Catalogue of the papers and correspondence of
Alexander George Ogston FRS
(b.1911)
CSAC catalogue 98/2/84
by Jeannine Alton and Peter Harper
A.G. Ogston
CSAC 98/2/84
Title:
Compiled by:
Catalogue of the papers and correspondence of Alexander
George Ogston FRS (b.1911), biochemist
Deposited in:
Reference code:
GB 0161
Date of material:
1933-1979
Description level:
Fonds
Extent of material:
133 items
Jeannine Alton and Peter Harper
Department of Western Manuscripts, Bodleian Library, Oxford
CSAC catalogue no. 98/2/84
© National Cataloguing Unit for the Archives of Contemporary Scientists, University
of Bath.
A.G. Ogston
CSAC 98/2/84
The work of the Contemporary Scientific Archives Centre, and the
production of this catalogue, are made possible by the support of the following
societies and institutions:
The Anatomical Society of Great Britain and Ireland
The Biochemical Society
The British Pharmacological Society
The Charles Babbage Foundation for the History of Information
Processing
The Institute of Physics —
The Nuffield Foundation
The Physiological Society
The Institution of Electrical Engineers
The Royal Society of London
A.G. Ogston
CSAC 98/2/84
LIST OF CONTENTS
GENERAL INTRODUCTION
SECTION A
BIOGRAPHICAL AND PERSONAL
SECTION 8
SCIENTIFIC RESEARCH
SECTION C
CORRESPONDENCE
List of research topics
Introduction to Section B
INDEX OF CORRESPONDENTS
A.G. Ogston
CSAC 98/2/84
GENERAL INTRODUCTION
PROVENANCE
The main bulk of the material was made available by Dr. Ogston on his
retirement from Oxford in 1978.
sets of late research notes and drafts passed on by Ogston in November 1980.
Items B.1 - B.3, B.25- B.27, B.88 - B.91 are
NOTE ON THE CAREER OF A.G. OGSTON
Ogston was educated at Eton and at Balliol College, Oxford; apart from
a period as Freedom Research Fellow at the London Hospital, he spent most of his
career at Oxford, being appointed Demonstrator (1938) and Reader (1955) in Biochemistry,
and Fellow and Tutor in Physical Chemistry at Balliol (1937).
appointment as Professor of Physical Biochemistry at the John Curtin School of Medical
Research, Australian National University, where he remained until 1970 when he
returned to Oxford as President of Trinity College.
Visiting Fellowships at the Institute for Cancer Research, Philadelphia, and the John
Curtin School of Medical Research, A.N.U., where the late research was undertaken.
On his retirement in 1978 he held
In 1959 he took up an
Ogston's main research interests include the thermo-dynamics of biological
systems, particularly in relation to connective tissue, and the use of physico-chemical
Attention is drawn to
methods to study the size, weight and structure of molecules.
Item A.9, a folder of material submitted for the D.Sc., Oxford, in 1970, and which
contains Ogston's own identification of his main areas of research and most significant
stereochemistry, the 'three-point attachment’ (see B.40 - B.45).
It should be noted that this does not include his important contribution to
papers.
A.G. Ogston
CSAC 98/2/84
DESCRIPTION OF THE COLLECTION
The surviving material is not large, mainly because of Ogston's travels
to and from Australia and his preference (stated in the correspondence) for travelling
light.
Thus, there is little biographical material or personal correspondence,
though Ogston's friendly approachable manner is always to be seen in the tone of
the letters addressed to or written by him.
The main content relates to research projects and publications.
Ogston's
own designations of his folders have been preserved, and the material follows where
possible his analysis of his work, already referred to,
at A.9.
ACKNOWLEDGEMENTS
We are grateful to Dr. L. Stocken and Dr. M.A. Foster for help in
identifying and describing material .
A.G. Ogston
CSAC 98/2/84
SECTION A
Ait, A:2
BIOGRAPHICAL AND PERSONAL A.1 -A.9
Miscellaneous biographical and autobiographical notes,
supplied by or prepared for Ogston at various dates.
A.]
1963
1965, to accompany article in British Medical Bulletin.
