THE
ROYAL
COMMISSION
ON
HISTORICAL
MANUSCRIPTS
Report on the correspondence and papers
OF
SIR ERNST BORIS CHAIN
(1906 - 1979)
biochemist
deposited in the
Contemporary Medical Archives Centre,
London
COSAC S2/G/e3)
Wellcome Institute for the History of Medicine,
Reproduced for the Contemporary Scientific Archives Centre
No: 83/7
THE ROYAL COMMISSION ON HISTORICAL MANUSCRIPTS
Quality House, Quality Court, Chancery Lane,
London
cWGZA
-TiHP
1983
All rights reserved
CSAC 92/3/83
CONTEMPORARY SCIENTIFIC ARCHIVES CENTRE
British National Committee for the History of Science, Medicine and Technology
under the guidance of the Royal Society’s
Catalogue of the papers and correspondence of
SIR ERNST BORIS CHAIN FRS
(1906 - 1979)
VOLUME II
Sections F
-
J
Compiled by:
Jeannine Alton and Julia Latham- Jackson
All rights reserved
Deposited in the Contemporary Medical Archives Centre,
Wellcome Institute for the History of Medicine,
London
1983
E.B. Chain
CSAC 92/3/83
SECTION F
INDUSTRIAL CONSULTANCIES AND COLLABORATIVE
RESEARCH
F.1 - F.346
INTRODUCTION AND LIST OF CONTENTS
Section F reflects Chain's continuing contact with a wide range of industrial
firms.
Although not all of the companies listed here had a formal consultancy
agreement with him, most of them sought his advice at one time or another and
they have been included as part of the general picture of industrial collaboration.
The largest group of papers (F.44 - F.174) relates to Chain's consultancy
with the Beecham Group which culminated in 1959 with the isolation of 6-amino-
penicillanic acid (the 'nucleus' of the penicillin molecule).
Chain continued
to be associated with the Beecham Group until his death in 1979 and the surviving
papers document the extent of his involvement with the expansion of their research
effort after 1959 as well as his friendly personal contacts, particularly with
H.G. Lazell (Chairman 1958 - 68).
Attention is also drawn to the very full record of Chain's collaboration with
D:, 127° = 1%. .130,
Inevitably, with so many contacts in the industrial world, Chain was often
collection is rather patchy.
at Imperial College.
Correspondence re the negotiation and administration of
such collaborative projects is to be found both here (see the references to this
Many of Chain's contacts with industry resulted in the funding of collabora-
Astra from 1948 to 1957, a period for which documentation in other parts of the
tive research projects conducted in his laboratory, both in Rome and, particularly,
Section under 'Imperial College’ in the General Index) and in Section D, especially
appropriate.
responsible for initiating collaborative projects between the various firms with whom
he was associated.
Such links are noted, but not generally cross-referenced in the
catalogue entries which follow.
Instead, each firm is included in the General
Index with a
list of references to this and other sections of the catalogue where
E.B. Chain
CSAC 92/3/83
Industrial consultancies and collaborative research
see
NESTLE
AC'CENT INTERNATIONAL INC.
ADVISORY SERVICES (CLINICAL & GENERAL) LTD.
AFICO LTD.
ALTHEA S.p.A.
AMERICAN CYANAMID COMPANY
ANIC S.p.A.
ANTIBIOTICOS S.A.
ASSORENI
ASTRA
BAYER
BEECHAM GROUP LTD.
BIOCHEMIE GMBH
BRISTOL LABORATORIES INC,
BRITISH PETROLEUM (BP)
BRITISH PETROLEUM
(BP) PROTEINS LTD.
CALMIC LTD.
CARLO ERBA
CIBA-GEIGY LTD.
COGER S.p.A.
CYANAMID OF GREAT BRITAIN LTD.
EDWARDS HIGH VACUUM
ENI (ENTE NAZIONALE IDROCARBUR!)
FARMITALIA
FISONS LTD.
GALENIKA
GRUNENTHAL (CHEMIE GRUNENTHAL GMBH)
HINDUSTAN ANTIBIOTICS LTD.
HOECHST (FARBWERKE HOECHST AG)
IMPERIAL CHEMICAL INDUSTRIES
LTD. (1.C.1.)
T
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a
12-F.4]
42, F.43
44-F 174
175
.176-F.178
179
.180, F.181
.182
.183
.184
.185
.186
.187
.188-F. 190
.191-F. 200
.201
.202
,203-F.211
.212-F.215
.216-F. 218
.219-F, 227
.228
£229
e
e
e
e
ISF S.p.A.
ISRAEL PENICILLIN AND BIOLOGICAL PRODUCTS CO,
ISTITUTO SIEROTERAPICO E VACCINOGENO TOSCANO
"SCLAVO"S.p.A.
