Oxford Magazine. E.P. Abraham NCUACS 103/2/02 Publications ‘Lord Florey’, Chemistry in Britain 4, No.9, May 1968. Letters typescript. re 3pp typescript draft with manuscript corrections; 2pp copy 2pp manuscript draft, with revisions, of obituary; copy of typescript corrected version; off-print. Publication unknown. [71968]. untitled typescript draft 1p Abraham and another, [71968]. Publication unknown. of obituary with manuscript corrections by Short account of Florey’s life, Sunday Times Magazine, 1969. Correspondence re publication, May 1969; 1p copy of typescript draft, with manuscript corrections, of short account of Florey’s life inscribed ‘Sunday Times April 1969’. D.40-D.89 D.40-D.57 8 folders. D.40-D.47 1968, 1969. organisations Florey and Correspondents include documentary records, former colleagues of acquaintances. individuals and Correspondence and papers re Abraham’s preparation of the memoir, 1968- 1971. ‘Howard Walter Florey, Baron Florey of Adelaide and Marston 1898-1968’, Biographical Memoirs of Fellows of the Royal Society 17, November 1971. In March 1968 Abraham was asked to write the Memoir for which he undertook a great deal of research into Florey’s life in Australia and at Oxford. Despite having to negotiate some sensitive issues, he produced an article considered by most to be authoritative and very interesting. 10 folders. with access to his family and D.48-D.57 1970-October 1971. E.P. Abraham NCUACS 103/2/02 Publications D.58-D.64 Correspondence arising from publication of the memoir, mostly letters of thanks from fellow scientists in receipt of copies, with congratulations and comments, September 1971-1972, 1974. 7 folders. Copy of off-print of memoir. D.66-D.89 D.66-D.69 Correspondence and preparation of the memoir. papers used by Abraham as_ background for Correspondence between Florey and the Medical Research Council re grants and assistance provided by the latter for research on penicillin, 1939- 1946. 4 folders. Contents of a file. 2 folders. Contents of a file. Photocopies of letters by Florey to John F. Fulton, 1947-1954. Carbon copies of extracts of letters by Florey, Lady (Ethel) Florey and Norman Heatley to John F. Fulton and Lucia Fulton, 1940-1945. Paginated 1-66. papers, 1945-1968. Photocopies of correspondence relating Australia and New Zealand in 1944 to photocopy of his report of the tour, 1945. Miscellaneous correspondence of Florey, mostly photocopies, with related to Florey’s fact-finding tour to visit medical establishments and Letters to Abraham from Florey, with related material, 1953-1968. E.P. Abraham NCUACS 103/2/02 Publications Correspondence re Florey’s life, 1957-1969. D.77-D.89 Miscellaneous printed and typescript material, manuscript notes by Abraham and correspondence relating to Florey’s life. Photographs in D.79. Article on Florey in A Biographical Dictionary of Scientists, London 1974. 8pp manuscript draft and 2 typescript drafts, all with manuscript revisions. Correspondence re publication with further copy of typescript draft, 1972; copy of proof with manuscript corrections. Review for Nature 282, No. 5735 (Autumn Books Supplement, November 1979) entitled ‘Florey’s creative power’: Howard Florey: The Making of a Great Scientist, by Gwyn Macfarlane, Oxford University Press 1979. Copy of proof with manuscript revisions. D.94-D.99 Other obituaries and articles on Florey written before his death, 1950-1968. Revised notice for Florey in Dictionary of National Biography 1986-1990, Oxford 1996. Correspondence re publication and letter arising; 11pp copy of typescript of review and proof with manuscript corrections; re-print. corrections. ‘The New Provost of Queen’s’, Oxford (published by the Oxford Society), 1962. A short article on Florey following his election to the Provostship of Queen’s College. Correspondence re publication; 2pp