1977, for a special edition of Japanese journal, Protein,
Nucleic Acid and Enzyme, which includes a tribute
to Ogston's contribution to the study of transport in
gels.
Includes a little correspondence, and a copy of the
journal.
Miscellaneous items of biographical interest, 1959-65.
Congratulations on appointment to Chair of Physical
Biochemistry, Australian National University, 1959.
Request by editor, Analytical Biochemistry, to referee
his own article, 1963.
error, has a ms. note 'The paper was accepted without
change: '
Ogston's reply, pointing out the
Election as Honorary Member, American Society of
Biological Chemists, 1964-65.
Correspondence re Ogston's election as President, Trinity
College, Oxford.
Correspondence on ‘Australian Frontier’ meetings, and on
‘Statement on the War in Vietnam’ which Ogston considered
unwisely worded, 1966-67.
Oxford.
Ogston was in Australia at the time;
includes miscellaneous arrangements re visits, Lodgings,
stipend, etc., 1969-71.
the correspondence
Also included is a letter of congratulation to Ogston on his
election to an Honorary Fellowship at Balliol College,
A.G. Ogston
CSAC 98/2/84
Biographical and personal
Miscellaneous items of biographical interest, 1971-77.
Br es ee ere re
ab
cr
proposed research on cartilage and
Ogst on hoped ¢ to undertake duri ng
his Presidency, 1971.
Invitation to serve on Lockey Bequest Committee, 1971.
Note on the Svedberg ultracentrifuge, set up by Ogston
in the Biochemistry Department, Oxford, in the early
1940s, published in Trends in Biochemical Sciences (TIBS),
September 1977.
‘Electrical Conductivities in non-aqueous Solvents.
(Their temperature coefficients. )'
Ogston's Part Il and B.Sc. thesis, June 1933.
‘Electrochemistry of solutions’
Ogston's D.Phil. thesis, October 1936.
Folder of material submitted for D.Sc., Oxford, 1970.
The ‘four related fields of work' are as follows:
Group II: equilibrium interactions of polymer molecules
in solution;
Group III: dynamic interactions between solutes;
'Group |:
hyaluronic acids;
the isolation and characterization of
This contains Ogston's own identification of his principal
areas of research and his accompanying notes on the published
papers chosen for submission.
and present the research material in Section B.
Group IV: aspects of the theory and practice of diffusion
and sedimentation. '
These headings have been used as far as possible to identify
A.G. Ogston
CSAC 98/2/84
SECTION 8
SCIENTIFIC RESEARCH B.1 - B.91
Introduction to Section B
The material is presented according to the alphabetical list of topics
overleaf. | Ogston's own designations of his folders have been retained, though
bulky files have sometimes been split for ease of reference.
Work on hyaluronic acids, B.64 - B.72, equilibrium reactions, B.46 - B.63,
complex boundaries, B.4 - B.7, and diffusion and sedimentation, B.9 - B.37,
correspond to Groups |
-
IV of Ogston's list of his research interests as described
in A.9.
Work on cell fusion, B.1
- B.3, transport through membranes, B.25 - B.27,
and oxidative phosphorylation, B.85 - B.91, represent late work, added to the
collection by Ogston in November 1980.
Ogston was almost always meticulous in supplying titles and descriptions
and dates for his own research notes, and in paginating various sequences of narrative
drafts.
The correspondence with colleagues, collaborators and editors is that
retained by Ogston in his research files. | Other correspondence with the same
colleagues may also be found in Section C.