F230
R
T
S
L
T
T
a
a
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T
E.B. Chain
CSAC 92/3/83
Industrial consultancies and collaborative research
LEPETIT S.p.A.
LILLY RESEARCH LABORATORIES, ELI LILLY AND CO,
MARKS
AND SPENCER LTD.
MERCK SHARP & DOHME
MONTECATINI EDISON S.p.A. (later MONTEDISON)
NATIONAL
DRUG COMPANY
NATIONAL IRANIAN OIL COMPANY (N.1.0.C.)
NESTLE ALIMENTANA S.A,
PFIZER (CHAS. PFIZER & CO. INC.)
PFLEGER (DR. R. PFLEGER CHEMISCHE FABRIK
PULLMAN ASSOCIATES GMBH
GMS8H)
.231-F. 233
234, F235
.236-F .251
.252-F . 257
.258-F . 267
268
.269-F 281
.282-F . 292
.293-F 297
.298-F .310
£311
310, R213
.314-F 324
e
N
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A
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1325
326
aoe
.328-F .330
.331
. 332
see
—USV
RANK PRECISION INDUSTRIES LTD.
RANKS HOVIS McDOUGALL LTD.
REVLON INC.
RICHARDSON-MERRELL INC,
ROCHE PRODUCTS LTD.
LABORATO IRE ROGER BELLON
SANDOZ LTD.
SCIAVO:.
see |.
'F.230
INDUSTRIELLE DU FROID)
see = AC'CENT INTERNATIONAL
UPJOHN INTERNATIONAL INC,
USIFROID (SOCIETE D'UTILISATION SCIENTIFIQUE ET
LABORATORI BIOCHIMICO-FARMACEUTICI SMIT
SMITH KLEINE & FRENCH LABORATORIES LTD.
WM. UNDERWOOD CO,
USV PHARMACEUTICAL CORPORATION
WESTFALIA SEPARATOR LTD.
WALLACE LABORATORIES
333, F.334
335
.336-F . 342
.343, F.344
345
E.B. Chain
CSAC 92/3/83
Industrial consultancies and collaborative research
AC'CENT INTERNATIONAL INC,
W7I=73; A979
Chain was introduced to the President of Ac'cent's parent
company, Wm. Underwood Co. by S.A. Goldblith in
October 1971, andasa resu!t he invited Chain to visit
Ac'cent's fermentation plant at San José, California,
in January 1972.
as a basis for several further discussions, but in August
1973 Wm. Underwood Co. negotiated the sale of Ac'cent
to the Stauffer Chemical Company.
Chain's report on this visit was used
Correspondence (mainly with President, Wm. Underwood
Co.) re arrangements for Chain's visit to San José.
Includes one letter from the President of Ac'cent with
miscellaneous background information on personnel,
production processes, etc.
Chain's 8 pp. typescript ‘Report on Visit to the Ac'cent
MSG Plant in San José, California! (on 10 and 11 January
1972), with miscellaneous letters to President, Wm.
Underwood Co. and others.
ADVISORY SERVICES (CLINICAL & GENERAL)
LTD.
1971 -7451977-79
Correspondence with the Presidents of Wm. Underwood
Co. and Ac'cent, January 1972-September 1973 (and
one letter, 1979).
Includes various arrangements for
meetings, 1972, and announcement of Wm. Underwood Co.'s
decision to sell Ac'cent in 1973.
Correspondence from the Managing Director (R. Kohn),
including copies of letters to colleagues at Farmitalia,
Carlo Erba and Nestlé re various scientific investigations
undertaken by his company.
contain arrangements with Chain for musical and social
activities.
July 1973-January 1974, 1977, 1979
Many of the letters also
January 1971-April 1973
May 1973
E.B. Chain
CSAC 92/3/83
Industrial consultancies and collaborative research
ALTHEA S.p.A.
1955
Correspondence, April-July 1955, re problems experienced
with a tomato concentrate, marketed under the brand name
"Fiordagosto'.
AMERICAN CYANAMID COMPANY
1968-69
Chain acted as expert witness for the Company in patent
infringement proceedings.
Correspondence with patent agents and legal representa-
tives.
other related papers.
Includes Chain's draft 'Proof of Evidence', and
ANIC S.p.A.
1978
Brief correspondence and report on interferon research
in Japan.
See also ENI.
ASSORENI
le societa
1979
1959,
1961, 1969
ANTIBIOTICOS, S.A.
Brief correspondence only.
and future visits by Chain to the Antibioticos laboratories.
1969 letter refers to past
(Associazione per la ricerca scientifica fra
del Gruppo EN1)
further progress of the project, June 1979.
