NATIONAL CATALOGUING UNIT FOR THE ARCHIVES OF CONTEMPORARY SCIENTISTS Catalogue of the papers and correspondence of Ralph Ambrose Kekwick FRS (1908-2000) NCUACS catalogue no. 118/4/03 by Timothy E. Powell and Peter Harper R.A. Kekwick NCUACS 118/4/03 Description level: Fonds Date of material: | 1920-2002 Deposited in: Title: Compiled by: Timothy E. Powell and Peter Harper Extent of material: 21 boxes, ca 430 items Catalogue of the papers and correspondence of Ralph Ambrose Kekwick FRS (1908-2000), biophysicist NCUACS catalogue no. 118/4/03 © 2003 National Cataloguing Unit for the Archives of Contemporary Scientists, University of Bath. Archives and Manuscripts section, Wellcome Library for the History and Understanding of Medicine, London Reference code: GB0120 PP/RAK R.A. Kekwick NCUACS 118/4/03 The work of the National Cataloguing Unit for the Archives of Contemporary Scientists is supported by the following societies and organisations: The Biochemical Society The British Computer Society The British Crystallographic Association The Geological Society Girton College Cambridge The Institute of Physics The Royal Society Trinity College Cambridge The Royal Society of Chemistry The Royal Astronomical Society The Wellcome Trust St John’s College Cambridge R.A. Kekwick NCUACS 118/4/03 NOT ALL THE MATERIAL IN THIS COLLECTION MAY YET BE AVAILABLE FOR CONSULTATION. ENQUIRIES SHOULD BE ADDRESSED IN THE FIRST INSTANCE TO: ARCHIVES AND MANUSCRIPTS SECTION UNDERSTANDING OF MEDICINE WELLCOME LIBRARY FOR THE HISTORY AND LONDON R.A. Kekwick NCUACS 118/4/03 LIST OF CONTENTS GENERAL INTRODUCTION SECTION A BIOGRAPHICAL SECTION B LISTER INSTITUTE OF PREVENTIVE MEDICINE SECTION C RESEARCH C.1-C.311 SECTION D PUBLICATIONS AND LECTURES D.1-D.33 SECTION E SOCIETIES AND ORGANISATIONS E.1-E.42 INDEX OF CORRESPONDENTS R.A. Kekwick NCUACS 118/4/03 GENERAL INTRODUCTION PROVENANCE The papers were received from Mrs Elizabeth Till, daughter of R.A. Kekwick, in 2000 and 2002. OUTLINE OF THE CAREER OF RALPH AMBROSE KEKWICK Ralph Ambrose Kekwick was born on 11 November 1908 in Leytonstone in Essex. He was educated at the Leyton County High School for Boys and University College London, from where he graduated with First Class Honours B.Sc. in Chemistry in 1928. He remained at University College to undertake research, initially in physical chemistry under F.G. Donnan, then moving to study physical biochemistry under J.C. Drummond during which time he worked in close association with R.K. Cannan. In 1930 he was awarded a Bayliss-Sterling Memorial Scholarship and was also appointed Demonstrator in Biochemistry at University College. In 1931-1933 Kekwick held a Commonwealth Fund Fellowship. This enabled him to spend two years in the United States, again studying with R.K. research on the effects of anaerobic conditions on permeability. study of protein molecules in blood plasma. It separated out protein molecules to leave a pure Kekwick’s career as he was introduced to the ultracentrifuge and electrophoresis apparatus, both Kekwick returned to the UK in 1933 to take up a post as Lecturer at University College London. In 1935 Kekwick travelled to Sweden as a Rockefeller Foundation Fellow to work under T. Svedberg at the Institute of Physical Chemistry, University of Uppsala. This proved to be a key moment in developed at Uppsala. The ultracentrifuge, designed by Svedberg and colleagues, was used for the Cannan, who had by then moved to the New York University College of Medicine, before moving on to Princeton University and the Marine Biological Laboratories at Woods Hole, Massachusetts for role of gamma globulin in combating infection and the role of albumin in maintaining the correct be measured to give a sedimentation co-efficient (a characteristic property of the protein). This towards the positive pole more rapidly. These techniques contributed to the general understanding of the part the proteins played in biological activity, the importance of fibrinogen in blood clotting, the protein preparation, for example plasma albumin and globulins while the rate of sedimentation could allowed the molecular weight to be calculated and the proteins identified. The electrophoresis apparatus, designed by A.W.K. Tiselius, worked through the measurement of the negative electrical charge of proteins. As the size of the charge varies according to the protein’s chemical structure, when an electrical charge was passed through a solution, proteins with a greater charge migrated R.A. Kekwick NCUACS 118/4/03 volume of blood. It also allowed for the diagnosis of medical conditions in which ratios of proteins in blood plasma were abnormal. Following this visit the Lister Institute for Preventive Medicine in London acquired an ultracentrifuge and in 1937 Kekwick was awarded a research grant from the Medical Research Council for ultracentrifuge and electrophoretic investigations on pathological and immune sera, which he undertook at the Lister Institute. He was formally taken on the Scientific Staff of the Institute in 1940. During the Second World War Kekwick remained at the Lister Institute undertaking experimental and production work for the Medical Research Council's Blood Transfusion Research Committee. With A.S. McFarlane he devised a process to clarify outdated blood plasma so as to render it suitable for transfusion. He was appointed Head of the Lister’s Biophysics Division in 1943 and he and his team worked on methods of freeze-drying plasma and then of separating out proteins in blood plasma. At the end of the war the MRC established a Blood Products Laboratory at the Lister Institute’s station at Elstree, Hertfordshire. Kekwick worked closely with this Laboratory, acting as an adviser to it, but continued his own research at his laboratory in London. He continued research on blood plasma analysis with ultracentrifuge and electrophoretic techniques and working on practical improvements in blood transfusion processes. In the 1950s he developed a method of fractionating out a fibrinogen fraction rich in Factor VIII, the anti-haemophilic globulin. This led to the first clinical use of this Factor in treating haemophilia in 1957 and the establishment of a national laboratory a personal Chair in Biophysics in 1966 (Emeritus and Fellow 1971). with blood transfusion, haemophilia and hypogammaglobulinaemia. He also served on the In addition to his pioneering work in blood plasma research, Kekwick contributed to developments in dedicated to plasma fractionation. Kekwick’s association with University College London also Committee of the British Biophysical Society 1967-1970. Kekwick was elected to the Fellowship of continued after the war. In 1954 he was appointed Reader in Chemical Biophysics and appointed to haematology through his service on a number of Medical Research Council committees concerned the Royal Society, vol. 48 (2002), 233-249. ‘Ralph Ambrose Kekwick 11 November 1908-17 January 2000’, Biographical Memoirs of Fellows of Kekwick married twice; in 1933 to Barbara Stone (d. 1973) whom he had met while in the USA and with whom he had one daughter, and in 1974 to Margaret Mackay (d. 1982). He died in Woodford For further information on the life and work of Kekwick see J.M. Creeth, L. Vallet and W.M. Watkins, the Royal Society in 1966. Wells in January 2000. R.A. Kekwick NCUACS 118/4/03 DESCRIPTION OF THE COLLECTION The collection is presented as given in the list of contents. It is dominated by very comprehensive documentation of Kekwick’s research. Section A, Biographical, is not extensive. It includes a copy of the Royal Society biographical memoir of Kekwick, obituaries, and material documenting Kekwick’s education, including a bound set of school reports from the Leyton County High School for Boys which indicate his early academic distinction. There is a small amount of correspondence and papers relating to scientific colleagues of Kekwick, including R.K. Cannan and C.S. Sherrington. The section concludes with a sequence of photographs, from a mounted photograph of Kekwick and F.G. Young as graduates in 1929 to 1971 photographs probably from Kekwick’s retirement party. Section B, Lister Institute of Preventive Medicine, presents very modest documentation of Kekwick’s long association with this Institute. The bulk of the material relates to the celebrations of the seventy- fifth anniversary of the Institute. Section C, Research, is the largest in the collection. It presents comprehensive documentation of Kekwick’s research over six decades, from earliest postgraduate study in 1929 up to retirement in (including photographic data), notes, graphs, calculations, correspondence and drafts of publications. 1929-1971 which document early work at University College London, the periods spent in the US in 1931-1933 and with T. Svedberg in Sweden in 1935, wartime work and ongoing postwar research. 