Scientific research
A.G. Ogston
CSAC 98/2/84
LIST OF RESEARCH TOPICS
CELL FUSION
COMPLEX BOUNDARIES
CORNEAL SWELLING
DIFFUSION AND SEDIMENTATION
B39
B.10
Diffusion homogeneity
ACh diffusion
-11-B.15
Hindered diffusion
.16-B.20A
Dextrans and Sephadex
.21-B.23
Gastric acid secretion
B.1-B.3
B.4-B.7
3.8
B.9 - B.37
.24-B.27
Membrane transport
B.40 - B.45
Partition in HA
Polysarcosine
Nucleic acid
B.31-B.37
Sedimentation
.28
oe
B.30
ENZYME KINETICS
ENZYME SPECIFICITY
ENZYMES: MOLECULAR WEIGHTS
and 'Three-point attachment’
B.38
B.39
A.G. Ogston
CSAC 98/2/84
EQUILIBRIUM REACTIONS
B.46- B.63
Scientific research
B.46
B.47
-48
By
B.63
Fibre space
Micelles
Molecular interaction exclusion
Sedimentation - HA, Dextran
Quaternary (polyelectrolyte) systems
Synaptosomes light-scattering
Ternary thermodynamics
Ternary systems phase relationships
Thermodynamic non-ideality
Virus collisions
HYALURONIC ACIDS (HA)
B.64 -B.72
B.73'-B.83
B.84 - B.87
B.83
Refractometer
MUSTARD GAS
B./3-8./9
Elastoviscometer
B.76-B.82
Osmometer
MEASURING DEVICES
OXIDATIVE PHOSPHORYLATION
B.88 - B.91
A.G. Ogston
CSAC 98/2/84
Scientific research
CELL FUSION
1978-79
Ogston describes this (private communication, 1980)
(in which | have long been interested)’.
It was undertaken
during Ogston's period as Visiting Scholar at the Institute for
Cancer Research, Philadelphia, and was not published.
5 bundles of ms. notes, December 1978- January 1979.
Drafts for paper, 'How water-soluble polymers may promote
fusion of cells’.
Correspondence with colleagues,
publication.
Includes referees' comments.
/
and with Nature re
Seinen EInieeneneeRnanmem
COMPLEX BOUNDARIES
1964-70
The material relates to research and to several collaborative
See also B.18, B.19.
1966
papers on dynamic interactions between solutes (Group II!
of Ogston's own analysis of his research interests in A.9).
The correspondence is principally with L.W. Nichol,
D.J. Winzor and A. Rescigno (Ogston's collaborators at
various stages), and includes revisions and discussions of
referees’ comments.
Bundles of ms. notes by Ogston, almost all dated and paginated
by him, various dates, 10 May 1964-14 December 1965.
Two of the sequences (5 and 15 June 1964) are in the form of
letters to L.W. Nichol.
| Hyperbolic boundaries’ .
Includes drafts, revisions, discussions of referees’ comments
etc. on papers titled 'Gel chromatography', 'Evaluation of
gel filtration data on systems interacting chemically and
physically’, 'Reaction boundaries and elution profiles in
column chromatography’.
Similar material, mainly on paper ‘Migrating boundaries
of interacting systems.
Correspondence with colleagues.
Correspondence with colleagues.
1968-70
A.G. Ogston
CSAC 98/2/84
Scientific research
Two ms. notes and narratives on gel chromatography and
gel electrophoresis, May 1971.
CORNEAL SWELLING
1968
Photocopy (only) of Ogston's letter to D.M. Maurice
of notes and calculations on swelling pressure of cornea.
DIFFUSION AND SEDIMENTATION
1948-78
The material relates to research and publications on
various aspects of the theory and practice of diffusion and
sedimentation (Group IV of Ogston's own analysis of his
research interests in A.9).
is much the largest topic
because of the wide variety of aspects studied.
It
See also B.49, B.50
'Diffusion homogeneity’
Miscellaneous ms. sequences of notes by Ogston, 19 February-
12 May 1948, and May 1950.
Correspondence with colleagues, 1948-49, re development
and naming of the 'Gouy Diffusiometer'’.
"ACh diffusion’
Miscellaneous ms. bundles of notes, calculations and graphs
by Ogston, only one dated (December 1954).
by diffusion’, to accompany paper by MacIntosh et al.
Correspondence with F.C. MacIntosh, 1949, 1951-52, re
research and publications.
Includes draft of appendix by
Ogston, 'Removal of acetylcholine from a limited volume
Ogston
A.G.
CSAC 98/2/84
B.11-B.15
'Hindered Diffusion’
Scientific research
A
B.12
Ms. notes on the literature, references, etc. on ‘hindered’
or 'restricted' diffusion, n.d. 1950s (in original folder).
Continuing ms. notes and narratives on Ogston's theories
and those of others, some in the form of letters to T.F. Sherman,
various dates, October 1959-September 1960.