typescript draft; proof with manuscript D.94 2pp typescript biographical inscribed ‘1950’ on first page. notes on Florey for unknown publication, E.P. Abraham NCUACS 103/2/02 Publications Short article on Florey for ‘News and Views’, Nature, probably published in 1963. Copy of letter enclosing 1p typescript of article. Two 12pp typescript drafts with manuscript revisions and inserts, entitled ‘Stock obituary notice for The Times — 5 yearly revision’, ca 1955-ca 1965; off-print of published obituary in The Times, 1968. ‘H.W. Florey — Nobel Prize for Medicine and Physiology 1945’, 1968. 19pp copy of typescript obituary so entitled, probably written by Abraham. Correspondence re declined invitation to write obituary, 1968. D.100-D.102 Broadcasts on Florey by, or with a contribution by, Abraham. D.100 ‘Portrait of Lord Florey’, B.B.C. Radio Four, 28 March 1969. Correspondence re script, with contract; 2pp typescript draft script with manuscript corrections, inscribed ‘Oxford studio’. B.B.C. radio broadcast: ‘Obituary on Lord Florey’, by Abraham, recorded 1 March 1965. Abraham contributed an interview to the programme. The other speakers were Dr C.M. Fletcher, Dr Sanders, John Prestwich and Norman Heatley. death, 1966-1969. Correspondence re preparations; contract; 4pp photocopy of typescript script, with manuscript corrections, inscribed ‘corrections put in by M[argaret] Florey’; photocopied scripts of other speakers on the programme; contract; 1p manuscript draft of a script, found with the other material in this folder and possibly related to it. Correspondence re plans for Abraham and / or Norman Heatley, 1966, 1967. a possible archival film featuring Florey, Miscellaneous correspondence etc re obituaries of Florey by Abraham and re other matters connected with his with members of Florey’s family, E.P. Abraham NCUACS 103/2/02 D.104, D.105 Publications Miscellaneous correspondence and (by individuals other than Abraham) and broadcasts on Florey and the history of penicillin, 1968-1989. mostly re publications papers, a is transcript, Included an autobiographical tape recording by Florey, with manuscript corrections by Abraham. An inscription by Abraham on the first page states that the recording was made towards the end of Florey’s life. entitled ‘HWF on penicillin, part of of Found with the material in D.33-D.103. 2 folders. D.106-D.113 Correspondence and papers re fundraising for a memorial stone to Florey in Westminster Abbey (unveiled 2 November 1981) and preparations for the unveiling ceremony, with correspondence arising. 1980-1983. A few photographs are included. Included at D.113 is brief correspondence re Abraham’s preparation of his Royal Society Biographical Memoir of Florey, 1968. 8 folders. 2pp copy of typescript obituary and letter re publication, October 1966. Obituary of Mary Ethel Hayter Florey, Lady Florey, by Abraham, British Medical Journal, 1966 or 1967. ‘Behaviour of alpha-Aminoadipoyl and Glutamylcysteines in the Presence of Intact and Disrupted Mycelium of a Cephalosporium sp.’, with P. Bronwen Loder and G.G.F. Newton, Biochemical Journal 112, 1969. This paper appears to have incorporated another paper, ‘Synthesis and Some Properties of alpha-Aminoadipoyl and Glutamy Cysteines’, with P. Bronwen Loder, which was initially written separately. figures. re submission of Letter manuscript revisions, of the 2 papers. Copy of typescript draft of combined paper with manuscript corrections; typescript drafts, papers; original with the 2 E.P. Abraham NCUACS 103/2/02 Publications ‘Some Properties of Two Cell-bound Beta-lactamases from Bacillus cereus 569/H’, with S. Kuwabara, Biochemical Journal 115, 1969. 