Reports in English and Italian of meeting in London, April
1979, to discuss 'ENI Interferon Project', brief corres-
pondence re visit to Rome in May, and letter outlining
E.B. Chain
CSAC 92/3/83
Industrial consultancies and collaborative research
R, t24F 41
ASTRA
1948-79
The documentation for the very
Chain's first contacts with Astra appear to date from the
end of 1945, although his formal collaboration began
in 1946 (see F.12).
early period is unfortunately rather sparse, but from mid-
1948 until the end of 1957 there is a very full range of
correspondence relating mainly to the development of
penicillin production processes.
exchanges of information, laboratory specimens and results,
drawings of equipment, arrangements for meetings and
visits and a little personal correspondence.
The material includes
After 1958 the surviving papers are very sparse (Chain's
carbons only, 1958-59 and less than half a dozen letters
for the whole of the 1960s), but there is a further sequence
from 1976-79 when Chain was asked to advise on Astra's
proposed links with Iran.
The brochure 'Astra and Antibiotics', a draft of which is
now at F.38, includes photographs of Chain and a summary
account of his collaboration with the Astra Group.
See also K.5.
The letters are numbered
3 letters from E. Sperber, June-July 1948, with details
of fermentation runs and arrangements for Chain to visit
the Astra laboratories in August.
3 letters from B. SjSgren and H. Berlin, April and July
1946, re detailed planning of penicillin plant and arrange-
ments for meeting in Oxford.
L, 2.and 5.
for information.
Correspondence with Sperber and Sj&gren, October 1948-
January 1949.
December and letter from Sj8gren enclosing summary of
discussions during Chain's visit and report on subsequent
experiments.
Summaries of further discussions at Astra laboratories on
research in progress, January-February 1949, sent to Chain
Also included is a letter from H. Berlin thanking Chain
for past collaboration and |
p. ms. notes.
Includes arrangements for visit by Chain in
E.Bz-@hain
CSAC 92/3/83
Industrial consultancies and collaborative research
_Correspondence with Sj&gren and Sperber, February-
April 1949, including comments and reports on fermenta-
tion runs.
Correspondence May-July 1949, mainly re penicillin
patents.
Includes arrangements for visit by Chain in
August.
Correspondence September-December 1949, mainly re
details of penicillin production process.
cussion of possible collaboration with the Czechoslovakian
Government.
Includes dis-
Correspondence February-June 1950, re progress with
penicillin production and methods of air filtration.
Includes personal letter from H. Berlin.
Correspondence July-November 1950.
Includes arrange-
ments for a visit to Rome by Sperber in September and for
Chain's visit to Stockholm with Professor Marotta and his
daughter in December.
Correspondence February-November 1951. — Includes
exchange re difficulty of obtaining Podbielniak extractors
and arrangements for visit to Rome by Sjégren in October.
Includes arrange-
See also F.25.
Includes related ms. and typescript notes and
Correspondence April-December 1952.
ments for visit by Chain in September, negotiations re
royalties on sales of benamide penicillin and discussion
of possible co-operation with the Danish company Roskilde.
Correspondence January-February 1953, mainly re
arrangements for meeting in Copenhagen to discuss co-operation
with Roskilde.
diagrams.
penicillin reports.
Correspondence March-December 1953, re arrangements for
meetings and visits, details of penicillin production, etc.
Correspondence re penicillin patents, June~December 1953.
Further correspondence re penicillin patents, January-June
1954.
a visit to Sweden in March, and extracts from 2 wartime
Includes arrangements for Chain to give evidence during
E.B. Chain
CSAC 92/3/83
Industrial consultancies and collaborative research
Correspondence, April -October 1954, mainly re details of
penicillin production process.
Correspondence, November 1954-January 1955, including
arrangements for visit to the Astra laboratories by A. Tonolo
andR. Falini to advise on penicillin production problems,
and related correspondence.
Correspondence, February-December 1955.
ments on fermentation results, more re penicillin patents,
and arrangements for ordering copies of the 10-litre fermenters
used in Chain's laboratory in Rome.
Includes com-
Correspondence, January-June 1956.
correspondence with Italian firm supplying the fermenters
and arrangements for visit to the Astra laboratories by G. Gualandi
to make aeration measurements.
Includes copies of
Correspondence, July-December 1956.
of Gualandi's results and further correspondence with firm
supplying the fermenters.
Includes evaluation
These are
Chain's
Correspondence, June-November 1957.
re award of Nobel Prize to D. Bovet (see also C.53).
Includes brief exchange
Correspondence, January-May 1957.
Includes drawings of
fermentation equipment and arrangements for a Swiss micro-
biologist to work for 3 months in Chain's laboratory before
taking up employment at Astra.