1971 and beyond. The section is divided into four components. There are research notebooks There are also papers and photographs of research equipment. The section is completed by a number of ‘instructional notebooks’ containing instructions for preparation of different substances, the Section D, Publications and lectures, is very patchy in its coverage. Publications material includes a Kekwick’s folders and boxfiles which may include data from ultracentrifuge and electrophoresis tests There are extensive research notes, mostly dating from the mid 1930s to the early 1970s, found in There is also documentation of also a set of Kekwick’s offprints. The lectures material is a sequence of drafts for public and few drafts of publications, including two 1935 papers with R.K. Cannan and his memoirs of Sir Alan Drury for the Royal Society biographical memoir and the Dictionary of National Biography. There is Section E, Societies and organisations, principally documents Kekwick’s association with the Medical Research Council: the largest component of the section is papers of the MRC’s Blood Transfusion Research Committee, on which Kekwick served from 1948 to 1978. conduct of experiments etc, and a little outsize material, chiefly graphs. invitation lectures from 1947 to the late 1960s, in which Kekwick gave accounts of his work in progress and its significance. R.A. Kekwick NCUACS 118/4/03 the Albumin Working Party of the World Health Organisation’s International Committee for Standardisation in Haematology on which Kekwick served from 1970. There is also an index of correspondents Timothy E. Powell Peter Harper Bath 2003 R.A. Kekwick NCUACS 118/4/03 SECTION A BIOGRAPHICAL, A.1-A.37 1920-2002 A.1-A.6 BIOGRAPHICAL AND AUTOBIOGRAPHICAL A.7-A.10 EDUCATION A.11-A.15 CAREER, HONOURS AND AWARDS A.16-A.19 SAMUEL PEPYS CLUB A.20 LESLIE OLIVER KEKWICK A.21-A.27 FRIENDS AND COLLEAGUES A.28-A.37 PHOTOGRAPHS R.A. Kekwick NCUACS 118/4/03 Biographical BIOGRAPHICAL AND AUTOBIOGRAPHICAL c 1943-2002 ‘Ralph Ambrose Kekwick 11 November 1908-17 January 2000’ by Vallet and W.M. Watkins, Biographical Memoirs of Fellows of the Royal Society, vol 48 (2002) Creeth, J.M. L. Photocopy. Obituaries The Independent, 16 February 2000 (by L. Vallet and W.M. Watkins); The Times, 23 March 2000. Curriculum vitae, with list of publications Duplicated typescript. 2pp typescript. 20pp typescript. ‘Notes on the scientific work of R.A. Kekwick’ ‘Biographical Notes concerning R.A. Kekwick’ 6pp typescript with 4pp typescript list of publications. ‘Brief notes on my life and work assembled for the Biochemical Society video recording December 1991’ 1991-1992 Leyton County High School for Boys 1920-1924, EDUCATION 1920-1992 R.A. Kekwick NCUACS 118/4/03 Biographical of Notice tabulated Programme for School Prize-Giving 1923 Junior Scholarship examination form the to results School, 1920; 1920-1924; 1920-1924 Bound set of School reports The reports, covering 1920-1925, were presented as as bound volume to Kekwick on his leaving the School in September 1925. ‘LCHS 1920-1925’, article for LCHS News 1991-1992 Draft of article, 2pp typescript; correspondence with P. Estcourt, including letter of 22 January with Kekwick’s reminiscences; copy of Kekwick’s entry in the Old Boys’ ‘Who’s Who’. Kekwick wrote this piece for the Old Boys newsletter at the invitation of Paul Estcourt, the editor. 1928-1931 Biophysics Section, Lister 1940-1971 University College London CAREER, HONOURS AND AWARDS of appointment to Letter Institute of Preventive Medicine University of London B.Sc. results, 1928 and Degree Day Programme, 8 May 1929; typescript ‘College Record’ of Kekwick’s student career, 1931. the Blood Products Laboratory, Elstree’. Includes scientific achievements and Kekwick’s 3pp typescript ‘Notes on the design of freeze-drying and fractionation equipment for Conferment of title of Professor of Biophysics, University of London Fellow, International Society of Hematology application A.11-A.15 setting out Kekwick’s R.A. Kekwick NCUACS 118/4/03 Biographical Retirement book Inscribed within ‘To Ralph Kekwick with affection and respect, from his colleagues, associates and friends. The Lister Institute of Preventive Medicine 1937-1971’. This volume of photographs of the Lister Institute and signatures of colleagues was presented to Kekwick on his retirement from the Institute in 1971. Conferment of title of Emeritus Professor of Biophysics, University of London. A.16-A.19 SAMUEL PEPYS CLUB 1984-1997 Kekwick joined the Samuel Pepys Club in 1986. It was a dining club founded in honour of the famous diarist on the two hundredth anniversary of his death. Occasional Papers Not a complete sequence. 1984-1990 Newsletters 1985-1991 1986-1994 Not a complete sequence. Correspondence re membership 1985-1997 Commemoration Addresses Not a complete sequence R.A. Kekwick NCUACS 118/4/03 Biographical LESLIE OLIVER KEKWICK 1920, 1923 University of London papers re undergraduate career of L.O. Kekwick. L.O. Kekwick was Ralph Kekwick’s older brother. He too attended the Leyton County High School for Boys and studied at University College London, graduating B.Sc. in 1923. A.21-A.27 FRIENDS AND COLLEAGUES Correspondence and papers re scientific colleagues of Kekwick’s. R.K. Cannan 1973-1983 1973-1983 typescript of Kekwick’s Includes biographical notes on Cannan. photocopy 4pp Correspondence with family and colleagues of Cannan, chiefly re biographical memoirs Cannan was a colleague of Kekwick’s at University College London to 1930. Kekwick visited him at the New York College of Medicine following his return to the USA. 1972-1974 Creeth was Kekwick’s deputy and then his successor in the Division of Biophysics at the Lister Institute. Typescript corrections (anonymous). Correspondence and papers re career. manuscript of memoir Memoirs of Cannan J.M. Creeth draft by by J.T. Edsall Kekwick; printed with copy R.A. Kekwick NCUACS 118/4/03 Biographical A.S. McFarlane Draft obituary notice by J.H. Humphrey; 2pp typescript biographical notes by Kekwick. McFarlane was Head of the Biophysics Division at the National Institute for Medical Research, Mill Hill, London, 1945-1970. A.25-A.27 C.S. Sherrington 1948-1967 This material was assembled by A.N. Drury who was researching particular reference to the first preparation of diphtheria antitoxin in the UK. Sherrington with the life of was Drury Director A.N. of Preventive Medicine and it was believed that the first such antitoxin to be made was created and exhibited at the Lister's predecessor institution. Institute Lister the of A.28-A.37 1948-1958 Correspondence PHOTOGRAPHS Letters and reminiscences sent to Drury Printed and duplicated typescript background material 1929 Mounted Degree Day photograph of Kekwick and F.G. Young Kekwick and Young had graduated together in 1928. Photograph of College London 1929-1971, n.d. Biochemistry Laboratory, 1949-1958 1966-1967 University R.A. Kekwick NCUACS 118/4/03 Biographical group Mounted ‘Commonwealth Photograph taken at Portman Square’ photograph Fellows Fund inscribed Group verso on 1931-1933. Kekwick is featured in front row. Group photograph inscribed on verso ‘UCL Biochemistry, Physiology, Biophysics and Pharmacology. Sometime between 1933 and 1938?’ Kekwick is featured at the top of the group. Mounted group photograph inscribed on verso ‘Lister Institute Chelsea and Elstree Staff’ Kekwick is featured in front row. Photographs of Kekwick at work in the Low Temperature Laboratory of Lister Institute Laboratory, Products Blood the with three annotated descriptive 2 photographs. Portrait photograph of Kekwick photographs, 5 information on verso. Photographs from Kekwick’s ?retirement party With key. Kekwick is in the front row. Mounted group photograph of ?staff of Lister Institute Portrait photograph of Kekwick Probably post-retirement. R.A. Kekwick NCUACS 118/4/03 SECTION B LISTER INSTITUTE OF PREVENTIVE MEDICINE, B.1- B.10 1965-1990 B.1-B.4 ADMINISTRATION OF THE INSTITUTE B.5-B.10 HISTORY OF THE INSTITUTE Kekwick joined the Lister Institute in 1937, being taken onto the Staff of the Institute in 1940. He remained at the Lister for the rest of his career to retirement in 1971. Although he maintained his laboratory at the Institute’s headquarters with colleagues at the Elstree laboratories in north London. London, closely in he worked A retirement book signed by colleagues at the Institute is at A.14. R.A. Kekwick NCUACS 118/4/03 Lister Institute of Preventive Medicine ADMINISTRATION OF THE INSTITUTE 1981-1990 Memorandum and New Articles of Association Correspondence and papers relating to changes to the Memorandum and Articles of Association 1981-1982 Includes papers for AGM of the 1982. Institute, 25 October Lister Research Fellowship applications Circulated at the AGM of the Institute, 25 October. 1965-1990 ‘Anniversary Correspondence and papers on work of Lister Research Fellows 1985, 1990 Kekwick's folder inscribed Seventy-fifth anniversary HISTORY OF THE INSTITUTE Contents Celeb. General’. of The Institute had been founded in 1891. It celebrated its 75th anniversary in 1966 with an exhibition of historical material and work in progress. 1965-1966 notes Typescript transfusion display Manuscript notes; found in envelope inscribed ‘Biophysics display’ layout of exhibition; 3 photographs With covering letter. by Kekwick for history of blood R.A. Kekwick NCUACS 118/4/03 Lister Institute of Preventive Medicine Historical photographs 3 photographs of the Lister Institute; 1 photograph of the first horse in England to be inoculated against diphtheria. Captions for exhibits Retained in original envelope. Folder also includes envelope containing metal ‘Plate from equipment bought by C.H. Martin with funds from Munro bequest’. Miscellaneous printed and typescript background material on the Institute Miscellaneous correspondence and papers 1988-1992 R.A. Kekwick NCUACS 118/4/03 SECTION C RESEARCH, C.1-C.311 1929-1989 C.1-C.54 RESEARCH NOTEBOOKS C.55-C.305 RESEARCH NOTES C.306-C.310 INSTRUCTIONAL NOTEBOOKS C.311 OUTSIZE MATERIAL R.A. Kekwick NCUACS 118/4/03 Research RESEARCH NOTEBOOKS 1929-1971 The notebooks span Kekwick’s research career from postgraduate research at University College London (C.1), the period spent as a Commonwealth Fund Fellow in New York (C.2-C.4) and the period working in Sweden with T. Svedberg at the Fysikalische Keminska Institution, Uppsala to (C.6), Kekwick’s postwar research. University wartime through work They are presented in chronological order as possible. far as Hardback notebook 1929-1930 Inscribed on first page ‘October 1929 Ralph A. Kekwick Biochemical Dept University College London. Enzyme Synthesis’. notes October 1929-June 1930. Used for postgraduate research Hardback notebook Hardback notebook Intercalated notes loose at front and back. Labelled on front cover ‘Laboratory Notes 1932 I’ and inscribed on first page ‘University & Bellevue Hospital Medical School New York City. Used for notes on research January-November 1932. 