2 copies of typescript drafts with manuscript revisions; correspondence re publication. ‘Biosynthesis of Peptides containing alpha-Aminoadipic Acid and Cysteine in Extracts of a Cephalosporium sp.’, with P. B. Loder, Biochemical Journal 123, 1971. First page of typescript of article; letter re submission of the paper. ‘Specificities of Haemagglutinating Antibodies Evoked by Members of the Cephalosporin C Family and Benzylpenicillin’, with J.M.T. Hamilton-Miller, Biochemical Journal 123, 1971. Proof with manuscript corrections. and cephalosporin- acylases and / in the D.121-D.123 Review for unknown publication: Yeast Mould and Plant Protoplasts, edited by J.R. Villanueva et a/., New York 1973. 2pp typescript draft with manuscript corrections; proof. Copy of 37pp manuscript (hand other than Abraham’s) and typescript draft, with manuscript revisions by Abraham. Draft paper with the draft title ‘On the (role / involvement) of microbial penicillin- biosynthesis (mechanism) of Beta-lactam antibiotics’. The authors were originally given as Abraham and E.J. Vandamme, though Abraham’s name has been crossed out. Inscribed ‘summer ’73 Oxford Univ’. manuscript revisions; later typescript draft and revised (or final) version. Articles contributed by Abraham to Methods in Enzymology, Vol. 30, New York 1974. Correspondence re preparation of paper; 7pp typescript draft with extensive ‘Acetyl Esterase, a Citrus Enzyme’, with P.A. Fawcett. E.P. Abraham NCUACS 103/2/02 Publications ‘8-(a-Aminoadipyl)cysteinylvaline Synthetase’, with P.A. Fawcett. 6pp typescript and proof with manuscript corrections. . Correspondence re publication, with a few miscellaneous papers. ‘Biosynthesis and Enzymic Hydrolysis of Penicillins and Cephalosporins’, University of Tokyo Press 1974. Paper resulting from an E.R. Squibb Lecture. 35pp copy of typescript with references and figures. of ‘Synthesis Aminopenicillanic Acid’, Journal 151, 1975. Tritium-labelled Isopenicillin with J.J. Usher and N, P. Penicillin B. 6- Loder, Biochemical and N Letter re publication of this paper and the one described in D.126; first page of copy of typescript article; proofs with manuscript corrections. of P. A. ‘Biosynthesis Biosynthesis IV: The Chemical Society Specialist Periodical Reports. Cephalosporins’, Penicillins with and First page of copy of typescript article; proof with manuscript corrections. 34pp copy of typescript of paper with references, figures etc; proof with manuscript corrections. ‘Behaviour of Tritium-labelled Isopenicillin N and 6-Aminopenicillanic Acid as Potential Penicillin Precursors in an Extract of Penicillium chrysogenum, with P. A. Fawcett and J.J. Usher, Biochemical Journal 153, 1975. corrections. ‘Synthesis of 5-(a-Aminoadipyl) cysteinylvaline and its Role in Biosynthesis’, with J. Usher, J. Bleaney, J. J. Nesbitt, Biochemical Journal 157, 1976. Correspondence re publication; 32pp copy of typescript draft with manuscript Penicillin C. A Huddleston, R. Fawcett, P. A. Fawcett, J. E.P. Abraham NCUACS 103/2/02 Publications Review for The Times Literary Supplement entitled ‘Bad news for bacteria’, 17 December 1976: Penicillin in Perspective, by David Wilson, London 1976. Correspondence re publication; typescript draft with extensive manuscript revisions and 6pp corrected version; copy of proof; off-print. Review for The Times Literary Supplement entitled ‘The Molecular Key’, 12 August 1977: New Worlds in Chemistry, London 1976. Correspondence re publication; 4pp copy of typescript of review; off-print. ‘The Stereochemistry of B-lactam Formation in Cephalosporin Biosynthesis’, with J. A. Huddleston et al., Biochemical Journal 169, 1978. 11pp copy of typescript draft with manuscript revisions. D.131-D.177 Articles by Abraham on Ernst Boris Chain arising from the latter's death in August 1979. Obituary for the Biochemical Society Bulletin Vol.1, no.5, 1979. Correspondence re publication and 4pp copy of typescript of obituary; off- print and copy of re-print. Included at D.172-D.177 are papers relating to a symposium held on the occasion of Chain’s 70th birthday. See D.228-D.230 for material relating to Abraham’s notice for Chain in the Dictionary of National Biography. Correspondence re obituary by Abraham for The International Journal of Environmental Studies, September-October 1979. Correspondence etc re publication and 3pp copy of typescript of the article. 