Correspondence, January 1958-December 1959.
second copies of Chain's letters only as the original Astra
file for this period does not seem to have survived.
letter of 19 December refers to the discovery of penicin in the
Beecham Research Laboratories and subsequent correspondence
comments on the progress of negotiations for research collabora-
tion between Astra and the Beecham Group.
is also included here.
Brief correspondence with B. Sj&berg, 1973 (request to see
Chain during a visit to London) and 1975 (invitation to
Chain to come to Astra during visit to Sweden in December).
A letter from Sj&gren's widow following his death in 1973
Correspondence, 1960-64 and n.d.
only, mainly from Sj&gren.
research in collaboration with the Beecham Research
Laboratories.
Includes several references to
A few scattered letters
E.B. Chain
CSAC 92/3/83
Industrial consultancies and collaborative research
Correspondence with SjSberg and others, 1976, mainly
re Astra's activities in lran.
Draft brochure describing Astra's antibiotic activities,
sent to Chain for approval, August 1976.
to the company's early collaboration with Chain in developing
methods of penicillin production.
The text refers
Correspondence, January-November 1977, mainly re
Astra's negotiations with the Iranian authorities, including
draft proposal for collaboration, June 1977.
Correspondence, May-August 1977, re invitation to Chain
to be present at the Award of the Astra prize in Brazil.
Correspondence, 1978-79, including draft letter frorn
Chain to the Iranian Army Health Department, January
1978, advocating collaboration with Astra.
r, 42° F045
BAYER
00-7 |
F.42
Chain's letter of 29? December 1958 discusses terms on
which he would act as a consultant to Bayer.
Correspondence 1963 re priority in the discovery of
enzymatic penicillin splitting is also included.
Correspondence, 1969-71, re interviews for a biographical
article on Chain for publication in 'Therapeutische
Correspondence, 1958-59, re arrangements for construction
in Chain's laboratories of an instrument for the measure-
ment of dissolved oxygen in agitated fermentation liquids
in the presence of microorganisms.
Berichte’.
E.B. Chain
CSAC 92/3/83
Industrial consultancies and collaborative research
F.44-F.174
BEECHAM GROUP LIMITED
Chain's association with the Beecham Group began at the instigation of Sir
Charles Dodds who introduced him to H.G. Lazell (Managing Director, later
Chairman of the Beecham Group) in 1955,
The result was a very fruitful collaboration culminating in 1959 with the
isolation of 6-aminopenicillanic acid (the 'nucleus' of the penicillin molecule)
which made possible the development of a whole series of new synthetic penicillins.
Chain continued to act as consultant to Beechams until his death in 1979 and
the company also sponsored various research projects and studentships at Imperial
College.
The following papers trace the development of his collaboration with
Beechams and the expansion of their research effort after 1959.
Unfortunately
some files have been lost and there are gaps for whole years (e.g. 1956, 1957) or
parts of years (e.g. November 1960-June 1961).
The material is presented more or less chronologically, with the exception
of correspondence with Lazell and his successor, Sir Ronald Edwards, which has
been kept separate and now appears at F.169-F.174.
F.44
For material relating to conferences and symposia organised by the Beecham
Group and attended by Chain, see J.77-J.80, J.99-J.111, J.112.
Letter from E.C. Dodds, 27 April 1955, suggesting a meeting
with Chain, |. Heilbron and members of the Beecham Group
(H.G. Lazell - Managing Director, W. McGeorge - Director
in charge of research, and J. Farquharson - Director of the
research laboratories) to discuss citric and tartaric acid
production.
lining his proposals for collaboration with the Beecham Group.
Includes arrangements for meeting in London, ms. notes
and letters re tartaric acid production, andarrangements for
meetings in Rome in June and July.
Correspondence with McGeorge and others, June-July 1955.
Includes arrangements for visits to Rome, letters of thanks
from McGeorge and Heilbron and letter from Chain, out-
Correspondence with Dodds and McGeorge, May 1955.
E.B. Chain
CSAC 92/3/83
Industrial consultancies and collaborative research
Correspondence with McGeorge, August-September 1955.
Mainly re arrangements for visit to London by Chain for
further discussions.
English and Italian versions of technical data prepared
in Chain's laboratory as a basis for his discussions with
Beechams in September (see F.47).
costing for a 'Fermentation Plant of Six Stainless Steel
Fermenters (each of a capacity of 30,000 L culture fluid)’.
Includes a detailed
Correspondence with McGeorge and Dodds, September-
October 1955.
Mainly re organisational details connected with the
establishment of research facilities in the field of chemical
microbiology and plans for penicillin production.