1932-1935 Labelled on front cover ‘Egg Albumin. Titration curves Data from literature Theoretical curves’ and inscribed inside and Used for Bellevue Hosp. Med. School New York City’. notes March 1932-1933 and for later adjustments to calculations April 1935. Inscribed on first page ‘[...] March 1932 Lab notes. University and Bellevue Hosp. Med. School New York City’. Used for notes on research November 1932-May 1933 (continuation of C.2). Hardback notebook front cover ‘[...] 1932-1933 March 1932 University R.A. Kekwick NCUACS 118/4/03 Research Intercalated loose at back is correspondence between G.J. Noback on R.K. Cannan, W.C. MacTavish and toxicology course, possible course. 1934-1935. typescript notes on with Hardback notebook 1933-1937 Inscribed inside front cover ‘November 1933 [...] Dept of Biochemistry Laboratory Notes 1933-34-35-36’. Used for notes on research on serum albumin, November 1933-June 1937. University London. College Intercalated notes loose at front and throughout. The notes may be continued in the notebook at C.306. Softback notebook 1935-1938 Inscribed on first page ‘Fysikalische Keminska Upsala April notes on research on serum albumin, April 1935-October 1938. Laboratory notes’. Used for 1935. 1938-1941 1938-1955 Hardback notebook Intercalated note loose at front. Human serum and plasma notebooks Intercalated notes and correspondence loose at front and throughout. Labelled on spine ‘Human plasma | 1938-1941’ and on first page ‘[...] Lister Institute 1938 Human serum |’. Used February 1938-June 1941. 1940-1943 Labelled on spine ‘Human plasma II 1940-43’ and on first page ‘[...] Lister Institute Sept 1940. Human serum II’. Used August 1940-March 1943. Intercalated Mawson, 1942, loose at front and throughout. correspondence from Hardback notebook notes and ?C.A. R.A. Kekwick NCUACS 118/4/03 Research Hardback notebook 1943-1948 Inscribed on first page ‘[...] The Lister Institute Carshalton May 1943 Human serum and plasma Ill’. Used April 1943-January 1948. Intercalated notes and correspondence loose at front and pasted to pages of the notebook throughout. Hardback notebook 1948-1952 Inscribed on first page ‘[...] Human serum and plasma’. 1952. Lister Institute Feb 1948. Used February 1948-May Intercalated notes and data loose at front and loose and pasted to pages of the notebook throughout. Hardback notebook 1952-1955 Inscribed on first page ‘[...] Lister Institute May 1952. Human sera and plasma’. Used May 1952-June 1955. Intercalated notes loose and pasted to pages of the notebook throughout. Work may continue in notebook at C.33. Hardback notebook 1939-1940 Labelled on methods and results 1940. front cover ‘Toxin’. Used for notes on of experiments April 1939-June 1939-1960 Inscribed on first page ‘Lister Institute [...] Oct. 1939 Hell Hilter. Used for notes chiefly on research on horse serum, October 1939-1946, 1950 and 1959-1960. Intercalated notes pasted to pages and loose throughout the notebook. Intercalated notes, data and correspondence loose at front and pasted to pages of the notebook throughout. Hardback notebook R.A. Kekwick NCUACS 118/4/03 Research Hardback notebook Labelled on front cover ‘Sera’. Used for work on horse sera April-November 1940. Intercalated correspondence and notes loose at front and pasted to pages of the notebook. Notebook 1946-1967 on Inscribed front cover ‘Plasma Processing Drying. STANDARDISATIONS’. Used intermittently June 1946- March 1949, 1952, 1957-1959, 1963, 1967. Notebook 1947-1958 Inscribed on first page ‘Pathological sera examinations’. Used intermittently thereafter to 1958. 1947-November 1948 April and _ C.15-C.31 1948-1961 ‘Book Five’. ‘Book One’. ‘Book Two’. Electrophoresis notebooks Series of spiral bound notebooks numbered 1-17, used for work on electrophoresis from April 1948-March 1961. There are experimental results and include work of a number of Kekwick’s colleagues and are in a number of hands. 1951-1952 ‘Book Three’. ‘Book Four’. 1948-1949. 1949-1950 1950-1951 R.A. Kekwick NCUACS 118/4/03 Research ‘Book six’. ‘Book seven’. ‘Book eight’. ‘Book nine’. ‘Book ten’. ‘Book eleven’. 1953-1954, 1954-1955 ‘Book twelve’. 1955-1956 Book 13’. ‘Book 14’. ‘Book 15’. 1957-1959 Graphs pasted to pages to the notebook. Inscribed homogeneity. Globulin Expts. Used February 1955-January 1956. Spiral bound notebook ‘Mol[ecular] & Path. [?] Bence Jones’. Wfeigh]t on front cover ‘Book 16’. ‘Book 17’. 1956-1957 1959-1961 1955-1956 R.A. Kekwick NCUACS 118/4/03 Research Hardback notebook 1955-1960 Inscribed on first page ‘[...] Lister Institute. June 1955. Human 1955- February 1960. Probably continues work from C.11. Fractionation’. Plasma Used June Intercalated notes loose throughout the notebook. Hypogammaglobulinaemia notebooks 1956-1958 Spiral bound notebook 1956 [...] April Labelled on front cover ‘Hypoglobulinaemia. 1 1956’ and to cases of hypogammaglobulinemia. March 1956’. Used for case notes, March-October 1956. first page ‘Data relating on Related correspondence taped to pages of the notebook. Spiral bound notebook 1956-1958 [...] Oct 1957-1964 C.36, C.37 C.36 Spiral bound notebook Anti-haemophiliac Factor notebooks Labelled on front cover ‘Hypoglobulinaemia. 1 1956’. Used for case notes, data and results, October 1956- February 1958. Labelled on front cover ‘Anti Haemophiliac Factor Assays |. [...] April 1957’. Used for data and results, April 1957- March 1959. 1959-1964 Loose material intercalated at front and graphs pasted to pages to the notebook. Labelled on front cover ‘Anti Haemophiliac Factor Assays Il. [...] March 1959’. Used April 1959-February 1964. Loose notebook and graphs pasted to pages of the notebook. intercalated throughout material Spiral bound notebook 1957-1959 loose the R.A. Kekwick NCUACS 118/4/03 Research Spiral bound notebook 1957-1958 Labelled on front page ‘Serum proteins of the foetus and young animal. Abstracts of papers Book 1 [...] Dec. 1957’. Spiral bound notebook 1958-1964 Labelled on front cover ‘Pathological Cases Book’. Used for notes on cases, January 1958-June 1964. Extensive data and pages of the notebook. related correspondence taped to C.40, C.41 Factor V notebooks C.40 Spiral bound notebook 1959-1964 1959 on front Labelled Brain Thromboplastic Lipid. Book 1. 1959-1963 [...] April 1959’. Used for notes on conduct and results of experiments, April 1959-May 1963. ‘Factor cover and V cover ‘Factor V and _ on front 1963-1964 Spiral bound notebook Spiral bound notebook Intercalated notes loose throughout the notebook. Brain Labelled Thromboplastic Lipid. Book 2. June 1963’. Used for notes on conduct and results of experiments, June 1963- February 1964. 1960-1966 Inscribed on first page ‘...] Human Plasma Fractionation’. March 1966. Probably continues work from C.33. Lister Institute. Feb 1960. February 1960- Untitled but chiefly used for notes on Fibrinogen. Intercalated notes loose throughout the notebook. Intercalated material loose at front and rear. Hardback notebook Used R.A. Kekwick NCUACS 118/4/03 Research Spiral bound notebook Untitled. lectures. Includes notes from visit to USA and drafts of C.45-C.49 Chromatography notebooks. C.45 Spiral bound notebook 1962-1971 1962-1963 front cover ‘Electrophoresis in Inscribed on cellulose acetate membrane’ and on back cover ‘Chromatography 1’. Used from the front for notes November-December 1962 but chiefly from the back for results of experiments, April-December 1963 Spiral bound notebook Inscribed on front cover ‘Chromatography Book 2’. Used for results of experiments, January -November 1964. Intercalated notes loose throughout notebook. Spiral bound notebook 1964-1965 Hardback notebook 1965-1970 Inscribed on front cover ‘Chromatography Book 3. Nov. 1964’. Used for results of experiments, November 1964- August 1965. Labelled on front cover ‘Chromatography 4’ and on the first page ‘August 1965’. Used for notes and data, August 1965-June 1970. 1970-1971 Labelled on front cover ‘Chromatography 5’ and on the first page ‘August 1970’. Used for notes and data, July 1970-March 1971. Includes material pasted to pages of notebook. Hardback notebook Includes material pasted to pages of notebook. R.A. Kekwick NCUACS 118/4/03 Research Immuno-electrophoresis notebooks. Spiral bound notebook 1963 1963-1967 Inscribed on front cover ‘Immuno-electrophoresis (micro) October Used September 1963-January 1967. Immuno-diffusion. 1963. Book 1’. Loose material intercalated at front of notebook including ‘Procedure Immuno- electrophoresis Experiment’. Immunodiffusion and for Spiral bound notebook 1967-1971 on ‘lmmuno-electrophoresis. Inscribed Immuno-diffusion. January 1967. Book 2’. Used January 1967-February 1971. cover front Extensive material material. intercalated including photographic 1967-1971 on front cover 1967-1971 ‘Ultracentrifuge Hardback notebook Hardback notebook Material intercalated loose and pasted to pages of the notebook. Inscribed on first page ‘[...] Lister Institute Jan 1967’. Used January 1967-March 1971. Labelled and inscribed on first page ‘...] Nov 1967 Ultracentrifuge experiments’. Used October 1967-September 1971. 