2 copies of typescript obituaries probably by Abraham, one with annotations by him, for unknown publications. Article on Chain in A Biographical Dictionary of Scientists, London 1982. E.P. Abraham NCUACS 103/2/02 Publications D.135-D.170 ‘Ernst Boris Chain’, Biographical Memoirs of Fellows of the Royal Society, 29, 1983. D.135-D.141 Correspondence etc re preparation and drafting of the memoir, 1979-July 1983. Included are a few letters re Abraham’s assistance to others compiling publications on related topics and re other matters such as arrangements for the cataloguing of Chain’s papers; and 3 photographs at D.141, including one of Chain in later years (inscribed ‘1976’ on back). 7 folders. D.142-D.159 Drafts of the Memoir. D.142-D.145 Extensive and detailed manuscript notes on Chain’s life and career extracted from cited correspondence and other documentary sources. 4 folders. D.146-D.148 (paginated 1-98, with gaps). 3 folders. Paginated 1-60. 4 folders. D.149-D.152 Typescript draft inscribed ‘1st Draft’ with manuscript revisions. Early manuscript draft, apparently incomplete, with extensive revisions. manuscript notes. A few typescript and manuscript pages from draft (or drafts), different to those described in D.146-D.158; drafts of figures; a few miscellaneous At D.158 is a page of typescript suggested alterations to the text inscribed ‘Trevor Williams’, with manuscript annotations by Abraham. Copy of circulated to various individuals for comment. later typescript draft, D.153-D.158 with bibliography etc, probably the draft E.P. Abraham NCUACS 103/2/02 Publications Re-print of the Memoir. D.161-D.163 Correspondence arising from publication of the Memoir, mostly letters of thanks from members of the scientific community and friends in receipt of a copy, with congratulations and comments, 1983, 1984, with a few letters 1985-1988. Included are a few letters publications on related topics. re Abraham’s assistance to others compiling 3 folders. D.164-D.170 Typescript and printed background material and correspondence, used in the preparation of the Memoir. Correspondence between Abraham and Chain mostly in connection with the former's preparation of the Royal Society Biographical Memoir of Florey, 1969. Included is a copy of a funding application made by the Sir William Dunn School to the Rockefeller Foundation in 1939 which is the subject of the correspondence. Correspondence with Government ministers and leading scientists re issues in biochemical and general scientific research, 1971-1976. Correspondence re controversies at Imperial College London, 1974, 1977. Correspondence with Sir Robert Robinson, mostly re the history of penicillin, March-May 1974. Copies of correspondence of Chain, 1969-1976. Letters by Chain to Sir Bernard Katz in which Chain complains of lack of recognition in Britain, 1969. Chain (copy), 1969, 1979 (found with the other material in this file). Sir Robert Robinson, Correspondence, mostly between Abraham and concerning claims made by Chain about his in the development of role penicillin, April 1974-January 1975; 2 unrelated letters by Abraham and E.P. Abraham NCUACS 103/2/02 D.167-D.170 Publications Miscellaneous typescript and manuscript development of penicillin. notes by Abraham printed material (some photocopies) and the Chain’s career and to relating 4 folders. Stock obituary of Chain for The Times. Correspondence re offer to write obituary and acceptance, and re drafting, November 1972-January 1973, and 4pp