Corres-
pondence with Dodds includes a discussion of acquired
resistance to penicillin.
Correspondence with McGeorge and others, November 1955.
Includes arrangements for Chain to visit the Beecham Research
Laboratories at Brockham Park and correspondence arising
from discussions during this visit.
Correspondence with McGeorge, December 1955.
Detailed financial estimates, March 1956.
‘Microbiological Project for Beecham Research Laboratories
Ltd.'
Mainly re arrangements for recruiting and training of staff
for the new Beecham research team.
Includes drafts of
letter from Mc George to Professor Marotta re scheme for
training Beecham scientists in Chain's laboratory in Rome.
twins).
There is no correspondence with Beechams for 1956 or 1957
apart from the mainly personal exchanges at F.53 below.
Letters from McGeorge, July-October 1957.
Mainly personal correspondence.
from Farquharson (congratulations on the birth of Chain's
Includes one letter
E.B. Chain
CSAC 92/3/83
Industrial consultancies and collaborative research
Correspondence with Farquharson and McGeorge,
January 1958.
letter from Farquharson reporting on research
Includes 8 pp.
in progress in the Microbiological Division of Beecham
Research Laboratories anda 5 pp. typescript 'Aims of the
research project ... on the production of penicillins with
improved properties by suitable modifications of the
penicillin molecule’.
Correspondence with Farquharson and McGeorge,
February-March 1958.
te research projects on antibiotics and on production of
ascorbic acid from blackcurrant pectin.
and report from V.L.S. Charley re the latter.
Includes letter
Correspondence with Farquharson and McGeorge,
April-May 1958.
re arrangements for meeting at Brockham Park, progress
of the ascorbic acid project and draft memorandum of the
Food Standards Committee on Glucose Beverages (see also
Foor).
Letter of comment from Dodds is also included in the folder.
Correspondence with Farquharson and McGeorge,
June-July 1958.
re various research projects in progress.
ms. notes by Chain.
Includes some
Correspondence with Farquharson and McGeorge,
September-October 1958.
‘Comments on Draft Report on Soft Drinks by the Food
Standards Committee of the Ministry of Agriculture,
Fisheries and Food'.
2 typescript drafts.
p-Aminobenzylpenicillin' by Chain and others.
Includes agenda for discussion on 12 September, arrange-
ments for meeting in October, and 2 pp. typescript by Chain
‘Some comments of [sic] the use of radioactive sugars in
the glucose research programme’.
re research projects on antibiotics and glucose metabolism.
Includes draft paper on ‘Penicillin
Correspondence with Farquharson and McGeorge,
November 1958.
cerivatives of
E.B. Chain
CSAC 92/3/83
Industrial consultancies and collaborative research
Correspondence with Farquharson, McGeorge and others,
December 1958.
re work on antibiotics and glucose metabolism.
2 pp. memorandum by G.N. Rolinson on future objectives
in 'Penicin-Penicillin Work' and 3 pp. note by $. Johnson
and F.R. Batchelor on 'Inhibition of Penicillinase by
Triphenylacety! Derivative of Penicin (AB. 1071)'.
Includes
See also F. 34,
Correspondence with McGeorge and others, January 1959.
Mainly re the report of the Food Standards Committee on
Soft Drinks.
A.H. Douthwaite commenting on the report.
from McGeorge, 30 January, also refers to negotiations re
manufacture of synthetic penicillins with various companies
in America.
Includes draft letters from Chain, Dodds and
Ms. letter
Correspondence with Farquharson, McGeorge and others,
February 1959,
Mainly re work on glucose metabolism.
"Progress Notes' by F.R. Batchelor on various projects in
the Microbiological Department of the Beecham Research
Laboratories, and arrangements for visit
We Lis. Charley.
Includes 5 pp.
to Rome by
Correspondence with McGeorge and others, March 1959.
Includes draft announcements in English and Italian of the
successful production by Beechams of the basic nucleus
of penicillin (6-aminopenicillanic acid) and further draft
of letter from Chain re the Food Standards Committee
Report on Soft Drinks.
With covering letter to Chain from F.P. Doyle.
Correspondence with McGeorge and others, April 1959.
Includes copy of press release in U.K. and U.S.A. re
collaboration with Bristol Laboratories (q.v.) in production
of synthetic penicillins.
Reports by two members of the Beecham Group as follows:
‘Report on a Visit to the United States during the period
Ist-16th April 1959', by F.P. Doyle.
"Report of Discussions with Members of Bristol Laboratories
at Syracuse, New York', by G.N. Rolinson.
E.B. Chain
CSAC 92/3/83
Industrial consultancies and collaborative research
Correspondence with McGeorge, May 1959.