1968-1971 Labelled and miscellaneous’ and inscribed on first page ‘[...] January 1968’. Used January 1967-April 1971. Loose photographic data pasted to pages of the notebook. and correspondence intercalated Correspondence photographic data pasted to pages of the notebook. intercalated Hardback notebook ‘Pathological on front cover loose; and_ notes_ _loose; data runs’ sera R.A. Kekwick NCUACS 118/4/03 Research C.55-C.305 RESEARCH NOTES 1950-1963 Contents of Kekwick’s folders and boxfiles. These date from the mid 1930s to the early 1970s. The material found within the boxes and folders included notes, data, calculations, correspondence and drafts of publications. The material is presented in alphabetical order by subject or name of research colleague as given on the folder or Some of the folders given a subject title also boxfile. bore the name of colleague and this has been recorded in the catalogue entries. At C.295-C.302 is material from an untitled boxfile and at C.303, C.304 are papers and photographs on research equipment. a research Much of the research work presented here relates to the data recorded in the notebooks in the sequence at C.1- C.54. C.55-C.90 ‘A-Z' 1940s-1950s Untitled material found at front of boxfile. Contents of Kekwick’s boxfile organised by alphabetical dividers. The material put under each letter corresponds, in most cases, to the surname of a correspondent or a topic of research. It is retained in the order in which it was filed. Much of the material is correspondence requesting or discussing results of electrophoretic and ultracentrifuge tests carried out by Kekwick, together with data, including photographs, from the tests. and n.d. 7pp ‘The typescript, requesting immuno- electrophoretic analyses of sera and dextrans, June 1957; data from ‘Cell tests’, 1948 and 1949; data from urinary protein tests 1958. Data from work on ‘Aerosporin’ February 1948, with letter and typescript on bovine plasma samples; data from work on ‘Anthrax Culture Filtrate’. ‘A’. preparation of n.d.; letter from crystalline ‘Bill’ hemoglobin’, 1948-1958 R.A. Kekwick NCUACS 118/4/03 Research ‘A’. Manuscript and typescript draft of ‘A new method for acetylating proteins’ by Kekwick, J. Baddiley and E.M. Thain, submitted to ‘Nature’, July 1952; correspondence with the editors of ‘Nature’, 1952; manuscript data. [eye 1948-1960 Data on plasma serum 1948. blood group substances 1957-1960; bovine ‘Cr. Correspondence J.C. Cruikshank, London School of Hygiene and Tropical Medicine on guinea pig data; data. Spooner E.T.C. with and Kekwick analysed samples of sera from guinea pigs infected with bracellae. from examination dextran samples, 1947, 1952 1947; of of serum from University Downie, re electrophoretic analysis Data correspondence Liverpool, generalised vaccinia case, 1952. fractionation of human plasma proteins with ether’, 1947, Includes draft prepared by Kekwick (though authorship is given as Kekwick, M.E. Mackay and B.R. Record), ‘The Correspondence and papers re work on fibrinogen. of A.W. with 1947-1949 R.A. Kekwick NCUACS 118/4/03 Research letter from B.R. Record commenting on the draft with and of with fibrinogen & the signicnance of the clottable/total N ratio’. manuscript purification ‘The note 2pp ‘PF 1951-1953 Correspondence and papers re fibrinogen. Includes correspondence with K. Bailey; manuscript and typescript by conversion to fibrin’. ‘Estimation fibrinogen drafts of of ‘PF’, Correspondence and data. ‘Gi Correspondence. 1956, 1959 1953-1956 1st dnl Correspondence with S.E. Keidan, University of Liverpool re test for gamma globulin deficiency. Data titled ‘Hochs Halogen-Antibody complex’, with letter to H. Hoch, May 1949. 1953-1955 Correspondence with J. Cambridge, re determination of molecular weight helicorubin and related research. Keilin, School of Biochemistry, of Correspondence with defiency. H.A. Krebs re gamma globulin ‘K’. Se R.A. Kekwick NCUACS 118/4/03 Research le 1949-1961 Correspondence re_ Infirmary, examination of samples sent to Kekwick. Latner, Tyne, A.L. upon Newcastle with Royal Victoria ultracentrifuge Le Data from ultracentrifuge tests for A.L. Latner. ee 1954-1955 1959-1960 H. Lehmann enclosing draft Letter from Nature’, alteration; data on haemoglobin examined for Lehmann. Letter to suggested Kekwick’s reply with and his of ‘M’. 1946-1950 with R.A. ‘M’. sera - chiefly inscribed: McCance, 1946-1949 ‘Malnutrition Contents of subfolder electrophoresis’. Data from tests on malnutrition sera Includes typescript ‘The ratio of arginine to lysine in the serum proteins’ by P.E.H. Jones, sent to Kekwick by McCance. Correspondence re electrophoretic tests on sera of malnourished British ex- Prisoners of War. 1946-1948 ‘The electrophoretic examination of serum from cases of malnutrition’ by Kekwick, 5pp typescript + table. Correspondence with tests on rabbit gamma globulin. J.R. Marrack re ultracentrifugal R.A. Kekwick NCUACS 118/4/03 Research ‘M’. 1938-1946 Contents inscribed: miscellaneous’: data from experiments. subfolder of ‘Electrophoresis A.S. McFarlane, NIMR, with data from ‘Mc’. from Letter Kekwick. iO; Letter from A.G. Ogston, January, with 2pp manuscript ‘Calculation of S’. Re 1948-1949 Correspondence pneumokoniosis. and papers re research on 1950-1956 Low re samples S.M. with Station, of human sera the Llandough Hospital, for Unit, Partridge, Cambridge, Miscellaneous correspondence. Kekwick analysed Pneumokoniosis Research Cardiff. Includes Temperature ultracentrifuge tests on proteins. correspondence Research 1949, 1956 Chiefly correspondence with L.M.N. Roy, Rheumatism Research Unit, Northern General Hospital, Edinburgh, re fractionation of rheumatoid plasma. Correspondence with A.E. Pierce, Agricultural Research Council Institute of Animal Physiology, Cambridge. 1956, 1962 ‘pi. ‘DY. antes R.A. Kekwick NCUACS 118/4/03 Research Su Correspondence with D.H. Sproull, Institute of Aviation Medicine, Farnborough, re electrophoresis tests. ‘Se 1958-1959 Correspondence with J.C. Smith and other colleagues at the University of Manchester Department of Chemical Pathology and Occupational Health, re work on cadmium and mercury poisoning. Department of Nuffield aie: Correspondence Medicine, Queen Elizabeth Hospital, Birmingham. colleagues with Department at of ‘W’. ‘Ww’. ‘W’. with A. Correspondence with E.M. Widdowson re tests on serum. Correspondence comments on paper by Wassermann on actomysin. Wassermann _ including Correspondence with G. Weber, School of Biochemistry, Cambridge, re tests on bovine serum albumin; data therefrom. 1957, 1960 Exchange of letters with Maltese correspondent enquiring about availability of AHF (arising from newspaper cutting reporting on Kekwick’s work); ‘Resume of work carried ‘AHF General. Manuscripts, laboratory directions, buffers etc’. Contents of folder so inscribed: correspondence and papers re anti-haemophilic factor (AHF). 1952-1953 1957-1968 C.91-C.96 R.A. Kekwick NCUACS 118/4/03 Research out during 1959-60 on the Purification of Human Anit- Haemophilic Factor (AHF)’, 19pp typescript. Manuscript and typescript instructions for preparation and purification of AHF. 1960-1962, n.d. ‘Some studies on the purification and stability of human Antihaemophilic Factor (Factor VIl)’ by Kekwick and P.L. Walton, 19pp typescript + tables and references. Copy of draft of ‘Assay of Factor VIII concentrates’ by J.G. Pool sent to Kekwick for comment, with Kekwick’s letter of reply. Medical Research Council report on work on human AHF by P. Wolf, April Wolf worked on AHF with Kekwick. Includes copy of draft report. ‘Albumin Agglutinating Effect’. Kekwick was not part of this study but was asked to comment on the draft report. Papers re MRC report on Collaborative Study of Factor VIIl Preparations. 1969-1973 Contents of folder so inscribed: correspondence, chiefly with K.L.G. Goldsmith of the Blood Group Reference Laboratory, National Research Development Corporation, re bovine serum albumin. Chemicals a patent Kekwick held of improved bovine serum albumen for the detection of rhesus antibodies and BDH Chemicals were given a license to continue development work on it. preparation covering the BDH Ltd and the R.A. Kekwick NCUACS 118/4/03 Research 1969-1971. Includes data from analysis of bovine serum albumin. 1972-1973. C.99-C.101 ‘Albumin Agg. Reports. Armour Corr[espondence]’ 1970-1974 Contents of folder so inscribed. Correspondence, chiefly with K.L.G. Goldsmith of the Armour Blood Pharmaceutical Co. on bovine serum albumin. re electrophoresis tests Laboratory Reference Group and Ltd, Includes data. 1971-1972. 1973-1974. Includes data from tests. ‘Anti-Coagulant Studies’ D immunnglobulin. Contents correspondence and manuscript notes phosphate citrate anti-coagulant solutions. Contents inscribed: correspondence and data re ultracentrifuge tests on Anti- inscribed: data on ‘Anti-D Gamma G.’ so _ and Kekwick’s’ folder so _ of Kekwick’s’ folder of 1968-1970 R.A. Kekwick NCUACS 118/4/03 Research ‘Austrian Gamma Globulin’ 1963-1964 Contents of Kekwick’s folder so incribed: correspondence and data on tests on Austrian samples of human gamma globulin. C.105, C.106 ‘Bonnell. Cd poisoning’ 1950-1963 Contents of Kekwick’s folder so inscribed. 1950-1953 Chiefly correspondence re case of cadmium poisoning 1953 and related material. Includes typescript draft on cadmium poisoning by J.A. Bonnell. 1954-1963 Stunt Electrophoresis. equilibrium. Sedimentation Refractive 1938-1942 C.107, C.108 by Kekwick, appendix to paper by Virus. Sedimentation ‘Bushy velocity. increment’. Contents of Kekwick’s folder so inscribed: data from work on Bushy stunt virus. Data from cadmium poisoning tests; correspondence; typescript draft of ‘Physico-chemical examination of the serum and urine proteins in some cases of cadmium poisoning’ J.A. Bonnell. electrophoresis tests on horse serum. Contents of Kekwick’s folder so inscribed: data from ultracentrifuge tests. ‘Electrophoresis runs. Animal sera and fractions’ Contents of Kekwick’s boxfile so labelled: results of ‘Centrifuge runs miscellaneous’ C.110-C.121 1939-1943 2 folders. 