Similar material, 1961-62.
Similar material, 1963-64, mainly referring to the results
of work by T.C. Laurent and Persson, and including corres~
pondence and data from Laurent.
Continuing notes, ideas and narratives, 1971-72.
correspondence from J.M. Hammersley, and a draft letter
from Ogston to T.C. Laurent and colleague on 'a new version
of the "hindered diffusion" theory which | stumbled on a few
The letter was not sent, and bears a ms. note
months ago'.
referring to notes for 22 May and 18 July 1972.
Notes and
narratives continue to 25 October 1972.
Includes
B.16-B.20A
Dextrans and Sephadex.
B.16
"Dextrans’
‘Sephadex swelling’
B.18, B.19
‘Spreading on Sephadex’
Notes, data, correspondence with colleagues re research
and publication, 1953, 1955.
Miscellaneous ms. notes and narratives on various aspects
of diffusion theory, elution volume, chromatography, etc.
November 1966-August 1967.
1969-70
principally D. J. Winzor, re paper provisionally titled
‘Boundary Spreading in Gel Filtration’ and eventually pub-
lished as 'An experimental and theoretical investigation of
boundary spreading in gel chromatography' by Ogston, Winzor
and Hibberd.
Includes referees' comments, revisions of material, etc.
Notes, narratives and correspondence with colleagues,
1967-68
A. G. Ogston
CSAC 98/2/84
B.20, B.20A
'SE-Sephadex'
Scientific research
B.20
Notes, narratives and calculations, 1967-68, some in
the form of a letter to E Edmond.
the form of
pondence from K. Granath.
E. Edmond, and inctucing corres
and includina corres-
a fetter
fo
Included here is a ms. narrative on 'Sephadex penetrating
solutes', 'with some corrections February 1969’.
B .20A
Similar material, 1970-71 (not all in Ogston's hand).
B.21-B.23
‘Gastric acid secretion’
B.2]
Notes, narratives, and correspondence, mainly with
R.E. Davies re collaborative research and paper on 'The
mechanism of acid secretion by gastric mucosa', January
1949- January 1951.
(Davies was working in the Medical Research Council
Unit for Research in Cell Metabolism directed in the University
of Sheffield by H.A. (later Sir Hans) Krebs, who is occasionally
referred to in the correspondence. )
B.23
B.24
'E.M.F. Transport’
B.24-B.27
‘Membrane transport’
Ms. draft and typescript abstract of paper.
Ms. narratives, some extensive, and notes on gastric mucosa,
most dated May 1955.
3 pp. typescript and ms. paper (untitled), on 'the interpretation
of electromotive measurements, in particular those which are
made upon biological systems’, submitted for comment to
R.P. Bell, witha few comments by him, n.d., ¢.1957.
Miscellaneous shorter drafts and narratives.
Ms. draft of a paper 'Use and abuse of the Nernst equation:
an alternative treatment', with extensive comment from a
colleague, n.d., later than above and probably related to
paper with C.C. Michel
Correspondence with A.L. Hodgkin re a similar paper by
Ogston on E.M.F. transport, submitted to Hodgkin for
comment, 1957.
(see below).
A.G. Ogston
CSAC 98/2/84
Scientific research
B, 2076.27
‘Transport through membranes'
This is described by Ogston (private communication,
.
;
‘
1980) as 'undertaken in collaboration with Dr. C.C.
Michel,
following a series of seminars on membrane transport which he
organised in the Department of Physiology EOxfordJ.
worked on this in intervals of my duties at Trinity, and it was
eventually published in Progress in Biophysics and Molecular
Biology (1978), 34.’
|
:
Miscellaneous ms. sequences of notes, calculations and
narratives, some in the form of letters exchanged with
C.C. Michel,,
January-November 1975.
Similar material, February 1976-November 1977.
Ms. and typescript drafts and revisions for paper, brief
correspondence with collaborator and editor, 1978.
'Nucleic acid!