Mainly re methods of tartaric acid production and progress
in collaboration with Bristol Laboratories.
announcement of a change in the structure of the Beecham
Group to allow for the expansion of the Research Laboratories.
Includes an
Correspondence with Farquharson, McGeorge and
C.D.W. Stafford, June-July 1959.
Mainly re tartaric acid production and negotiations with
Farmitalia and Astra re production of synthetic penicillins.
Correspondence with Farquharson and McGeorge,
July-August 1959.
Mainly re progress in production of new penicillins and
negotiations re Cephalosporin C.
Includes letter from
Farquharson re invitation to Chain to take part ina
symposium at Bristol Laboratories.
Correspondence with Farquharson, McGeorge and
R.J.L. Allen, September 1959.
te penicillin research, visit to Bristol laboratories, death
of Sir lan Heilbron, negotiations with Farmitalia, and
‘slimming’ qualities of PLJ.
Correspondence with Farquharson, McGeorge and
R.J. Allen, November 1959.
re progress in work on penicillins and glucose research.
Includes 2 reports by Allen on glucose projects.
Correspondence with Farquharson and McGeorge,
December 1959.
re penicillin, including negotiations with Astra and
others, and Cephalosporin C.
the folder.
‘Quantitative Radiopaperchromatographic Studies on the
Absorption of Sugars from the Isolated Surviving Rat
Small Intestine’.
Draft of paper by Chain, K.R.L. Mansford and F. Pocchiari,
December 1959.
Correspondence with McGeorge, January 1960, with
suggestions for alterations to the draft,
is also included in
E. Be Chain
CSAC 92/3/83
Industrial consultancies and collaborative research
Correspondence with Farquharson and McGeorge,
January 1960.
Mainly re work on penicillins and negotiations with
Farmitalia.
Correspondence with Farquharson and McGeorge,
February 1960,
Mainly re progress of penicillin work.
from McGeorge for an account by Chain of the early
history of penicillin.
Includes request
19 pp. typescript ‘Annotations to the history of the penicillin
discovery published in "Antibiotics" (... Oxford University
Press, 1949)', sent with covering letter to McGeorge,
23 February 1960.
For other accounts by Chain of the history of the penicillin
work at Oxford, see B.61-B.92.
‘The Story of the New Penicillins'
8 pp. typescript draft by McGeorge, sent to the London
Press Exchange Ltd., 23 February 1960.
Folder also includes draft of Beecham Research Laboratories
brochure on the new penicillins.
Correspondence with Farquharson and McGeorge,
March 1960.
A further draft of 'The Story of the New Penicillins' incor-
porating Chain's additions and sent to him by McGeorge,
10 March 1960, is also included in the folder.
5 pp. typescript on 'The Problem of the Penicillin Resistant
Staphylococcus' and 3 pp. describing Chain's initial
collaborative work with Beechams, both sent to McGeorge,
4 March 1960.
See also F.81.
Mainly re progress of penicillin work and negotiations with
Farmitalia.
and reports on penicillin and other research.
Includes copies of correspondence re 'Broxil'
Correspondence with Farquharson and McGeorge,
April 1960.
E.B. Chain
CSAC 92/3/83
Industrial consultancies and collaborative research
"Man-Made Penicillins.
Research Laboratories Ltd.'
An Achievement of Beecham
Ath draft of typescript describing the story of the new
penicillins, sent to Chain by McGeorge, 12 April 1960.
Correspondence with Farquharson, McGeorge and Stafford,
May~-October 1960.
Includes arrangements for meetings and visits and discussion
of the content of forthcoming lectures by Chain on the new
penicillins.
Correspondence and papers, July and October 1961.
Includes letter from McGeorge, 31 October, enclosing a
copy of the Patent Office Decision on H.S, Burton versus
‘his colleagues' re assignment of the patent for Cephalospirin N.
See also K.22-K.25.
Correspondence, November-December 1961.
Chain's carbons only, with the exception of brief notes
from Farquharson and G.N. Rolinson.
Figen F396
March-April
Aujen, Wa
dae
k,
Correspondence with members of the Beecham Group, 1962.
re amount of caffeine in an average cup
of coffee.
From 1962 the record of Chain's collaboration with Beechams
is more diverse, both in number of correspondents and spread
of subject-matter, and it
is therefore presented year by year,
with a brief indication of subject-matter.
July-December
Doyle succeeded Farquharson (q.v.) as Director
of Research at Brockham Park in March.
Corres
pondence is mainly re arrangements for meetings,
research planned and in progress and publication of
penicillin story.
re antibiotics used in treatment of typhoid.
Includes a report ona visit to Rome by Croydon to
discuss trials of Beecham preparations in Sardinia.