1938-1941 R.A. Kekwick NCUACS 118/4/03 Research are two sequences that 157-194 There (covering 1939-1940) and 371-568 (1940-1943). Neither is complete. from run 12 folders. C.122-C.125 ‘Electrophoresis runs. Egg albumin’ 1938-1940 Contents of Kekwick’s folder so inscribed divided into four. Includes work on diphtheria antitoxins. C.122, C.123 Data from electrophoresis tests on egg albumin 2 folders. Correspondence and papers Chiefly correspondence with C.R. Amies of the Lister Institute re tests on samples of diphtheria antitoxins. 1938-1950 of papers presented, including C.126-C.148 Papers from Lister Institute Discussion on the Purification and Properties of Diphtheria Antitoxin, 5 January 1940 ‘Electrophoresis runs. Human sera and fractions urine proteins’. Abstracts Kekwick’s contribution on ‘The antibodies of antidiphtheritic horse serum’; recommendations for future work. 11 folders. Contents of Kekwick’s boxfile so inscribed: chiefly data on human sera from numbered electrophoretic tests (normal and with myeloma) 1938-1945. The numbered sequence is continuous but includes both normal and myeloma human sera. Contents of Kekwick’s folder so inscribed: data from electrophoresis tests on human sera, numbered 3 (1938) to 222 (1945). Not a complete sequence. ‘Normal human sera’ C.126-C.136 1938-1945 R.A. Kekwick NCUACS 118/4/03 Research Miscellaneous unnumbered data found with C.126-C.136 C.138-C.140 ‘Myeloma sera electrophoresis’ 1938-1943 Contents of Kekwick’s folder so inscribed: data from electrophoresis tests on human sera, numbered 1 (1938) to 140 (1945), not a complete sequence. 3 folders. Case notes etc. found with C.138-C.140 1939-1946 C.142-C.144 ‘Myeloma Globulin Electrophoresis’ and ‘Normal human gamma globulin electrophoresis’ Contents of Kekwick’s folder so labelled. Myeloma urine electrophoresis tests 1-10 1941-1942 Myeloma globulin electrophoresis tests 1-19a 1939-1941 Human gamma globulin electrophoresis tests 1-7 Graphs of results of human sera electrophoresis tests. electrophoresis data. of Correspondence Medicine, University of Cambridge, found with human Contents of Kekwick’s folder so inscribed: electrophoresis tests. Miscellaneous data from human electrophoresis tests. ‘Immune globulin - human electrophoresis’ 1946-1948 data from 1946-1950 from W. Bradley, Department R.A. Kekwick NCUACS 118/4/03 Research C.149, C.150 ‘Electrophoretic [illegible]’ 1938-1942 Contents of Kekwick’s folder so inscribed: miscellaneous data from electrophoresis; envelopes of photographic data. 2 folders. C.151-C.157 ‘Embryonic sera etc’. 1950-1964 Kekwick’s folder Contents of Chiefly correspondence with F.W.R. Brambell, Department of Zoology, University College of North Wales, Bangor, re work on sera of pregnant female rabbits. inscribed. so Kekwick was a co-author with Brambell and others of ‘Electrophoretic studies of serum protein of foetal rabbits’, ‘Proceedings of the Royal Society’ B vol. 141 (1953), pp 300-314. Correspondence with Brambell and W.A. Hemmings on results of tests on rabbit sera. 1951-1952 Includes manuscript data intercalated. Correspondence with Brambell and Hemmings on results of tests on rabbit sera. ‘Electrophoretic studies of serum protein of foetal rabbits’ by Kekwick, Brambell, Hemmings et al, ‘Proceedings of the Royal Society’ B vol. 141 (1953), pp 300-314. Brambell. Correspondence and papers re tests on rabbit sera for 1963-1964 C.154-C.156 Data and analysis. 3 folders. R.A. Kekwick NCUACS 118/4/03 Research C.158-C.160 ‘Factor V’. 1956-1959 Contents of Kekwick’s folder so inscribed. Report on ‘The purification of prothrombin 2nd July 1956’, 13pp typescript + figures. Typescript preparation of Factor V. and manuscript notes and drafts on 1958-1959 2 folders. ‘Report on Human Factor V Preparations 7th January 1959’, 10pp typescript; envelope of photographic data of ‘Bovine Factor V. Starch gel electrophoresis’, 1961-1962. 1959-1962 C.161-C.167 ‘Fibrinogen’. 1945-1957 1945-1946 Data from human sera electrophoresis Contents of Kekwick’s folder so inscribed: material chiefly on purification of fibrinogen. ‘The fractionation of human plasma with ether’, typescript draft, latest bibliographical reference 1949 ‘The purification of human fibrinogen’, typescript draft + figures, latest bibliographical reference 1948. 1950-1954 Includes by conversion to fibrin - The clottable nitrogen : total nitrogen ratio’ by Record. Correspondence, chiefly with B.R. Record. manuscript ‘Estimation of fibrinogen Manuscript fractionation 1950-1954 and typescript notes on _ fibrinogen R.A. Kekwick NCUACS 118/4/03 Research ‘Observations fibrinogen’ by Kekwick and E.A. Caspary molecular the on weight of human 3pp typescript and published copy (Communication to the Biochemical Society, January 1954). Correspondence from L. Lorand Includes 4pp typescript draft of ‘Purification of the serum factor (fibrin stabilising factor: FSF) which with Ca ions together renders the plasmaclot insoluble in 30% urea’ by Kekwick and Lorand. ‘Fish myosin’ Data from tests. C.169-C.180 ‘G2/2 Heavy Component Separation’ 1958-1968 the inscriptions are reproduced in part in Includes photographic data. Contents of Kekwick’s folder so inscribed. ‘Data on preparative ultracentrifuge purification of "IGS" fraction and recoveries in pellet and G2/2’. The bulk of the material was found further divided within envelopes and paper folders which were inscribed with a description of the contents. These have been retained and the catalogue entries. The material has been retained in the order found inside the main folder. 2 folders. ‘Centrifuge runs. Mostly G2/2 preparations and pellets’. ‘Separation on G.200 as 1st step’. CAli25 C1738 C.170, C.171 2 folders. 1964-1967 1965-1967 R.A. Kekwick NCUACS 118/4/03 Research ‘Summary of expts by JMJ on reduction and separation of components’ C.175, C.176 ‘Centrifuge preliminary chromatographic fractions’ runs and some chromatographic data on 1964-1965 2 folders. ‘Ouchterlong prints’ Photographic prints. ‘Gamma-macroglobulin. Prints of LIC U.C. mins’. 1964-1965 Photographic prints. Typescript buffer pH65 [...]’ by S. Szuchet. ‘Extraction of G2 with acetate-phosphate C.182 1964-1967 1964-1972 C.182-C.197 Miscellaneous loose data With manuscript annotations by Kekwick. ‘Dr Goldsmith. Fractionation of goat antisera’. Contents of Kekwick’s folder so inscribed: data from tests on goat antisera; brief correspondence. 1951 Contents _ of labelled: correspondence and papers re research work on anti- haemophilic factor (AHF). ‘Haemophilia. Experimental data. Clinical reports. Large scale batches’. Letter from R.G. Macfarlane, Radcliffe Infirmary, Oxford, enclosing results of experiments, August. Kekwick’s boxfile so C.182-C.186 ‘Haemophilia. Experimental data’. 1951-1956 R.A. Kekwick NCUACS 118/4/03 Research Correspondence, chiefly with J.V. Dacie, Postgraduate School of Medicine, London, re tests on human sera. 1952, 1954 Patient data Duplicated typescript 1951-1952 C.185, C.186 Manuscript and typescript test results, graph plots etc. 1954-1956 2 folders. C.187-C.193 ‘Haemophilia. Clinical reports. Large scale batches’. 1956-1959 Contents Kekwick’s correspondence and papers of folder so inscribed: Correspondence and data from tests Correspondence and patient notes 1957-1958 Correspondence and data from tests Correspondence, chiefly with W. d’A. Maycock. 1958-1959 Duplicated ‘Human Antihaemophilic Factor Informal Meeting, 7th November 1958 [...] Lister Institute’ ‘A concentrate of human antihaemophilic factor and its use in six cases of haemophilia’ by Kekwick and P. Wolf Correspondence typescript material for 23pp typescript. R.A. Kekwick NCUACS 118/4/03 C.194, C.195 Research Manuscript and typescript data and notes on AHF assays AHF. & ‘Human Robinson, Biggs, Wolf-HP), Results of comparing Pool & Robinson with Wolf-HP etc’. methods Details assay (Pool of 1958-1960 Correspondence and papers re assay of antihaemophilic globulin. ‘HP’ refers to the Hicks Pitney test 1958-1959 1960, n.d. Includes typescript of ‘The thromboplastin generation test as a method for assaying anti-haemophilic factor’, 1960; newspaper cuttings on possible use of peanut seed in treating haemophilia, and duplicated typescript ‘Assay of Antihaemophilic globulin’, n.d. 1960; offprints by P. Wolf, 1954-1957 Kekwick’s research Includes colleague. Miscellaneous material found loose 9pp typescript + manuscript graphs. ‘Report of experiments on the assay of A.H.F.’ by R.H. Painter. Contents of Kekwick’s folder so inscribed. Contents of Kekwick’s folder so inscribed: results and data from ultracentrifuge tests on horse serum, ‘Ho.S.1’ to ‘Ho.S.25’. ‘Human AHF Standard checks with Elstree’ ‘Horse Serum Centrifuge Runs’ C.199-C.202 preparations assays. Cross 1959-1965 1939-1941 R.A. Kekwick NCUACS 118/4/03 Research Correspondence with W. d’A. Maycock, L. Vallet and Rosemary Biggs re data from tests on antihaemophilic globulin 1959-1960 Correspondence with W. d’A. Maycock and Edith Bidwell re data from tests on antihaemophilic globulin 1961-1965 ‘AHF International Standard Comparison’ Contents of Kekwick’s envelope: chiefly correspondence and papers re tests on AHF factor VIII and IX. Miscellaneous material C.203-C.205 ‘Human AHF Summary of experimental results’. 