typescript draft of notice with manuscript revisions; copy of revised (or final) typescript version. D.172-D.177 ‘Biologically Active Substances — exploration and exploitation’, a symposium to mark Chain’s 70th birthday held at the Royal Society, 15, 16 June 1976. The papers relating to this event, at which Abraham gave a paper, were found with the material in D.135-D.170. D.172, D.173 Correspondence re arrangements, with programme etc, and a few letters arising, 1975, 1976. D.174 2 folders. D.174-D.177 D176. D177 Copy of typescript corrected version. ‘The Biosynthesis of B-lactam Antibiotics’, Abraham’s paper. 14pp manuscript draft with revisions; 2 typescript drafts, one incomplete, with manuscript revisions; copy of 2pp typescript outline. 2 folders. Correspondence re publication, 1976, 1977, and proof of Abraham’s paper with manuscript corrections. Publication Exploration and Exploitation, edited by D.A. Hems, Wiley 1977. of Abraham’s paper Biologically Active Substances — in E.P. Abraham NCUACS 103/2/02 Publications ‘Transport and Metabolism of Bacilysin and Other Peptides by Suspensions of Staphylococcus aureus, with D. Perry, Journal of General Microbiology 115, 1979. Proof with manuscript corrections. Incorporation 6- -(L-c-Amino[4,5-°H]adipyl)-L- -cysteinyl-D-[4,4- SHIvaline into Isopenicillin N’, with Joseph O'Sullivan, Roger C. Bleaney and J. A. Huddleston, Biochemical Journal 184, 1979. from °H of Proof with manuscript corrections. Review for Endeavour, [?1979]: purification’, Journal of Chromatography Library Vol. Weinstein and G.H. Wagman, [71978]. ‘Antibiotics: isolation, separation and 15, edited by MJ. Correspondence re publication; 2pp typescript of review with manuscript corrections. N E. D.183 - D - Valine to Extract a by Baldwin Cell-free al, et 5pp copy of typescript draft. Isopenicillin J. with 17pp copy of typescript draft (with reference, figures etc) with manuscript corrections. ‘A Spectroscopic Study of Metal lon and Ligand Binding to B-Lactamase II’, with G. S. Baldwin, Alphonse Galdes, H. A. O. Hill and S. G. Waley, Journal of Inorganic Biochemistry 13, no.3, 1980. ‘Penicillin Biosynthesis: Conversion of Deuterated 5-(L-a-Aminoadipyl) - L — Cysteinyl of Cephalosporium acremonium, Chemical Communications 1981. Correspondence arising, July-October 1981. ‘The B-lactam Antibiotics’, Scientific American 244, No.6, 1981. Correspondence re publication, February-May 1981. Included a few letters, 1979, concerning other matters. D.183-D.189 E.P. Abraham NCUACS 103/2/02 Publications typescript 28pp Cephalosporins and Their Successors’. notes. manuscript draft with revisions ‘Penicillins, Included are a few manuscript entitled This appears to be an early draft of ‘The B-lactam Antibiotics’. Revised version of the draft in D.185 (with the same title). D.187, D.188 and drawings Draft some with annotations on back, others mounted on to annotated cards; manuscript notes and drafts for captions; typescript drafts of captions, with manuscript revisions. photographic illustrations, prints for 2 folders. Off-print. N in N into Cell-free Penicillin Isopenicillin D.191-D.195 D.192-D.194 Correspondence re publication, 1978-1980. Copy of 12pp typescript draft with manuscript corrections. ‘Biosynthesis of B-Lactam Antibiotics’, with J. O’Sullivan, in Antibiotics IV: ‘Biosynthesis’, ed. by J.W. Corcoran, Berlin 1981. ‘Conversion of Extracts of Cephalosporium acremonium, with G.S. Jayatilake and J.A. Huddleston, Biochemical Journal 194 (part 2), 1981. Proof with manuscript corrections. 30pp typescript draft (with references, figures etc) with manuscript revisions. 3 folders. E.P. Abraham NCUACS 103/2/02 Publications ‘Biosynthesis of Penicillins and Cephalosporins in Cell-free Systems’, with J. O’Sullivan and J.A. Huddleston, Philosophical Transactions of the Royal Society, 1980 or 1981. 