Croydon, E.
A.
Pr;
F.87, F.88
Doyle, FE.
By
March-December
March~May
March- June
E.B. Chain
CSAC 92/3/83
Industrial consultancies and collaborative research
Farquharson, J.
January-March
re meetings, publications policy, research, etc.
Includes personal correspondence following the
announcement of Farquharson's retirement as Director
of Research for reasons of ill health.
his wife following his death in 1964 is also included
here.
A letter from
tO Paes
McGeorge, W.
January- November
Includes copies of
te research, meetings, etc.
reports sent to McGeorge on 'Spartase' (January),
"Impairment of Glucose Tolerance by Low Carbohydrate
Diet’ (April) and
research conference, October 1962, at which Chain
gave the opening address.
'Fucidin' (May), and programme for
January-March
April- November
Mallett, A.
A.
May-December
See also F.100.
Rolinsenioe > Ni
June- September
Mansford, K. — R.
Li
November-December
re research equipment and experimental details.
Includes drafts of a note on 'Glucose and Brain
Metabolism', intended for publication in The Lancet.
Includes reports on research planned and in progress,
typescript draft of ‘Studies on Penicillinase Produced
by a Strain of Staphylococcus Aureus’, by
F.R. Batchelor, J. Cameron Wood, Chain and Rolinson,
and note from Batchelor, 6 November, re submission
of the typescript for publication in Proc. Roy. SG
(Bibliog. 103).
technology.
Mainly re talk given by Chain at Journeés Bretonneaux
(see J.39) and correspondence with M. Barber (see
K.8).
re research, meetings, and development of fermentation
SIOEGt. aar 6 Ea
Wa
March-October
Wiking, to.
i
February- September
E.B. Chain
CSAC 92/3/83
Industrial consultancies and collaborative research
F.97¢-F. 103
Correspondence, 1963.
In alphabetical order.
F.97
Doyle, F.
rs
Janvary-October
Arrangements for meetings and visits, reports on
research.
McGeorge, W.
January-October
re resistance to penicillin, research on brain
metabolism, and negotiations for collaboration
with A. Isaacs.
Mallett, A.
A.
re BRL 700.
October
Manton, Wo
RL,
February, October
Including further draft on 'Glucose and Brain
Metabolism! (see also F.93).
Rolinson, G.
N.
February-May
re methods and results of research in progress.
F.104-F.115
Stafford C .
W.,
January- September
Wilk ing;
Gis
as
Mainly re tetracycline patents.
Correspondence and papers, 1964.
Mainly re resistance to penicillin. Includes
some personal correspondence.
In alphabetical order.
this period does not appear to have survived.
Correspondence from Chain for
also £19);
3 folders containing data and printed matter are included
at the end of the sequence.
Mainly re work on penicillin allergy.
letter re use of ampicillin against typhoid (see
re fermentation problems.
Carrington, T.
R.
February-November
Doyle, :
fa.
-
ee
July-November
July, October
Includes
E.B. Chain
CSAC 92/3/83
Industrial consultancies and collaborative research
Gilby, J.
cA.
September
re fermentation costs.
Knudsen; E34
41.
January, July
Includes copy of memorandum on 'Penbritin in
Acute Typhoid and Carriers’.
McGeorge, W.
April, May
Includes press-cutting re penicillin allergy and
letters from R.J.L. Allen and E. Stenton.
Mallett, A.
A.
January, October
re fermentation techniques.
Rolinson, G.
oN.
July
Enclosing typescript of paper by M.O. Moss.
stafford, Ga
DoW,
July, August
Includes press-cutting re the drug industry.
Wilking; Gi.
September-October
Miscellaneous printed matter re American legislation on
antibiotics.
Reports and data, originally contained in folder labelled
‘Worthing Production Reports’.
Miscellaneous typescript and printed matter re treatment
of typhoid and salmonella with ampicillin (see also F.105).
re licencing arrangements and invitation to
meeting of the Canadian Pharmaceutical Manu~
facturers Association.
on Bacterial Tomato Canker.
The main correspondent is F.P. Doyle, often with informa-
tion or enclosures for meetings of the Consultants Com-
mittee of which Chain was a member.
The material is
presented chronologically.
from Chain in the sequence.
PAO SPoETS
Correspondence and papers, 1965.
.114
ae
There are virtually no letters
Januvary~April
Includes note by R.J.L. Allen of discussion with
J. Yudkin re sucrose and glucose and note by Doyle
E.B. Chain
CSAC 92/3/83
Industrial consultancies and collaborative research
May~August
October-December
Includes note from McGeorge re cholesterol levels
and glucose, 3 pp. typescript 'Notes on the Use of
Antibiotics in the Veterinary Field', and copy of
letter to the Medical Research Council re virus research.
rd feria a.