The material relates to a research programme to examine
The
A collaborative paper was prepared, and Ogston also
Folder includes notes and graphs, correspondence, detailed
research programme, meetings, etc., 1946-47, and later
correspondence and draft for paper 1950.
wrote a later paper 'Sedimentation and diffusion of dioxyribose
nucleic acid' (Trans. Faraday Soc., 46, 1950) a draft for which
is included.
the sedimentation constant of a nucleic acid sample.
enquiry was first made in 1946 by J.M. Gulland to R.A. Peters,
who passed it on to Ogston; the experiments were then carried
out in collaboration by Ogston and R.G. Cecil in Oxford and
D.O. Jordan in Nottingham.
Folder contains notes, results, correspondence, 1949-50.
the sedimentation, viscosity and molecular weight of sarcosine
polymers.
The work was originally undertaken at the request
of S. Waley (Courtaulds Limited).
Brief correspondence and draft only, for paper on ‘Exclusion
of inulin from solutions of hyaluronic acid', 1960.
The material relates to a research programme to investigate
‘Partition in HA'
'Polysarcosine’
A.G. Ogston
CSAC 98/2/84
Scientific research
‘Sedimentation.
Plug Theory’
Correspondence, 1950-51, with collaborator and colleagues
re research and paper on ‘Studies of the sedimentation,
diffusion and viscosity of some sarcosine polymers in aqueous
solution’, by Ogston and J.N. Fessler, published in Trans.
Includes discussion of referees’
Faraday Soc., 47, 1951.
comments and Ogston's ms. narrative 'Plug model of sedimentation’
pp.4-22, various dates, May 1950.
B.32-B.36
‘Sedimentation and diffusion theory’
B.32
5.30
B. 34
Miscellaneous ms. notes and narratives, some by Ogston but
mainly by R.L. Baldwin.
Only one set is dated (1952).
Correspondence with R.L. Baldwin, 1953-54.
Correspondence with L.H. Kent, 1955.
Miscellaneous ms. drafts by Ogston, on 'The Random Walk
and transport processes’ (sent with a covering note to R.P. Bell),
'Diffusion and movement’, etc.
Also included are two referees' comments on a paper by Ogston,
'A comparison of methods of describing diffusion in liquid
systems’ .
Later correspondence on subject, with R.H. Stokes, 1962.
‘Sedimentation in HA-protein mixtures’
Laurent.
Ms. sequences of notes and narratives on equilibrium sedi-
etc. on Johnston-
Ms. notes by Ogston ‘Effect of sector cell,
Ogston effect', June 1963 anda ms. draft letter on the subject
to T.C_
mentation, September~November 1965.
Ogston
A.G.
CSAC 98/2/84
Sc ientific research
ENZYME KINETICS
Ms. notes and calculations on 'phosphotransferase kinetics’,
September 1962.
Also included are two earlier papers on the subject by Ogston
and collaborators, 1955 and 1961 (offprints only).
ENZYMES: MOLECULAR WEIGHTS
Notes and correspondence, May 1962, for a paper ‘Molecular
weights of enzymes', Nature, 13 October 1962.
B.40-B.45
ENZYME SPECIFICITY
and 'Three-point attachment’
The material is mainly concerned with Ogston's note
‘On the interpretation of experiments on metabolic processes,
using isotopic tracer elements', published in Nature, December
18, 1948, and with correspondence and research arising there-
The argument he advanced attracted very wide interest
from.
and continues to be recognised as of fundamental importance
to stereochemistry (see B.45 as example only).
Curiously, Ogston does not include the paper, nor refer
Ina later autobiographical note (Nature, 276,
he wrote a modest disclaimer: '"Three-point attachment”
to the work, in his list of his principal contributions in A.9,
presumably because it lay somewhat outside his usual fields
of activity.
1978)
was a gift, out of the blue, for which | have never felt able
to claim much credit’.
comment from H.A. Krebs, 1950.
Correspondence arising from 1948 paper, from H.A. Krebs
(1948), V.R. Potter (enclosing manuscript, 1949), P.E. Wilcox
(enclosing manuscript, 1949).
Ms. and typescript draft of Ogston's paper 'On the specificity
of the enzyme aconitase' (Nature, 167, 1951), with letter of
Typescript draft for original paper, diagram, offprint of
published paper, 1948.
A.G. Ogston
CSAC 98/2/84
Scientific research
Miscellaneous ms. and typescript drafts for a paper by
Ogston, variously titled, on the differential reaction of
‘identical’ chemical groups.