6pp copy of typescript with biographical note on Abraham. D.197-D.208 ‘Isolation and Properties of an Inducible and a Constitutive B-Lactamase from Pseudomonas aeruginosa, with M. Berks and K. Redhead, Journal of General Microbiology, 1982. Various drafts and other material re the preparation and publication of this paper. Contents of 4 files. D.197-D.201 Contents of a file. D.197 Correspondence re preparation and publication of the paper, 1978-1981. D.198-D.201 Typescript and manuscript drafts and reports, one headed with manuscript corrections. 4 folders. Contents of a file. D.203, D.204 2 folders. D.203-D.205 Contents of a file. Typescript draft of report headed ‘Paper II’ with manuscript corrections. Typescript drafts, some incomplete, with manuscript corrections, and figures. Typescript draft with manuscript revisions. Figures with manuscript annotations, photographic prints and manuscript notes. D.206-D.208 Contents of a file. D.206 E.P. Abraham NCUACS 103/2/02 Publications Later typescript drafts (submitted for publication) and brief correspondence re publication, 1981. ‘Inhibition of Glucosamine Synthetase by Bacilysin and Anticapsin’, by H. Chmara, Journal of General Microbiology, [71984]. A paper was revised by Abraham prior to publication. Found with the material in D.197-D.208. Letter re publication, 1984; copy of typescript draft, with manuscript revisions by Abraham, and figures. ‘Stoichiometry of Oxygen Consumption in the Biosynthesis of Isopenicllin N from a Tripeptide’, with R. L. White et a/, Biochemical Journal 203, 1982. of Correspondence article; correspondence re publication of a later paper in the Biochemical Journal, 1984. publication; typescript copy 8pp re of a paper entitled 5pp copy of typescript of paper; 3pp manuscript notes found with typescript. ‘Penicillin Biosynthesis. Dual Pathways from a Modified Substrate’, with R. M. Adlington et al, Journal of Chemical Studies: ‘Chemical Communications’, 1983. Copy of typescript of ‘Penicillin Biosynthesis: Oxygen Stoichiometry of Isopenicillin N Synthesis in a Cell-free System’, with R. L. White et al, on which is inscribed the same publication reference as for the paper described in D.210. The texts of the articles are different; the authors are the same. 8pp copy of typescript of paper, with figures. ‘Conversion of '70/"80 Labelled 5- -(L-a-Aminoadipyl)-L-cysteinyl-D-valine to O/"®O Labelled Isopenicillin N a Cell-free Extract of Cephalosporium acremonium, with R. M. Adlington et al, Tetrahedron 39, 1983. in E.P. Abraham NCUACS 103/2/02 Publications D.214, D.215 ‘Stereochemistry of the Incorporation of the Methyl Groups of ‘Chiral Methyl Valine’ into Methylene Groups in Cephalosporin C’, with C.-P. Pang et al, Journal of Chemical Studies: ‘Chemical Communications’, 1983. Letter re preparation; 23pp photocopy of typescript draft with manuscript revisions. Copy of typescript draft with revisions (later than those in D.214). D.216-D.220 ‘History of B-lactam Antibiotics’, a chapter in Handbook of Experimental Pharmacology, Vol. 67/1: Antibiotics Containing the Beta-Lactam Structure, Part 1, edited by A.L. Demain and N.A. Solomon, Berlin 1983. Correspondence etc, mostly re preparation and publication, 1979-1984. 34pp copy of typescript draft of Abraham’s chapter, with letter. 2 folders. Pang ef al. D.218, B.219 D.221, D.222 ‘Purification Biochemical Journal 222, 1984. Isopenicillin of N Proof and off-print. Stamped ‘23 Nov. 1982’ on first page. Copy of typescript draft with manuscript revisions. Proofs with manuscript corrections. 20pp copy of typescript, with figures, and correspondence re publication; manuscript notes (hand other than Abraham’s). Synthetase’, with C.-P. E.P. Abraham NCUACS 103/2/02 Publications ‘Stereochemistry Methylene Groups in Cephalosporin C’, Journal 222, 1984. Incorporation the of Valine of C.