Correspondence and papers, 1966
In chronological order. | There are no letters from Chain
for this year.
January-April
Arrangements for meetings and visits, miscellaneous
correspondence re research.
May-August
Includes invitation to speak at Beecham Representatives'
Conference in October, report of meeting re Micro-
bial Protein project at Imperial College, review of
the South African ethical medicine market and
miscellaneous correspondence re research.
September- December
In chronological order.
January-April
Fy 122“F 329
Correspondence and papers, 1967
Includes drafts of letter from Doyle to Chain re proposal
of Beecham Research Laboratories to sponsor a research
project at Imperial College on microbial
metabolites,
and miscellaneous correspondence re research.
See also F.124.
Includes draft affidavit by Chain for use in proceedings
by the Beecham Group against Bristol Laboratories for
infringement of hetacillin patents, a note on negotia-
tions re liquid glucose with Ranks Hovis McDougall and
miscellaneous correspondence re research and meetings.
Includes correspondence re alleged cure for baldness
discovered by Israeli scientists, copy of typescript on
‘Sucrose and Cariogenesis', and 2 memoranda on inter-
feron sent to Chain for information,
May-August
E.B. Chain
CSAC 92/3/83
Industrial consultancies and collaborative research
Correspondence re journey
arrangements for collaboration between Beechams and
Plantex of Natanya.
to Israel, July 1967, to discuss
September-December
Includes correspondence te arrangements for work at
Imperial College financed by Beecham Research
Laboratories and letter from R.J.L. Allen re vitamin
C and colds.
F.126-F.128
Correspondence and papers, 1968
In chronological order.
January-April
Includes notes of discussion with M. Sela and others
re collaboration with the Weizmann Institute and Yeda,
correspondence and press~cuttings re infective drug
resistance, and typescript on 'Vitamin C and the
common cold',
May-August
September- December
Correspondence and papers, 1968-70, sent to Chain as a
member of Beechams' Agricultural Projects Consultants
Committee.
Most of these are concerned with the Report
Includes 'Notes on Meetings at the Weizmann Institute,
Israel, 23-26 May 1968', announcement of reorganisa-
tion of research departments at Brockham Park, and
miscellaneous correspondence re meetings and visits.
Includes drafts of letter from Beechams offering to
sponsor a three-year research project at Imperial
College on the mode of action of penicillins, corres-
pondence re grant for research on microbial metabolites
(see D.127, D.128) and miscellaneous correspondence
re research,meetings and visits.
of the Joint Committee on Antibiotics in Animal Husbandry.
E.B. Chain
CSAC 92/3/83
Industrial consultancies and collaborative research
Ps LO0eP hoe
Correspondence and papers, 1969
In alphabetical order.
Batchelor, F.
R.
July
te proposed Penicillin Symposia in Australia.
Sritioh, Ra
te
Ww,
October
re Consultants Committee Meetings.
Brown, D.
M.
December
re double~stranded (ds) RNA research.
Cole, M.
July
re screening of microbial metabolites for
insecticidal activity.
Craydon, EE.
A;
<
April
Invitation to speak at symposium in New York.
Dewdney, J.
M.
June- December
Figo
Naylér J.
oh
eG.
F193, #134
movie. f,
FP;
January-December
Miscellaneous correspondence re meetings,
research, etc.
Includes reports and notes of meetings re ds-RNA
research.
re organisation and funding of Beecham research
project on 'Mode of action of penicillins', con-
ducted at Imperial College.
Enclosing research data.
Rolinson, G.
ON.
March-December
August
December
E.B. Chain
CSAC 92/3/83
Industrial consultancies and collaborative research
F.136-F.138
Smither, R.
September-October
3 letters enclosing copies of evidence re
action of Beecham Group Ltd. vs. Zenith Laboratories
Inc. (over ampicillin patents), as follows:
Letter of 17 September enclosing copy of transcript
of Chain's deposition given on 2 September 1969.
Letter of 14 October enclosing copies of affidavits
by others for Chain's perusal.
Letter of 23 October enclosing draft of ‘Second Affidavit
of Ernst B. Chain' commenting on material in F.137.
Stoo, Ge
Be
WwW,
Personal correspondence.
October
Wilking? a"
f.
January-May
re symposia in Moscow and Australia.
8 May contains some background information to the
Beecham vs. Zenith case.
Letter of
Invitation to lecture.
February-March
F.140-F.145
Dewdney, J.
M.
March-August
Croydon, £....A.
i
January
Corrtigion,. 1.
CHAIN, Ernst Boris Vol2
Published: 16 January, 2024 Author: admin