1959-1966, n.d. 1964-1966, n.d. 1959-1960 1961-1962 Contents of Kekwick’s folder so labelled: chiefly data and graph plots. Includes envelope of photographic data, 1962, inscribed ‘Immuno electrophoresis prints L.34 /1,2 & 3’. 1951-1952 Contents of Kekwick’s folder graphs. ‘Human gamma globulin Human gamma globulin G.4. February 1963’ G.4. Ultracentrifuge Contents of Kekwick’s folder so inscribed: graph plots. ‘Human diphtheria Immunization data’. C.207, C.208 runs. so inscribed: data and R.A. Kekwick NCUACS 118/4/03 Research Includes ultracentrifuge test results numbered HGG 1- HGG 20. 2 folders. ‘Human serum albumin. Ultracentrifuge runs’. Contents of Kekwick’s folder so labelled. C.210-C.214 ‘Human serum centrifuge runs’ 1938-1941 Results of electrophoresis tests. The bulk of the material is a sequence that runs from HS 1 to HS 84. 5 folders. C.215-C.235 ‘Hypogammaglobulinaemia. ultracentrifuge analyses’ Electrophoretic and 1956-1974 C.215-C.219 Correspondence re samples of globulin sent to Kekwick for analysis 1956-1967 Contents of Kekwick’s folder so labelled: correspondence and papers re work of Medical Research Council Working Party on Hypogammaglobulinaemia and analysis of sera samples. Kekwick was a member of the MRC Working Party on Hypogammaglobulinaemia (see E.30). Samples of sera from cases of this condition were sent ot Kekwick for analysis. 3 folders. Letters sent covering samples with Kekwick’s replies, with typescript and manuscript notes of test results. C.220-C.222 Data from ultracentrifuge tests 1956-1962 Includes photographic data. 5 folders. R.A. Kekwick NCUACS 118/4/03 Research C.223-C.225 Graph plots 1956-1966 3 folders. ‘Hypogammaglobulinaemia. Sedimentation analysis gamma globulin preparations used in the clinical trial’. of App typescript + covering letter, 4 August 1959. estimation ‘The gamma_ electrophoresis’ by Kekwick and L. Vallet. serum of globulin by 7pp typescript; 7pp typescript ‘Corrected copy’; covering letter, 22 September 1959. Miscellaneous correspondence 1965-1974 2 folders. C.229, C.230 ‘Gamma-G paper’ ‘Hypogammaglobulin paper. Retyped version 29.2.68. Final version 11.3.68’. Contents of Kekwick’s envelope so inscribed: typescript drafts of sections of paper, related correspondence. Contents of Kekwick’s envelope so inscribed: typescript draft of ‘Preparation and characterisation of concentrates of human normal gamma-G immunoglobulin’ by Kekwick et al. Contents of Kekwick’s folder so inscribed. C.232-C.235 C.236-C.238 ‘Lactalbumin’ Data 4 folders. 1967-1968 1956-1957 1935-1936 R.A. Kekwick NCUACS 118/4/03 Research ‘Research 1935’ Report. Upsala, Sweden, April-December 1935-1936 3pp typescript, with letter from K.O. Pedersen, January 1936. Manuscript rough draft of ‘The isolation and properties of an albumin from cow’s milk’. includes Also captions. figures (photographic) with typescript Manuscript notes, graphs and data ‘Lactoglobulin’ Contents of Kekwick’s folder so inscribed: manuscript and photographic data. 1970-1971 Correspondence 1970-1971 C.240,C.241 ‘M[acroglobulin] Contents of Kekwick’s folder so inscribed. Manuscript notes; annotated photocopies of articles by others report’. Kekwick’s reports to the Medical Research Council for 1966-1967 the his macroglobulin of normal human plasma Typescript ‘Corrected’ copies; manuscript draft of ‘1968 ‘Macroglobulin. Thiol Treatment Experiments’ and 1967-1968 on work on _ 1967-1969 1967, 1968 C.242-C.245 Contents of Kekwick’s folder so inscribed. R.A. Kekwick NCUACS 118/4/03 Research C.243, C.244 Notes and data. Includes photographic data. 2 folders. Envelopes of photographic data. 1967-1969 The envelopes bear inscriptions idenfiying the contents. 7 envelopes. ‘Macroglobulin. Treatment with maleic anhydride’. Contents of Kekwick’s folder so inscribed: manuscript and photographic data. C.247-C.251 ‘Plasma Fractionation’ 1948-1954 and n.d. ‘285 & 291’. 1948-1954 Contents of Kekwick’s folders so inscribed. This series of folders contained data and graph from numbered experiments. These numbers are reproduced in the catalogue entries. ‘344 & 353’ R.A. Kekwick NCUACS 118/4/03 Research C.252-C.254 ‘Plasma Protein Fractionation’ 1964-1967 Contents of Kekwick’s folder so labelled. Correspondence with L. Vallet and data Includes photographic prints from ultracentrifuge runs. Chiefly data 1965-1966 Includes photographic prints from ultracentrifuge runs. Correspondence and papers Chiefly with L. Vallet and D.R. Bangham, Director of the National of Biological Standards. for Medical Research, Institute Division ‘Prothrombin’ 2 folders. C.256-C.259 C.256, C.257 and manuscript draft Prothrombin and_ ‘Rabbit Serum Protein Fractions’. Data from tests on normal rabbit serum Kekwick’s folder: of purification Contents of Kekwick’s folder so inscribed. The data is numbered in a sequence from R.S. 1 to R.S. 20. ‘The Contents of separation its conversion to thrombin’, paginated 5-12; manuscript data. sheet 5). A sequence running from ‘Sheet 1’ Data from tests on rabbit serum 1938, 1947 to ‘Sheet 6’ (lacks R.A. Kekwick NCUACS 118/4/03 Research ‘Rabbit serum electrophoresis’ 1938-1939 Contents of Kekwick’s folder data from electrophoresis tests in a sequence numbered R.S.E. 22- R.S.E. 30. labelled: so C.261-C.266 ‘Dr Halliday Rat Serum data’. 1955-1960 Contents of Kekwick’s folder so inscribed. of North Wales, This material relates to collaborative research between Kekwick, R. Halliday and F.W.R. Bramball of University principally College correspondence, of electrophoretic tests on rat sera from Kekwick, but also includes drafts of joint publications and a little original data. It typescript including Bangor. results is Correspondence and papers of the typescript copy of Includes the capacity of young rats to absorb antibody from the milk’ by Halliday, sent to Kekwick for interest. ‘The termination of and joint draft paper Includes alterations. Correspondence and papers Correspondence re draft of ‘The electrophoretic analysis of the sera of young rats from suckling to maturity’, by Kekwick and Halliday 1959-1960 Includes correspondence re joint paper. Correspondence with Halliday Correspondence with Halliday suggested R.A. Kekwick NCUACS 118/4/03 Research Conference on the transmission of serum proteins to the young mammals, Department of Zoology, University College of North Wales, Bangor, 14 December 1959 Programme; duplicated typescript abstracts. Kekwick and Halliday gave a paper ‘The selection of antibodies by the young rat’. C.267-C.272 ‘Serum albumin’ 1935-1938 Contents of Kekwick’s folder so inscribed: chiefly data from tests on English and Swedish samples of serum albumin. Most of the data within the (card) folder was found sub- divided within paper folders with an inscription of the subject These have been retained and the inscriptions reproduced in the catalogue entries. thereon. ‘Serum albumin diffusion’ ‘Serum albumin A.3’ and ‘S a A.3 Reference scales’ ‘Serum albumin A. Absorption runs’ and ‘Serum albumin A. Electrophoresis’ ‘Serum albumin B. Absorption runs’ and ‘Serum albumin B. Cataphoresis’ 1937, 1938 ‘Serum albumin B.2’ and ‘Serum albumin B.2 Ref scales cy} Kekwick’s Relates crystallisable albumin Journal’ vol 32 (1938). Material found loose within the folder Letters commenting on the draft; proof copy, abstract; figures. Cannan from K.O. R.K. and on the ‘Biochemical ‘Observations of horse serum’, to paper Pedersen R.A. Kekwick NCUACS 118/4/03 Research C.273-C.279 ‘Transfusion cases. Clinical notes. Electrophoresis runs’ Contents of Kekwick’s envelope so inscribed. Correspondence to Kekwick and Mcfarlane chiefly from 2A. van der Walt, with samples of human sera. Van der Walt worked at the North West London Blood Supply Depot. C.274-C.276 Data from human sera electrophoresis tests, numbered HSE 89-HSE 125 (not a complete sequence) 3 folders. C.277-C.279 Case notes 3 folders. 1957-1965 1960-1961 1957-1965 C.280-C.285 C.280, C.281 on patients with Flynn worked at the Department of Clinical ‘Ultracentrifuge runs. Dr F.V. Flynn’ Contents of Kekwick’s folder so labelled Includes photographic data from ultracentrifuge tests. Correspondence with Flynn re tests macroglobulinaemia F.V. Pathology, University College Hospital London. 1960-1961 Correspondence re macroglobulinaemia Includes Kekwick’s suggested corrections. C.282, C.283 draft of paper by Flynn on 2 folders. Data 2 folders. R.A. Kekwick NCUACS 118/4/03 Research ‘An ultracentrifuge study of urine proteins with particular reference to the proteinuria of renal tubular disorders’ by Kekwick, Flynn et al. 15pp typescript + references etc, as submitted to ‘Clin. Chem. Acta’, with covering letter. C.286-C.288 ‘Urine proteins. Spinco runs and calculations. Jan 1962’ 1960-1962 Contents of Kekwick’s folder so inscribed. ‘Notes on procedure for determining molecular weight by the Archibald method’ by Kekwick and J.M. Creeth 12pp typescript + figures. Manuscript data from tests on urine protein samples 1961-1962 The data is in a sequence numbered UP 1-UP 12. 1961-1962 C.289-C.291 folder of | Kekwick’s’ ‘Walker, Caroline M. (Butterworth)’ Letter to Kekwick from F.V. Flynn, April 1962; manuscript notes Contents so ___ inscribed: correspondence and papers relating to work with C.M. Walker (later Butterworth) Caroline Walker worked at the Lister Institute as an MRC- funded Scientific Assistant to Kekwick from 1968 to 1971. She human gamma macroglobulin and submitted her Ph.D. in 1972. 