-P. Pang et Methyl Groups into al., Biochemical Correspondence re publication; proof with manuscript corrections. Review article entitled ‘Benefactors’ Benefactor for The Times Literary Supplement, 27 January 1984: The Legacy of Alfred Nobel: The Story Behind the Nobel Prizes, by Ragnar Sohlman, London 1983. Correspondence re publication; 7pp copy of typescript draft of review; proof; off-print. D.225, D.226 Review entitled ‘The Shooter and the Shot’: Alexander Fleming: The Man and the Myth, The review was published in a special supplement by Nature, ‘Spring Books’, April 1984. by Gwyn Macfarlane, London 1984. Copy of 9pp typescript ‘first draft’ with manuscript revisions; copy of revised draft and copy of off-print; correspondence re publication. Correspondence re publication and 2pp copy of typescript of review. On Perutz’s typescript are minor manuscript annotations by Abraham. Letter to Abraham from Max Perutz, December 1985, enclosing a copy of his review of Macfarlane’s book, entitled ‘Lucky Alec’, for comment. Review for FEBS Letters, [?May] 1984: The Target of Penicillin. The Murein Sacculus of Bacterial Cell Walls. Architecture and Growth, edited by R. Hakenbeck et a/., Berlin 1983. including press copy of the article, 1985, 1986. Notice for Ernst Chain in Dictionary of National Biography 1971-1980, Oxford 1986. For the main body of papers relating to Abraham’s articles on Chain see D.131-D.177. Contents of file inscribed ‘Oxford University Press’. D.228-D.230 D.228-D.234 Correspondence mostly re the invitation to contribute and publication, E.P. Abraham NCUACS 103/2/02 Publications 6pp manuscript draft with revisions; 9pp typescript draft with manuscript revisions. Copy of revised typescript draft with further manuscript revisions; copy of version sent to publishers. D.231, D.232 Notice for Sir Harry Jephcott in Dictionary of National Biography 1971-1980, Oxford 1986. Correspondence re preparation and publication, December 1984-1985, and 1 letter arising, 1989. 7pp typescript draft with manuscript corrections; copy of typescript inscribed ‘Edited version’; background material. D.233, D.234 Correspondence with Oxford University Press re Abraham’s involvement in various publications, 1979-1991. Correspondence re proposed book on penicillin by Abraham, 1979, 1980. No definite plans for the book emerge from this correspondence. Miscellaneous correspondence etc, 1985-1991. Relates to Abraham's advisory role History of the University of Oxford, Oxford 1992. in various publications including the D.235-D.240 Chapter for proposed book The Cephalosporin Antibiotics. 3 folders. The title The publishers, Adis Press Ltd (New Zealand), eventually abandoned publication of the book. The material was published instead in a special supplement to Adis Press’s international supplement Drugs, 1987. Correspondence etc re proposed publication and proof of the chapter (at D.237), 1984-1986. of Abraham’s chapter was ‘Cephalosporins 1945-1985’. D.235-D.237 E.P. Abraham NCUACS 103/2/02 D.239, D.240 Publications 34pp copy of typescript draft of the chapter, with references etc. Correspondence re supplement Drugs, and proof with manuscript corrections, 1987. of Abraham’s original publication chapter in the 2 folders. and _ ‘Purification with Deacetoxycephalosporin C Synthetase and Hydroxylase Activities’, with J. E. Baldwin et al., Biochemical Journal 245, 1987. Characterization Enzyme Initial an of Typescript draft with manuscript revisions; 31pp copy of typescript revised version and figures. D.242-D.245 ‘Factors Affecting the Isopenicillin N Synthetase Reaction’, with D. Perry and J.E. Baldwin, Biochemical Journal 255, 1988. Correspondence re preparation and publication, 1987, 1988. 