With letters of comment by
Heo
A
bbe TN
Kraehe (1954) and is Ge Hodgkin (rn
INITEMO LEZ ee] Mi w
papers by other Liflanaues catia to in
dad. ) and including
ne
draft.
Photocopy (only) of ms. notes headed '1977.
Krebs.
A problem of isotope distribution in gluconeogenesis’ .
To Sir Hans
Copies of articles by J.W. Cornforth, 'Enzymes and Stereo-
chemistry’, Tetrahedron, 30,
Enzyme action’,
Ogston's work.
Ogston's 1948 paper as
1974, and 'Asymmetry and
Nobel Prize Lecture, 1975, alluding to
In the first of these, Cornforth describes
'a short classic note’.
Krebs, ‘Reminiscences and Reflections',
See also H.A.
O.U.P. 1981; Chapter 14 is devoted almost entirely to a
discussion of Ogston's 'penetrating theoretical analysis’ .
B.46-B.63
EQUILIBRIUM INTERACTIONS
The material relates to research and publications on
(Group II of Ogston's own analysis
a uniform random suspension of fibres’ (Trans.
‘Fibre space’
Ms. notes and drafts, November 1957, April 1958.
various aspects of equilibrium interactions of polymer
molecules in solution
of his research interests in A.9).
Ms. draft for paper ‘Spaces between fibres’, with referees’
comments, and offprint of version published under title
‘The spaces in
Faraday Soc., 54, November 1958).
correspondence.
Ms. draft for paper 'On the co-volume concept of interaction
between unlike molecules', submitted to J. Phys. Chem.,
December 1970, with referees’ comments and brief editorial
2 ms. narratives, 'Micelles viewed as interphases', 1967,
‘Aggregation treatment of micelles', 1972.
Miscellaneous notes and narratives, May 1967, March, May 1970.
'Micelles'
‘Molecular interaction exclusion’
Ogston
A.G.
CSAC 98/2/84
B.49, B.50
'Sedimentation - HA, Dextran’
Scientific research
Despite this designation on the original folder, Ogston
lists the paper on equilibrium sedimentation in Group II
of A.9 and it has therefore been included here.
Ms. notes and narratives by Ogston, January-August 1965.
Correspondence with editors, and referees' comments, re
publication in Biopolymers (February 1966) and The Biochemical
Journal (July 1966) of two papers by Ogston, L.W. Nichol
and B.N. Preston, 'The measurement of thermodynamic
non-ideality in polymers by sedimentation equilibrium’ and
'The equilibrium sedimentation of hyaluronic acid'.
letter from L.W. Nichol.
Includes
‘Quaternary (polyelectrolyte) systems'
Miscellaneous sequences of notes and narratives, 1965, 1967,
1969; 1971 ;
‘Synaptosomes light-scattering’
Correspondence on subject from R.M. Marchbanks, 1968.
8 a-BO7
‘Ternary thermodynamics’
Bo
2 ms. narratives, ‘Possibility of determining the character-
istics of synaptosomes by light-scattering’, ‘Measurement
of sizes of synaptosomes by light-scattering’, both May 1968.
Miscellaneous sequences of notes and narratives, various
dates, May-October 1961, leading up to and including ms.
draft for paper 'Some thermodynamic relationships in ternary
systems ...', published in Arch. Biochem. Biophys. Suppl. 1,
1962.
for joint paper in the Biochemical Journal, 1961-63.
Work in both these folders contains references to the work of
T. C. Laurent, see B.57 below.
Similar material, 1962.
Similar material, 1963-64.
Correspondence and comments on papers from D.H. Everett,
R.H. Stokes, 1961-62.
Correspondence with T.C. Laurent, including results and drafts
A.G. Ogston
CSAC 98/2/84
B.58-B .60
'Ternary systems phase relationships’
Scientific research
B.58
B. 59
B.60
Initial correspondence with colleagues on the problem,
line= duly 1966
SUIS Uy Fre
Miscellaneous sequences of notes and narratives, July 1966-
October 1968, and including correspondence with M.P. Tombs
Miscellaneous sequences of notes and narratives, and corres~
pondence with H. Tompa, February- July 1971.