1968-1982 ‘Report to Medical Research Council for 1969-1970. Studies by Kekwick on human gamma macroglobulin (IgM)’ 9pp + 1p references typescript. assisted in work on normal R.A. Kekwick NCUACS 118/4/03 Research ‘Report to the Medical Research Council for 1968-1971. Studies on human immunoglobulin M. 0968/87/B’ by Kekwick 12pp + ‘Corrected copy 11.5.72’. references and tables typescript. Annotated Research and career C.292-C.294 ‘Miscellaneous investigations’ 1968, 1972, 1982 1961-1971 Contents of Kekwick’s folder so labelled: ultracentrifuge examinations of gamma globulin samples. Includes photographic data. 3 folders. C.295-C.302 Contents of Kekwick’s untitled boxfile 1940-1945 Includes photographic data. Includes photographic data. 3 folders. C.295-C.298 Data from various electrophoresis tests 1940 Correspondence and papers re jaundice cases 1944-1945 C.300-C.302 Data from human serum electrophoresis tests Numbered 313-427. Not a complete sequence. 1936-1989 Numbered H.S.E. 156-H.S.E. 187 and 586-632. complete sequences. At C.302 is a manuscript and typescript data. C.303, C.304 Research equipment Not little miscellaneous R.A. Kekwick NCUACS 118/4/03 Research Photographs of equipment A Upsala photographs: ‘Ultracentrifuge Six 19367; ‘Elstree: Plasma Fractionation Laboratory’; ‘Apparatus for the electrophoretic separation of proteins’; ‘Svedberg ultracentrifuge showing rotor housing [...] operator Mr Chandraskhar a visiting scientist’; ‘Pilot plant for human plasma protein Mr Chandrasekhar [...];; ‘Freeze drying hall at Blood Reference Laboratory, Lister Institute, Elstree [...] 1957/58’. fractionation. For photographs of Kekwick working with apparatus for fractionation of plasma proteins see A.33. Papers on equipment Includes photocopied article (1977) and manuscript notes on of operating equipment. Ultracentrifuge instructions Svedberg (1989); Miscellaneous research correspondence 1939-1971 on front cover ‘Standard Reagents’ 1930-1955 C.306-C.310 Hardback notebook INSTRUCTIONAL NOTEBOOKS These notebooks contain instructions for preparation of compounds, use of equipment etc. 1937-1955 and Labelled inscribed on first page ‘Department of Physiology and Standard Biochemistry. Departmental and Solutions November 1930’. Used for instructions on preparation of compounds 1930. Also includes research notes from work at University College London, July 1937, continuing work documented in the notebook at C.5. Used for graphs correction curves; and preparations data instructions Hardback binder tables of standard Reagents and _ and for R.A. Kekwick NCUACS 118/4/03 Research electrophoresis; and miscellaneous data and instructions. Includes typescript and photographic material pasted to pages of the binder. A little loose manuscript material at front and back of binder. ‘Memoranda and communications on the preparation of Normal Human Serum Albumin. Department of Physical Chemistry, Harvard Medical School’ This volume was possibly prepared for the US Navy. Bound duplicated typescript papers 1942-1943. ‘Memoranda and Reports on Human Fibrinogen and Thrombin and derived products. Prepared under contract OEMcemr-139’ notes by A few the and _ protein, other of ‘Separation carbohydrate, components of plasma’ the Formed Elements - lipid, peptide sterioid, Typescript manuscript annotations on pages of the volume. intercalated. Kekwick Bound duplicated typescript papers on preparation of fibrinogen etc. 1941-1944. This volume was prepared for the US Committee on Medical Research of the Office of Scientific Research and Development. Bound duplicated typescript and printed papers. This volume was prepared by the Harvard University Laboratory of Physical Chemistry related to Medicine and Public Health, possibly to accompany an exhibition of new apparatus and techniques, 11 July 1950. R.A. Kekwick NCUACS 118/4/03 Research OUTSIZE MATERIAL 1956-1969 Miscellaneous ultracentrifuge and electrophoresis tests. showing graphs results from Retained in original order. R.A. Kekwick NCUACS 118/4/03 SECTION D PUBLICATIONS AND LECTURES, D.1-D.33 1935-1995, n.d. D.1-D.15 PUBLICATIONS D.16-D.33 LECTURES R.A. Kekwick NCUACS 118/4/03 Publications and lectures PUBLICATIONS ‘The amphoteric properties of crystalline egg albumin. I. The hydrogen ion dissociation curve’ by Kekwick and R.K. Cannan 19pp typescript with manuscript annotations; manuscript list of corrections; typescript table. 1935-1995, n.d. 1935 Published as the crystalline albumin of the hen’s egg’, Biochemical Journal vol 30 (1936). ‘The hydrogen ion dissociation of ‘The amphoteric properties of crystalline egg albumin. II. The ion dissociation curve’ by Kekwick and R.K. Cannan of formaldehyde hydrogen effect the on Published hydrogen Biochemical Journal vol 30 (1936). ‘The effect dissociation of curve as ion formaldehyde of egg on the albumin’, the — of influencing human P.L. Walton, stability by Kekwick and ‘Conditions antihaemophilic factor’ Nature, vol 194 (1962) 4pp typescript + references etc, annotated ‘2nd draft Corrected copy 3.4.62’.; covering letter; abstract. Letter from Cannan to Kekwick enclosing typescript data for papers D.1 and D.2. draft Dece 1964’; correspondence with editor, 1965. ‘Studies on the purification and stability of human anti- haemophilic of Haematology, vol 11 (1965) 22pp typescript + legends for figures, references etc, Final ‘annotated Corrected copy 1st draft 23.9.64 [...] 1964-1965 Journal (Factor British factor VIII)’, R.A. Kekwick NCUACS 118/4/03 Publications and lectures and ‘Preparation of human normal gamma-G immunoglobulin’ by Kekwick, M.E. Mackay, W. d’A. Maycock and L. Vallet of concentrates characterisation 29pp typescript with manuscript corrections annotated ‘Corrected copy R.A.K. 14.1.68 Revised 22.2.68’. ‘The influence of polymers on the efficacy of serum albumin as a potentiator of "incomplete" Rh-agglutinins’ by Kekwick, J.M. Jones and K.L.G. Goldsmith, Nature, vol 224 (1969) App typescript + table, references etc; corrected proof. ‘A summary of macroglobulin’ studies made on human gamma-2 1970, 1971 10pp typescript edition 28.5.70’; incomplete typescript annotated ‘[...] Extra data on urea distribution April 1971’. references annotated ‘2nd + 6pp typescript; letter accepting the article for publication. ‘Human blood products in the UK 1939-1955’ by Kekwick, Trends in Biochemical Sciences, c 1978 ‘Alan Nigel Drury 1889-1980’ by Kekwick, Biographical Memoirs of Fellows of the Royal Society, vol 27 (1981) Chiefly background material assembled by Kekwick for the Memoir (reused the Dictionary of National Biography, see D.12, D.13). 1980, n.d. Drury’s Newspaper obituaries; memorial service and 5pp typescript copy of the address by P.L. Mollison photocopy Autobiographical typescript; two portrait photographs notes by preparing service the entry for order of in for Drury, 11pp R.A. Kekwick NCUACS 118/4/03 Publications and lectures ‘Sir Alan Nigel Drury CBE, FRS. 1889-1980’ by Kekwick, Dictionary of National Biography Supplement 1971-1980 1980-1995 3pp typescript; correspondence with DNB 1984-1985 Correspondence with family and colleague of Drury 1980-1995 ‘Preparation of human gamma-2 macroglobulin’ 6pp typescript with manuscript corrections. Offprints 1932-1981 Set of offprints of Kekwick’s publications. Not a complete sequence. D.16-D.33 LECTURES 1947-1968, n.d. Lecture to Chemistry Society, Bristol, 13 February 1947 These are drafts, nearly all typescript, for public and invitation lectures delivered by Kekwick. ?late 1940s Two differently titled drafts both headed as delivered to the Chemistry Society 1947: ‘Human plasma protein fractionation’ (also titled as ‘Paper for the Royal Society ‘Some of physico-chemical 11pp typescript ‘The fractionation of human plasma proteins with ether’ by Kekwick, M.E. Mackay and B.R. Record aspects of plasma proteins’, Medicine’), 10pp typescript + references; 5pp typescript. R.A. Kekwick NCUACS 118/4/03 Publications and lectures ‘The fractionation of human plasma proteins in systems containing solvents’ Found with label: ‘Notes for lecture Liege February 22nd 1951’. 18pp typescript + manuscript notes. ‘Blood coagulation and the treatment of haemophilia’ 15pp typescript with manuscript corrections. Latest bibliographical reference 1953. physico-chemical ‘The globulin’ characterisation of gamma 5pp typescript + tables and references. Latest bibliographical reference 1953. Latest bibliographical reference 1954. 8pp typescript. ‘Methods of fractionating human plasma’ ‘The plasma proteins’, delivered in a series on The Scientific Basis of Medicine to the British Postgraduate Medical Federation, 1955 15pp typescript. ‘The homogeneity and molecular weight of Manchester College of Technology, October 1955. proteins’, ‘Final draft 4.5.55’. 15pp typescript + references. R.A. Kekwick NCUACS 118/4/03 Publications and lectures ‘Solvent fractionation of human plasma proteins’, January 1959 20 12pp manuscript. ‘The organisation of research at (Biophysics Division) or Carpe Diem’ the Lister Institute c 1950s 5pp typescript. This is a humorous account of Kekwick’s research with a visiting Belgian scientist, Dr Hamoir in 1949, relating to attempts to secure supplies of Mirror Carp for use in experiments. Untitled ‘Lecture at Farnborough 1960’ Manuscript draft. 17pp typescript. ‘The purification of fibrinogen’ 15pp typescript. antihaemophilic factor: some _ Annotated ‘Corrected 12.7.63 Lecture copy’. ‘Human biochemical problems’, Manchester Medical Society, 10 October 1962 Manuscript draft. ‘Some lecture in Immunological Aspects of Haematology, April 196[79] ‘Blood coagulation’, Royal Free Hospital Medical School, London, 10 March 1967 human Recent Advances immunoglobulins’, the characterisitics in ?series a of on 10pp manuscript draft. R.A. Kekwick NCUACS 118/4/03 Publications and lectures ‘The preparation and impact of human plasma protein fractions’, Edinburgh late 1960s 17pp typescript and manuscript. ‘Working with big molecules’ 11pp manuscript. Typescript ‘Index of Lantern Slides’ R.A. Kekwick NCUACS 118/4/03 SECTION E SOCIETIES AND ORGANISATIONS, E.1-E.42 1948-1998 L’ACADEMIE ROYAL DE MEDECINE DE BELGIQUE DEPARTMENT OF HEALTH AND SOCIAL SECURITY E.3-E.30 MEDICAL RESEARCH COUNCIL E.31, E.32 ROYAL SOCIETY E.33-E.42 WORLD HEALTH ORGANISATION R.A. Kekwick NCUACS 118/4/03 Societies and organisations L'ACADEMIE ROYAL DE MEDECINE DE BELGIQUE Brochure for October 1966. 