17pp copy of typescript inscribed ‘copy for press’, with figures etc. 2 typescript drafts with manuscript revisions, one including manuscript drafts of figures. Typescript and manuscript draft of the article, with extensive manuscript revisions. version inscribed ‘Final copy revised’, with figures. ‘Acyl from Penicillium chrysogenum and Aspergillus nidulans’, with P.A Whiteman et al., FEBS Letters 262, 1990. Typescript draft with manuscript revisions and inserts; 6pp typescript revised 6-aminopenicillinanic Acyltransferase Coenzyme A: Acid E.P. Abraham NCUACS 103/2/02 Publications D.247-D.250 Early Research on ‘Selective Reminiscences of B-lactam Antibiotics. Penicillin and Cephalosporins’, for ‘Roots’ column, BioEssays: Advances in Molecular, Cellular and Developmental Biology, Vol. 12, No.12, December 1990. The ‘Roots’ column presented first-hand accounts of key discoveries or breakthroughs in the biological sciences. Correspondence re publication with 18pp copy of amended [?final] typescript of article. 17pp manuscript draft of article with revisions and 1p manuscript notes; typescript draft with manuscript revisions. Copy of revised typescript version. Off-print. D.251, D.252 D.253-D.270 D.253 correspondence etc re publication and proof with manuscript Undated publications. Brief corrections. Review for Nature, published 1990: Miracle Cure. The Story of Antibiotics, by Milton Wainwright, Blackwell 1990. 6pp typescript draft with extensive manuscript revisions; copy of revised version. Copy of 8pp typescript draft with manuscript revisions. ‘Possible Intermediates in the Biosynthesis of Cephalosporin’, with G.G.F. Newton. Copy of 11pp typescript draft so entitled, with manuscript corrections. ‘The Cephalosporins’. E.P. Abraham NCUACS 103/2/02 Publications ‘Enzymes Involved in the Biosynthesis of Cephalosporin C.’ Copy of 7pp typescript draft, so entitled, with manuscript corrections. ‘Biosynthesis of Penicillins and Cephalosporins’, with G.G.F. Newton. Copy of 40pp typescript draft, with manuscript corrections, and index of subjects. D.257, D.258 ‘B-Lactamases and their Réle in Resistance to B-Lactam Antibiotics’. 58pp copy of typescript draft so entitled, with figures. 2 folders. D.259-D.265 Untitled manuscript and typescript draft extensive manuscript revisions, n.d. of a book on antibiotics, with The draft is divided into sections or chapters on particular antibiotics. 7 folders. 5 folders. 1948-1998 D.266-D.270 to unidentified publications, or possible D.271-D.288 Miscellaneous material publications, by Abraham, n.d. relating The material mostly consists of parts of manuscript and typescript drafts and notes. Shorter correspondence is at D.284-D.288. Correspondence and papers re refereeing of papers intended for publication, general editorial business and publications by Abraham. EDITORIAL CORRESPONDENCE E.P. Abraham NCUACS 103/2/02 Publications D.271-D.274 The Biochemical Journal 1949-1988 Abraham served on the Editorial Board, ca 1955-1960. Included is correspondence re publication of papers by Abraham in the Journal found with the editorial correspondence. 4 folders. D.275, D.276 Elsevier Publishing Company 1960-1964 Correspondence, Publishing Company, re Comprehensive Biochemistry, edited by Marcel Florkin and Elmer H. Stotz, Elsevier 1962. including Elsevier re-print, mostly with Abraham wrote a chapter for Volume 2. 2 folders. D.277-D.281 The Journal of Antibiotics 1988-1998 5 folders. 1960-1962 Pharmacological Reviews Abraham was an Emeritus Member. Mostly re the business of the Editorial Board. Correspondence re review by Abraham of a book The Cephalosporins for Pharmacological Reviews 14, 1962. Abraham contributed a chapter to the book. Correspondence etc Antibiotics for Clinical Use, edited by Queener et al., New York 1986. Sherry F. Queener re Beta-Lactam mostly with Sherry F. Queener 1983-1987 E.P. Abraham NCUACS 103/2/02 Publications D.284-D.288 Shorter correspondence 1948-1998 Arranged chronologically. 5 folders.