'Thermodynamic non-ideality'
Mainly related to collaborative paper with D. J. Winzor,
'The treatment of thermodynamic non-ideality', submitted
to J. Phys. Chem., 1975.
Miscellaneous sequences of notes and narratives, October~-
December 1974.
Correspondence with collaborator and with editor.
referees' comments, 1975.
Includes
'Virus collisions’
B.64
B.65
B.64-B.72
HYALURONIC ACID (HA)
The material relates to research and publications on
the isolation and characterisation of hyaluronic acids (Group |
of Ogston's own analysis of his research interests in A.9).
Notes and correspondence, 1962, mainly relating to Ogston's
paper 'On uncertainties inherent in the determination of the
efficiency of collision between virus particles and cells’,
published in Biochim. Biophys. Acta, 66, 1963.
See B.73-B.75.
Correspondence, 1949-51, with Medical Research Council re
grants for research on ox synovial fluid.
Includes statement
of intended research, 1949, and of progress of work, October
1950 and May 1951.
Ogston obtained a grant from the Council for the construction
of an 'elastoviscometer'.
Notes and narratives by Ogston, and a 'Summary of U.F.R. -
protein position', by C.C. Curtain.
None dated.
B.64-B.69
‘Hyaluronic acid (HA) earlier calculations’
A.G. Ogston
CSAC 98/2/84
Scientific research
Correspondence with colleagues re research, supply of
specimens, discussion of results and publications.
In
chronological order.
1949-50.
195]
Includes ms. notes and calculations by Ogston, sent
to J.P. Johnston.
lyoze5s..
Notes, drafts and correspondence for later research paper on
subject, for publication in Nature, 1965.
HA 'Faraday Soc.'
Ms. notes of contributions to discussion at a meeting of the
Faraday Society in August 1952, at which papers on hyaluronic
acid were presented.
Includes proofs of papers by K. Meyer, and by Ogston and
J.E. Stanier, read and discussed at the meeting.
‘Bacterial HA'
'HA Light-scattering'
Notes, drafts and correspondence with collaborators, some
dated 1954.
Miscellaneous sequences of notes and drafts, November 1964-
May 1965, and Ogston's copy of his letter to B. N. Preston
on results.
his ideas for the apparatus.
(see 8.55 ff.), and built by a commercial supplier from design
sketches by Ogston who purchased the apparatus with the help
of a grant from the Medical Research Council.
Correspondence with B.A. Toms re research and publications
on synovial fluid, 1949.
Ogston's letter of 16 September outlines
This was developed for the work on ox synovial fluid
B.73-B.83
MEASURING DEVICES
B.73-8.75
ELASTOVISCOMETER
A.G. Ogston
CSAC 98/2/84
Scientific research
Correspondence with colleagues and with supplier re
'elastometer'.
1950 and one letter 1951.
Includes Ogston's specification and drawings.
Bs/e
Miscellaneous sequences of notes, graphs and calculations
on elastoviscosity.
Various dates, January-April 1952.
B.76-B.82
OSMOMETER
B.76
‘Sephadex bead osmometry'
Photographs, notes and correspondence, 1969-70.
Includes programme of Royal Society Conversazione, May 1972,
at which Ogston presented an exhibit on 'Use of gels for
micro-osmometry'.
'Loops'
Material mainly related to collaborative work with
Correspondence with collaborator and colleague
1972.
Ms. sequences of notes and narratives, October 1971, May-
June 1972.
B.N. Preston and a joint paper 'A sensitive and accurate gel
osmometer', published in Biochemical Journal, 1973.
sample of the work was displayed in the exhibition of Ogston's
career and research held in the Department of Biochemistry,
Oxford, in 1980, when it was described as ‘another of Professor
Ogston's original and very novel ideas for solving physico-
chemical problems involved in the use of acrylamide gel
bilayers to measure osmotic pressure’ .
A
Included here is a proof with ms. corrections of the osmometer
paper.
P. Silpananta, mainly 1972 but one set dated September 1966.
P. Silpananta and a joint paper submitted for publication in
Biochemical Journal, and later published in Biochem. Soc.