125th Anniversary Celebrations, 12-15 Kekwick attended on behalf of the Royal Society. DEPARTMENT OF HEALTH AND SOCIAL SECURITY Papers re Kekwick’s report on his Fractionation Centre, Edinburgh, 9 October 1973. visit to the Protein Includes correspondence re arrangements; manuscript notes; typescript draft of Kekwick’s ‘Comments arising from the visit’. 1948-1978 1948-1978 under the Medical had worked MEDICAL RESEARCH COUNCIL Blood Transfusion Research Committee notes. Kekwick Research Council’s Blood Transfusion Research Committee during the Second World War. The Committee was wound up at the end of the war but re-established in 1949 with the following terms of reference: ‘to advise and assist [...] in dealing with new problems arising in the course of work on dried blood and dried blood products’. Kekwick was a member of the committee and served on its Biological Standards Subcommittee. The committee was dissolved in 1965 but re-constituted in 1967 ‘to advise the Council on matters relating to the research aspects of blood transfusion’. Kekwick was again invited to serve and also was the Cryoprecipitate Method of Preparing AHF Concentrates (E.25-E.29). The material is chiefly agenda, minutes and other papers for meetings, some annotated by Kekwick, with a little related correspondence and manuscript and typescript member of a its Working Party on R.A. Kekwick NCUACS 118/4/03 Societies and organisations Papers re the establishment of the Committee and first two meetings Papers for meetings; related correspondence with P.L. Mollison 1950-1951 Chiefly re clinical trials of dextran. Papers for meetings Includes material re trials of dextran. Papers for meetings Includes papers for meeting of the Biological Standards Subcommittee, 12 March 1953. Papers for meetings 1954-1955 Papers for meetings Papers for meeting of Biological Standards Papers Subcommittee, 12 April meeting for This met to consider a specification for dextran solution for clinical use. 1962-1963 Papers for meetings; related correspondence Papers for meetings Papers for meetings 1958-1959 R.A. Kekwick NCUACS 118/4/03 Societies and organisations Papers for work and meeting of ad hoc subcommittee to advise on the production of gamma globulin Papers for meeting; related correspondence The material concerns the future operation of the Blood Products Laboratory. Papers for meeting, 21 December This was the final meeting before the Committee was reconstituted in 1967. Papers for meeting, 22 June This was the first meeting of the reconstituted committee. Papers for meeting, 1 July Papers for meeting, 28 March Papers for meeting, 28 September Papers for meeting, 8 November 1977, 1978 Papers for meeting, 4 March Papers for meeting, 5 March Papers for meetings R.A. Kekwick NCUACS 118/4/03 E.25-E.29 Societies and organisations Working Preparing AHF Concentrates Party the on Cryoprecipitate Method of 1967-1973 in production constituted Committee, This was a Working Party of the Blood Transfusion Research the following terms of reference: ‘to consider the preparation and the cryoprecipitate method and the effects which the wider use of the research programme for plasma fractionation’. Kekwick was a member from its establishment. this preparation might have on concentrates 1967 AHF with by _ of Papers for first meeting, 20 November Papers for Special Meeting, 1 October Sample forms for survey of incidence of jaundice in haemophilia and with patients ‘Sypnosis haemophilia Papers for meeting, 8 May Working Party on Hypogammaglobulinaemia Final Report on ‘Jaundice and factor-VIll antibodies in treated Christmas Disease’, June Correspondence and papers re work of Working Party. Includes and characterisation of human normal gamma G globulin’ by Kekwick et al, prepared for the Working Party, July. 1967-1968 See also C.215-C.235. preparation the of R.A. Kekwick NCUACS 118/4/03 Societies and organisations E.31, E.32 ROYAL SOCIETY 1968-1998 Kekwick was elected a Fellow of the Royal Society in 1966. He was elected to the Royal Society Club in 1968. General correspondence Royal Society Club papers 1982-1996 1968-1998 E.33-E.42 WORLD HEALTH ORGANISATION 1970-1975 This material relates to the Albumin Working Party of the World Health Organisation’s International Committee for Standardisation the Working Party in 1970. in Haematology. Kekwick joined Correspondence and papers from ultracentrifuge runs on Includes invitations to serve on the Working Party. Letter covering albumin samples sent to Kekwick, with photographic prints the samples 1971-1972 the ‘Results International in Haematology Albumin Working Party’, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam the ‘WHO Serum Albumin Samples: Examination in Ultracentrifuge and by Molecular Sieve Chromatography’ by Kekwick Photocopy manuscript notes by Kekwick atached. the Committee investigation for on albumin for Standardisation November 1971, with from typescript, dated R.A. Kekwick NCUACS 118/4/03 Societies and organisations 3pp typescript with manuscript corrections + tables and figures; letter returning the draft to Kekwick, December 1971; draft of Kekwick’s letter of reply, January 1972. Data from Canadian Red Cross tests on albumin With manuscript notes by Kekwick. Data from ‘Swiss Red Cross’, ‘Japanese results’ and ‘Australian tests’ With manuscript notes by Kekwick. Correspondence with papers K.L.G. Goldsmith and related 1972, 1974 Includes manuscript notes by Kekwick. Haematology by their in A report to the 9pp typescript. ‘International in Haematology Albumin Working Party’ by T.T.B. Phillips and K.L.G. Goldsmith Standardisation Committee for ‘A study performed on batches of serum albumin used as diluents in Rh testing. International Society of Blood Transfusion/International Committee for Standardisation Albumin Working Party’ 11pp typescript + tables, references, figures etc. 17pp typescript + tables, references etc. ‘Amended version’ ‘Original version’ R.A. Kekwick NCUACS 118/4/03 INDEX OF CORRESPONDENTS L'NCADEMIE ROYAL DE MEDECINE DE BELGIQUE ADAIR, Gilbert Smithson ALLOTT, [?] AMIES, C. R. ANNIS, David ARMITAGE, P. ARMOUR PHARMACEUTICAL CO. LTD BAILEY, Kenneth BANGHAM, Derek R. BAUER, D. J. BDH CHEMICALS LTD El C.63 C.9 C.12A C.56 C.227 C.99-C.101 C.64 C.253, C.254 C.9 C.97, C.98 BRAIN, Peter BHASKAR, K. R. BIDSTRUP, P. Lesley BIDWELL, Ethel BIGGS, Rosemary BONNELL, J. A. C.14, C.199 C.105, C.106 BOWEN, T. J. BRADLEY, W. C.82 C.148 C.12 BRAMBELL, Francis William Rogers C.81 C.151, C.152, C.157, C.261- C.263 BUTTERWORTH (nee WALKER), Caroline Mary BRITISH JOURNAL OF HAEMATOLOGY A.21, A.22, C.4, C.272, D.3 D.5 C.289-C.291 COCHRANE, Archibald L. CANNAN, Robert Keith CLEEVE, H. J. W. C.228 C.105 C.200 C.102 R.A. Kekwick NCUACS 118/4/03 CREETH, James Michael CRUIKSHANK, J. C. DENT, Charles E. DOWNIE, Allan Waitt DRURY, Sir Alan Nigel EATON, C. ELLIS, Drummond E.[?], George H.[?]- FLYNN, Freddie V Index of correspondents A.23 C.59 C.14 C.61 A.25-A.27, E.6 See also D.10-D.13 C.8 C.164 C.12 C.65, C.280, C.281, C.284, C.285, GELL, Philip George Houthem C.66 C.97-C.101, C.181, E.39 C.14, C.261-C.265 HALLIDAY, R. HARVEY, Douglas Graham GREENBURY, C. L’ GUTFREUND, Herbert E2 C.66 C.12 C.188 C.105 HAEMOPHILIA SOCIETY GOLDSMITH, Kenneth Leslie Grant GREAT BRITAIN AND NORTHERN IRELAND DEPARTMENT OF HEALTH AND SOCIAL SECURITY C.68 HEMMINGS, William Archer HILL, Lisa HOCH, H. C.151, C.152 C.288, E.30 C.67 C.102 INGRAM, G. Ilsley C. KEIDAN, S. E. Index of correspondents R.A. Kekwick NCUACS 118/4/03 KEILIN, Joan KEKWICK, Leslie Oliver KENCH, J. E. KING, Earl J. KREBS, Sir Hans Adolf LATNER, Albert Louis LEHMANN, Hermann LISTER INSTITUTE OF PREVENTIVE MEDICINE LORAND, Laszlo LOUTIT, John Freeman McCANCE, Robert Alexander McCLEAN, D. C.9 C.74 C.9 MAYCOCK, Sir William d’A. McGIBBON, Barbara MACTAVISH, W.C. MARRACK, J. R. McFARLANE, Arthur Sproul A.24, C.79 C.189, C.273 MACFARLANE, Robert Gwyn C.194 C.4 C.76 MEDICAL RESEARCH COUNCIL C.54, C.102, C.187, C.188, C.190, C.199, C.200, C.215 -C.219, C.226, C.228-C.230, E.14, E.30 C.4 NATIONAL RESEARCH DEVELOPMENT CORPORATION C.64 C.7 C.97 MITCHELL, R. F. MOLLISON, P. L. C.228, C.242, E.3-E.30 A.13, C.204 E.4, E.14, £.15 MILES, Sir (Arnold) Ashley MORISON, J. Edgar NOBACK, G.J. R.A. Kekwick NCUACS 118/4/03 Index of correspondents OGSTON, Alexander George (‘Sandy’) OTTOLANDER,, G. J. H. PARTRIDGE, S. Miles PEDERSEN, Kai Oluf PHIFEIRS Hil: B: PIERCE, Alan E. POOL, Judith G PORTER, Rodney Robert RECORD, Basil Roland RINSLER, A. H. ROY, Lynda M. H. C.80 C.201 C.82 C.236, C.272 C.53 C.83 C.94 C.82 C.63, C.164 C.81 C.84 ROYAL SOCIETY Erol, E.o2 E.32 C.97 RUSSELL, M. A. A.16-A.19 See A.25-A.27 SAMUEL PEPYS CLUB ROYAL SOCIETY CLUB SHERRINGTON, Sir Charles Scott SPOONER, Edward Tenney Caswell C.201 C.190, C.199, C.228, C.252- C.254, E.30 TRENDS IN BIOCHEMICAL SCIENCES UNIVERSITY OF LONDON C.86 C.59 C.85 C.181 D.9 A.13 VERSTRAETE, M SMITH, J. C. SPROULL, D. H. TURK, John L. VALLET, Leon Index of correspondents R.A. Kekwick NCUACS 118/4/03 WALT, Adie van der WALTON, Peter L. WASSERMANN, Albert WAUGH, Jan WEBER, Gregorio WELLS, A. R. WESEEY,E:'D: WIDDOWSON, Elsie May WOLF, Peter WORLD HEALTH ORGANISATION C.273 C.195, C.205 C.90 C.273 C.89 C.86 C.54, C.102 C.88 C.188 E.33-E.42
KEKWICK, Ralph Ambrose v1
Published: 16 January, 2024 Author: admin