Transactions (1973).
B.79=B 8!
'Phase separation osmometry'
The material relates principally to collaborative work with
Notes, calculations and graphs, a few in the hand of
A.G. Ogston
CSAC 98/2/84
Scientific research
Miscellaneous ms. drafts for papers, on ‘Penetration of gel
by polymer at phase separation’ (February-March 1973),
and 'On the use of phase separation in mixed gels for the
micro-measurement of osmotic pressure’ (n.d. but with a
later ms. note 'This was never published’).
Correspondence with P. Silpananta and with editor, Biochemical
Journal, re joint paper 'Micro-gel osmometry by phase
separation', 1973.
Includes draft of paper, and photographs.
'Osmometry’
Later ms. notes and drafts, 1973, 1975, with a letter to
M.P. Tombs and related offprints on osmometer design.
REFRACTOMETER
Miscellaneous notes, calculations and drafts, only one set
dated 1963.
MUSTARD GAS
Research reports on the chemical reactivity of mustard
The reports are
gas, most by Ogston, a few collaborative.
almost all headed 'Research Item 21' (the code reference)
Duplicated reports, various dates, 1940-42.
(Linstead was
Two typescript reports, by Ogston and collaborators, n.d.
Included here is a 'Table of Competition Factors' annotated
and signed by RP. Linstead, June 1942.
then working at Harvard.)
Three ms. reports by Ogston, n.d.
Three ms. reports by Ogston, n.d.
A.G. Ogston
CSAC 98/2/84
B.88-B.91
OXIDATIVE PHOSPHORYLATION
Scientific research
san was described by Ogston (private communication,
1980) as ‘undertaken at the invitation of the Editor
of oe begun during my tenure of a Visiting Fellowship
at the Institute for Cancer Research, Philadelphia and com-
pleted during my tenure of a Visiting Fellowship at the John
Curtin School of Medical Research, A.N.U. in 1979’.
The paper, 'Some thoughts on oxidative phosphorylation’,
was not published.
Miscellaneous ms. and typescript drafts, and final typescript
of paper as submitted.
Miscellaneous ms. notes and narratives.
Notes for two short talks on the subject, given at Philadelphia
and Melbourne.
Correspondence with Nature, 1978-79.
Includes invitation to Ogston to write on 'chemiosmotic theory’,
later correspondence re paper and referees reports.
Correspondence with colleagues, 1979.
Ogston's letter of 19 April in reply to a historical enquiry
from B.H. Weber gives an account of his early (1948) involve-
ment in the subject.
A.G. Ogston
CSAC 98/2/84
SECTION C
CORRESPONDENCE C.1 - C.33
The correspondence is presented in an alphabetical sequence, indexed and
dated, with a brief note of any material of particular personal or scientific interest.
ie |
Alexander, A.
E.
PVA 'beads'.
Alexandrowitz, Z.
Osmotic pressures.
Armstrong, J.
McD.
Aschaffenburg, R.
1968
1965-66
1957
Comments on a paper by Ogston.
Balazs) br 2 A
1960, 1964-65
Research and publications, chiefly on equilibrium
sedimentation of hyaluronic acid.
Includes referees’ comments.
Batdwint,: Ry
Ei;
1955-356
Barnett; Gyr.
Synovial fluid viscosity.
THE BIOCHEMICAL JOURNAL
1963-65
Research and publications, chiefly on boundary
spreading .
Synovial fluid in joints.
Mainly re papers submitted by Ogston and colleagues
for publication.
Correspondence 1961 includes invitation to Ogston to
join Editorial Board (declined).
Mainly re papers submitted by Ogston for publication.
BIOCHIMICA ET BIOPHYSICA ACTA
1961-63
Budtz-Olsen, O.
EE.
1967
Arrangements for Ogston to lecture at Brisbane.
Charnley, J.
A.G. Ogston
CSAC 98/2/84
Crank, J.
Diffusion.
Cranston, R.
W.
Dale: bys
cH.
Correspondence
1960-61
Comments on a paper by Ogston.
Davenport, H.
Diffusion through gastric mucosa.
Davies, D:.
OGSTON, Alexander George
Published: 20 November, 2023 Author: admin